Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization

Journal of the American Chemical Society

Volumn 136, Issue 28, 2014, Pages 9822-9825

  Seamon, Kyle J ^a   Hansen, Erik C ^a   Kadina, Anastasia P ^b   Kashemirov, Boris A ^b   McKenna, Charles E ^b   Bumpus, Namandjé N ^a   Stivers, James T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRIDGES;

ALLOSTERIC MECHANISMS; COMPETITIVE INHIBITION; METHYLENE BRIDGE; SMALL MOLECULES; TETRAMER DESTABILIZATION; TETRAMERS;

ENZYME INHIBITION;

ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATE; MOLECULAR LIBRARY; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; SAMHD1 PROTEIN, HUMAN;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYME ACTIVATION; MOLECULAR LIBRARY; SYNTHESIS;

DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; GUANOSINE TRIPHOSPHATE; MONOMERIC GTP-BINDING PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84904438593     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5035717     Document Type: Article

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