Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats

Laboratory Investigation

Volumn 92, Issue 10, 2012, Pages 1440-1450

  Klein, Sabine ^a   Klösel, Jeremias ^a   Schierwagen, Robert ^a   Körner, Christian ^a   Granzow, Michaela ^a   Huss, Sebastian ^a   Mazar, Irela Gretchen Reza ^a   Weber, Susanne ^b   Van Den Ven, Peter F M ^a   Pieper Fürst, Ursula ^a   Fürst, Dieter O ^a   Nattermann, Jacob ^a   Lammert, Frank ^b   Sauerbruch, Tilman ^a   Trebicka, Jonel ^a  

^a UNIVERSITY OF BONN   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

cytokines; fibrogenesis; hepatic stellate cells; HMG CoA reductase inhibitor; myofibroblasts; senescence

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ATORVASTATIN; BETA GALACTOSIDASE; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DESMIN; LIPOCORTIN 5; PROCOLLAGEN; PROCOLLAGEN 1A; PROPIDIUM IODIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL AGING; CELL ISOLATION; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; FIBROGENESIS; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CULTURE; LIVER FIBROSIS; LIVER PROTECTION; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

ACTINS; AGING; ANIMALS; APOPTOSIS; BETA-GALACTOSIDASE; CELL PROLIFERATION; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; DESMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HEPATIC STELLATE CELLS; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; LIVER CIRRHOSIS; MALE; MYOFIBROBLASTS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84866858655     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.106     Document Type: Article

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