메뉴 건너뛰기




Volumn 75, Issue 2, 2015, Pages 207-215

Update on the role of Interleukin 17 in rheumatologic autoimmune diseases

Author keywords

Autoimmune diseases; Biological agents; Interleukin 17

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; IXEKIZUMAB; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SECUKINUMAB; USTEKINUMAB;

EID: 84939777306     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2015.01.003     Document Type: Article
Times cited : (30)

References (107)
  • 1
    • 84899922972 scopus 로고    scopus 로고
    • An anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials
    • PubMed PMID: 24553909; PubMed Central PMCID: PMC4033146
    • Kavanaugh A., Ritchlin C., Rahman P., Puig L., Gottlieb A.B., Li S., et al. an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials. Annals Rheum Diseases 2014, 73(6):1000-1006. PubMed PMID: 24553909; PubMed Central PMCID: PMC4033146. 10.1136/annrheumdis-2013-204741.
    • (2014) Annals Rheum Diseases , vol.73 , Issue.6 , pp. 1000-1006
    • Kavanaugh, A.1    Ritchlin, C.2    Rahman, P.3    Puig, L.4    Gottlieb, A.B.5    Li, S.6
  • 2
    • 84901029678 scopus 로고    scopus 로고
    • Systematic review of interleukin-12, interleukin-17, and interleukin-23 pathway inhibitors for the treatment of moderate-to-severe chronic plaque psoriasis: ustekinumab, briakinumab, tildrakizumab, guselkumab, secukinumab, ixekizumab, and brodalumab
    • PubMed PMID: 24518655
    • Tausend W., Downing C., Tyring S. Systematic review of interleukin-12, interleukin-17, and interleukin-23 pathway inhibitors for the treatment of moderate-to-severe chronic plaque psoriasis: ustekinumab, briakinumab, tildrakizumab, guselkumab, secukinumab, ixekizumab, and brodalumab. J. Cutaneous Med Surgery 2014, 18:1-14. PubMed PMID: 24518655.
    • (2014) J. Cutaneous Med Surgery , vol.18 , pp. 1-14
    • Tausend, W.1    Downing, C.2    Tyring, S.3
  • 3
    • 84893079702 scopus 로고    scopus 로고
    • Ustekinumab for the treatment of psoriatic arthritis
    • PubMed PMID: 24410536
    • Wofford J., Menter A. Ustekinumab for the treatment of psoriatic arthritis. Exp Rev Clinical Immunol 2014, 10(2):189-202. PubMed PMID: 24410536. 10.1586/1744666X.2014.878649.
    • (2014) Exp Rev Clinical Immunol , vol.10 , Issue.2 , pp. 189-202
    • Wofford, J.1    Menter, A.2
  • 4
    • 0027215897 scopus 로고
    • CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    • PubMed PMID: 8390535
    • Rouvier E., Luciani M.F., Mattei M.G., Denizot F., Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol 1993, 150(12):5445-5456. PubMed PMID: 8390535.
    • (1993) J Immunol , vol.150 , Issue.12 , pp. 5445-5456
    • Rouvier, E.1    Luciani, M.F.2    Mattei, M.G.3    Denizot, F.4    Golstein, P.5
  • 5
    • 0028858556 scopus 로고
    • Human IL-17: a novel cytokine derived from T cells
    • PubMed PMID: 7499828
    • Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., et al. Human IL-17: a novel cytokine derived from T cells. J Immunol 1995, 155(12):5483-5486. PubMed PMID: 7499828.
    • (1995) J Immunol , vol.155 , Issue.12 , pp. 5483-5486
    • Yao, Z.1    Painter, S.L.2    Fanslow, W.C.3    Ulrich, D.4    Macduff, B.M.5    Spriggs, M.K.6
  • 6
    • 17944368518 scopus 로고    scopus 로고
    • IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
    • PubMed PMID: 11574464; PubMed Central PMCID: PMC125646
    • Hymowitz S.G., Filvaroff E.H., Yin J.P., Lee J., Cai L., Risser P., et al. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 2001, 20(19):5332-5341. PubMed PMID: 11574464; PubMed Central PMCID: PMC125646. 10.1093/emboj/20.19.5332.
    • (2001) EMBO J , vol.20 , Issue.19 , pp. 5332-5341
    • Hymowitz, S.G.1    Filvaroff, E.H.2    Yin, J.P.3    Lee, J.4    Cai, L.5    Risser, P.6
  • 7
    • 34250305962 scopus 로고    scopus 로고
    • Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
    • PubMed PMID: 17355969
    • Wright J.F., Guo Y., Quazi A., Luxenberg D.P., Bennett F., Ross J.F., et al. Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells. J Biol Chem 2007, 282(18):13447-13455. PubMed PMID: 17355969. 10.1074/jbc.M700499200.
    • (2007) J Biol Chem , vol.282 , Issue.18 , pp. 13447-13455
    • Wright, J.F.1    Guo, Y.2    Quazi, A.3    Luxenberg, D.P.4    Bennett, F.5    Ross, J.F.6
  • 8
    • 34248574863 scopus 로고    scopus 로고
    • A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
    • PubMed PMID: 17452998
    • Chang S.H., Dong C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res 2007, 17(5):435-440. PubMed PMID: 17452998. 10.1038/cr.2007.35.
    • (2007) Cell Res , vol.17 , Issue.5 , pp. 435-440
    • Chang, S.H.1    Dong, C.2
  • 9
    • 53149138236 scopus 로고    scopus 로고
    • The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
    • PubMed PMID: 18684971
    • Wright J.F., Bennett F., Li B., Brooks J., Luxenberg D.P., Whitters M.J., et al. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. J Immunol 2008, 181(4):2799-2805. PubMed PMID: 18684971.
    • (2008) J Immunol , vol.181 , Issue.4 , pp. 2799-2805
    • Wright, J.F.1    Bennett, F.2    Li, B.3    Brooks, J.4    Luxenberg, D.P.5    Whitters, M.J.6
  • 10
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
    • PubMed PMID: 10323452
    • Chabaud M., Durand J.M., Buchs N., Fossiez F., Page G., Frappart L., et al. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheumatism 1999, 42(5):963-970. PubMed PMID: 10323452. 10.1002/1529-0131(199905)42:5<963::AID-ANR153.0.CO;2-E.
    • (1999) Arthritis Rheumatism , vol.42 , Issue.5 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3    Fossiez, F.4    Page, G.5    Frappart, L.6
  • 12
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • PubMed PMID: 14634133
    • Nakae S., Nambu A., Sudo K., Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003, 171(11):6173-6177. PubMed PMID: 14634133.
    • (2003) J Immunol , vol.171 , Issue.11 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 13
    • 0033083111 scopus 로고    scopus 로고
    • IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells
    • PubMed PMID: 9973376
    • Aarvak T., Chabaud M., Miossec P., Natvig J.B. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J Immunol 1999, 162(3):1246-1251. PubMed PMID: 9973376.
