메뉴 건너뛰기




Volumn 11, Issue 9, 2015, Pages 1435-1447

Drug-drug interactions that interfere with statin metabolism

Author keywords

Atorvastatin; CYP2C9; CYP3A4; Electric medical record; Fluvastatin; Lovastatin; Simvastatin

Indexed keywords

CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; HYPOCHOLESTEROLEMIC AGENT;

EID: 84939802008     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2015.1056149     Document Type: Review
Times cited : (71)

References (141)
  • 2
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990;343(6257):425-30
    • (1990) Nature , vol.343 , Issue.6257 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 3
    • 0017043554 scopus 로고
    • Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity
    • Endo A, Kuroda M, Tanzawa K. Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Lett 1976;72(2):323-6
    • (1976) FEBS Lett , vol.72 , Issue.2 , pp. 323-326
    • Endo, A.1    Kuroda, M.2    Tanzawa, K.3
  • 5
    • 33645875021 scopus 로고    scopus 로고
    • Statin safety: An assessment using an administrative claims database
    • Cziraky MJ, Willey VJ, McKenney JM, et al. Statin safety: an assessment using an administrative claims database. Am J Cardiol 2006;97(8A):61C-8C
    • (2006) Am J Cardiol , vol.97 , Issue.8 A , pp. 61C-8C
    • Cziraky, M.J.1    Willey, V.J.2    McKenney, J.M.3
  • 6
    • 3042623891 scopus 로고    scopus 로고
    • Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy
    • Chang JT, Staffa JA, Parks M, Green L. Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy. Pharmacoepidemiol Drug Saf 2004;13(7):417-26
    • (2004) Pharmacoepidemiol Drug Saf , vol.13 , Issue.7 , pp. 417-426
    • Chang, J.T.1    Staffa, J.A.2    Parks, M.3    Green, L.4
  • 7
    • 0036051323 scopus 로고    scopus 로고
    • Effects of HMG-CoA reductase inhibitors on skeletal muscle: Are all statins the same
    • Evans M, Rees A. Effects of HMG-CoA reductase inhibitors on skeletal muscle: are all statins the same? Drug Saf 2002;25(9):649-63
    • (2002) Drug Saf , vol.25 , Issue.9 , pp. 649-663
    • Evans, M.1    Rees, A.2
  • 9
    • 0023697436 scopus 로고
    • Efficacy and long-term adverse effect pattern of lovastatin
    • Tobert JA. Efficacy and long-term adverse effect pattern of lovastatin. Am J Cardiol 1988;62(15):28J-34J
    • (1988) Am J Cardiol , vol.62 , Issue.15 , pp. 28J-34J
    • Tobert, J.A.1
  • 10
    • 10244249180 scopus 로고    scopus 로고
    • Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the scandinavian simvastatin survival study
    • Pedersen TR, Berg K, Cook TJ, et al. Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the scandinavian simvastatin survival study. Arch Int Med 1996;156(18):2085-92
    • (1996) Arch Int Med , vol.156 , Issue.18 , pp. 2085-2092
    • Pedersen, T.R.1    Berg, K.2    Cook, T.J.3
  • 11
    • 33846704936 scopus 로고    scopus 로고
    • Safety profile of rosuvastatin: Results of a prescription-event monitoring study of 11,680 patients
    • Kasliwal R, Wilton LV, Cornelius V, et al. Safety profile of rosuvastatin: results of a prescription-event monitoring study of 11,680 patients. Drug Saf 2007;30(2):157-70
    • (2007) Drug Saf , vol.30 , Issue.2 , pp. 157-170
    • Kasliwal, R.1    Wilton, L.V.2    Cornelius, V.3
  • 12
    • 32444444724 scopus 로고    scopus 로고
    • Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients - The PRIMO study
    • Bruckert E, Hayem G, Dejager S, et al. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study. Cardiovasc Drugs Ther 2005;19(6):403-14
    • (2005) Cardiovasc Drugs Ther , vol.19 , Issue.6 , pp. 403-414
    • Bruckert, E.1    Hayem, G.2    Dejager, S.3
  • 13
    • 0027936936 scopus 로고
    • Prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats by mevalonic acid supplementation
    • Hrab RV, Hartman HA, Cox RH. Prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats by mevalonic acid supplementation. Teratology 1994;50(1):19-26
    • (1994) Teratology , vol.50 , Issue.1 , pp. 19-26
    • Hrab, R.V.1    Hartman, H.A.2    Cox, R.H.3
  • 14
    • 0031193851 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitor-induced myotoxicity: Pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular-weight proteins in neonatal rat muscle cell culture
    • Flint OP, Masters BA, Gregg RE, Durham SK. HMG CoA reductase inhibitor-induced myotoxicity: pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular-weight proteins in neonatal rat muscle cell culture. Toxicol Appl Pharmacol 1997;145(1):99-110
    • (1997) Toxicol Appl Pharmacol , vol.145 , Issue.1 , pp. 99-110
    • Flint, O.P.1    Masters, B.A.2    Gregg, R.E.3    Durham, S.K.4
  • 15
    • 0028973458 scopus 로고
    • Differential sensitivity of C2-C12 striated muscle cells to lovastatin and pravastatin
    • Gadbut AP, Caruso AP, Galper JB. Differential sensitivity of C2-C12 striated muscle cells to lovastatin and pravastatin. J Molecul Cell Cardiol 1995;27(10):2397-402
    • (1995) J Molecul Cell Cardiol , vol.27 , Issue.10 , pp. 2397-2402
    • Gadbut, A.P.1    Caruso, A.P.2    Galper, J.B.3
  • 16
    • 0025818108 scopus 로고
    • HMG-CoA reductase inhibitorinduced myopathy in the rat: Cyclosporine A interaction and mechanism studies
    • Smith PF, Eydelloth RS, Grossman SJ, et al. HMG-CoA reductase inhibitorinduced myopathy in the rat: cyclosporine A interaction and mechanism studies. J Pharmacol Exp Ther 1991;257(3):1225-35
    • (1991) J Pharmacol Exp Ther , vol.257 , Issue.3 , pp. 1225-1235
    • Smith, P.F.1    Eydelloth, R.S.2    Grossman, S.J.3
  • 17
    • 0030635481 scopus 로고    scopus 로고
    • The efficacy and six-week tolerability of simvastatin 80 and 160 mg/day
    • Davidson MH, Stein EA, Dujovne CA, et al. The efficacy and six-week tolerability of simvastatin 80 and 160 mg/day. Am J Cardiol 1997;79(1):38-42
    • (1997) Am J Cardiol , vol.79 , Issue.1 , pp. 38-42
    • Davidson, M.H.1    Stein, E.A.2    Dujovne, C.A.3
  • 18
    • 0031021614 scopus 로고    scopus 로고
    • Enhanced myopathy following administration of hypolipidemic agents under urethane anesthesia
    • Nakai A, Nishikata M, Uchida T, et al. Enhanced myopathy following administration of hypolipidemic agents under urethane anesthesia. Biol Pharmaceut Bull 1997;20(1):104-6
    • (1997) Biol Pharmaceut Bull , vol.20 , Issue.1 , pp. 104-106
    • Nakai, A.1    Nishikata, M.2    Uchida, T.3
  • 19
    • 34250742590 scopus 로고    scopus 로고
    • Interactions between statins and macrolide antibiotics
