-
1
-
-
84872119357
-
The worldwide economic impact of dementia 2010
-
Wimo A, Jonsson L, Bond J, Prince M, Winblad B The worldwide economic impact of dementia 2010. Alzheimers Dement 2013, 9:1-11.e3.
-
(2013)
Alzheimers Dement
, vol.9
, pp. 1-11.e3
-
-
Wimo, A.1
Jonsson, L.2
Bond, J.3
Prince, M.4
Winblad, B.5
-
2
-
-
84863611722
-
Is dementia incidence declining? Trends in dementia incidence since 1990 in the Rotterdam Study
-
Schrijvers EM, Verhaaren BF, Koudstaal PJ, Hofman A, Ikram MA, Breteler MM Is dementia incidence declining? Trends in dementia incidence since 1990 in the Rotterdam Study. Neurology 2012, 78:1456-1463.
-
(2012)
Neurology
, vol.78
, pp. 1456-1463
-
-
Schrijvers, E.M.1
Verhaaren, B.F.2
Koudstaal, P.J.3
Hofman, A.4
Ikram, M.A.5
Breteler, M.M.6
-
3
-
-
38949104188
-
The coming acceleration of global population ageing
-
Lutz W, Sanderson W, Scherbov S The coming acceleration of global population ageing. Nature 2008, 451:716-719.
-
(2008)
Nature
, vol.451
, pp. 716-719
-
-
Lutz, W.1
Sanderson, W.2
Scherbov, S.3
-
4
-
-
84872109456
-
The global prevalence of dementia: a systematic review and metaanalysis
-
Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement 2013, 9:63-75.e2.
-
(2013)
Alzheimers Dement
, vol.9
, pp. 63-75.e2
-
-
Prince, M.1
Bryce, R.2
Albanese, E.3
Wimo, A.4
Ribeiro, W.5
Ferri, C.P.6
-
5
-
-
34249697099
-
Forecasting the global burden of Alzheimer's disease
-
Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM Forecasting the global burden of Alzheimer's disease. Alzheimers Dement 2007, 3:186-191.
-
(2007)
Alzheimers Dement
, vol.3
, pp. 186-191
-
-
Brookmeyer, R.1
Johnson, E.2
Ziegler-Graham, K.3
Arrighi, H.M.4
-
6
-
-
84904264999
-
Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
-
Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol 2014, 13:788-794.
-
(2014)
Lancet Neurol
, vol.13
, pp. 788-794
-
-
Norton, S.1
Matthews, F.E.2
Barnes, D.E.3
Yaffe, K.4
Brayne, C.5
-
7
-
-
55249083121
-
Dementia prevention: methodological explanations for inconsistent results
-
Coley N, Andrieu S, Gardette V, et al. Dementia prevention: methodological explanations for inconsistent results. Epidemiol Rev 2008, 30:35-66.
-
(2008)
Epidemiol Rev
, vol.30
, pp. 35-66
-
-
Coley, N.1
Andrieu, S.2
Gardette, V.3
-
8
-
-
77955487508
-
National Institutes of Health State-of-the-Science Conference statement: preventing Alzheimer disease and cognitive decline
-
Daviglus ML, Bell CC, Berrettini W, et al. National Institutes of Health State-of-the-Science Conference statement: preventing Alzheimer disease and cognitive decline. Ann Intern Med 2010, 153:176-181.
-
(2010)
Ann Intern Med
, vol.153
, pp. 176-181
-
-
Daviglus, M.L.1
Bell, C.C.2
Berrettini, W.3
-
9
-
-
77955870204
-
Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors
-
Ritchie K, Carriere I, Ritchie CW, Berr C, Artero S, Ancelin ML Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors. BMJ 2010, 341:c3885.
-
(2010)
BMJ
, vol.341
, pp. c3885
-
-
Ritchie, K.1
Carriere, I.2
Ritchie, C.W.3
Berr, C.4
Artero, S.5
Ancelin, M.L.6
-
10
-
-
80051669619
-
The projected effect of risk factor reduction on Alzheimer's disease prevalence
-
Barnes DE, Yaffe K The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 2011, 10:819-828.
-
(2011)
Lancet Neurol
, vol.10
, pp. 819-828
-
-
Barnes, D.E.1
Yaffe, K.2
-
11
-
-
0037042299
-
Alzheimer disease
-
Cummings JL, Cole G Alzheimer disease. JAMA 2002, 287:2335-2338.
-
(2002)
JAMA
, vol.287
, pp. 2335-2338
-
-
Cummings, J.L.1
Cole, G.2
-
12
-
-
34248593249
-
Primary prevention and delay of onset of AD/dementia
-
Feldman HH, Jacova C Primary prevention and delay of onset of AD/dementia. Can J Neurol Sci 2007, 34(suppl 1):S84-S89.
-
(2007)
Can J Neurol Sci
, vol.34
, pp. S84-S89
-
-
Feldman, H.H.1
Jacova, C.2
-
13
-
-
84886747917
-
A conceptual framework and ethics analysis for prevention trials of Alzheimer disease
-
Peters KR, Lynn Beattie B, Feldman HH, Illes J A conceptual framework and ethics analysis for prevention trials of Alzheimer disease. Prog Neurobiol 2013, 110:114-123.
