SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

Nucleic Acids Research

Volumn 43, Issue 13, 2015, Pages 6486-6499

  Seamon, Kyle J ^a   Sun, Zhiqiang ^b   Shlyakhtenko, Luda S ^b   Lyubchenko, Yuri L ^b   Stivers, James T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' DNA EXONUCLEASE; 3' RNA EXONUCLEASE; 5' DNA EXONUCLEASE; 5' RNA EXONUCLEASE; DEOXYRIBONUCLEASE; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE HYDROLASE; ENZYME; EXONUCLEASE; HYDROLASE; NUCLEIC ACID BINDING PROTEIN; SINGLE STRANDED DNA; SINGLE STRANDED RNA; STERILE ALPHA MOTIF AND HISTIDINE ASPARTATE DOMAIN 1 PROTEIN; TETRAMER; UNCLASSIFIED DRUG; ZINC ION; DNA BINDING PROTEIN; EXODEOXYRIBONUCLEASE; EXORIBONUCLEASE; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NUCLEOSIDE TRIPHOSPHATASE; PROTEIN BINDING; RNA BINDING PROTEIN; SAMHD1 PROTEIN, HUMAN; ZINC;

AMINO TERMINAL SEQUENCE; ANISOTROPY; ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING AFFINITY; BINDING SITE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE ANISOTROPY; GEL MOBILITY SHIFT ASSAY; HD DOMAIN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IN VIVO STUDY; ION EXCHANGE CHROMATOGRAPHY; MOLECULAR WEIGHT; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN RNA BINDING; STRUCTURE ACTIVITY RELATION; U937 CELL LINE; VIRUS INHIBITION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CATALYTIC DOMAIN; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; EXODEOXYRIBONUCLEASES; EXORIBONUCLEASES; HUMANS; MONOMERIC GTP-BINDING PROTEINS; MUTATION; NUCLEOSIDE-TRIPHOSPHATASE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RNA-BINDING PROTEINS; ZINC;

EID: 84939626708     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv633     Document Type: Article

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