    • Molden E, Andersson KS, Jacobsen D. Interactions between statins and macrolide antibiotics. Tidsskr Nor Laegeforen 2007;127(12):1660-1
    • (2007) Tidsskr Nor Laegeforen , vol.127 , Issue.12 , pp. 1660-1661
    • Molden, E.1    Andersson, K.S.2    Jacobsen, D.3
  • 20
    • 33845876333 scopus 로고    scopus 로고
    • Risks associated with statin therapy: A systematic overview of randomized clinical trials
    • Kashani A, Phillips CO, Foody JM, et al. Risks associated with statin therapy: a systematic overview of randomized clinical trials. Circulation 2006;114(25):2788-97
    • (2006) Circulation , vol.114 , Issue.25 , pp. 2788-2797
    • Kashani, A.1    Phillips, C.O.2    Foody, J.M.3
  • 21
    • 0035012075 scopus 로고    scopus 로고
    • Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes
    • Nakai D, Nakagomi R, Furuta Y, et al. Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J Pharmacol Exp Ther 2001;297(3):861-7
    • (2001) J Pharmacol Exp Ther , vol.297 , Issue.3 , pp. 861-867
    • Nakai, D.1    Nakagomi, R.2    Furuta, Y.3
  • 22
    • 33645868967 scopus 로고    scopus 로고
    • Statin safety and drug interactions: Clinical implications
    • Bottorff MB. Statin safety and drug interactions: clinical implications. Am J Cardiol 2006;97(8A):27C-31C
    • (2006) Am J Cardiol , vol.97 , Issue.8 A , pp. 27C-31C
    • Bottorff, M.B.1
  • 23
    • 34249045146 scopus 로고    scopus 로고
    • Age-related differences in the prevalence of potential drug-drug interactions in ambulatory dyslipidaemic patients treated with statins
    • Egger SS, Rätz Bravo AE, Hess L, et al. Age-related differences in the prevalence of potential drug-drug interactions in ambulatory dyslipidaemic patients treated with statins. Drugs Aging 2007;24(5):429-40
    • (2007) Drugs Aging , vol.24 , Issue.5 , pp. 429-440
    • Egger, S.S.1    Rätz Bravo, A.E.2    Hess, L.3
  • 24
    • 30344436628 scopus 로고    scopus 로고
    • Statin/fibrate combination in patients with metabolic syndrome or diabetes: Evaluating the risks of pharmacokinetic drug interactions
    • Davidson MH. Statin/fibrate combination in patients with metabolic syndrome or diabetes: evaluating the risks of pharmacokinetic drug interactions. Expert Opin Drug Saf 2006;5(1):145-56
    • (2006) Expert Opin Drug Saf , vol.5 , Issue.1 , pp. 145-156
    • Davidson, M.H.1
  • 25
    • 0034476733 scopus 로고    scopus 로고
    • The potential for drug interactions with statin therapy in Ireland
    • Heerey A, Barry M, Ryan M, Kelly A. The potential for drug interactions with statin therapy in Ireland. Ir J Med Sci 2000;169(3):176-9
    • (2000) Ir J Med Sci , vol.169 , Issue.3 , pp. 176-179
    • Heerey, A.1    Barry, M.2    Ryan, M.3    Kelly, A.4
  • 26
    • 0036707908 scopus 로고    scopus 로고
    • Hospital admissions resulting from preventable adverse drug reactions
    • McDonnell PJ, Jacobs MR. Hospital admissions resulting from preventable adverse drug reactions. Ann Pharmacother 2002;36(9):1331-6
    • (2002) Ann Pharmacother , vol.36 , Issue.9 , pp. 1331-1336
    • McDonnell, P.J.1    Jacobs, M.R.2
  • 28
    • 58549096276 scopus 로고    scopus 로고
    • Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence
    • Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85(2):198-203
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.2 , pp. 198-203
    • Schwartz, J.B.1
  • 29
    • 0036291921 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors
    • Williams D, Feely J. Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. Clin Pharmacokinet 2002;41(5):343-70
    • (2002) Clin Pharmacokinet , vol.41 , Issue.5 , pp. 343-370
    • Williams, D.1    Feely, J.2
  • 31
    • 33748042671 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions
    • Shitara Y, Sugiyama Y. Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions. Pharmacol Ther 2006;112(1):71-105
    • (2006) Pharmacol Ther , vol.112 , Issue.1 , pp. 71-105
    • Shitara, Y.1    Sugiyama, Y.2
  • 32
    • 45549091043 scopus 로고    scopus 로고
    • Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin
    • Neuvonen PJ, Backman JT, Niemi M. Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin. Clin Pharmacokinet 2008;47(7):463-74
    • (2008) Clin Pharmacokinet , vol.47 , Issue.7 , pp. 463-474
    • Neuvonen, P.J.1    Backman, J.T.2    Niemi, M.3
  • 33
    • 0242383181 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of atorvastatin
    • Lennernäs H. Clinical pharmacokinetics of atorvastatin. Clin Pharmacokinet 2003;42(13):1141-60
    • (2003) Clin Pharmacokinet , vol.42 , Issue.13 , pp. 1141-1160
    • Lennernäs, H.1
  • 34
    • 0035434397 scopus 로고    scopus 로고
    • Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins)
    • Igel M, Sudhop T, von Bergmann K. Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins). Eur J Clin Pharmacol 2001;57(5):357-64
    • (2001) Eur J Clin Pharmacol , vol.57 , Issue.5 , pp. 357-364
    • Igel, M.1    Sudhop, T.2    Von Bergmann, K.3
  • 35
    • 57049187605 scopus 로고    scopus 로고
    • Interaction between statins and clopidogrel: Is there anything clinically relevant
    • Bhindi R, Ormerod O, Newton J, et al. Interaction between statins and clopidogrel: is there anything clinically relevant? QJM 2008;101(12):915-25
    • (2008) QJM , vol.101 , Issue.12 , pp. 915-925
    • Bhindi, R.1    Ormerod, O.2    Newton, J.3
  • 36
    • 33845420011 scopus 로고    scopus 로고
    • Drug interactions with lipid-lowering drugs: Mechanisms and clinical relevance
    • Neuvonen PJ, Niemi M, Backman JT. Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther 2006;80(6):565-81
    • (2006) Clin Pharmacol Ther , vol.80 , Issue.6 , pp. 565-581
    • Neuvonen, P.J.1    Niemi, M.2    Backman, J.T.3
  • 37
    • 0034495168 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of pravastatin: Mechanisms of pharmacokinetic events
    • Hatanaka T. Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events. Clin Pharmacokinet 2000;39(6):397-412
    • (2000) Clin Pharmacokinet , vol.39 , Issue.6 , pp. 397-412
    • Hatanaka, T.1
  • 38
    • 0036708020 scopus 로고    scopus 로고
    • A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin
    • White CM. A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin. J Clin Pharmacol 2002;42(9):963-70
    • (2002) J Clin Pharmacol , vol.42 , Issue.9 , pp. 963-970
    • White, C.M.1
  • 39
    • 3242695305 scopus 로고    scopus 로고
    • Effect of gemfibrozil on the metabolism of pitavastatin-determining the best animal model for human CYP and UGT activities
