Improving the catalytic performance of an artificial metalloenzyme by computational design

Journal of the American Chemical Society

Volumn 137, Issue 32, 2015, Pages 10414-10419

  Heinisch, Tillmann ^a   Pellizzoni, Michela ^a   Dürrenberger, Marc ^a   Tinberg, Christine E ^b   Köhler, Valentin ^a   Klehr, Juliane ^a   Häussinger, Daniel ^a   Baker, David ^b,c   Ward, Thomas R ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CATALYST SELECTIVITY; CATALYSTS; CRYSTAL STRUCTURE; DESIGN; ENANTIOSELECTIVITY; ENZYMES; HYDROPHOBICITY; IRIDIUM; IRIDIUM COMPOUNDS; PROTEINS;

ARTIFICIAL TRANSFER; ASYMMETRIC REDUCTION; CATALYTIC PERFORMANCE; CATALYTIC PROPERTIES; COMPUTATIONAL DESIGN; COMPUTATIONAL MODEL; GENETIC OPTIMIZATION; HIGH ENANTIOSELECTIVITY;

STRUCTURAL DESIGN;

AMINO ACID; ARTIFICIAL TRANSFER HYDROGENASE; CARBONATE DEHYDRATASE II; CARBONYL DERIVATIVE; ENZYME; HYDROGENASE; IRIDIUM; SULFONAMIDE; UNCLASSIFIED DRUG; 5-DIMETHYLAMINONAPHTHALENE-1-SULFONAMIDE; COENZYME; DANSYL CHLORIDE; IMINE; METALLOPROTEIN; RECOMBINANT PROTEIN; SALSOLIDINE; SALSOLINE DERIVATIVE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENANTIOSELECTIVITY; HYDROPHOBICITY; CHEMICAL PHENOMENA; CHEMISTRY; COENZYME; GENETICS; HUMAN; METABOLISM; MUTATION; PROCEDURES; PROTEIN ENGINEERING; SOFTWARE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CARBONIC ANHYDRASE II; CATALYSIS; COENZYMES; CRYSTALLOGRAPHY, X-RAY; DANSYL COMPOUNDS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMINES; IRIDIUM; METALLOPROTEINS; MUTATION; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SALSOLINE ALKALOIDS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84939865243     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b06622     Document Type: Article

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