-
(2013)
Prog Neurobiol
, vol.110
, pp. 114-123
-
-
Peters, K.R.1
Lynn Beattie, B.2
Feldman, H.H.3
Illes, J.4
-
15
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:280-292.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
-
16
-
-
82655173747
-
Testing the right target and right drug at the right stage
-
Sperling RA, Jack CR, Aisen PS Testing the right target and right drug at the right stage. Sci Transl Med 2011, 3:111cm33.
-
(2011)
Sci Transl Med
, vol.3
, pp. 33-111
-
-
Sperling, R.A.1
Jack, C.R.2
Aisen, P.S.3
-
17
-
-
84863869296
-
Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-beta plaques: a prospective cohort study
-
Clark CM, Pontecorvo MJ, Beach TG, et al. Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-beta plaques: a prospective cohort study. Lancet Neurol 2012, 11:669-678.
-
(2012)
Lancet Neurol
, vol.11
, pp. 669-678
-
-
Clark, C.M.1
Pontecorvo, M.J.2
Beach, T.G.3
-
18
-
-
84865683216
-
Brain amyloid imaging-FDA approval of florbetapir F18 injection
-
Yang L, Rieves D, Ganley C Brain amyloid imaging-FDA approval of florbetapir F18 injection. N Engl J Med 2012, 367:885-887.
-
(2012)
N Engl J Med
, vol.367
, pp. 885-887
-
-
Yang, L.1
Rieves, D.2
Ganley, C.3
-
19
-
-
85027933989
-
Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association
-
Johnson KA, Minoshima S, Bohnen NI, et al. Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association. Alzheimers Dement 2013, 9:e1-e16.
-
(2013)
Alzheimers Dement
, vol.9
, pp. e1-e16
-
-
Johnson, K.A.1
Minoshima, S.2
Bohnen, N.I.3
-
21
-
-
0032564132
-
Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial
-
Forette F, Seux ML, Staessen JA, et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998, 352:1347-1351.
-
(1998)
Lancet
, vol.352
, pp. 1347-1351
-
-
Forette, F.1
Seux, M.L.2
Staessen, J.A.3
-
22
-
-
0038669268
-
Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease
-
Tzourio C, Anderson C, Chapman N, et al. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med 2003, 163:1069-1075.
-
(2003)
Arch Intern Med
, vol.163
, pp. 1069-1075
-
-
Tzourio, C.1
Anderson, C.2
Chapman, N.3
-
23
-
-
2942755831
-
Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
-
Shumaker SA, Legault C, Kuller L, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004, 291:2947-2958.
-
(2004)
JAMA
, vol.291
, pp. 2947-2958
-
-
Shumaker, S.A.1
Legault, C.2
Kuller, L.3
-
24
-
-
0038386058
-
Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial
-
Shumaker SA, Legault C, Rapp SR, et al. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003, 289:2651-2662.
-
(2003)
JAMA
, vol.289
, pp. 2651-2662
-
-
Shumaker, S.A.1
Legault, C.2
Rapp, S.R.3
-
25
-
-
59649085600
-
Plasma Aβ, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial
-
Viswanathan A, Raj S, Greenberg SM, et al. Plasma Aβ, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial. Neurology 2009, 72:268-272.
-
(2009)
Neurology
, vol.72
, pp. 268-272
-
-
Viswanathan, A.1
Raj, S.2
Greenberg, S.M.3
-
26
-
-
0037073256
-
Effects of cognitive training interventions with older adults: a randomized controlled trial
-
Ball K, Berch DB, Helmers KF, et al. Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA 2002, 288:2271-2281.
-
(2002)
JAMA
, vol.288
, pp. 2271-2281
-
-
Ball, K.1
Berch, D.B.2
Helmers, K.F.3
-
27
-
-
21144447586
-
A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
-
Thal LJ, Ferris SH, Kirby L, et al. A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology 2005, 30:1204-1215.
-
(2005)
Neuropsychopharmacology
, vol.30
, pp. 1204-1215
-
-
Thal, L.J.1
Ferris, S.H.2
Kirby, L.3
-
28
-
-
20344381835
-
Vitamin E and donepezil for the treatment of mild cognitive impairment
-
Petersen RC, Thomas RG, Grundman M, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005, 352:2379-2388.
-
(2005)
N Engl J Med
, vol.352
, pp. 2379-2388
-
-
Petersen, R.C.1
Thomas, R.G.2
Grundman, M.3
-
29
-
-
34248372938
-
Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study
-
Feldman HH, Ferris S, Winblad B, et al. Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol 2007, 6:501-512.
-
(2007)
Lancet Neurol
, vol.6
, pp. 501-512
-
-
Feldman, H.H.1
Ferris, S.2
Winblad, B.3
-
30
-
-
30744433314
-
Randomized, controlled, six-month trial of yoga in healthy seniors: effects on cognition and quality of life
-
Oken BS, Zajdel D, Kishiyama S, et al. Randomized, controlled, six-month trial of yoga in healthy seniors: effects on cognition and quality of life. Altern Ther Health Med 2006, 12:40-47.
-
(2006)
Altern Ther Health Med
, vol.12
, pp. 40-47
-
-
Oken, B.S.1
Zajdel, D.2
Kishiyama, S.3
-
31
-
-
4143052423
-
Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial
-
Salloway S, Ferris S, Kluger A, et al. Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial. Neurology 2004, 63:651-657.