    • Fujino H, Saito T, Tsunenari Y, Kojima J. Effect of gemfibrozil on the metabolism of pitavastatin-determining the best animal model for human CYP and UGT activities. Drug Metabol Drug Interact 2004;20(1-2):25-42
    • (2004) Drug Metabol Drug Interact , vol.20 , Issue.1-2 , pp. 25-42
    • Fujino, H.1    Saito, T.2    Tsunenari, Y.3    Kojima, J.4
  • 40
    • 78650832968 scopus 로고    scopus 로고
    • Effects of atorvastatin and rosuvastatin on thromboxane-dependent platelet activation and oxidative stress in hypercholesterolemia
    • Puccetti L, Santilli F, Pasqui AL, et al. Effects of atorvastatin and rosuvastatin on thromboxane-dependent platelet activation and oxidative stress in hypercholesterolemia. Atherosclerosis 2011;214(1):122-8
    • (2011) Atherosclerosis , vol.214 , Issue.1 , pp. 122-128
    • Puccetti, L.1    Santilli, F.2    Pasqui, A.L.3
  • 41
    • 38949204984 scopus 로고    scopus 로고
    • Cytochromes P450: A structure-based summary of biotransformations using representative substrates
    • Brown CM, Reisfeld B, Mayeno AN. Cytochromes P450: a structure-based summary of biotransformations using representative substrates. Drug Metabol Rev 2008;40(1):1-100
    • (2008) Drug Metabol Rev , vol.40 , Issue.1 , pp. 1-100
    • Brown, C.M.1    Reisfeld, B.2    Mayeno, A.N.3
  • 42
    • 54949144309 scopus 로고    scopus 로고
    • Functional pharmacogenetics/ genomics of human cytochromes P450 involved in drug biotransformation
    • Zanger UM, Turpeinen M, Klein K, Schwab M. Functional pharmacogenetics/ genomics of human cytochromes P450 involved in drug biotransformation. Anal Bioanal Chem 2008;392(6):1093-108
    • (2008) Anal Bioanal Chem , vol.392 , Issue.6 , pp. 1093-1108
    • Zanger, U.M.1    Turpeinen, M.2    Klein, K.3    Schwab, M.4
  • 43
    • 50249098738 scopus 로고    scopus 로고
    • Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin
    • Park J-EE, Kim K-BB, Bae SK, et al. Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin. Xenobiotica 2008;38(9):1240-51
    • (2008) Xenobiotica , vol.38 , Issue.9 , pp. 1240-1251
    • Park, J.-E.E.1    Kim, K.-B.B.2    Bae, S.K.3
  • 44
    • 0032805692 scopus 로고    scopus 로고
    • New insights into the pharmacodynamic and pharmacokinetic properties of statins
    • Corsini A, Bellosta S, Baetta R, et al. New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacol Ther 1999;84(3):413-28
    • (1999) Pharmacol Ther , vol.84 , Issue.3 , pp. 413-428
    • Corsini, A.1    Bellosta, S.2    Baetta, R.3
  • 45
    • 0036909541 scopus 로고    scopus 로고
    • Safety considerations for statins
    • Bolego C, Baetta R, Bellosta S, et al. Safety considerations for statins. Cur Opin Lipidol 2002;13(6):637-44
    • (2002) Cur Opin Lipidol , vol.13 , Issue.6 , pp. 637-644
    • Bolego, C.1    Baetta, R.2    Bellosta, S.3
  • 46
    • 0346433752 scopus 로고    scopus 로고
    • CYP3A4 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin in primary hypercholesterolemia
    • Kajinami K, Brousseau ME, Ordovas JM, Schaefer EJ. CYP3A4 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin in primary hypercholesterolemia. Am J Cardiol 2004;93(1):104-7
    • (2004) Am J Cardiol , vol.93 , Issue.1 , pp. 104-107
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 47
    • 0032547341 scopus 로고    scopus 로고
    • Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    • Rebbeck TR, Jaffe JM, Walker AH, et al. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Nat Cancer Instit 1998;90(16):1225-9
    • (1998) J Nat Cancer Instit , vol.90 , Issue.16 , pp. 1225-1229
    • Rebbeck, T.R.1    Jaffe, J.M.2    Walker, A.H.3
  • 48
    • 0032825907 scopus 로고    scopus 로고
    • Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4
    • Ball SE, Scatina J, Kao J, et al. Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4. Clin Pharmacol Ther 1999;66(3):288-94
    • (1999) Clin Pharmacol Ther , vol.66 , Issue.3 , pp. 288-294
    • Ball, S.E.1    Scatina, J.2    Kao, J.3
  • 49
    • 0345643389 scopus 로고    scopus 로고
    • Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5'-upstream regulatory region
    • Westlind A, Lofberg L, Tindberg N, et al. Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region. Biochem Biophys Res Commun 1999;259(1):201-5
    • (1999) Biochem Biophys Res Commun , vol.259 , Issue.1 , pp. 201-205
    • Westlind, A.1    Lofberg, L.2    Tindberg, N.3
  • 50
    • 0033632228 scopus 로고    scopus 로고
    • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity
    • Sata F, Sapone A, Elizondo G, et al. CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. Clin Pharmacol Ther 2000;67(1):48-56
    • (2000) Clin Pharmacol Ther , vol.67 , Issue.1 , pp. 48-56
    • Sata, F.1    Sapone, A.2    Elizondo, G.3
  • 51
    • 0033861614 scopus 로고    scopus 로고
    • CYP3A activity in African American and European American men: Population differences and functional effect of the CYP3A4 1B5'-promoter region polymorphism
    • Wandel C, Witte JS, Hall JM, et al. CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4 1B5'-promoter region polymorphism. Clin Pharmacol Ther 2000;68(1):82-91
    • (2000) Clin Pharmacol Ther , vol.68 , Issue.1 , pp. 82-91
    • Wandel, C.1    Witte, J.S.2    Hall, J.M.3
  • 52
    • 0034959461 scopus 로고    scopus 로고
    • Identification and functional characterization of eight CYP3A4 protein variants
    • Eiselt R, Domanski TL, Zibat A, et al. Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics 2001;11(5):447-58
    • (2001) Pharmacogenetics , vol.11 , Issue.5 , pp. 447-458
    • Eiselt, R.1    Domanski, T.L.2    Zibat, A.3
  • 53
    • 84896792376 scopus 로고    scopus 로고
    • Effect of CYP3A4∗22, CYP3A5 3, and CYP3A combined genotypes on cyclosporine, everolimus, and tacrolimus pharmacokinetics in renal transplantation
    • Moes DJ, Swen JJ, den Hartigh J, et al. Effect of CYP3A4∗22, CYP3A5 3, and CYP3A combined genotypes on cyclosporine, everolimus, and tacrolimus pharmacokinetics in renal transplantation. CPT 2014;3:e100
    • (2014) CPT , vol.3 , pp. e100
    • Moes, D.J.1    Swen, J.J.2    Den Hartigh, J.3
  • 54
    • 38849209078 scopus 로고    scopus 로고
    • Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms
    • Hirota T, Takane H, Higuchi S, Ieiri I. Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms. Cur Drug Metabol 2008;9(1):34-8
    • (2008) Cur Drug Metabol , vol.9 , Issue.1 , pp. 34-38
