The role of recombinant pro-urokinase (r-pro-UK) and intra-arterial thrombolysis in acute ischaemic stroke: The PROACT trials

Current Medical Research and Opinion

Volumn 18, Issue SUPPL. 2, 2002, Pages

  Furlan, Anthony J ^a   Abou Chebl, Alex ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Acute stroke; Intra arterial; Pro urokinase; Thrombolysis; Treatment

Indexed keywords

RECOMBINANT PROTEIN; SARUPLASE; UROKINASE;

ACUTE DISEASE; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; FIBRINOLYTIC THERAPY; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; META ANALYSIS; METABOLISM; RANDOMIZED CONTROLLED TRIAL;

ACUTE DISEASE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; HUMANS; INFUSIONS, INTRA-ARTERIAL; RANDOMIZED CONTROLLED TRIALS; RECOMBINANT PROTEINS; THROMBOLYTIC THERAPY; URINARY PLASMINOGEN ACTIVATOR;

EID: 0036362078     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/030079902125000723     Document Type: Article

References (20)

1. Nenci GG, Gresele P, Taramelli M, et al. Thrombolytic therapy for thromboembolism of vertebrobasilar artery. Angiology 1983;34:561-71
2. del Zoppo GJ, Ferbert A, Otis S, et al. Local intra-arterial fibrinolytic therapy in acute carotid territory stroke: a pilot study. Stroke 1988;19:307-13
3. Hacke W, Zeumer H, Ferbert A, et al. Intra-arterial throm-bolytic therapy improves outcome in patients with acute vertebrobasilar occlusive disease. Stroke 1988;19:1216-22
4. Credo RB, Burke SE, Barker WM, et al. Recombinant glycosylated pro-urokinase: biochemistry, pharmacology, and early clinical experience. In Sasahara AA, Loscalzo J, eds. New Therapeutic Agents in Thrombosis and Thrombolysis. New York: Marcel Dekker, 1997:561-89
5. Gurewich V. Pro-urokinase: history, mechanisms of action and clinical development. In Sasahara AA, Loscalzo J, eds. New Therapeutic Agents in Thrombosis and Thrombolysis. New York: Marcel Dekker, 1997:539-59
6. Zeumer H, Freitag HJ, Zanella F, et al. Local intra-arterial fibrinolytic therapy in patients with stroke: urokinase versus recombinant tissue plasminogen activator (rt-PA). Neuroradiology 1993;35:159-62
7. Nesbit GM, Clark WM, O'Neil OR, Barnwell SL. Intra-cranial intra-arterial thrombolysis facilitated by micro-catheter navigation through an occluded cervical internal carotid artery. J Neurosurg 1996;84:387-92
8. Adams HP, Brott TG, Furlan AJ, Gomez CR, et al. Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke. Circulation 1996;94:1167-74
9. del Zoppo GJ, Higashida RT, Furlan AJ, et al. and the PROACT Investigators. PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. Stroke 1998;29: 4-11
10. Furlan AJ, Higashida R, Wechsler L, Schulz G, PROACT II investigators. PROACT II: recombinant prourokinase (r-proUK) in acute cerebral thromboembolism. Initial trial results. Stroke 1999;30:234 (Abstr)
11. TIMI Study Group. Special report: the Thrombolysis in Myocardial Infarction (TIMI) trial. N Engl J Med 1985; 312:932-6
12. Hacke W, Kaste M, Fieschi C, Toni D, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 1995;274: 1017-25
13. NINDS rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333:1581-7
14. Hacke W, Kaste M, Fieschi C, et al. Randomized double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischemic stroke (ECASS II). Lancet 1998;352:1245-51
15. Clark WM, Wissman S, Albers GW, et al. for the ATLANTIS Study Investigators. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours afters symptom onset: the ATLANTIS study: a randomized controlled trial. JAMA 1999;282:2019-26
16. Emergency Management of Stroke (EMS) Investigators. Combined intra-arterial and intravenous tPA for stroke. Stroke 1997; 28:273 (Abstr)
17. Pannell R, Black J, Gurewich V. The complementary modes of action of tissue plasminogen activator (t-PA) and pro-urokinase (pro-UK) by which their synergistic effect on clot lysis may be explained. J Clin Invest 1988;81:853-9
18. del Zopo GJ, Sasahara AA. Interventional use of plasminogen activators in central nervous system diseases. Med Clin N Am 1998;82:545-68
19. Van de Werf F. New fibrinolytics. In Topol E, ed. Textbook of Cardiovascular Medicine, Vol 2, No. 6. Philadelphia: Lippincott Williams & Wilkins, 1999
20. Ueda T, Sakaki S, Nochide I, et al. Angioplasty after intra-arterial thrombolysis for acute occlusion of intracranial arteries. Stroke 1998;29:2568-74