-
(2004)
Neurology
, vol.63
, pp. 651-657
-
-
Salloway, S.1
Ferris, S.2
Kluger, A.3
-
32
-
-
78149240857
-
Vitamins B(12), B(6), and folic acid for cognition in older men
-
Ford AH, Flicker L, Alfonso H, et al. Vitamins B(12), B(6), and folic acid for cognition in older men. Neurology 2010, 75:1540-1547.
-
(2010)
Neurology
, vol.75
, pp. 1540-1547
-
-
Ford, A.H.1
Flicker, L.2
Alfonso, H.3
-
33
-
-
56649112752
-
Ginkgo biloba for prevention of dementia: a randomized controlled trial
-
DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 2008, 300:2253-2262.
-
(2008)
JAMA
, vol.300
, pp. 2253-2262
-
-
DeKosky, S.T.1
Williamson, J.D.2
Fitzpatrick, A.L.3
-
34
-
-
67349152620
-
A randomized double-blind trial of the effects of hormone therapy on delayed verbal recall in older women
-
Tierney MC, Oh P, Moineddin R, et al. A randomized double-blind trial of the effects of hormone therapy on delayed verbal recall in older women. Psychoneuroendocrinology 2009, 34:1065-1074.
-
(2009)
Psychoneuroendocrinology
, vol.34
, pp. 1065-1074
-
-
Tierney, M.C.1
Oh, P.2
Moineddin, R.3
-
35
-
-
34249058674
-
Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
-
Lyketsos CG, Breitner JC, Green RC, et al. Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology 2007, 68:1800-1808.
-
(2007)
Neurology
, vol.68
, pp. 1800-1808
-
-
Lyketsos, C.G.1
Breitner, J.C.2
Green, R.C.3
-
36
-
-
46949106968
-
Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial
-
Peters R, Beckett N, Forette F, et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol 2008, 7:683-689.
-
(2008)
Lancet Neurol
, vol.7
, pp. 683-689
-
-
Peters, R.1
Beckett, N.2
Forette, F.3
-
37
-
-
45149132039
-
Safety and efficacy of galantamine in subjects with mild cognitive impairment
-
Winblad B, Gauthier S, Scinto L, et al. Safety and efficacy of galantamine in subjects with mild cognitive impairment. Neurology 2008, 70:2024-2035.
-
(2008)
Neurology
, vol.70
, pp. 2024-2035
-
-
Winblad, B.1
Gauthier, S.2
Scinto, L.3
-
38
-
-
84866445630
-
Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial
-
Vellas B, Coley N, Ousset PJ, et al. Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial. Lancet Neurol 2012, 11:851-859.
-
(2012)
Lancet Neurol
, vol.11
, pp. 851-859
-
-
Vellas, B.1
Coley, N.2
Ousset, P.J.3
-
39
-
-
33745652285
-
A controlled trial of homocysteine lowering and cognitive performance
-
McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006, 354:2764-2772.
-
(2006)
N Engl J Med
, vol.354
, pp. 2764-2772
-
-
McMahon, J.A.1
Green, T.J.2
Skeaff, C.M.3
Knight, R.G.4
Mann, J.I.5
Williams, S.M.6
-
40
-
-
67649293283
-
Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial
-
Doody RS, Ferris SH, Salloway S, et al. Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology 2009, 72:1555-1561.
-
(2009)
Neurology
, vol.72
, pp. 1555-1561
-
-
Doody, R.S.1
Ferris, S.H.2
Salloway, S.3
-
41
-
-
80054748660
-
Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy
-
Launer LJ, Miller ME, Williamson JD, et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol 2011, 10:969-977.
-
(2011)
Lancet Neurol
, vol.10
, pp. 969-977
-
-
Launer, L.J.1
Miller, M.E.2
Williamson, J.D.3
-
42
-
-
33748427825
-
Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial
-
Eussen SJ, de Groot LC, Joosten LW, et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006, 84:361-370.
-
(2006)
Am J Clin Nutr
, vol.84
, pp. 361-370
-
-
Eussen, S.J.1
de Groot, L.C.2
Joosten, L.W.3
-
43
-
-
78649407752
-
Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: a randomized controlled trial
-
Muscari A, Giannoni C, Pierpaoli L, et al. Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: a randomized controlled trial. Int J Geriatr Psychiatry 2010, 25:1055-1064.
-
(2010)
Int J Geriatr Psychiatry
, vol.25
, pp. 1055-1064
-
-
Muscari, A.1
Giannoni, C.2
Pierpaoli, L.3
-
44
-
-
50949110086
-
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
-
Lautenschlager NT, Cox KL, Flicker L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 2008, 300:1027-1037.
-
(2008)
JAMA
, vol.300
, pp. 1027-1037
-
-
Lautenschlager, N.T.1
Cox, K.L.2
Flicker, L.3
-
45
-
-
77958567930
-
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial
-
Smith AD, Smith SM, de Jager CA, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One 2010, 5:e12244.
-
(2010)
PLoS One
, vol.5
, pp. e12244
-
-
Smith, A.D.1
Smith, S.M.2
de Jager, C.A.3
-
46
-
-
49049099040
-
Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial
-
van de Rest O, Geleijnse JM, Kok FJ, et al. Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology 2008, 71:430-438.
-
(2008)
Neurology
, vol.71
, pp. 430-438
-
-
van de Rest, O.1
Geleijnse, J.M.2
Kok, F.J.3
-
47
-
-
78049528932
-
Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
-
Yurko-Mauro K, McCarthy D, Rom D, et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement 2010, 6:456-464.