    • Hirota, T.1    Takane, H.2    Higuchi, S.3    Ieiri, I.4
  • 55
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl P, Zhang J, Lin Y, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Gen 2001;27(4):383-91
    • (2001) Nat Gen , vol.27 , Issue.4 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3
  • 56
    • 4143049054 scopus 로고    scopus 로고
    • Lipid-lowering response to statins is affected by CYP3A5 polymorphism
    • Kivisto KT, Niemi M, Schaeffeler E, et al. Lipid-lowering response to statins is affected by CYP3A5 polymorphism. Pharmacogenetics 2004;14(8):523-5
    • (2004) Pharmacogenetics , vol.14 , Issue.8 , pp. 523-525
    • Kivisto, K.T.1    Niemi, M.2    Schaeffeler, E.3
  • 57
    • 28144440151 scopus 로고    scopus 로고
    • The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment
    • Fiegenbaum M, da Silveira FR, Van der Sand CR, et al. The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. Clin Pharmacol Ther 2005;78(5):551-8
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.5 , pp. 551-558
    • Fiegenbaum, M.1    Da Silveira, F.R.2    Van Der Sand, C.R.3
  • 58
    • 28744439821 scopus 로고    scopus 로고
    • Catalytic activities of human cytochrome P450 2C9 1, 2C9 3 and 2C9 13
    • Guo Y, Wang Y, Si D, et al. Catalytic activities of human cytochrome P450 2C9 1, 2C9 3 and 2C9 13. Xenobiotica 2005;35(9):853-61
    • (2005) Xenobiotica , vol.35 , Issue.9 , pp. 853-861
    • Guo, Y.1    Wang, Y.2    Si, D.3
  • 59
    • 0042627731 scopus 로고    scopus 로고
    • Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterollowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers
    • Kirchheiner J, Kudlicz D, Meisel C, et al. Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterollowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers. Clin Pharmacol Ther 2003;74(2):186-94
    • (2003) Clin Pharmacol Ther , vol.74 , Issue.2 , pp. 186-194
    • Kirchheiner, J.1    Kudlicz, D.2    Meisel, C.3
  • 60
    • 84866131000 scopus 로고    scopus 로고
    • Lipid-lowering effect of fluvastatin in relation to cytochrome P450 2C9 variant alleles frequently distributed in the Czech population
    • Buzková H, Pechandová K, Danzig V, et al. Lipid-lowering effect of fluvastatin in relation to cytochrome P450 2C9 variant alleles frequently distributed in the Czech population. Med Sci Monit 2012;18(8):CR512-17
    • (2012) Med Sci Monit , vol.18 , Issue.8 , pp. CR512-CR517
    • Buzková, H.1    Pechandová, K.2    Danzig, V.3
  • 61
    • 0037490080 scopus 로고    scopus 로고
    • Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis
    • Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003;326(7404):1423
    • (2003) BMJ , vol.326 , Issue.7404 , pp. 1423
    • Law, M.R.1    Wald, N.J.2    Rudnicka, A.R.3
  • 62
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: A systematic review
    • Law M, Rudnicka AR. Statin safety: a systematic review. Am J Cardiol 2006;97(8A):52C-60C
    • (2006) Am J Cardiol , vol.97 , Issue.8 A , pp. 52C-60C
    • Law, M.1    Rudnicka, A.R.2
  • 63
    • 0031803373 scopus 로고    scopus 로고
    • Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin
    • Kivisto KT, Kantola T, Neuvonen PJ. Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. Br J Clin Pharmacol 1998;46(1):49-53
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.1 , pp. 49-53
    • Kivisto, K.T.1    Kantola, T.2    Neuvonen, P.J.3
  • 64
    • 0029758869 scopus 로고    scopus 로고
    • Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid
    • Neuvonen PJ, Jalava KM. Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther 1996;60(1):54-61
    • (1996) Clin Pharmacol Ther , vol.60 , Issue.1 , pp. 54-61
    • Neuvonen, P.J.1    Jalava, K.M.2
  • 65
    • 0034961379 scopus 로고    scopus 로고
    • Inhibition of in vitro metabolism of simvastatin by itraconazole in humans and prediction of in vivo drug-drug interactions
    • Ishigam M, Uchiyama M, Kondo T, et al. Inhibition of in vitro metabolism of simvastatin by itraconazole in humans and prediction of in vivo drug-drug interactions. Pharmaceut Res 2001;18(5):622-31
    • (2001) Pharmaceut Res , vol.18 , Issue.5 , pp. 622-631
    • Ishigam, M.1    Uchiyama, M.2    Kondo, T.3
  • 66
    • 34047192918 scopus 로고    scopus 로고
    • Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients
    • Molden E, Andersson KS. Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients. Pharmacotherapy 2007;27(4):603-7
    • (2007) Pharmacotherapy , vol.27 , Issue.4 , pp. 603-607
    • Molden, E.1    Andersson, K.S.2
  • 67
    • 7044237064 scopus 로고    scopus 로고
    • Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors
    • Jacobson TA. Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors. Am J Cardiol 2004;94(9):1140-6
    • (2004) Am J Cardiol , vol.94 , Issue.9 , pp. 1140-1146
    • Jacobson, T.A.1
  • 68
    • 0033813398 scopus 로고    scopus 로고
    • Safety and efficacy of HMG-CoA reductase inhibitors for treatment of hyperlipidemia in patients with HIV infection
    • Penzak SR, Chuck SK, Stajich GV. Safety and efficacy of HMG-CoA reductase inhibitors for treatment of hyperlipidemia in patients with HIV infection. Pharmacotherapy 2000;20(9):1066-71
    • (2000) Pharmacotherapy , vol.20 , Issue.9 , pp. 1066-1071
    • Penzak, S.R.1    Chuck, S.K.2    Stajich, G.V.3
  • 69
    • 1542640490 scopus 로고    scopus 로고
    • Rhabdomyolysis due to interaction of simvastatin with mibefradil
    • Schmassmann-Suhijar D, Bullingham R, Gasser R, et al. Rhabdomyolysis due to interaction of simvastatin with mibefradil. Lancet 1998;351(9120):1929-30
    • (1998) Lancet , vol.351 , Issue.9120 , pp. 1929-1930
    • Schmassmann-Suhijar, D.1    Bullingham, R.2    Gasser, R.3
  • 70
    • 0029876284 scopus 로고    scopus 로고
    • Metabolism of the new immunosuppressor cyclosporin G by human liver cytochromes P450
    • Pichard L, Domergue J, Fourtanier G, et al. Metabolism of the new immunosuppressor cyclosporin G by human liver cytochromes P450. Biochem Pharmacol 1996;51(5):591-8
    • (1996) Biochem Pharmacol , vol.51 , Issue.5 , pp. 591-598
    • Pichard, L.1    Domergue, J.2    Fourtanier, G.3
  • 71
    • 0027327029 scopus 로고
    • Altered disposition of pravastatin following concomitant drug therapy with cyclosporin A in transplant recipients
    • Regazzi MB, Iacona I, Campana C, et al. Altered disposition of pravastatin following concomitant drug therapy with cyclosporin A in transplant recipients. Transplant Proc 1993;25(4):2732-4
