The topology of pen-2, a γ-secretase subunit, revisited: Evidence for a reentrant loop and a single pass transmembrane domain

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Zhang, Xulun ^a   Yu, Chunjiang J ^a   Sisodia, Sangram S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Pen 2; Topology; secretase

Indexed keywords

AMINO ACID; GAMMA SECRETASE; PRESENILIN ENHANCER 2; UNCLASSIFIED DRUG; HYBRID PROTEIN; LIPID BILAYER; MEMBRANE PROTEIN; PSENEN PROTEIN, HUMAN; SECRETASE; SREBF1 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CYTOPLASM; EMBRYO; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBUNIT; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIPID BILAYER; PROTEIN DEGRADATION; PROTEIN DOMAIN; AMINO ACID SEQUENCE; ANIMAL; CATALYSIS; CELL CULTURE; CHEMICAL PHENOMENA; CHEMISTRY; DEFICIENCY; FIBROBLAST; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; MOUSE; NEUROBLASTOMA; PATHOLOGY; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

MAMMALIA;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CATALYSIS; CELL LINE, TUMOR; CELLS, CULTURED; FIBROBLASTS; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPID BILAYERS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84939638284     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0037-4     Document Type: Article

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