-
(2010)
Alzheimers Dement
, vol.6
, pp. 456-464
-
-
Yurko-Mauro, K.1
McCarthy, D.2
Rom, D.3
-
48
-
-
77953066352
-
Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial
-
Dangour AD, Allen E, Elbourne D, et al. Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. Am J Clin Nutr 2010, 91:1725-1732.
-
(2010)
Am J Clin Nutr
, vol.91
, pp. 1725-1732
-
-
Dangour, A.D.1
Allen, E.2
Elbourne, D.3
-
49
-
-
63849214997
-
A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study
-
Smith GE, Housen P, Yaffe K, et al. A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc 2009, 57:594-603.
-
(2009)
J Am Geriatr Soc
, vol.57
, pp. 594-603
-
-
Smith, G.E.1
Housen, P.2
Yaffe, K.3
-
50
-
-
77952965326
-
Complex mental and physical activity in older women and cognitive performance: a 6-month randomized controlled trial
-
Klusmann V, Evers A, Schwarzer R, et al. Complex mental and physical activity in older women and cognitive performance: a 6-month randomized controlled trial. J Gerontol A Biol Sci Med Sci 2010, 65:680-688.
-
(2010)
J Gerontol A Biol Sci Med Sci
, vol.65
, pp. 680-688
-
-
Klusmann, V.1
Evers, A.2
Schwarzer, R.3
-
51
-
-
84867101906
-
A randomized controlled trial of dietetic interventions to prevent cognitive decline in old age hostel residents
-
Kwok TC, Lam LC, Sea MM, Goggins W, Woo J A randomized controlled trial of dietetic interventions to prevent cognitive decline in old age hostel residents. Eur J Clin Nutr 2012, 66:1135-1140.
-
(2012)
Eur J Clin Nutr
, vol.66
, pp. 1135-1140
-
-
Kwok, T.C.1
Lam, L.C.2
Sea, M.M.3
Goggins, W.4
Woo, J.5
-
52
-
-
84928902456
-
Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study-a randomized controlled trial
-
Mastroiacovo D, Kwik-Uribe C, Grassi D, et al. Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study-a randomized controlled trial. Am J Clin Nutr 2015, 101:538-548.
-
(2015)
Am J Clin Nutr
, vol.101
, pp. 538-548
-
-
Mastroiacovo, D.1
Kwik-Uribe, C.2
Grassi, D.3
-
53
-
-
84865458738
-
Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study
-
Desideri G, Kwik-Uribe C, Grassi D, et al. Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study. Hypertension 2012, 60:794-801.
-
(2012)
Hypertension
, vol.60
, pp. 794-801
-
-
Desideri, G.1
Kwik-Uribe, C.2
Grassi, D.3
-
54
-
-
75749096280
-
Resistance training and executive functions: a 12-month randomized controlled trial
-
Liu-Ambrose T, Nagamatsu LS, Graf P, Beattie BL, Ashe MC, Handy TC Resistance training and executive functions: a 12-month randomized controlled trial. Arch Intern Med 2010, 170:170-178.
-
(2010)
Arch Intern Med
, vol.170
, pp. 170-178
-
-
Liu-Ambrose, T.1
Nagamatsu, L.S.2
Graf, P.3
Beattie, B.L.4
Ashe, M.C.5
Handy, T.C.6
-
55
-
-
84907862086
-
Multifactorial vascular risk factor intervention to prevent cognitive impairment after stroke and TIA: a 12-month randomized controlled trial
-
Ihle-Hansen H, Thommessen B, Fagerland MW, et al. Multifactorial vascular risk factor intervention to prevent cognitive impairment after stroke and TIA: a 12-month randomized controlled trial. Int J Stroke 2014, 9:932-938.
-
(2014)
Int J Stroke
, vol.9
, pp. 932-938
-
-
Ihle-Hansen, H.1
Thommessen, B.2
Fagerland, M.W.3
-
56
-
-
84928047295
-
The PACE study: a randomized clinical trial of cognitive activity strategy training for older people with mild cognitive impairment
-
Vidovich MR, Lautenschlager NT, Flicker L, Clare L, McCaul K, Almeida OP The PACE study: a randomized clinical trial of cognitive activity strategy training for older people with mild cognitive impairment. Am J Geriatr Psychiatry 2015, 23:360-372.
-
(2015)
Am J Geriatr Psychiatry
, vol.23
, pp. 360-372
-
-
Vidovich, M.R.1
Lautenschlager, N.T.2
Flicker, L.3
Clare, L.4
McCaul, K.5
Almeida, O.P.6
-
57
-
-
80755154380
-
Exergaming and older adult cognition: a cluster randomized clinical trial
-
Anderson-Hanley C, Arciero PJ, Brickman AM, et al. Exergaming and older adult cognition: a cluster randomized clinical trial. Am J Prev Med 2012, 42:109-119.
-
(2012)
Am J Prev Med
, vol.42
, pp. 109-119
-
-
Anderson-Hanley, C.1
Arciero, P.J.2
Brickman, A.M.3
-
58
-
-
84863351551
-
Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial
-
Hajjar I, Hart M, Chen YL, et al. Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial. Arch Intern Med 2012, 172:442-444.
-
(2012)
Arch Intern Med
, vol.172
, pp. 442-444
-
-
Hajjar, I.1
Hart, M.2
Chen, Y.L.3
-
59
-
-
84877773817
-
The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults
-
Barnes DE, Santos-Modesitt W, Poelke G, et al. The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults. JAMA Intern Med 2013, 173:797-804.