    • (1999) J Immunol , vol.162 , Issue.3 , pp. 1246-1251
    • Aarvak, T.1    Chabaud, M.2    Miossec, P.3    Natvig, J.B.4
  • 14
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • PubMed PMID: 16200070
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005, 6(11):1123-1132. PubMed PMID: 16200070. 10.1038/ni1254.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6
  • 15
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • PubMed PMID: 16200068; PubMed Central PMCID: PMC1618871
    • Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6(11):1133-1141. PubMed PMID: 16200068; PubMed Central PMCID: PMC1618871. 10.1038/ni1261.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6
  • 16
    • 33749138039 scopus 로고    scopus 로고
    • IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection
    • PubMed PMID: 16982905
    • Lockhart E., Green A.M., Flynn J.L. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol 2006, 177(7):4662-4669. PubMed PMID: 16982905.
    • (2006) J Immunol , vol.177 , Issue.7 , pp. 4662-4669
    • Lockhart, E.1    Green, A.M.2    Flynn, J.L.3
  • 17
    • 33947677787 scopus 로고    scopus 로고
    • Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production
    • PubMed PMID: 17372004
    • Shibata K., Yamada H., Hara H., Kishihara K., Yoshikai Y. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol 2007, 178(7):4466-4472. PubMed PMID: 17372004.
    • (2007) J Immunol , vol.178 , Issue.7 , pp. 4466-4472
    • Shibata, K.1    Yamada, H.2    Hara, H.3    Kishihara, K.4    Yoshikai, Y.5
  • 18
    • 42649110747 scopus 로고    scopus 로고
    • Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion
    • PubMed PMID: 18390697; PubMed Central PMCID: PMC2442579
    • Rachitskaya A.V., Hansen A.M., Horai R., Li Z., Villasmil R., Luger D., et al. Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 2008, 180(8):5167-5171. PubMed PMID: 18390697; PubMed Central PMCID: PMC2442579.
    • (2008) J Immunol , vol.180 , Issue.8 , pp. 5167-5171
    • Rachitskaya, A.V.1    Hansen, A.M.2    Horai, R.3    Li, Z.4    Villasmil, R.5    Luger, D.6
  • 19
    • 38449093216 scopus 로고    scopus 로고
    • Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
    • PubMed PMID: 17911645; PubMed Central PMCID: PMC2768546
    • Roark C.L., French J.D., Taylor M.A., Bendele A.M., Born W.K., O'Brien R.L. Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells. J Immunol 2007, 179(8):5576-5583. PubMed PMID: 17911645; PubMed Central PMCID: PMC2768546.
    • (2007) J Immunol , vol.179 , Issue.8 , pp. 5576-5583
    • Roark, C.L.1    French, J.D.2    Taylor, M.A.3    Bendele, A.M.4    Born, W.K.5    O'Brien, R.L.6
  • 20
    • 0036144194 scopus 로고    scopus 로고
    • IL-17: prototype member of an emerging cytokine family
    • PubMed PMID: 11781375
    • Aggarwal S., Gurney A.L. IL-17: prototype member of an emerging cytokine family. J Leukocyte Biol 2002, 71(1):1-8. PubMed PMID: 11781375.
    • (2002) J Leukocyte Biol , vol.71 , Issue.1 , pp. 1-8
    • Aggarwal, S.1    Gurney, A.L.2
  • 22
    • 0029555301 scopus 로고
    • Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
    • PubMed PMID: 8777726
    • Yao Z., Fanslow W.C., Seldin M.F., Rousseau A.M., Painter S.L., Comeau M.R., et al. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995, 3(6):811-821. PubMed PMID: 8777726.
    • (1995) Immunity , vol.3 , Issue.6 , pp. 811-821
    • Yao, Z.1    Fanslow, W.C.2    Seldin, M.F.3    Rousseau, A.M.4    Painter, S.L.5    Comeau, M.R.6
  • 23
    • 38449094307 scopus 로고    scopus 로고
    • Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F
    • PubMed PMID: 17911633; PubMed Central PMCID: PMC2849293
    • Kuestner R.E., Taft D.W., Haran A., Brandt C.S., Brender T., Lum K., et al. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol 2007, 179(8):5462-5473. PubMed PMID: 17911633; PubMed Central PMCID: PMC2849293.
    • (2007) J Immunol , vol.179 , Issue.8 , pp. 5462-5473
    • Kuestner, R.E.1    Taft, D.W.2    Haran, A.3    Brandt, C.S.4    Brender, T.5    Lum, K.6
  • 24
    • 58149231532 scopus 로고    scopus 로고
    • Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
    • PubMed PMID: 19144317
    • Ishigame H., Kakuta S., Nagai T., Kadoki M., Nambu A., Komiyama Y., et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 2009, 30(1):108-119. PubMed PMID: 19144317. 10.1016/j.immuni.2008.11.009.
    • (2009) Immunity , vol.30 , Issue.1 , pp. 108-119
    • Ishigame, H.1    Kakuta, S.2    Nagai, T.3    Kadoki, M.4    Nambu, A.5    Komiyama, Y.6
  • 25
    • 38949194566 scopus 로고    scopus 로고
    • Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy
    • PubMed PMID: 18178098; PubMed Central PMCID: PMC2667118
    • Shen F., Gaffen S.L. Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy. Cytokine 2008, 41(2):92-104. PubMed PMID: 18178098; PubMed Central PMCID: PMC2667118. 10.1016/j.cyto.2007.11.01.
    • (2008) Cytokine , vol.41 , Issue.2 , pp. 92-104
    • Shen, F.1    Gaffen, S.L.2
  • 26
    • 30744437656 scopus 로고    scopus 로고
    • Evidence for ligand-independent multimerization of the IL-17 receptor
    • PubMed PMID: 16393951; PubMed Central PMCID: PMC2973994
    • Kramer J.M., Yi L., Shen F., Maitra A., Jiao X., Jin T., et al. Evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol 2006, 176(2):711-715. PubMed PMID: 16393951; PubMed Central PMCID: PMC2973994.
    • (2006) J Immunol , vol.176 , Issue.2 , pp. 711-715
    • Kramer, J.M.1    Yi, L.2    Shen, F.3    Maitra, A.4    Jiao, X.5    Jin, T.6
  • 27
    • 38449092511 scopus 로고    scopus 로고
    • Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor
    • PubMed PMID: 17982023; PubMed Central PMCID: PMC2973996
    • Kramer J.M., Hanel W., Shen F., Isik N., Malone J.P., Maitra A., et al. Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. J Immunol 2007, 179(10):6379-6383. PubMed PMID: 17982023; PubMed Central PMCID: PMC2973996.
    • (2007) J Immunol , vol.179 , Issue.10 , pp. 6379-6383
    • Kramer, J.M.1    Hanel, W.2    Shen, F.3    Isik, N.4    Malone, J.P.5    Maitra, A.6
  • 28
    • 46649098062 scopus 로고    scopus 로고
    • Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
    • PubMed PMID: 18348982; PubMed Central PMCID: PMC2376247
    • Lindemann M.J., Hu Z., Benczik M., Liu K.D., Gaffen S.L. Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem 2008, 283(20):14100-14108. PubMed PMID: 18348982; PubMed Central PMCID: PMC2376247. 10.1074/jbc.M801357200.
