Antiplatelet mechanisms of TA-993 and its metabolite MB3 in ADP-induced platelet aggregation

European Journal of Pharmacology

Volumn 399, Issue 2-3, 2000, Pages 91-96

  Katoh, Makoto ^a   Karasawa, Tadashi ^a   Doi, Hisayoshi ^a   Odawara, Akio ^a   Takagi, Michino ^a   Ikeo, Tomihiro ^a   Narita, Hiroshi ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Actin polymerization; ADP; Ca2+, intracellular; Glycoprotein IIb IIIa receptor; Platelet; TA 993

Indexed keywords

3 ACETOXY 5 [2 (DIMETHYLAMINO)ETHYL] 2,3 DIHYDRO 8 METHYL 2 (4 METHYLPHENYL) 1,5 BENZOTHIAZEPIN 4(5H) ONE MALEATE; ADENOSINE DIPHOSPHATE; CALCIUM ION; CYCLIC AMP; CYCLIC GMP; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN 2B 3A RECEPTOR ANTAGONIST; MB3; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; TECHNIQUE; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ACTINS; ADENOSINE DIPHOSPHATE; BLOOD PLATELETS; CALCIUM; CYCLIC AMP; CYCLIC GMP; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOGEN; FURA-2; HUMANS; MALE; OLIGOPEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING;

EID: 0034617442     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00352-6     Document Type: Article

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