-
(2013)
JAMA Intern Med
, vol.173
, pp. 797-804
-
-
Barnes, D.E.1
Santos-Modesitt, W.2
Poelke, G.3
-
60
-
-
84906014769
-
Effects of a multidomain lifestyle modification on cognitive function in older adults: an eighteen-month community-based cluster randomized controlled trial
-
Lee KS, Lee Y, Back JH, et al. Effects of a multidomain lifestyle modification on cognitive function in older adults: an eighteen-month community-based cluster randomized controlled trial. Psychother Psychosom 2014, 83:270-278.
-
(2014)
Psychother Psychosom
, vol.83
, pp. 270-278
-
-
Lee, K.S.1
Lee, Y.2
Back, J.H.3
-
61
-
-
84939570984
-
Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep
-
Diamond K, Mowszowski L, Cockayne N, et al. Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep. J Alzheimers Dis 2015, 44:1181-1191.
-
(2015)
J Alzheimers Dis
, vol.44
, pp. 1181-1191
-
-
Diamond, K.1
Mowszowski, L.2
Cockayne, N.3
-
62
-
-
84934294678
-
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
-
Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 2015, 385:2255-2263.
-
(2015)
Lancet
, vol.385
, pp. 2255-2263
-
-
Ngandu, T.1
Lehtisalo, J.2
Solomon, A.3
-
63
-
-
84877047918
-
A randomized controlled trial of cognitive training using a visual speed of processing intervention in middle aged and older adults
-
Wolinsky FD, Vander Weg MW, Howren MB, Jones MP, Dotson MM A randomized controlled trial of cognitive training using a visual speed of processing intervention in middle aged and older adults. PLoS One 2013, 8:e61624.
-
(2013)
PLoS One
, vol.8
, pp. e61624
-
-
Wolinsky, F.D.1
Vander Weg, M.W.2
Howren, M.B.3
Jones, M.P.4
Dotson, M.M.5
-
64
-
-
84874355169
-
Effectiveness of cognitive training for Chinese elderly in Hong Kong
-
Kwok T, Wong A, Chan G, et al. Effectiveness of cognitive training for Chinese elderly in Hong Kong. Clin Interv Aging 2013, 8:213-219.
-
(2013)
Clin Interv Aging
, vol.8
, pp. 213-219
-
-
Kwok, T.1
Wong, A.2
Chan, G.3
-
65
-
-
84876064944
-
A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment
-
Suzuki T, Shimada H, Makizako H, et al. A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One 2013, 8:e61483.
-
(2013)
PLoS One
, vol.8
, pp. e61483
-
-
Suzuki, T.1
Shimada, H.2
Makizako, H.3
-
66
-
-
43249085300
-
A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study
-
Gomez-Isla T, Blesa R, Boada M, et al. A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study. Alzheimer Dis Assoc Disord 2008, 22:21-29.
-
(2008)
Alzheimer Dis Assoc Disord
, vol.22
, pp. 21-29
-
-
Gomez-Isla, T.1
Blesa, R.2
Boada, M.3
-
67
-
-
84864121047
-
A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI
-
Peters O, Lorenz D, Fesche A, et al. A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI. J Nutr Health Aging 2012, 16:544-548.
-
(2012)
J Nutr Health Aging
, vol.16
, pp. 544-548
-
-
Peters, O.1
Lorenz, D.2
Fesche, A.3
-
68
-
-
84876899290
-
Does a multicomponent exercise program improve dual-task performance in amnestic mild cognitive impairment? A randomized controlled trial
-
Makizako H, Doi T, Shimada H, et al. Does a multicomponent exercise program improve dual-task performance in amnestic mild cognitive impairment? A randomized controlled trial. Aging Clin Exp Res 2012, 24:640-646.
-
(2012)
Aging Clin Exp Res
, vol.24
, pp. 640-646
-
-
Makizako, H.1
Doi, T.2
Shimada, H.3
-
69
-
-
77953518555
-
Alzheimer's disease: clinical trials and drug development
-
Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M Alzheimer's disease: clinical trials and drug development. Lancet Neurol 2010, 9:702-716.
-
(2010)
Lancet Neurol
, vol.9
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
Mecocci, P.4
Kivipelto, M.5
-
71
-
-
35848962080
-
Disease-modifying therapies for Alzheimer disease: challenges to early intervention
-
Cummings JL, Doody R, Clark C Disease-modifying therapies for Alzheimer disease: challenges to early intervention. Neurology 2007, 69:1622-1634.
-
(2007)
Neurology
, vol.69
, pp. 1622-1634
-
-
Cummings, J.L.1
Doody, R.2
Clark, C.3
-
72
-
-
84867463345
-
Alzheimer's drugs take a new tack
-
Callaway E Alzheimer's drugs take a new tack. Nature 2012, 489:13-14.
-
(2012)
Nature
, vol.489
, pp. 13-14
-
-
Callaway, E.1
-
73
-
-
80054090078
-
The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults
-
Danthiir V, Burns NR, Nettelbeck T, Wilson C, Wittert G The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. Nutr J 2011, 10:117.
-
(2011)
Nutr J
, vol.10
, pp. 117
-
-
Danthiir, V.1
Burns, N.R.2
Nettelbeck, T.3
Wilson, C.4
Wittert, G.5
-
74
-
-
70349095579
-
Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress
-
Richard E, Van den Heuvel E, Moll van Charante EP, et al. Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress. Alzheimer Dis Assoc Disord 2009, 23:198-204.
