Effect of food on the pharmacodynamics and pharmacokinetics of atorvastatin, an inhibitor of HMG-CoA reductase

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 2, 2000, Pages 97-101

  Whitfield, L R ^a   Stern, R H ^a   Sedman, A J ^a   Abel, R ^a   Gibson, D M ^a  

^a PFIZER INC   (United States)

Author keywords

Atorvastatin; Food; HMG CoA reductase; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ATORVASTATIN; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AREA UNDER THE CURVE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG TOLERABILITY; FEMALE; FOOD DRUG INTERACTION; HUMAN; HUMAN EXPERIMENT; LIPOPROTEIN BLOOD LEVEL; MALE; NORMAL HUMAN; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0033679135     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190074     Document Type: Article

References (10)

1. Reduction of LDL-cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor
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3. Development and validation of an enzyme inhibition assay for quantitation of CI-981 in human plasma
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5. Pharmacokinetics of fluvastatin and specific drag interactions
6. Clinical implications of the biopharmaceutical properties of fluvastatin
7. Effects of food on the pharmacokinetics and pharmacodynamics of pravastatin, an HMG CoA reductase inhibitor
8. Effect of food on pravastatin pharmacokinetics and pharmacodynamics