    • (2008) J Biol Chem , vol.283 , Issue.20 , pp. 14100-14108
    • Lindemann, M.J.1    Hu, Z.2    Benczik, M.3    Liu, K.D.4    Gaffen, S.L.5
  • 29
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • PubMed PMID: 2419430
    • Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986, 136(7):2348-2357. PubMed PMID: 2419430.
    • (1986) J Immunol , vol.136 , Issue.7 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 30
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • PubMed PMID: 19710487
    • Miossec P., Korn T., Kuchroo V.K. Interleukin-17 and type 17 helper T cells. New England J Med 2009, 361(9):888-898. PubMed PMID: 19710487. 10.1056/NEJMra0707449.
    • (2009) New England J Med , vol.361 , Issue.9 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 31
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • PubMed PMID: 7636184
    • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155(3):1151-1164. PubMed PMID: 7636184.
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 32
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • PubMed PMID: 15785760
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005, 6(4):345-352. PubMed PMID: 15785760. 10.1038/ni1178.
    • (2005) Nat Immunol , vol.6 , Issue.4 , pp. 345-352
    • Sakaguchi, S.1
  • 33
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • PubMed PMID: 16990136
    • Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126(6):1121-1133. PubMed PMID: 16990136. 10.1016/j.cell.2006.07.035.
    • (2006) Cell , vol.126 , Issue.6 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 34
    • 39549091298 scopus 로고    scopus 로고
    • Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
    • PubMed PMID: 18166487; PubMed Central PMCID: PMC2323678
    • Chen Z., Laurence A., O'Shea J.J. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Seminars Immunol 2007, 19(6):400-408. PubMed PMID: 18166487; PubMed Central PMCID: PMC2323678. 10.1016/j.smim.2007.10.015.
    • (2007) Seminars Immunol , vol.19 , Issue.6 , pp. 400-408
    • Chen, Z.1    Laurence, A.2    O'Shea, J.J.3
  • 35
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: the second decade
    • PubMed PMID: 8521507
    • Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., et al. The nuclear receptor superfamily: the second decade. Cell 1995, 83(6):835-839. PubMed PMID: 8521507.
    • (1995) Cell , vol.83 , Issue.6 , pp. 835-839
    • Mangelsdorf, D.J.1    Thummel, C.2    Beato, M.3    Herrlich, P.4    Schutz, G.5    Umesono, K.6
  • 36
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    • PubMed PMID: 14691482
    • Eberl G., Marmon S., Sunshine M.J., Rennert P.D., Choi Y., Littman D.R. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 2004, 5(1):64-73. PubMed PMID: 14691482. 10.1038/ni1022.
    • (2004) Nat Immunol , vol.5 , Issue.1 , pp. 64-73
    • Eberl, G.1    Marmon, S.2    Sunshine, M.J.3    Rennert, P.D.4    Choi, Y.5    Littman, D.R.6
  • 37
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    • PubMed PMID: 18164222; PubMed Central PMCID: PMC2587175
    • Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 2008, 28(1):29-39. PubMed PMID: 18164222; PubMed Central PMCID: PMC2587175. 10.1016/j.immuni.2007.11.016.
    • (2008) Immunity , vol.28 , Issue.1 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3    Akimzhanov, A.4    Kang, H.S.5    Chung, Y.6
  • 38
    • 34247593586 scopus 로고    scopus 로고
    • STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
    • PubMed PMID: 17277312
    • Yang X.O., Panopoulos A.D., Nurieva R., Chang S.H., Wang D., Watowich S.S., et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 2007, 282(13):9358-9363. PubMed PMID: 17277312. 10.1074/jbc.C600321200.
    • (2007) J Biol Chem , vol.282 , Issue.13 , pp. 9358-9363
    • Yang, X.O.1    Panopoulos, A.D.2    Nurieva, R.3    Chang, S.H.4    Wang, D.5    Watowich, S.S.6
  • 39
    • 34548128307 scopus 로고    scopus 로고
    • The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    • PubMed PMID: 17676043
    • Brustle A., Heink S., Huber M., Rosenplanter C., Stadelmann C., Yu P., et al. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 2007, 8(9):958-966. PubMed PMID: 17676043. 10.1038/ni1500.
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 958-966
    • Brustle, A.1    Heink, S.2    Huber, M.3    Rosenplanter, C.4    Stadelmann, C.5    Yu, P.6
  • 40
    • 54549100120 scopus 로고    scopus 로고
    • Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    • PubMed PMID: 18849990
    • Zhang F., Meng G., Strober W. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol 2008, 9(11):1297-1306. PubMed PMID: 18849990. 10.1038/ni.1663.
    • (2008) Nat Immunol , vol.9 , Issue.11 , pp. 1297-1306
    • Zhang, F.1    Meng, G.2    Strober, W.3
  • 41
    • 33646164362 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulation of immune responses
    • PubMed PMID: 16551245
    • Li M.O., Wan Y.Y., Sanjabi S., Robertson A.K., Flavell R.A. Transforming growth factor-beta regulation of immune responses. Annual Rev Immunol 2006, 24:99-146. PubMed PMID: 16551245. 10.1146/annurev.immunol.24.021605.090737.
    • (2006) Annual Rev Immunol , vol.24 , pp. 99-146
    • Li, M.O.1    Wan, Y.Y.2    Sanjabi, S.3    Robertson, A.K.4    Flavell, R.A.5
  • 42
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • PubMed PMID: 16648837
    • Mangan P.R., Harrington L.E., O'Quinn D.B., Helms W.S., Bullard D.C., Elson C.O., et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006, 441(7090):231-234. PubMed PMID: 16648837. 10.1038/nature04754.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3    Helms, W.S.4    Bullard, D.C.5    Elson, C.O.6
  • 43
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • PubMed PMID: 16473830
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24(2):179-189. PubMed PMID: 16473830. 10.1016/j.immuni.2006.01.001.
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 44
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • PubMed PMID: 16648838
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441(7090):235-238. PubMed PMID: 16648838. 10.1038/nature04753.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 45
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • PubMed PMID: 12610626
    • Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421(6924):744-748. PubMed PMID: 12610626. 10.1038/nature01355.
    • (2003) Nature , vol.421 , Issue.6924 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 46
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • PubMed PMID: 14662908; PubMed Central PMCID: PMC2194162
    • Murphy C.A., Langrish C.L., Chen Y., Blumenschein W., McClanahan T., Kastelein R.A., et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003, 198(12):1951-1957. PubMed PMID: 14662908; PubMed Central PMCID: PMC2194162. 10.1084/jem.20030896.
    • (2003) J Exp Med , vol.198 , Issue.12 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3    Blumenschein, W.4    McClanahan, T.5    Kastelein, R.A.6
  • 47
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • PubMed PMID: 15657292; PubMed Central PMCID: PMC2212798
    • Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005, 201(2):233-240. PubMed PMID: 15657292; PubMed Central PMCID: PMC2212798. 10.1084/jem.20041257.