-
(2009)
Alzheimer Dis Assoc Disord
, vol.23
, pp. 198-204
-
-
Richard, E.1
Van den Heuvel, E.2
Moll van Charante, E.P.3
-
75
-
-
84878500301
-
Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective sub study (KEEPS Cog)
-
Wharton W, Gleason CE, Miller VM, Asthana S Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective sub study (KEEPS Cog). Brain Res 2013, 1514:12-17.
-
(2013)
Brain Res
, vol.1514
, pp. 12-17
-
-
Wharton, W.1
Gleason, C.E.2
Miller, V.M.3
Asthana, S.4
-
76
-
-
84887370094
-
Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial
-
ASPREE Investigator Group
-
Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemp Clin Trials 2013, 36:555-564. ASPREE Investigator Group.
-
(2013)
Contemp Clin Trials
, vol.36
, pp. 555-564
-
-
-
77
-
-
84907507193
-
The LIFE Cognition Study: design and baseline characteristics
-
Sink KM, Espeland MA, Rushing J, et al. The LIFE Cognition Study: design and baseline characteristics. Clin Interv Aging 2014, 9:1425-1436.
-
(2014)
Clin Interv Aging
, vol.9
, pp. 1425-1436
-
-
Sink, K.M.1
Espeland, M.A.2
Rushing, J.3
-
78
-
-
84867237403
-
Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial
-
Cyarto EV, Lautenschlager NT, Desmond PM, et al. Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial. BMC Psychiatry 2012, 12:167.
-
(2012)
BMC Psychiatry
, vol.12
, pp. 167
-
-
Cyarto, E.V.1
Lautenschlager, N.T.2
Desmond, P.M.3
-
79
-
-
84908257905
-
MAPT study: a multidomain approach for preventing Alzheimer's disease: design and baseline data
-
Vellas B, Carrie I, Gillette-Guyonnet S, et al. MAPT study: a multidomain approach for preventing Alzheimer's disease: design and baseline data. J Prev Alzheimers Dis 2014, 1:13-22.
-
(2014)
J Prev Alzheimers Dis
, vol.1
, pp. 13-22
-
-
Vellas, B.1
Carrie, I.2
Gillette-Guyonnet, S.3
-
80
-
-
84908166637
-
The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)
-
Ambrosius WT, Sink KM, Foy CG, et al. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Clin Trials 2014, 11:532-546.
-
(2014)
Clin Trials
, vol.11
, pp. 532-546
-
-
Ambrosius, W.T.1
Sink, K.M.2
Foy, C.G.3
-
81
-
-
84872686057
-
Using genetics to enable studies on the prevention of Alzheimer's disease
-
Crenshaw DG, Gottschalk WK, Lutz MW, et al. Using genetics to enable studies on the prevention of Alzheimer's disease. Clin Pharmacol Ther 2013, 93:177-185.
-
(2013)
Clin Pharmacol Ther
, vol.93
, pp. 177-185
-
-
Crenshaw, D.G.1
Gottschalk, W.K.2
Lutz, M.W.3
-
82
-
-
42749100518
-
Cholinesterase inhibitors for Alzheimer's disease
-
CD005593.
-
Birks J Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev 2006, 1. CD005593.
-
(2006)
Cochrane Database Syst Rev
, vol.1
-
-
Birks, J.1
-
83
-
-
22144451172
-
The age-dependent relation of blood pressure to cognitive function and dementia
-
Qiu C, Winblad B, Fratiglioni L The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol 2005, 4:487-499.
-
(2005)
Lancet Neurol
, vol.4
, pp. 487-499
-
-
Qiu, C.1
Winblad, B.2
Fratiglioni, L.3
-
84
-
-
84884271395
-
Current status of renin-aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease
-
Ashby EL, Kehoe PG Current status of renin-aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease. Expert Opin Investig Drugs 2013, 22:1229-1242.
-
(2013)
Expert Opin Investig Drugs
, vol.22
, pp. 1229-1242
-
-
Ashby, E.L.1
Kehoe, P.G.2
-
85
-
-
84862976418
-
Calcium channel blockers and Alzheimer's disease: potential relevance in treatment strategies of metabolic syndrome
-
Goodison WV, Frisardi V, Kehoe PG Calcium channel blockers and Alzheimer's disease: potential relevance in treatment strategies of metabolic syndrome. J Alzheimers Dis 2012, 30(suppl 2):S269-S282.
-
(2012)
J Alzheimers Dis
, vol.30
, pp. S269-S282
-
-
Goodison, W.V.1
Frisardi, V.2
Kehoe, P.G.3
-
86
-
-
0030769501
-
The role of estrogen in the treatment and prevention of dementia: introduction
-
Birge SJ The role of estrogen in the treatment and prevention of dementia: introduction. Am J Med 1997, 103:1S-2S.
-
(1997)
Am J Med
, vol.103
, pp. 1S-2S
-
-
Birge, S.J.1
-
87
-
-
84856483459
-
The potential use of hormone-based therapeutics for the treatment of Alzheimer's disease
-
Carroll JC, Rosario ER The potential use of hormone-based therapeutics for the treatment of Alzheimer's disease. Curr Alzheimer Res 2012, 9:18-34.