    • (1993) Transplant Proc , vol.25 , Issue.4 , pp. 2732-2734
    • Regazzi, M.B.1    Iacona, I.2    Campana, C.3
  • 72
    • 1642523136 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression
    • Hedman M, Neuvonen PJ, Neuvonen M, et al. Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression. Clin Pharmacol Ther 2004;75(1):101-9
    • (2004) Clin Pharmacol Ther , vol.75 , Issue.1 , pp. 101-109
    • Hedman, M.1    Neuvonen, P.J.2    Neuvonen, M.3
  • 73
    • 0037287596 scopus 로고    scopus 로고
    • Interactions between cyclosporin and lipid-lowering drugs: Implications for organ transplant recipients
    • Asberg A. Interactions between cyclosporin and lipid-lowering drugs: implications for organ transplant recipients. Drugs 2003;63(4):367-78
    • (2003) Drugs , vol.63 , Issue.4 , pp. 367-378
    • Asberg, A.1
  • 74
    • 3542992126 scopus 로고    scopus 로고
    • Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine
    • Simonson SG, Raza A, Martin PD, et al. Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine. Clin Pharmacol Ther 2004;76(2):167-77
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.2 , pp. 167-177
    • Simonson, S.G.1    Raza, A.2    Martin, P.D.3
  • 75
    • 33745243715 scopus 로고    scopus 로고
    • Drug-drug interaction between pitavastatin and various drugs via OATP1B1
    • Hirano M, Maeda K, Shitara Y, Sugiyama Y. Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Drug Metab Dispos 2006;34(7):1229-36
    • (2006) Drug Metab Dispos , vol.34 , Issue.7 , pp. 1229-1236
    • Hirano, M.1    Maeda, K.2    Shitara, Y.3    Sugiyama, Y.4
  • 77
    • 0031969657 scopus 로고    scopus 로고
    • Influence of erythromycin pre-and cotreatment on single-dose pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin
    • Mück W, Ochmann K, Rohde G, et al. Influence of erythromycin pre-and cotreatment on single-dose pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin. Eur J Clin Pharmacol 1998;53(6):469-73
    • (1998) Eur J Clin Pharmacol , vol.53 , Issue.6 , pp. 469-473
    • Mück, W.1    Ochmann, K.2    Rohde, G.3
  • 78
    • 0242543259 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C9 gene
    • Schwarz UI. Clinical relevance of genetic polymorphisms in the human CYP2C9 gene. Eur J Clin Invest 2003;33(Suppl 2):23-30
    • (2003) Eur J Clin Invest , vol.33 , pp. 23-30
    • Schwarz, U.I.1
  • 79
    • 0033920666 scopus 로고    scopus 로고
    • Effect of fluconazole on plasma fluvastatin and pravastatin concentrations
    • Kantola T, Backman JT, Niemi M, et al. Effect of fluconazole on plasma fluvastatin and pravastatin concentrations. Eur J Clin Pharmacol 2000;56(3):225-9
    • (2000) Eur J Clin Pharmacol , vol.56 , Issue.3 , pp. 225-229
    • Kantola, T.1    Backman, J.T.2    Niemi, M.3
  • 80
    • 0033406334 scopus 로고    scopus 로고
    • Rhabdomyolysis and acute renal failure due to combination therapy with simvastatin and warfarin
    • Mogyorósi A, Bradley B, Showalter A, Schubert ML. Rhabdomyolysis and acute renal failure due to combination therapy with simvastatin and warfarin. J Int Med 1999;246(6):599-602
    • (1999) J Int Med , vol.246 , Issue.6 , pp. 599-602
    • Mogyorósi, A.1    Bradley, B.2    Showalter, A.3    Schubert, M.L.4
  • 81
    • 0035997137 scopus 로고    scopus 로고
    • Pharmacology of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), including rosuvastatin and pitavastatin
    • Igel M, Sudhop T, von Bergmann K. Pharmacology of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), including rosuvastatin and pitavastatin. J Clin Pharmacol 2002;42(8):835-45
    • (2002) J Clin Pharmacol , vol.42 , Issue.8 , pp. 835-845
    • Igel, M.1    Sudhop, T.2    Von Bergmann, K.3
  • 82
    • 33947097991 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics of cholesterollowering therapy
    • Schmitz G, Schmitz-Madry A, Ugocsai P. Pharmacogenetics and pharmacogenomics of cholesterollowering therapy. Cur Opin Lipidol 2007;18(2):164-73
    • (2007) Cur Opin Lipidol , vol.18 , Issue.2 , pp. 164-173
    • Schmitz, G.1    Schmitz-Madry, A.2    Ugocsai, P.3
  • 83
    • 0036843479 scopus 로고    scopus 로고
    • Effects of fibrates on metabolism of statins in human hepatocytes
    • Prueksaritanont T, Tang C, Qiu Y, et al. Effects of fibrates on metabolism of statins in human hepatocytes. Drug Metabol Dispos 2002;30(11):1280-7
    • (2002) Drug Metabol Dispos , vol.30 , Issue.11 , pp. 1280-1287
    • Prueksaritanont, T.1    Tang, C.2    Qiu, Y.3
  • 84
    • 0032948727 scopus 로고    scopus 로고
    • Effect of itraconazole on cerivastatin pharmacokinetics
    • Kantola T, Kivisto KT, Neuvonen PJ. Effect of itraconazole on cerivastatin pharmacokinetics. Eur J Clin Pharmacol 1999;54(11):851-5
    • (1999) Eur J Clin Pharmacol , vol.54 , Issue.11 , pp. 851-855
    • Kantola, T.1    Kivisto, K.T.2    Neuvonen, P.J.3
  • 85
    • 4644301418 scopus 로고    scopus 로고
    • Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/ OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: Analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
    • Shitara Y, Hirano M, Sato H, Sugiyama Y. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/ OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther 2004;311(1):228-36
    • (2004) J Pharmacol Exp Ther , vol.311 , Issue.1 , pp. 228-236
    • Shitara, Y.1    Hirano, M.2    Sato, H.3    Sugiyama, Y.4
  • 86
    • 8644235696 scopus 로고    scopus 로고
    • A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin
    • Ishikawa C, Ozaki H, Nakajima T, et al. A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin. J Human Gen 2004;49(10):582-5
    • (2004) J Human Gen , vol.49 , Issue.10 , pp. 582-585
    • Ishikawa, C.1    Ozaki, H.2    Nakajima, T.3
  • 87
    • 34547154774 scopus 로고    scopus 로고
    • Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid
    • Goosen TC, Bauman JN, Davis JA, et al. Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid. Drug Metab Dispos 2007;35(8):1315-24
    • (2007) Drug Metab Dispos , vol.35 , Issue.8 , pp. 1315-1324
    • Goosen, T.C.1    Bauman, J.N.2    Davis, J.A.3
  • 88
    • 0030812885 scopus 로고    scopus 로고
    • In vitro metabolism of simvastatin in humans [SBT] identification of metabolizing enzymes and effect of the drug on hepatic P450s
    • Prueksaritanont T, Gorham LM, Ma B, et al. In vitro metabolism of simvastatin in humans [SBT] identification of metabolizing enzymes and effect of the drug on hepatic P450s. Drug Metab Dispos 1997;25(10):1191-9