    • (2005) J Exp Med , vol.201 , Issue.2 , pp. 233-240
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3    Mattson, J.4    Basham, B.5    Sedgwick, J.D.6
  • 48
    • 57449105853 scopus 로고    scopus 로고
    • IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor
    • PubMed PMID:2315; PubMed Central PMCID: PMC2633410
    • Chen Q., Yang W., Gupta S., Biswas P., Smith P., Bhagat G., et al. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity 2008, 29(6):899-911. PubMed PMID:2315; PubMed Central PMCID: PMC2633410. 10.1016/j.immuni.2008.10.011.
    • (2008) Immunity , vol.29 , Issue.6 , pp. 899-911
    • Chen, Q.1    Yang, W.2    Gupta, S.3    Biswas, P.4    Smith, P.5    Bhagat, G.6
  • 49
    • 58549094107 scopus 로고    scopus 로고
    • IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    • PubMed PMID: 19088203; PubMed Central PMCID: PMC2634912
    • Huber M., Brustle A., Reinhard K., Guralnik A., Walter G., Mahiny A., et al. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc National Acad Sci United States of America 2008, 105(52):20846-20851. PubMed PMID: 19088203; PubMed Central PMCID: PMC2634912. 10.1073/pnas.0809077106.
    • (2008) Proc National Acad Sci United States of America , vol.105 , Issue.52 , pp. 20846-20851
    • Huber, M.1    Brustle, A.2    Reinhard, K.3    Guralnik, A.4    Walter, G.5    Mahiny, A.6
  • 50
    • 73249136480 scopus 로고    scopus 로고
    • IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?
    • PubMed PMID: 20192994 PubMed Central PMCID: PMC2920730
    • Biswas P.S., Bhagat G., Pernis A.B. IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?. Immunol Rev 2010, 233(1):79-96. PubMed PMID: 20192994 PubMed Central PMCID: PMC2920730. 10.1111/j.0105-2896.2009.00864.x.
    • (2010) Immunol Rev , vol.233 , Issue.1 , pp. 79-96
    • Biswas, P.S.1    Bhagat, G.2    Pernis, A.B.3
  • 51
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L., Ivanov I.I., Spolski R., Min R., Shenderov K., Egawa T., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007, 8(9):967-974. 10.1038/ni1488.
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6
  • 52
    • 79951682333 scopus 로고    scopus 로고
    • Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
    • Yang X.P., Ghoreschi K., Steward-Tharp S.M., Rodriguez-Canales J., Zhu J., Grainger J.R., et al. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol 2011, 12(3):247-254. 10.1038/ni.1995. PubMed PMID: 21278738; PubMed Central PMCID: PMC3182404.
    • (2011) Nat Immunol , vol.12 , Issue.3 , pp. 247-254
    • Yang, X.P.1    Ghoreschi, K.2    Steward-Tharp, S.M.3    Rodriguez-Canales, J.4    Zhu, J.5    Grainger, J.R.6
  • 53
    • 77953293952 scopus 로고    scopus 로고
    • Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
    • PubMed PMID: 20493732; PubMed Central PMCID: PMC3148263
    • Durant L., Watford W.T., Ramos H.L., Laurence A., Vahedi G., Wei L., et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 2010, 32(5):605-615. PubMed PMID: 20493732; PubMed Central PMCID: PMC3148263. 10.1016/j.immuni.2010.05.003.
    • (2010) Immunity , vol.32 , Issue.5 , pp. 605-615
    • Durant, L.1    Watford, W.T.2    Ramos, H.L.3    Laurence, A.4    Vahedi, G.5    Wei, L.6
  • 54
    • 79952761637 scopus 로고    scopus 로고
    • Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2
    • Chen Y., Haines C.J., Gutcher I., Hochweller K., Blumenschein W.M., McClanahan T., et al. Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2. Immunity 2011, 34(3):409-421. 10.1016/j.immuni.2011.02.011.
    • (2011) Immunity , vol.34 , Issue.3 , pp. 409-421
    • Chen, Y.1    Haines, C.J.2    Gutcher, I.3    Hochweller, K.4    Blumenschein, W.M.5    McClanahan, T.6
  • 55
    • 34848821989 scopus 로고    scopus 로고
    • Distinct regulation of interleukin-17 in human T helper lymphocytes
    • PubMed PMID: 17763419; PubMed Central PMCID: PMC2323677
    • Chen Z., Tato C.M., Muul L., Laurence A., O'Shea J.J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheumatism 2007, 56(9):2936-2946. PubMed PMID: 17763419; PubMed Central PMCID: PMC2323677. 10.1002/art.22866.
    • (2007) Arthritis Rheumatism , vol.56 , Issue.9 , pp. 2936-2946
    • Chen, Z.1    Tato, C.M.2    Muul, L.3    Laurence, A.4    O'Shea, J.J.5
  • 56
    • 84866756039 scopus 로고    scopus 로고
    • The role of epigenetic mechanisms and processes in autoimmune disorders
    • PubMed PMID: 23055689; PubMed Central PMCID: PMC3459549
    • Greer J.M., McCombe P.A. The role of epigenetic mechanisms and processes in autoimmune disorders. Biol: Targets Ther 2012, 6:307-327. PubMed PMID: 23055689; PubMed Central PMCID: PMC3459549. 10.2147/BTT.S24067.
    • (2012) Biol: Targets Ther , vol.6 , pp. 307-327
    • Greer, J.M.1    McCombe, P.A.2
  • 57
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson B., Scheinbart L., Strahler J., Gross L., Hanash S., Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheumatism 1990, 33(11):1665-1673.
    • (1990) Arthritis Rheumatism , vol.33 , Issue.11 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 58
    • 34147138648 scopus 로고    scopus 로고
    • Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
    • PubMed PMID: 17218320
    • Akimzhanov A.M., Yang X.O., Dong C. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem 2007, 282(9):5969-5972. PubMed PMID: 17218320. 10.1074/jbc.C600322200.
    • (2007) J Biol Chem , vol.282 , Issue.9 , pp. 5969-5972
    • Akimzhanov, A.M.1    Yang, X.O.2    Dong, C.3
  • 59
    • 79958189845 scopus 로고    scopus 로고
    • Histone acetyltransferases are crucial regulators in NF-kappaB mediated inflammation
    • PubMed PMID: 21477662
    • Ghizzoni M., Haisma H.J., Maarsingh H., Dekker F.J. Histone acetyltransferases are crucial regulators in NF-kappaB mediated inflammation. Drug Discovery Today 2011, 16(11-12):504-511. PubMed PMID: 21477662. 10.1016/j.drudis.2011.03.009.
    • (2011) Drug Discovery Today , vol.16 , Issue.11-12 , pp. 504-511
    • Ghizzoni, M.1    Haisma, H.J.2    Maarsingh, H.3    Dekker, F.J.4
  • 60
    • 0034807936 scopus 로고    scopus 로고
    • Interleukin-17 and lung host defense against Klebsiella pneumoniae infection
    • PubMed PMID: 11588011
    • Ye P., Garvey P.B., Zhang P., Nelson S., Bagby G., Summer W.R., et al. Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respiratory Cell Mol Biol 2001, 25(3):335-340. PubMed PMID: 11588011. 10.1165/ajrcmb.25.3.4424.
