Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells

Journal of Hepatology

Volumn 53, Issue 4, 2010, Pages 702-712

  Trebicka, Jonel ^a   Hennenberg, Martin ^a   Odenthal, Margarete ^c   Shir, Khanwali ^a   Klein, Sabine ^a   Granzow, Michaela ^a   Vogt, Annabelle ^a   Dienes, Hans Peter ^c   Lammert, Frank ^a,d   Reichen, Jürg ^b   Heller, Jörg ^a   Sauerbruch, Tilman ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF COLOGNE   (Germany)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

Apoptosis; Cytokines; Fibrogenesis; Hepatic stellate cells; HMG CoA reductase inhibitor; Proliferation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ATORVASTATIN; CASPASE 3; CATHEPSIN B; CATHEPSIN D; CYCLINE; CYTOKINE; GELATINASE A; HYDROXYPROLINE; KI 67 ANTIGEN; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROCOLLAGEN;

ANALYTICAL PARAMETERS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC EFFECT; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; EXPERIMENTAL RAT; EXTRACELLULAR MATRIX; HEPATITIS; IN VIVO STUDY; LIVER FIBROSIS; LIVER HISTOLOGY; MALE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM; SIRIUS RED STAINING; STAINING; STELLATE CELL; TURNOVER TIME; ZYMOGRAPHY;

ANIMALS; BILE DUCTS; CELL PROLIFERATION; HEPATIC STELLATE CELLS; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIGATION; LIVER CIRRHOSIS; MALE; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77956268976     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.04.025     Document Type: Article

References (32)

1. J.G. Abraldes, A. Rodriguez-Vilarrupla, M. Graupera, C. Zafra, H. Garcia-Caldero, and J.C. Garcia-Pagan Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl(4) cirrhotic rats J Hepatol 46 2007 1040 1046
2. I. Aprigliano, J. Dudas, G. Ramadori, and B. Saile Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells Liver Int 28 2008 546 557
3. R. Bataller, and D.A. Brenner Liver fibrosis J Clin Invest 115 2005 209 218
4. G.J. Becker, V. Perkovic, and T.D. Hewitson Pharmacological intervention in renal fibrosis and vascular sclerosis J Nephrol 14 2001 332 339
5. A.E. Black, R.N. Hayes, B.D. Roth, P. Woo, and T.F. Woolf Metabolism and excretion of atorvastatin in rats and dogs Drug Metab Dispos 27 1999 916 923
6. H.P. Dinges, and H. Redl Comparative evaluation of immunohistochemistry and enzyme histochemistry for granulocyte visualization in formalin-fixed and paraffin-embedded liver and lung biopsies Histochemistry 77 1983 9 14
7. S. Friedman The hepatic stellate cell P. Bedossa, Semin Liver Dis 2001 Thieme New York 307 452
8. S.L. Friedman Mechanisms of hepatic fibrogenesis Gastroenterology 134 2008 1655 1669
9. J.L. Gardner, S.M. Turner, A. Bautista, G. Lindwall, M. Awada, and M.K. Hellerstein Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions Am J Physiol Gastrointest Liver Physiol 292 2007 G1695 G1705
10. A. Gianella, E. Nobili, M. Abbate, C. Zoja, P. Gelosa, and L. Mussoni Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats Am J Pathol 170 2007 1165 1177
11. A.M. Gressner, and R. Weiskirchen Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets J Cell Mol Med 10 2006 76 99
12. J.B. Gross Jr., J. Reichen, T.B. Zeltner, and A. Zimmermann The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: correlation with morphometric measurement of hepatocyte mass Hepatology 7 1987 457 463
13. S. Hillebrandt, C. Goos, S. Matern, and F. Lammert Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15 Gastroenterology 123 2002 2041 2051
14. I.S. Jamall, V.N. Finelli, and S.S. Que Hee A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues Anal Biochem 112 1981 70 75
15. M. Kato, H. Iwamoto, N. Higashi, R. Sugimoto, K. Uchimura, and S. Tada Role of Rho small GTP binding protein in the regulation of actin cytoskeleton in hepatic stellate cells J Hepatol 31 1999 91 99
16. U. Kucich, J.C. Rosenbloom, G. Shen, W.R. Abrams, A.D. Hamilton, and S.M. Sebti TGF-β1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2 Arch Biochem Biophys 374 2000 313 324
17. U. Laufs, D. Marra, K. Node, and J.K. Liao 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1) J Biol Chem 274 1999 21926 21931
18. A. Moles, N. Tarrats, J.C. Fernandez-Checa, and M. Mari Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential Hepatology 49 2009 1297 1307
19. M. Moreno, L.N. Ramalho, P. Sancho-Bru, M. Ruiz-Ortega, F. Ramalho, and J.G. Abraldes Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver Am J Physiol Gastrointest Liver Physiol 296 2009 G147 G156
20. L. Nie, M. Imamura, H. Itoh, and H. Ueno Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin II receptor blocker, on CCl4-induced liver fibrosis in rats J UOEH 26 2004 165 177
21. F. Oberti, C. Pilette, H. Rifflet, M.Y. Maiga, A. Moreau, and Y. Gallois Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation J Hepatol 26 1997 1363 1371
22. M. Parola, F. Marra, and M. Pinzani Myofibroblast - like cells and liver fibrogenesis: emerging concepts in a rapidly moving scenario Mol Aspects Med 29 2008 58 66
23. M. Pinzani PDGF and signal transduction in hepatic stellate cells Front Biosci 7 2002 d1720 d1726
24. K. Rombouts, E. Kisanga, K. Hellemans, A. Wielant, D. Schuppan, and A. Geerts Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells J Hepatol 38 2003 564 572
25. J. Rosenbloom, B. Saitta, S. Gaidarova, N. Sandorfi, J.C. Rosenbloom, and W.R. Abrams Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I Arthritis Rheum 43 2000 1624 1632
26. S. Schulte, A. Oidtmann, N. Kociok, M. Demir, M. Odenthal, and U. Drebber Hepatocyte expression of angiotensin II type 1 receptor is downregulated in advanced human liver fibrosis Liver Int 29 2009 384 391
27. D. Schuppan, D. Strobel, and E.G. Hahn Hepatic fibrosis - therapeutic strategies Digestion 59 1998 385 390
28. J. Trebicka, M. Hennenberg, W. Laleman, N. Shelest, E. Biecker, and M. Schepke Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase Hepatology 46 2007 242 253
29. J. Trebicka, L. Leifeld, M. Hennenberg, E. Biecker, A. Eckhardt, and N. Fischer Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats Hepatology 47 2008 1264 1276
30. S. Wassmann, U. Laufs, A.T. Baumer, K. Muller, K. Ahlbory, and W. Linz HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species Hypertension 37 2001 1450 1457
31. T. Watanabe, M. Niioka, A. Ishikawa, S. Hozawa, M. Arai, and K. Maruyama Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat J Hepatol 35 2001 465 473
32. K.L. Watts, E.M. Sampson, G.S. Schultz, and M.A. Spiteri Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts Am J Respir Cell Mol Biol 32 2005 290 300