-
(2012)
Curr Alzheimer Res
, vol.9
, pp. 18-34
-
-
Carroll, J.C.1
Rosario, E.R.2
-
88
-
-
77957088739
-
Estrogen therapy and Alzheimer's dementia
-
Craig MC, Murphy DG Estrogen therapy and Alzheimer's dementia. Ann N Y Acad Sci 2010, 1205:245-253.
-
(2010)
Ann N Y Acad Sci
, vol.1205
, pp. 245-253
-
-
Craig, M.C.1
Murphy, D.G.2
-
89
-
-
70350304150
-
Estrogen therapy: is time of initiation critical for neuroprotection?
-
Sherwin BB Estrogen therapy: is time of initiation critical for neuroprotection?. Nat Rev Endocrinol 2009, 5:620-627.
-
(2009)
Nat Rev Endocrinol
, vol.5
, pp. 620-627
-
-
Sherwin, B.B.1
-
90
-
-
84861314593
-
Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
-
CD006378.
-
Jaturapatporn D, Isaac MG, McCleery J, Tabet N Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst Rev 2012, 2. CD006378.
-
(2012)
Cochrane Database Syst Rev
, vol.2
-
-
Jaturapatporn, D.1
Isaac, M.G.2
McCleery, J.3
Tabet, N.4
-
91
-
-
84899519009
-
Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?
-
Imbimbo BP, Solfrizzi V, Panza F Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?. Front Aging Neurosci 2010, 2:19.
-
(2010)
Front Aging Neurosci
, vol.2
, pp. 19
-
-
Imbimbo, B.P.1
Solfrizzi, V.2
Panza, F.3
-
92
-
-
79960769591
-
Extended results of the Alzheimer's disease anti-inflammatory prevention trial
-
Breitner JC, Baker LD, Montine TJ, et al. Extended results of the Alzheimer's disease anti-inflammatory prevention trial. Alzheimers Dement 2011, 7:402-411.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 402-411
-
-
Breitner, J.C.1
Baker, L.D.2
Montine, T.J.3
-
93
-
-
0035936004
-
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
-
in t'Veld BA, Ruitenberg A, Hofman A, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001, 345:1515-1521.
-
(2001)
N Engl J Med
, vol.345
, pp. 1515-1521
-
-
In t'Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
-
94
-
-
77949892092
-
Mechanisms of action of non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease
-
Cole GM, Frautschy SA Mechanisms of action of non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease. CNS Neurol Disord Drug Targets 2010, 9:140-148.
-
(2010)
CNS Neurol Disord Drug Targets
, vol.9
, pp. 140-148
-
-
Cole, G.M.1
Frautschy, S.A.2
-
95
-
-
0028338749
-
The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761
-
Marcocci L, Maguire JJ, Droy-Lefaix MT, Packer L The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761. Biochem Biophys Res Commun 1994, 201:748-755.
-
(1994)
Biochem Biophys Res Commun
, vol.201
, pp. 748-755
-
-
Marcocci, L.1
Maguire, J.J.2
Droy-Lefaix, M.T.3
Packer, L.4
-
96
-
-
0031080693
-
Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761)
-
Pietri S, Maurelli E, Drieu K, Culcasi M Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J Mol Cell Cardiol 1997, 29:733-742.
-
(1997)
J Mol Cell Cardiol
, vol.29
, pp. 733-742
-
-
Pietri, S.1
Maurelli, E.2
Drieu, K.3
Culcasi, M.4
-
97
-
-
0037126035
-
Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761
-
Luo Y, Smith JV, Paramasivam V, et al. Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci USA 2002, 99:12197-12202.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12197-12202
-
-
Luo, Y.1
Smith, J.V.2
Paramasivam, V.3
-
98
-
-
29044449855
-
Risk of dementia in diabetes mellitus: a systematic review
-
Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 2006, 5:64-74.
-
(2006)
Lancet Neurol
, vol.5
, pp. 64-74
-
-
Biessels, G.J.1
Staekenborg, S.2
Brunner, E.3
Brayne, C.4
Scheltens, P.5
-
99
-
-
84883733870
-
Molecular links between Alzheimer's disease and diabetes mellitus
-
Yang Y, Song W Molecular links between Alzheimer's disease and diabetes mellitus. Neuroscience 2013, 250:140-150.
-
(2013)
Neuroscience
, vol.250
, pp. 140-150
-
-
Yang, Y.1
Song, W.2
-
100
-
-
84863002103
-
Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin
-
Moreira PI Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin. J Alzheimers Dis 2012, 30(suppl 2):S199-S215.
-
(2012)
J Alzheimers Dis
, vol.30
, pp. S199-S215
-
-
Moreira, P.I.1
-
101
-
-
84862992514
-
Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease
-
Searcy JL, Phelps JT, Pancani T, et al. Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. J Alzheimers Dis 2012, 30:943-961.
-
(2012)
J Alzheimers Dis
, vol.30
, pp. 943-961
-
-
Searcy, J.L.1
Phelps, J.T.2
Pancani, T.3
-
102
-
-
67650128395
-
Therapeutic potential of statins in Alzheimer's disease
-
Kandiah N, Feldman HH Therapeutic potential of statins in Alzheimer's disease. J Neurol Sci 2009, 283:230-234.
-
(2009)
J Neurol Sci
, vol.283
, pp. 230-234
-
-
Kandiah, N.1
Feldman, H.H.2
-
103
-
-
0036523032
-
Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease
-
Kruman II, Kumaravel TS, Lohani A, et al. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 2002, 22:1752-1762.