    • (2001) Am J Respiratory Cell Mol Biol , vol.25 , Issue.3 , pp. 335-340
    • Ye, P.1    Garvey, P.B.2    Zhang, P.3    Nelson, S.4    Bagby, G.5    Summer, W.R.6
  • 61
    • 17944364849 scopus 로고    scopus 로고
    • Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    • PubMed PMID: 11514607; PubMed Central PMCID: PMC2193502
    • Ye P., Rodriguez F.H., Kanaly S., Stocking K.L., Schurr J., Schwarzenberger P., et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med 2001, 194(4):519-527. PubMed PMID: 11514607; PubMed Central PMCID: PMC2193502.
    • (2001) J Exp Med , vol.194 , Issue.4 , pp. 519-527
    • Ye, P.1    Rodriguez, F.H.2    Kanaly, S.3    Stocking, K.L.4    Schurr, J.5    Schwarzenberger, P.6
  • 62
    • 84890136526 scopus 로고    scopus 로고
    • Nlrp-3-driven interleukin 17 production by gammadeltaT cells controls infection outcomes during Staphylococcus aureus surgical site infection
    • PubMed PMID: 24082072; PubMed Central PMCID: PMC3837970
    • Maher B.M., Mulcahy M.E., Murphy A.G., Wilk M., O'Keeffe K.M., Geoghegan J.A., et al. Nlrp-3-driven interleukin 17 production by gammadeltaT cells controls infection outcomes during Staphylococcus aureus surgical site infection. Infection Immunity 2013, 81(12):4478-4489. PubMed PMID: 24082072; PubMed Central PMCID: PMC3837970. 10.1128/IAI.01026-13.
    • (2013) Infection Immunity , vol.81 , Issue.12 , pp. 4478-4489
    • Maher, B.M.1    Mulcahy, M.E.2    Murphy, A.G.3    Wilk, M.4    O'Keeffe, K.M.5    Geoghegan, J.A.6
  • 63
    • 84898662109 scopus 로고    scopus 로고
    • Staphylococcus aureus infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection
    • PubMed PMID: 24623128; PubMed Central PMCID: PMC3979672
    • Murphy A.G., O'Keeffe K.M., Lalor S.J., Maher B.M., Mills K.H., McLoughlin R.M. Staphylococcus aureus infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection. J Immunol 2014, 192(8):3697-3708. PubMed PMID: 24623128; PubMed Central PMCID: PMC3979672. 10.4049/jimmunol.1303420.
    • (2014) J Immunol , vol.192 , Issue.8 , pp. 3697-3708
    • Murphy, A.G.1    O'Keeffe, K.M.2    Lalor, S.J.3    Maher, B.M.4    Mills, K.H.5    McLoughlin, R.M.6
  • 64
    • 0037442137 scopus 로고    scopus 로고
    • IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger
    • PubMed PMID: 12574382
    • Ferretti S., Bonneau O., Dubois G.R., Jones C.E., Trifilieff A. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol 2003, 170(4):2106-2112. PubMed PMID: 12574382.
    • (2003) J Immunol , vol.170 , Issue.4 , pp. 2106-2112
    • Ferretti, S.1    Bonneau, O.2    Dubois, G.R.3    Jones, C.E.4    Trifilieff, A.5
  • 65
    • 0033119051 scopus 로고    scopus 로고
    • Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway
    • PubMed PMID: 10328864
    • Shin H.C., Benbernou N., Esnault S., Guenounou M. Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine 1999, 11(4):257-266. PubMed PMID: 10328864. 10.1006/cyto.1998.0433.
    • (1999) Cytokine , vol.11 , Issue.4 , pp. 257-266
    • Shin, H.C.1    Benbernou, N.2    Esnault, S.3    Guenounou, M.4
  • 66
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • PubMed PMID: 16818675; PubMed Central PMCID: PMC2118338
    • Sutton C., Brereton C., Keogh B., Mills K.H., Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006, 203(7):1685-1691. PubMed PMID: 16818675; PubMed Central PMCID: PMC2118338. 10.1084/jem.20060285.
    • (2006) J Exp Med , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5
  • 67
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • PubMed PMID: 19575028; PubMed Central PMCID: PMC2821718
    • Gaffen S.L. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 2009, 9(8):556-567. PubMed PMID: 19575028; PubMed Central PMCID: PMC2821718. 10.1038/nri2586.
    • (2009) Nat Rev Immunol , vol.9 , Issue.8 , pp. 556-567
    • Gaffen, S.L.1
  • 68
    • 77953541639 scopus 로고    scopus 로고
    • The IL-17 family cytokines in immunity and disease
    • PubMed PMID: 20177959
    • Pappu R., Ramirez-Carrozzi V., Ota N., Ouyang W., Hu Y. The IL-17 family cytokines in immunity and disease. J Clin Immunol 2010, 30(2):185-195. PubMed PMID: 20177959. 10.1007/s10875-010-9369-6.
    • (2010) J Clin Immunol , vol.30 , Issue.2 , pp. 185-195
    • Pappu, R.1    Ramirez-Carrozzi, V.2    Ota, N.3    Ouyang, W.4    Hu, Y.5
  • 69
    • 33846022750 scopus 로고    scopus 로고
    • Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
    • PubMed PMID: 17035243
    • Chang S.H., Park H., Dong C. Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem 2006, 281(47):35603-35607. PubMed PMID: 17035243. 10.1074/jbc.C600256200.
    • (2006) J Biol Chem , vol.281 , Issue.47 , pp. 35603-35607
    • Chang, S.H.1    Park, H.2    Dong, C.3
  • 70
    • 34247873196 scopus 로고    scopus 로고
    • The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease
    • PubMed PMID: 17277779
    • Qian Y., Liu C., Hartupee J., Altuntas C.Z., Gulen M.F., Jane-Wit D., et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol 2007, 8(3):247-256. PubMed PMID: 17277779. 10.1038/ni1439.
    • (2007) Nat Immunol , vol.8 , Issue.3 , pp. 247-256
    • Qian, Y.1    Liu, C.2    Hartupee, J.3    Altuntas, C.Z.4    Gulen, M.F.5    Jane-Wit, D.6
  • 71
    • 0036785194 scopus 로고    scopus 로고
    • Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro
    • PubMed PMID: 12228154; PubMed Central PMCID: PMC1753923
    • Van Bezooijen R.L., Van Der Wee-Pals L., Papapoulos S.E., Lowik C.W. Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro. Annals Rheumatic Diseases 2002, 61(10):870-876. PubMed PMID: 12228154; PubMed Central PMCID: PMC1753923.
    • (2002) Annals Rheumatic Diseases , vol.61 , Issue.10 , pp. 870-876
    • Van Bezooijen, R.L.1    Van Der Wee-Pals, L.2    Papapoulos, S.E.3    Lowik, C.W.4
  • 72
    • 33750351338 scopus 로고    scopus 로고
    • Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis
    • Suppl 3:iii29-33, PubMed PMID: 17038468; PubMed Central PMCID: PMC1798387
    • Koenders M.I., Joosten L.A., van den Berg W.B. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Annals Rheumatic Diseases 2006, 65. Suppl 3:iii29-33, PubMed PMID: 17038468; PubMed Central PMCID: PMC1798387. 10.1136/ard.2006.058529.
