A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy

Free Radical Biology and Medicine

Volumn 53, Issue 9, 2012, Pages 1729-1737

  Santos, Julia M ^a   Tewari, Shikha ^a   Kowluru, Renu A ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Diabetic retinopathy; Mitochondria; mtDNA biogenesis; mtDNA damage

Indexed keywords

GLUCOSE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOGENESIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; ENDOTHELIUM CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RESPIRATORY CHAIN; RETINA; RETINA CAPILLARY; RETINAL ENDOTHELIAL CELL; RETINAL MITOCHONDRIA; STREPTOZOCIN DIABETES;

ANIMALS; CATTLE; CELLS, CULTURED; CYTOCHROMES B; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; DNA DAMAGE; DNA GLYCOSYLASES; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; ELECTRON TRANSPORT; ENDOTHELIAL CELLS; GENE DOSAGE; GENE EXPRESSION; GLUCOSE; MALE; MITOCHONDRIA; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RETINA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS;

EID: 84867374188     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.08.588     Document Type: Article

References (37)

1. R. Klein, B.E.K. Klein, S.C. Jensen, and S.E. Moss The relation of socioeconomic factors to the incidence of proliferative diabetic retinopathy and loss of vision Ophthalmology 101 1994 68 76
2. E.Y. Chew Epidemiology of diabetic retinopathy Hosp. Med. 64 2003 396 399
3. M. Mizutani, T.S. Kern, and M. Lorenzi Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy J. Clin. Invest 97 1996 2883 2890
4. T.S. Kern, J. Tang, M. Mizutani, R. Kowluru, R. Nagraj, and M. Lorenzi Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol. Vis. Sci 41 2000 3972 3978
5. J.K. Krady, A. Basu, C.M. Allen, Y. Xu, K.F. LaNoue, and T.W. Gardner Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy Diabetes 54 2005 1559 1565
6. M. Brownlee The pathobiology of diabetic complications: a unifying mechanism Diabetes 54 2005 1615 1625
7. T.S. Kern, R. Kowluru, and R.L. Engerman Abnormalities of retinal metabolism in diabetes or galactosemia. ATPases and glutathione Invest. Ophthalmol. Vis. Sci. 35 1994 2962 2967
8. R.A. Kowluru, T.S. Kern, and R.L. Engerman Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system Free Radic. Biol. Med 22 1997 587 592
9. R.A. Kowluru, and S.N. Abbas Diabetes-induced mitochondrial dysfunction in the retina Invest. Ophthalmol. Vis. Sci. 44 2003 5327 5334
10. S.G. Jarrett, H. Lin, B.F. Godley, M.E. Boulton, and D.N.A. Mitochondrial damage and its potential role in retinal degeneration Prog. Retin. Eye Res 27 2008 596 607
11. S.A. Madsen-Bouters, G. Mohammad, M. Kanwar, and R.A. Kowluru Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression Antioxid. Redox Signal 13 2010 797 805
12. J.M. Santos, S. Tewari, A.F.X. Goldberg, and R.A. Kowluru Mitochondria biogenesis and the development of diabetic retinopathy Free Radic. Biol. Med. 51 2011 1849 1860
13. S. Tewari, J.M. Santos, and R.A. Kowluru Damaged mitochondrial DNA replication system and the development of diabetic retinopathy Antioxid. Redox Signal 17 2012 492 504
14. R.A. Kowluru, T.S. Kern, R.L. Engerman, and D. Armstrong Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxidants Diabetes 45 1996 1233 1237
15. R.A. Kowluru, L. Atasi, and Y.S. Ho Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy. Invest Ophthalmol. Vis. Sci 47 2006 1594 1599
16. T.M. Best, R. Fiebig, D.T. Corr, S. Brickson, and L. Ji Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits J. Appl. Physiol 87 1999 74 82
17. S. Leutner, A. Eckert, and W. Müller ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain J. Neural Transm 108 2001 955-567
18. P.S. Chan, M. Kanwar, and R.A. Kowluru Resistance of retinal inflammatory mediators to suppress after re-institution of good glycemic control: novel mechanism for metabolic memory J. Diabetes Complications 24 2010 55 63
19. M. Kanwar, and R. Kowluru Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy Diabetes 58 2009 227 234
20. Q. Zhong, and R.A. Kowluru Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon J. Cell. Biochem 110 2010 1306 1313
21. Q. Zhong, and R.A. Kowluru Diabetic retinopathy and damage to mitochondrial structure and transport machinery. Invest Ophthalmol. Vis. Sci 52 2011 8739 8746
22. Q. Zhong, and R.A. Kowluru Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy Diabetes 60 2011 1304 1313
23. V. Parra, V. Eisner, and M. Chiong Criollo A, Moraga F, Garcia A, et al. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis Cardiovasc. Res 77 2008 387 397
24. K. Ohgaki, T. Kanki, A. Fukuoh, H. Kurisaki, Y. Aoki, and M. Ikeuchi The C-terminal tail of mitochondrial transcription factor a markedly strengthens its general binding to DNA J. Biochem 141 2007 201 211
25. R.N. Frank Diabetic retinopathy N. Engl. J. Med. 350 2004 48 58
26. J.G. Cunha-Vaz The blood-retinal barriers Doc. Ophthalmol. 41 1976 287 327
27. H.P. Hammes Pericytes and the pathogenesis of diabetic retinopathy Horm. Metab. Res. 37 2005 39 43
28. R.A. Kowluru, and P.S. Chan Metabolic memory in diabetes - from in vitro oddity to in vivo problem: role of apoptosis Brain Res. Bull 87 2010 297 302
29. R.A. Kowluru, R.L. Engerman, and T.S. Kern Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine Curr. Eye Res 21 2000 814 819
30. R.A. Kowluru, P. Koppolu, S. Chakrabarti, and S. Chen Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants Free Radic. Res 37 2003 1169 1180
31. S. Madsen-Bouterse, Q. Zhong, G. Mohammad, Y.S. Ho, and R.A. Kowluru Oxidative damage of mitochondrial DNA in diabetes, and its protection by manganese superoxide dismutase Free Radic. Res 44 2010 313 321
32. R.C. Scarpulla Transcriptional paradigms in mammalian mitochondrial biogenesis and function Physiol. Rev 88 2008 611 638
33. R.C. Scarpulla Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator Ann. N. Y. Acad. Sci 1147 2008 321 334
34. C.S. Malarkey, M. Bestwick, J.E. Kuhlwilm, G.S. Shadel, and M.E. Churchill Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA Nucleic Acids Res 40 2012 614 624
35. G. Mohammad, and R.A. Kowluru Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction Lab. Invest 90 2010 1365 1372
36. A.J. Barber, E. Lieth, S.A. Khin, D.A. Antonetti, A.G. Buchanan, and T.W. Gardner Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin J. Clin. Invest 102 1998 783 791
37. J.Y. Durham, and I.M. Herman Microvascular modifications in diabetic retinopathy Curr. Diab. Res 11 2011 253 264