    • (1997) Drug Metab Dispos , vol.25 , Issue.10 , pp. 1191-1199
    • Prueksaritanont, T.1    Gorham, L.M.2    Ma, B.3
  • 89
    • 0033846824 scopus 로고    scopus 로고
    • Plasma concentrations of active simvastatin acid are increased by gemfibrozil
    • Backman JT, Kyrklund C, Kivisto KT, et al. Plasma concentrations of active simvastatin acid are increased by gemfibrozil. Clin Pharmacol Ther 2000;68(2):122-9
    • (2000) Clin Pharmacol Ther , vol.68 , Issue.2 , pp. 122-129
    • Backman, J.T.1    Kyrklund, C.2    Kivisto, K.T.3
  • 90
    • 0035337643 scopus 로고    scopus 로고
    • Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate
    • Kyrklund C, Backman JT, Kivisto KT, et al. Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate. Clin Pharmacol Ther 2001;69(5):340-5
    • (2001) Clin Pharmacol Ther , vol.69 , Issue.5 , pp. 340-345
    • Kyrklund, C.1    Backman, J.T.2    Kivisto, K.T.3
  • 91
    • 0037310871 scopus 로고    scopus 로고
    • Inhibition of transporter-mediated hepatic uptake as a mechanism for drugdrug interaction between cerivastatin and cyclosporin A
    • Shitara Y, Itoh T, Sato H, et al. Inhibition of transporter-mediated hepatic uptake as a mechanism for drugdrug interaction between cerivastatin and cyclosporin A. J Pharmacol Exp Ther 2003;304(2):610-16
    • (2003) J Pharmacol Exp Ther , vol.304 , Issue.2 , pp. 610-616
    • Shitara, Y.1    Itoh, T.2    Sato, H.3
  • 92
    • 84859346272 scopus 로고    scopus 로고
    • In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions
    • Karlgren M, Ahlin G, Bergstrom CA, et al. In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions. Pharmaceut Res 2012;29(2):411-26
    • (2012) Pharmaceut Res , vol.29 , Issue.2 , pp. 411-426
    • Karlgren, M.1    Ahlin, G.2    Bergstrom, C.A.3
  • 94
    • 84896113758 scopus 로고    scopus 로고
    • Interaction of novel plateletincreasing agent eltrombopag with rosuvastatin via breast cancer resistance protein in humans
    • Takeuchi K, Sugiura T, Matsubara K, et al. Interaction of novel plateletincreasing agent eltrombopag with rosuvastatin via breast cancer resistance protein in humans. Drug Metab Dispos 2014;42(4):726-34
    • (2014) Drug Metab Dispos , vol.42 , Issue.4 , pp. 726-734
    • Takeuchi, K.1    Sugiura, T.2    Matsubara, K.3
  • 95
    • 0000156212 scopus 로고
    • Effects of dose and food on HMG-CoA reductase inhibitor profiles after lovastatin (mevacor)
    • Dobrinska MR, Stubbs RJ, Gregg MH. Effects of dose and food on HMG-CoA reductase inhibitor profiles after lovastatin (mevacor). Pharm Res 1988;5:S182
    • (1988) Pharm Res , vol.5 , pp. S182
    • Dobrinska, M.R.1    Stubbs, R.J.2    Gregg, M.H.3
  • 96
    • 0027222917 scopus 로고
    • Effect of food on pravastatin pharmacokinetics and pharmacodynamics
    • Pan HY, DeVault AR, Brescia D, et al. Effect of food on pravastatin pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol 1993;31(6):291-4
    • (1993) Int J Clin Pharmacol , vol.31 , Issue.6 , pp. 291-294
    • Pan, H.Y.1    Devault, A.R.2    Brescia, D.3
  • 97
    • 0028845878 scopus 로고
    • Effect of food on the bioavailability of atorvastatin, an HMG-CoA reductase inhibitor
    • Radulovic LL, Cilla DD, Posvar EL, et al. Effect of food on the bioavailability of atorvastatin, an HMG-CoA reductase inhibitor. J Clin Pharmacol 1995;35(10):990-4
    • (1995) J Clin Pharmacol , vol.35 , Issue.10 , pp. 990-994
    • Radulovic, L.L.1    Cilla, D.D.2    Posvar, E.L.3
  • 98
    • 0033679135 scopus 로고    scopus 로고
    • Effect of food on the pharmacodynamics and pharmacokinetics of atorvastatin, an inhibitor of HMGCoA reductase
    • Whitfield LR, Stern RH, Sedman AJ, et al. Effect of food on the pharmacodynamics and pharmacokinetics of atorvastatin, an inhibitor of HMGCoA reductase. Eur J Drug Metabol Pharmacokinet 2000;25(2):97-101
    • (2000) Eur J Drug Metabol Pharmacokinet , vol.25 , Issue.2 , pp. 97-101
    • Whitfield, L.R.1    Stern, R.H.2    Sedman, A.J.3
  • 99
    • 0028282809 scopus 로고
    • Fluvastatin administration at bedtime versus with the evening meal: A multicenter comparison of bioavailability, safety, and efficacy
    • Dujovne CA, Davidson MH. Fluvastatin administration at bedtime versus with the evening meal: a multicenter comparison of bioavailability, safety, and efficacy. Am J Med 1994;96(6A):37S-40S
    • (1994) Am J Med , vol.96 , Issue.6 A , pp. 37S-40S
    • Dujovne, C.A.1    Davidson, M.H.2
  • 101
    • 0026099498 scopus 로고
    • Interaction of citrus juices with felodipine and nifedipine
    • Bailey DG, Spence JD, Munoz C, Arnold JM. Interaction of citrus juices with felodipine and nifedipine. Lancet 1991;337(8736):268-9
    • (1991) Lancet , vol.337 , Issue.8736 , pp. 268-269
    • Bailey, D.G.1    Spence, J.D.2    Munoz, C.3    Arnold, J.M.4
  • 102
    • 0031741901 scopus 로고    scopus 로고
    • Grapefruit juice-simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMGCoA reductase inhibitors
    • Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMGCoA reductase inhibitors. Clin Pharmacol Ther 1998;64(5):477-83
    • (1998) Clin Pharmacol Ther , vol.64 , Issue.5 , pp. 477-483
    • Lilja, J.J.1    Kivisto, K.T.2    Neuvonen, P.J.3
  • 103
    • 0031954328 scopus 로고    scopus 로고
    • Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid
    • Kantola T, Kivisto KT, Neuvonen PJ. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther 1998;63(4):397-402
    • (1998) Clin Pharmacol Ther , vol.63 , Issue.4 , pp. 397-402
    • Kantola, T.1    Kivisto, K.T.2    Neuvonen, P.J.3
  • 104
    • 0242645646 scopus 로고    scopus 로고
    • Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin
    • Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Clin Pharmacol Ther 1999;66(2):118-27
    • (1999) Clin Pharmacol Ther , vol.66 , Issue.2 , pp. 118-127
    • Lilja, J.J.1    Kivisto, K.T.2    Neuvonen, P.J.3
  • 105
    • 27444434929 scopus 로고    scopus 로고
    • Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin
    • Ando H, Tsuruoka S, Yanagihara H, et al. Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. Br J Clin Pharmacol 2005;60(5):494-7
    • (2005) Br J Clin Pharmacol , vol.60 , Issue.5 , pp. 494-497
    • Ando, H.1    Tsuruoka, S.2    Yanagihara, H.3
  • 106
    • 79961164198 scopus 로고    scopus 로고
    • Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily
    • Reddy P, Ellington D, Zhu Y, et al. Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily. Br J Clin Pharmacol 2011;72(3):434-41