    • (2006) Annals Rheumatic Diseases , pp. 65
    • Koenders, M.I.1    Joosten, L.A.2    van den Berg, W.B.3
  • 73
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • PubMed PMID: 17088434; PubMed Central PMCID: PMC2118166
    • Sato K., Suematsu A., Okamoto K., Yamaguchi A., Morishita Y., Kadono Y., et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006, 203(12):2673-2682. PubMed PMID: 17088434; PubMed Central PMCID: PMC2118166. 10.1084/jem.20061775.
    • (2006) J Exp Med , vol.203 , Issue.12 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3    Yamaguchi, A.4    Morishita, Y.5    Kadono, Y.6
  • 74
    • 77949454280 scopus 로고    scopus 로고
    • Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors
    • PubMed PMID: 20167120; PubMed Central PMCID: PMC2875663
    • Adamopoulos I.E., Chao C.C., Geissler R., Laface D., Blumenschein W., Iwakura Y., et al. Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. Arthritis Res Ther 2010, 12(1):R29. PubMed PMID: 20167120; PubMed Central PMCID: PMC2875663. 10.1186/ar2936.
    • (2010) Arthritis Res Ther , vol.12 , Issue.1 , pp. R29
    • Adamopoulos, I.E.1    Chao, C.C.2    Geissler, R.3    Laface, D.4    Blumenschein, W.5    Iwakura, Y.6
  • 75
    • 21244482587 scopus 로고    scopus 로고
    • Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1
    • PubMed PMID: 15972960; PubMed Central PMCID: PMC1603454
    • Koenders M.I., Lubberts E., Oppers-Walgreen B., van den Bersselaar L., Helsen M.M., Di Padova F.E., et al. Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1. Am J Pathol 2005, 167(1):141-149. PubMed PMID: 15972960; PubMed Central PMCID: PMC1603454. 10.1016/S0002-9440(10)62961-6.
    • (2005) Am J Pathol , vol.167 , Issue.1 , pp. 141-149
    • Koenders, M.I.1    Lubberts, E.2    Oppers-Walgreen, B.3    van den Bersselaar, L.4    Helsen, M.M.5    Di Padova, F.E.6
  • 76
    • 79961122266 scopus 로고    scopus 로고
    • Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1beta, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis
    • PubMed PMID: 21520013
    • Koenders M.I., Marijnissen R.J., Devesa I., Lubberts E., Joosten L.A., Roth J., et al. Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1beta, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis. Arthritis Rheumatism 2011, 63(8):2329-2339. PubMed PMID: 21520013. 10.1002/art.30418.
    • (2011) Arthritis Rheumatism , vol.63 , Issue.8 , pp. 2329-2339
    • Koenders, M.I.1    Marijnissen, R.J.2    Devesa, I.3    Lubberts, E.4    Joosten, L.A.5    Roth, J.6
  • 77
    • 80052611560 scopus 로고    scopus 로고
    • Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA
    • PubMed PMID: 21874405
    • Metawi S.A., Abbas D., Kamal M.M., Ibrahim M.K. Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA. Clin Rheumatol 2011, 30(9):1201-1207. PubMed PMID: 21874405. 10.1007/s10067-011-1737-y.
    • (2011) Clin Rheumatol , vol.30 , Issue.9 , pp. 1201-1207
    • Metawi, S.A.1    Abbas, D.2    Kamal, M.M.3    Ibrahim, M.K.4
  • 78
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • PubMed PMID: 14872510
    • Lubberts E., Koenders M.I., Oppers-Walgreen B., van den Bersselaar L., Coenen-de Roo C.J., Joosten L.A., et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheumatism 2004, 50(2):650-659. PubMed PMID: 14872510. 10.1002/art.20001.
    • (2004) Arthritis Rheumatism , vol.50 , Issue.2 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    van den Bersselaar, L.4    Coenen-de Roo, C.J.5    Joosten, L.A.6
  • 79
    • 0035459750 scopus 로고    scopus 로고
    • Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci
    • PubMed PMID: 11592370
    • LeGrand A., Fermor B., Fink C., Pisetsky D.S., Weinberg J.B., Vail T.P., et al. Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. Arthritis Rheumatism 2001, 44(9):2078-2083. PubMed PMID: 11592370. 10.1002/1529-0131(200109)44:9<2078::AID-ART3583.0.CO;2-J.
    • (2001) Arthritis Rheumatism , vol.44 , Issue.9 , pp. 2078-2083
    • LeGrand, A.1    Fermor, B.2    Fink, C.3    Pisetsky, D.S.4    Weinberg, J.B.5    Vail, T.P.6
  • 80
    • 79951471683 scopus 로고    scopus 로고
    • Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity
    • PubMed PMID: 21199257
    • Muhl H., Bachmann M., Pfeilschifter J. Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity. Cell Microbiol 2011, 13(3):340-348. PubMed PMID: 21199257. 10.1111/j.1462-5822.2010.01559.x.
    • (2011) Cell Microbiol , vol.13 , Issue.3 , pp. 340-348
    • Muhl, H.1    Bachmann, M.2    Pfeilschifter, J.3
  • 81
    • 84880664114 scopus 로고    scopus 로고
    • Synovial fibroblasts directly induce Th17 pathogenicity via the cyclooxygenase/prostaglandin E2 pathway, independent of IL-23
    • Paulissen S.M., van Hamburg J.P., Davelaar N., Asmawidjaja P.S., Hazes J.M., Lubberts E. Synovial fibroblasts directly induce Th17 pathogenicity via the cyclooxygenase/prostaglandin E2 pathway, independent of IL-23. J. Immunol 2013, 191(3):1364-1372. 10.4049/jimmunol.1300274.
    • (2013) J. Immunol , vol.191 , Issue.3 , pp. 1364-1372
    • Paulissen, S.M.1    van Hamburg, J.P.2    Davelaar, N.3    Asmawidjaja, P.S.4    Hazes, J.M.5    Lubberts, E.6
  • 82
    • 0034069815 scopus 로고    scopus 로고
    • IL-17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts
    • PubMed Central PMCID: PMC1905614
    • Katz Y., Nadiv O., Rapoport M.J., Loos M. IL-17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts. Clin Exp Immunol 2000, 120(1):22-29. PubMed Central PMCID: PMC1905614.
    • (2000) Clin Exp Immunol , vol.120 , Issue.1 , pp. 22-29
    • Katz, Y.1    Nadiv, O.2    Rapoport, M.J.3    Loos, M.4
  • 83
    • 66149153423 scopus 로고    scopus 로고
    • Interleukin 17 (IL-17) increases the expression of Toll-like receptor-2, 4, and 9 by increasing IL-1beta and IL-6 production in autoimmune arthritis
    • PubMed PMID: 19228664
    • Lee J.H., Cho M.L., Kim J.I., Moon Y.M., Oh H.J., Kim G.T., et al. Interleukin 17 (IL-17) increases the expression of Toll-like receptor-2, 4, and 9 by increasing IL-1beta and IL-6 production in autoimmune arthritis. J Rheumatol 2009, 36(4):684-692. PubMed PMID: 19228664. 10.3899/jrheum.080169.
