Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 56, Issue 5, 2015, Pages 2985-2992

  Kumar, Binit ^a   Kowluru, Anjan ^b,c   Kowluru, Renu A ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diabetic retinopathy; Hyperlipidemia; Mitochondria; NADPH oxidase; Oxidative stress

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL] AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; CERAMIDE; CYTOCHROME B; PALMITIC ACID; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG; CYBB PROTEIN, HUMAN; GLUCOSE; MEMBRANE PROTEIN; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; BOVINE; CELL ACTIVATION; DIABETIC RETINOPATHY; DNA DAMAGE; ENDOTHELIUM CELL; GENE EXPRESSION; GLUCOTOXICITY INDUCED MITOCHONDRIAL DAMAGE; HUMAN; LIPOTOXICITY; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; DRUG EFFECTS; DRUG POTENTIATION; GENETICS; HYPERGLYCEMIA; METABOLISM; MITOCHONDRION; PATHOLOGY; RETINA; VASCULAR ENDOTHELIUM;

ANIMALS; CYTOCHROMES B; DIABETIC RETINOPATHY; DNA DAMAGE; DNA, MITOCHONDRIAL; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; GLUCOSE; HUMANS; HYPERGLYCEMIA; MEMBRANE GLYCOPROTEINS; MITOCHONDRIA; NADPH OXIDASE; PALMITIC ACID; POLYMERASE CHAIN REACTION; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; RETINA;

EID: 84939838760     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-16466     Document Type: Article

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