    • (2011) Br J Clin Pharmacol , vol.72 , Issue.3 , pp. 434-441
    • Reddy, P.1    Ellington, D.2    Zhu, Y.3
  • 107
    • 84876765967 scopus 로고    scopus 로고
    • Effects of grapefruit juice and SLCO1B1 388A>G polymorphism on the pharmacokinetics of pitavastatin
    • Hu M, Mak VW, Yin OQ, et al. Effects of grapefruit juice and SLCO1B1 388A>G polymorphism on the pharmacokinetics of pitavastatin. Drug Metab Pharmacokinet 2013;28(2):104-8
    • (2013) Drug Metab Pharmacokinet , vol.28 , Issue.2 , pp. 104-108
    • Hu, M.1    Mak, V.W.2    Yin, O.Q.3
  • 108
    • 0032911163 scopus 로고    scopus 로고
    • Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver
    • Jacobsen W, Kirchner G, Hallensleben K, et al. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos 1999;27(2):173-9
    • (1999) Drug Metab Dispos , vol.27 , Issue.2 , pp. 173-179
    • Jacobsen, W.1    Kirchner, G.2    Hallensleben, K.3
  • 109
    • 0033736174 scopus 로고    scopus 로고
    • Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin
    • Lilja JJ, Kivisto KT, Neuvonen PJ. Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin. Clin Pharmacol Ther 2000;68(4):384-90
    • (2000) Clin Pharmacol Ther , vol.68 , Issue.4 , pp. 384-390
    • Lilja, J.J.1    Kivisto, K.T.2    Neuvonen, P.J.3
  • 110
    • 0035206829 scopus 로고    scopus 로고
    • Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3
    • Thummel KE, Brimer C, Yasuda K, et al. Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Mol Pharmacol 2001;60(6):1399-406
    • (2001) Mol Pharmacol , vol.60 , Issue.6 , pp. 1399-1406
    • Thummel, K.E.1    Brimer, C.2    Yasuda, K.3
  • 111
    • 0036925905 scopus 로고    scopus 로고
    • Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements
    • Thompson PD, Jurutka PW, Whitfield GK, et al. Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements. Biochem Biophys Res Commun 2002;299(5):730-8
    • (2002) Biochem Biophys Res Commun , vol.299 , Issue.5 , pp. 730-738
    • Thompson, P.D.1    Jurutka, P.W.2    Whitfield, G.K.3
  • 112
    • 0037067665 scopus 로고    scopus 로고
    • Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes
    • Drocourt L, Ourlin J, Pascussi J, et al. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 2002;277(28):25125-32
    • (2002) J Biol Chem , vol.277 , Issue.28 , pp. 25125-25132
    • Drocourt, L.1    Ourlin, J.2    Pascussi, J.3
  • 113
    • 1542407269 scopus 로고    scopus 로고
    • Carbamazepine markedly reduces serum concentrations of simvastatin and simvastatin acid
    • Ucar M, Neuvonen M, Luurila H, et al. Carbamazepine markedly reduces serum concentrations of simvastatin and simvastatin acid. Eur J Clin Pharmacol 2004;59(12):879-82
    • (2004) Eur J Clin Pharmacol , vol.59 , Issue.12 , pp. 879-882
    • Ucar, M.1    Neuvonen, M.2    Luurila, H.3
  • 114
    • 0034527327 scopus 로고    scopus 로고
    • Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations
    • Kyrklund C, Backman JT, Kivisto KT, et al. Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations. Clin Pharmacol Ther 2000;68(6):592-7
    • (2000) Clin Pharmacol Ther , vol.68 , Issue.6 , pp. 592-597
    • Kyrklund, C.1    Backman, J.T.2    Kivisto, K.T.3
  • 115
    • 1242284362 scopus 로고    scopus 로고
    • Effect of rifampicin on pravastatin pharmacokinetics in healthy subjects
    • Kyrklund C, Backman JT, Neuvonen M, Neuvonen PJ. Effect of rifampicin on pravastatin pharmacokinetics in healthy subjects. Br J Clin Pharmacol 2004;57(2):181-7
    • (2004) Br J Clin Pharmacol , vol.57 , Issue.2 , pp. 181-187
    • Kyrklund, C.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 116
    • 33646507052 scopus 로고    scopus 로고
    • Use of an indirect effect model to describe the LDL cholesterol-lowering effect by statins in hypercholesterolaemic patients
    • Faltaos DW, Urien S, Carreau V, et al. Use of an indirect effect model to describe the LDL cholesterol-lowering effect by statins in hypercholesterolaemic patients. Fundam Clin Pharmacol 2006;20(3):321-30
    • (2006) Fundam Clin Pharmacol , vol.20 , Issue.3 , pp. 321-330
    • Faltaos, D.W.1    Urien, S.2    Carreau, V.3
  • 117
    • 84964312456 scopus 로고    scopus 로고
    • Population pharmacodynamic analysis of LDL-cholesterol lowering effects by statins and co-medications based on electronic medical records
    • Kakara M, Nomura H, Fukae M, et al. Population pharmacodynamic analysis of LDL-cholesterol lowering effects by statins and co-medications based on electronic medical records. Br J Clin Pharmacol 2014;78(4):824-35
    • (2014) Br J Clin Pharmacol , vol.78 , Issue.4 , pp. 824-835
    • Kakara, M.1    Nomura, H.2    Fukae, M.3
  • 118
    • 35548994573 scopus 로고    scopus 로고
    • Pitavastatin: Efficacy and safety in intensive lipid lowering
    • Hayashi T, Yokote K, Saito Y, Iguchi A. Pitavastatin: efficacy and safety in intensive lipid lowering. Expert Opin Pharmacot 2007;8(14):2315-27
    • (2007) Expert Opin Pharmacot , vol.8 , Issue.14 , pp. 2315-2327
    • Hayashi, T.1    Yokote, K.2    Saito, Y.3    Iguchi, A.4
  • 120
    • 84867873811 scopus 로고    scopus 로고
    • Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: It's not just about OATP1B1
    • Elsby R, Hilgendorf C, Fenner K. Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1. Clin Pharmacol Ther 2012;92(5):584-98
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.5 , pp. 584-598
    • Elsby, R.1    Hilgendorf, C.2    Fenner, K.3
  • 122
    • 21544472342 scopus 로고    scopus 로고
    • Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: Results of AIDS Clinical Trials Group 5108 Study
    • Gerber JG, Rosenkranz SL, Fichtenbaum CJ, et al. Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study. J Acquir Immune Defic Syndr 2005;39(3):307-12
    • (2005) J Acquir Immune Defic Syndr , vol.39 , Issue.3 , pp. 307-312
    • Gerber, J.G.1    Rosenkranz, S.L.2    Fichtenbaum, C.J.3
  • 123
    • 0036157484 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic assessments of HMGCoA reductase inhibitors when coadministered with everolimus
    • Kovarik JM, Hartmann S, Hubert M, et al. Pharmacokinetic and pharmacodynamic assessments of HMGCoA reductase inhibitors when coadministered with everolimus. J Clin Pharmacol 2002;42(2):222-8
    • (2002) J Clin Pharmacol , vol.42 , Issue.2 , pp. 222-228
    • Kovarik, J.M.1    Hartmann, S.2    Hubert, M.3
  • 124
    • 23444452547 scopus 로고    scopus 로고
    • Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites
    • Backman JT, Luurila H, Neuvonen M, Neuvonen PJ. Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites. Clin Pharmacol Ther 2005;78(2):154-67
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.2 , pp. 154-167
    • Backman, J.T.1    Luurila, H.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 125
    • 0031847115 scopus 로고    scopus 로고
    • Effect of itraconazole on the pharmacokinetics of atorvastatin
    • Kantola T, Kivisto KT, Neuvonen PJ. Effect of itraconazole on the pharmacokinetics of atorvastatin. Clin Pharmacol Ther 1998;64(1):58-65
    • (1998) Clin Pharmacol Ther , vol.64 , Issue.1 , pp. 58-65
    • Kantola, T.1    Kivisto, K.T.2    Neuvonen, P.J.3
  • 126
    • 0033745108 scopus 로고    scopus 로고
    • Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatin
    • Mazzu AL, Lasseter KC, Shamblen EC, et al. Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatin. Clin Pharmacol Ther 2000;68(4):391-400
    • (2000) Clin Pharmacol Ther , vol.68 , Issue.4 , pp. 391-400
    • Mazzu, A.L.1    Lasseter, K.C.2    Shamblen, E.C.3
  • 127
    • 79959982280 scopus 로고    scopus 로고
    • Effects of lamotrigine and phenytoin on the pharmacokinetics of atorvastatin in healthy volunteers
    • Bullman J, Nicholls A, Van Landingham K, et al. Effects of lamotrigine and phenytoin on the pharmacokinetics of atorvastatin in healthy volunteers. Epilepsia 2011;52(7):1351-8
    • (2011) Epilepsia , vol.52 , Issue.7 , pp. 1351-1358
    • Bullman, J.1    Nicholls, A.2    Van Landingham, K.3
  • 128
    • 84876205079 scopus 로고    scopus 로고
    • Pharmacokinetic interaction studies of co-administration of ticagrelor and atorvastatin or simvastatin in healthy volunteers
    • Teng R, Mitchell PD, Butler KA. Pharmacokinetic interaction studies of co-administration of ticagrelor and atorvastatin or simvastatin in healthy volunteers. Eur J Clin Pharmacol 2013;69(3):477-87
    • (2013) Eur J Clin Pharmacol , vol.69 , Issue.3 , pp. 477-487
    • Teng, R.1    Mitchell, P.D.2    Butler, K.A.3
  • 129
    • 0031718706 scopus 로고    scopus 로고
    • The interaction of diltiazem with lovastatin and pravastatin
    • Azie NE, Brater DC, Becker PA, et al. The interaction of diltiazem with lovastatin and pravastatin. Clin Pharmacol Ther 1998;64(4):369-77
    • (1998) Clin Pharmacol Ther , vol.64 , Issue.4 , pp. 369-377
    • Azie, N.E.1    Brater, D.C.2    Becker, P.A.3
  • 130
    • 84939809566 scopus 로고    scopus 로고
    • Merck & Co Inc Last accessed 19 November
    • Merck & Co. Inc. MEVACOR (lovastatin) tablets. Available from: http://www. merck. com/product/usa/pi circulars/m/mevacor/mevacor-pi. pdf [Last accessed 19 November 2014]
    • (2014) MEVACOR (Lovastatin) Tablets
  • 131
    • 84877129431 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects
    • Hoch M, Hoever P, Alessi F, et al. Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects. Eur J Clin Pharmacol 2013;69(3):523-32
    • (2013) Eur J Clin Pharmacol , vol.69 , Issue.3 , pp. 523-532
    • Hoch, M.1    Hoever, P.2    Alessi, F.3
  • 132
    • 84939803578 scopus 로고    scopus 로고
    • Merck & Co Inc[Last accessed 19 November
    • Merck & Co. Inc. ZOCOR (simvastatin) tablets prescribing information. Available from: http://www. merck. com/product/ usa/pi-circulars/z/zocor/zocor-pi. pdf [Last accessed 19 November 2014]
    • (2014) ZOCOR (Simvastatin) Tablets Prescribing Information
  • 133
    • 0034922434 scopus 로고    scopus 로고
    • Study of the drug-drug interaction between simvastatin and cisapride in man
    • Simard C, O'Hara GE, Prévost J, et al. Study of the drug-drug interaction between simvastatin and cisapride in man. Eur J Clin Pharmacol 2001;57(3):229-34
    • (2001) Eur J Clin Pharmacol , vol.57 , Issue.3 , pp. 229-234
    • Simard, C.1    O'hara, G.E.2    Prévost, J.3
  • 134
    • 0031670167 scopus 로고    scopus 로고
    • Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations
    • Kantola T, Kivisto KT, Neuvonen PJ. Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations. Clin Pharmacol Ther 1998;64(2):177-82
    • (1998) Clin Pharmacol Ther , vol.64 , Issue.2 , pp. 177-182
    • Kantola, T.1    Kivisto, K.T.2    Neuvonen, P.J.3
  • 135
    • 0031892901 scopus 로고    scopus 로고
    • Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole
    • Neuvonen PJ, Kantola T, Kivisto KT. Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole. Clin Pharmacol Ther 1998;63(3):332-41
    • (1998) Clin Pharmacol Ther , vol.63 , Issue.3 , pp. 332-341
    • Neuvonen, P.J.1    Kantola, T.2    Kivisto, K.T.3
  • 136
    • 84939848849 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between simvastatin and setipiprant, a CRTH2 antagonist
    • In press
    • Gehin M, Sidharta PN, Gnerre C, et al. Pharmacokinetic interactions between simvastatin and setipiprant, a CRTH2 antagonist. Eur J Clin Pharmacol 2014; In press
    • (2014) Eur J Clin Pharmacol
    • Gehin, M.1    Sidharta, P.N.2    Gnerre, C.3
  • 138
    • 0028200059 scopus 로고
    • Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • Blum CB. Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Am J Cardiol 1994;73(14):3D-11D
    • (1994) Am J Cardiol , vol.73 , Issue.14 , pp. 3D-11D
    • Blum, C.B.1
  • 139
    • 34247324400 scopus 로고    scopus 로고
    • Effect of clopidogrel on the steady-state pharmacokinetics of fluvastatin
    • Ayalasomayajula SP, Vaidyanathan S, Kemp C, et al. Effect of clopidogrel on the steady-state pharmacokinetics of fluvastatin. J Clin Pharmacol 2007;47(5):613-19
    • (2007) J Clin Pharmacol , vol.47 , Issue.5 , pp. 613-619
    • Ayalasomayajula, S.P.1    Vaidyanathan, S.2    Kemp, C.3
  • 140
    • 0029042641 scopus 로고
    • Pharmacokinetics of the combination of fluvastatin and gemfibrozil
    • Spence JD, Munoz CE, Hendricks L, et al. Pharmacokinetics of the combination of fluvastatin and gemfibrozil. Am J Cardiol 1995;76(2):80A-3A
    • (1995) Am J Cardiol , vol.76 , Issue.2 , pp. 80A-3A
    • Spence, J.D.1    Munoz, C.E.2    Hendricks, L.3
  • 141
    • 0027146460 scopus 로고
    • Pharmacokinetics of fluvastatin and specific drug interactions
    • Smith HT, Jokubaitis LA, Troendle AJ, et al. Pharmacokinetics of fluvastatin and specific drug interactions. Am J Hypertens 1993;6(11 Pt 2):375S-82S
    • (1993) Am J Hypertens , vol.6 , Issue.11 , pp. 375S-82S
    • Smith, H.T.1    Jokubaitis, L.A.2    Troendle, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.