    • (2009) J Rheumatol , vol.36 , Issue.4 , pp. 684-692
    • Lee, J.H.1    Cho, M.L.2    Kim, J.I.3    Moon, Y.M.4    Oh, H.J.5    Kim, G.T.6
  • 84
    • 70449625015 scopus 로고    scopus 로고
    • The role of toll-like receptors in rheumatoid arthritis
    • PubMed PMID: 19772831; PubMed Central PMCID: PMC2913446
    • Huang Q.Q., Pope R.M. The role of toll-like receptors in rheumatoid arthritis. Curr Rheumatol Rep 2009, 11(5):357-364. PubMed PMID: 19772831; PubMed Central PMCID: PMC2913446.
    • (2009) Curr Rheumatol Rep , vol.11 , Issue.5 , pp. 357-364
    • Huang, Q.Q.1    Pope, R.M.2
  • 85
    • 84863686039 scopus 로고    scopus 로고
    • The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha
    • PubMed PMID: 22660635
    • Zhu S., Pan W., Song X., Liu Y., Shao X., Tang Y., et al. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha. Nat Med 2012, 18(7):1077-1086. PubMed PMID: 22660635. 10.1038/nm.2815.
    • (2012) Nat Med , vol.18 , Issue.7 , pp. 1077-1086
    • Zhu, S.1    Pan, W.2    Song, X.3    Liu, Y.4    Shao, X.5    Tang, Y.6
  • 86
    • 84873963986 scopus 로고    scopus 로고
    • IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation
    • PubMed PMID: 23421940; PubMed Central PMCID: PMC3672783
    • Lee S.Y., Kwok S.K., Son H.J., Ryu J.G., Kim E.K., Oh H.J., et al. IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation. Arthritis Res Ther 2013, 15(1):R31. PubMed PMID: 23421940; PubMed Central PMCID: PMC3672783. 10.1186/ar4179.
    • (2013) Arthritis Res Ther , vol.15 , Issue.1 , pp. R31
    • Lee, S.Y.1    Kwok, S.K.2    Son, H.J.3    Ryu, J.G.4    Kim, E.K.5    Oh, H.J.6
  • 87
    • 45249097325 scopus 로고    scopus 로고
    • Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
    • PubMed PMID: 18373953
    • Wong C.K., Lit L.C., Tam L.S., Li E.K., Wong P.T., Lam C.W. Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol 2008, 127(3):385-393. PubMed PMID: 18373953. 10.1016/j.clim.2008.01.019.
    • (2008) Clin Immunol , vol.127 , Issue.3 , pp. 385-393
    • Wong, C.K.1    Lit, L.C.2    Tam, L.S.3    Li, E.K.4    Wong, P.T.5    Lam, C.W.6
  • 88
    • 70349238893 scopus 로고    scopus 로고
    • The role of IL-23/IL-17 axis in lupus nephritis
    • PubMed PMID: 19657089; PubMed Central PMCID: PMC2766304
    • Zhang Z., Kyttaris V.C., Tsokos G.C. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol 2009, 183(5):3160-3169. PubMed PMID: 19657089; PubMed Central PMCID: PMC2766304. 10.4049/jimmunol.0900385.
    • (2009) J Immunol , vol.183 , Issue.5 , pp. 3160-3169
    • Zhang, Z.1    Kyttaris, V.C.2    Tsokos, G.C.3
  • 89
    • 77953196382 scopus 로고    scopus 로고
    • Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice
    • PubMed PMID: 20308633; PubMed Central PMCID: PMC2926666
    • Kyttaris V.C., Zhang Z., Kuchroo V.K., Oukka M., Tsokos G.C. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol 2010, 184(9):4605-4609. PubMed PMID: 20308633; PubMed Central PMCID: PMC2926666. 10.4049/jimmunol.0903595.
    • (2010) J Immunol , vol.184 , Issue.9 , pp. 4605-4609
    • Kyttaris, V.C.1    Zhang, Z.2    Kuchroo, V.K.3    Oukka, M.4    Tsokos, G.C.5
  • 90
    • 58849162766 scopus 로고    scopus 로고
    • Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys
    • PubMed PMID: 19050297; PubMed Central PMCID: PMC2596652
    • Crispin J.C., Oukka M., Bayliss G., Cohen R.A., Van Beek C.A., Stillman I.E., et al. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol 2008, 181(12):8761-8766. PubMed PMID: 19050297; PubMed Central PMCID: PMC2596652.
    • (2008) J Immunol , vol.181 , Issue.12 , pp. 8761-8766
    • Crispin, J.C.1    Oukka, M.2    Bayliss, G.3    Cohen, R.A.4    Van Beek, C.A.5    Stillman, I.E.6
  • 91
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • PubMed PMID: 17187052
    • Zheng Y., Danilenko D.M., Valdez P., Kasman I., Eastham-Anderson J., Wu J., et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007, 445(7128):648-651. PubMed PMID: 17187052. 10.1038/nature05505.
    • (2007) Nature , vol.445 , Issue.7128 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3    Kasman, I.4    Eastham-Anderson, J.5    Wu, J.6
  • 92
    • 37549011317 scopus 로고    scopus 로고
    • Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    • PubMed PMID: 18039949; PubMed Central PMCID: PMC2150965
    • Zaba L.C., Cardinale I., Gilleaudeau P., Sullivan-Whalen M., Suarez-Farinas M., Fuentes-Duculan J., et al. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med 2007, 204(13):3183-3194. PubMed PMID: 18039949; PubMed Central PMCID: PMC2150965. 10.1084/jem.20071094.
    • (2007) J Exp Med , vol.204 , Issue.13 , pp. 3183-3194
    • Zaba, L.C.1    Cardinale, I.2    Gilleaudeau, P.3    Sullivan-Whalen, M.4    Suarez-Farinas, M.5    Fuentes-Duculan, J.6
  • 93
    • 58149316658 scopus 로고    scopus 로고
    • Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis
    • PubMed PMID: 18802076; PubMed Central PMCID: PMC2677162
    • Kryczek I., Bruce A.T., Gudjonsson J.E., Johnston A., Aphale A., Vatan L., et al. Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 2008, 181(7):4733-4741. PubMed PMID: 18802076; PubMed Central PMCID: PMC2677162.
    • (2008) J Immunol , vol.181 , Issue.7 , pp. 4733-4741
    • Kryczek, I.1    Bruce, A.T.2    Gudjonsson, J.E.3    Johnston, A.4    Aphale, A.5    Vatan, L.6
  • 94
    • 42149087160 scopus 로고    scopus 로고
    • Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
    • Lowes M.A., Kikuchi T., Fuentes-Duculan J., Cardinale I., Zaba L.C., Haider A.S., et al. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 2008, 128(5):1207-1211. 10.1038/sj.jid.5701213.
    • (2008) J Invest Dermatol , vol.128 , Issue.5 , pp. 1207-1211
    • Lowes, M.A.1    Kikuchi, T.2    Fuentes-Duculan, J.3    Cardinale, I.4    Zaba, L.C.5    Haider, A.S.6
  • 95
    • 47249125726 scopus 로고    scopus 로고
    • Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
    • Pene J., Chevalier S., Preisser L., Venereau E., Guilleux M.H., Ghannam S., et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008, 180(11):7423-7430.
    • (2008) J Immunol , vol.180 , Issue.11 , pp. 7423-7430
    • Pene, J.1    Chevalier, S.2    Preisser, L.3    Venereau, E.4    Guilleux, M.H.5    Ghannam, S.6
  • 96
    • 79959207913 scopus 로고    scopus 로고
    • Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response
    • PubMed PMID: 21689402; PubMed Central PMCID: PMC3218910
    • Appel H., Maier R., Wu P., Scheer R., Hempfing A., Kayser R., et al. Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 2011, 13(3):R95. PubMed PMID: 21689402; PubMed Central PMCID: PMC3218910. 10.1186/ar3370.
    • (2011) Arthritis Res Ther , vol.13 , Issue.3 , pp. R95
    • Appel, H.1    Maier, R.2    Wu, P.3    Scheer, R.4    Hempfing, A.5    Kayser, R.6
  • 97
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • PubMed PMID: 18486739
    • Leonardi C.L., Kimball A.B., Papp K.A., Yeilding N., Guzzo C., Wang Y., et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 2008, 371(9625):1665-1674. PubMed PMID: 18486739. 10.1016/S0140-6736(08)60725-4.
    • (2008) Lancet , vol.371 , Issue.9625 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6
  • 98
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • PubMed PMID: 18486740
    • Papp K.A., Langley R.G., Lebwohl M., Krueger G.G., Szapary P., Yeilding N., et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008, 371(9625):1675-1684. PubMed PMID: 18486740. 10.1016/S0140-6736(08)60726-6.
    • (2008) Lancet , vol.371 , Issue.9625 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3    Krueger, G.G.4    Szapary, P.5    Yeilding, N.6
  • 99
    • 84883134297 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial
    • PubMed PMID: 23769296
    • McInnes I.B., Kavanaugh A., Gottlieb A.B., Puig L., Rahman P., Ritchlin C., et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet 2013, 382(9894):780-789. PubMed PMID: 23769296. 10.1016/S0140-6736(13)60594-2.
    • (2013) Lancet , vol.382 , Issue.9894 , pp. 780-789
    • McInnes, I.B.1    Kavanaugh, A.2    Gottlieb, A.B.3    Puig, L.4    Rahman, P.5    Ritchlin, C.6
  • 100
    • 84899991797 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial
    • PubMed PMID: 24482301; PubMed Central PMCID: PMC4033144
    • Ritchlin C., Rahman P., Kavanaugh A., McInnes I.B., Puig L., Li S., et al. Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial. Annals Rheumatic Diseases 2014, 73(6):990-999. PubMed PMID: 24482301; PubMed Central PMCID: PMC4033144. 10.1136/annrheumdis-2013-204655.
    • (2014) Annals Rheumatic Diseases , vol.73 , Issue.6 , pp. 990-999
    • Ritchlin, C.1    Rahman, P.2    Kavanaugh, A.3    McInnes, I.B.4    Puig, L.5    Li, S.6
  • 101
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • PubMed PMID: 20926833
    • Hueber W., Patel D.D., Dryja T., Wright A.M., Koroleva I., Bruin G., et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 2010, 2(52):52ra72. PubMed PMID: 20926833. 10.1126/scitranslmed.3001107.
    • (2010) Sci Transl Med , vol.2 , Issue.52 , pp. 52ra72
    • Hueber, W.1    Patel, D.D.2    Dryja, T.3    Wright, A.M.4    Koroleva, I.5    Bruin, G.6
  • 102
    • 84873124241 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study
    • PubMed PMID: 23106107
    • Papp K.A., Langley R.G., Sigurgeirsson B., Abe M., Baker D.R., Konno P., et al. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. Brit J Dermatol 2013, 168(2):412-421. PubMed PMID: 23106107. 10.1111/bjd.12110.
    • (2013) Brit J Dermatol , vol.168 , Issue.2 , pp. 412-421
    • Papp, K.A.1    Langley, R.G.2    Sigurgeirsson, B.3    Abe, M.4    Baker, D.R.5    Konno, P.6
  • 103
    • 84873168729 scopus 로고    scopus 로고
    • Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study
    • PubMed PMID: 23362969
    • Rich P., Sigurgeirsson B., Thaci D., Ortonne J.P., Paul C., Schopf R.E., et al. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Brit J Dermatol 2013, 168(2):402-411. PubMed PMID: 23362969. 10.1111/bjd.12112.
    • (2013) Brit J Dermatol , vol.168 , Issue.2 , pp. 402-411
    • Rich, P.1    Sigurgeirsson, B.2    Thaci, D.3    Ortonne, J.P.4    Paul, C.5    Schopf, R.E.6
  • 104
    • 84895465850 scopus 로고    scopus 로고
    • One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: phase II, dose-finding, double-blind, randomized, placebo-controlled study
    • PubMed PMID: 24429175
    • Genovese M.C., Durez P., Richards H.B., Supronik J., Dokoupilova E., Aelion J.A., et al. One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: phase II, dose-finding, double-blind, randomized, placebo-controlled study. J Rheumatol 2014, 41(3):414-421. PubMed PMID: 24429175. 10.3899/jrheum.130637.
    • (2014) J Rheumatol , vol.41 , Issue.3 , pp. 414-421
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3    Supronik, J.4    Dokoupilova, E.5    Aelion, J.A.6
  • 105
    • 84877603562 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study
    • PubMed PMID: 22730366
    • Genovese M.C., Durez P., Richards H.B., Supronik J., Dokoupilova E., Mazurov V., et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Annals Rheumatic Diseases 2013, 72(6):863-869. PubMed PMID: 22730366. 10.1136/annrheumdis-2012-201601.
    • (2013) Annals Rheumatic Diseases , vol.72 , Issue.6 , pp. 863-869
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3    Supronik, J.4    Dokoupilova, E.5    Mazurov, V.6
  • 106
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • PubMed PMID: 22455413
    • Leonardi C., Matheson R., Zachariae C., Cameron G., Li L., Edson-Heredia E., et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. New England J Med 2012, 366(13):1190-1199. PubMed PMID: 22455413. 10.1056/NEJMoa1109997.
    • (2012) New England J Med , vol.366 , Issue.13 , pp. 1190-1199
    • Leonardi, C.1    Matheson, R.2    Zachariae, C.3    Cameron, G.4    Li, L.5    Edson-Heredia, E.6
  • 107
    • 84903478179 scopus 로고    scopus 로고
    • A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors
    • PubMed PMID: 24623718
    • Genovese M.C., Greenwald M., Cho C.S., Berman A., Jin L., Cameron G.S., et al. A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors. Arthritis Rheumatol 2014, 66(7):1693-1704. PubMed PMID: 24623718. 10.1002/art.38617.
    • (2014) Arthritis Rheumatol , vol.66 , Issue.7 , pp. 1693-1704
    • Genovese, M.C.1    Greenwald, M.2    Cho, C.S.3    Berman, A.4    Jin, L.5    Cameron, G.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.