-
(2002)
J Neurosci
, vol.22
, pp. 1752-1762
-
-
Kruman, I.I.1
Kumaravel, T.S.2
Lohani, A.3
-
104
-
-
27744603884
-
Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials
-
Homocysteine Lowering Trialists' Collaboration
-
Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005, 82:806-812. Homocysteine Lowering Trialists' Collaboration.
-
(2005)
Am J Clin Nutr
, vol.82
, pp. 806-812
-
-
-
105
-
-
84859889194
-
Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
-
de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 2012, 27:592-600.
-
(2012)
Int J Geriatr Psychiatry
, vol.27
, pp. 592-600
-
-
de Jager, C.A.1
Oulhaj, A.2
Jacoby, R.3
Refsum, H.4
Smith, A.D.5
-
106
-
-
0032902974
-
Oxidative alterations in Alzheimer's disease
-
Markesbery WR, Carney JM Oxidative alterations in Alzheimer's disease. Brain Pathol 1999, 9:133-146.
-
(1999)
Brain Pathol
, vol.9
, pp. 133-146
-
-
Markesbery, W.R.1
Carney, J.M.2
-
107
-
-
85027924487
-
A randomized controlled Alzheimer's disease prevention trial's evolution into an exposure trial: the PREADViSE Trial
-
Kryscio RJ, Abner EL, Schmitt FA, et al. A randomized controlled Alzheimer's disease prevention trial's evolution into an exposure trial: the PREADViSE Trial. J Nutr Health Aging 2013, 17:72-75.
-
(2013)
J Nutr Health Aging
, vol.17
, pp. 72-75
-
-
Kryscio, R.J.1
Abner, E.L.2
Schmitt, F.A.3
-
108
-
-
33745498488
-
Nutrition in brain development and aging: role of essential fatty acids
-
Uauy R, Dangour AD Nutrition in brain development and aging: role of essential fatty acids. Nutr Rev 2006, 64:S24-S33.
-
(2006)
Nutr Rev
, vol.64
, pp. S24-S33
-
-
Uauy, R.1
Dangour, A.D.2
-
109
-
-
84655167890
-
Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease
-
Williams RJ, Spencer JP Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic Biol Med 2012, 52:35-45.
-
(2012)
Free Radic Biol Med
, vol.52
, pp. 35-45
-
-
Williams, R.J.1
Spencer, J.P.2
-
110
-
-
84863091991
-
Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis
-
Etgen T, Sander D, Bickel H, Sander K, Forstl H Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis. Dement Geriatr Cogn Disord 2012, 33:297-305.
-
(2012)
Dement Geriatr Cogn Disord
, vol.33
, pp. 297-305
-
-
Etgen, T.1
Sander, D.2
Bickel, H.3
Sander, K.4
Forstl, H.5
-
111
-
-
84900993069
-
1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease
-
Durk MR, Han K, Chow EC, et al. 1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease. J Neurosci 2014, 34:7091-7101.
-
(2014)
J Neurosci
, vol.34
, pp. 7091-7101
-
-
Durk, M.R.1
Han, K.2
Chow, E.C.3
-
112
-
-
5444219980
-
Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease
-
Scarmeas N, Stern Y Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease. Curr Neurol Neurosci Rep 2004, 4:374-380.
-
(2004)
Curr Neurol Neurosci Rep
, vol.4
, pp. 374-380
-
-
Scarmeas, N.1
Stern, Y.2
-
113
-
-
33845717310
-
Long-term effects of cognitive training on everyday functional outcomes in older adults
-
Willis SL, Tennstedt SL, Marsiske M, et al. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA 2006, 296:2805-2814.
-
(2006)
JAMA
, vol.296
, pp. 2805-2814
-
-
Willis, S.L.1
Tennstedt, S.L.2
Marsiske, M.3
-
114
-
-
80755137169
-
Exercise, brain, and cognition across the life span
-
Voss MW, Nagamatsu LS, Liu-Ambrose T, Kramer AF Exercise, brain, and cognition across the life span. J Appl Physiol (1985) 2011, 111:1505-1513.
-
(2011)
J Appl Physiol (1985)
, vol.111
, pp. 1505-1513
-
-
Voss, M.W.1
Nagamatsu, L.S.2
Liu-Ambrose, T.3
Kramer, A.F.4
-
115
-
-
84919342870
-
Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling
-
Phillips C, Baktir MA, Srivatsan M, Salehi A Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling. Front Cell Neurosci 2014, 8:170.
-
(2014)
Front Cell Neurosci
, vol.8
, pp. 170
-
-
Phillips, C.1
Baktir, M.A.2
Srivatsan, M.3
Salehi, A.4
-
116
-
-
68849119553
-
Physical activity, diet, and risk of Alzheimer disease
-
Scarmeas N, Luchsinger JA, Schupf N, et al. Physical activity, diet, and risk of Alzheimer disease. JAMA 2009, 302:627-637.
-
(2009)
JAMA
, vol.302
, pp. 627-637
-
-
Scarmeas, N.1
Luchsinger, J.A.2
Schupf, N.3
-
117
-
-
84875514732
-
Regulatory innovation and drug development for early-stage Alzheimer's disease
-
Kozauer N, Katz R Regulatory innovation and drug development for early-stage Alzheimer's disease. N Engl J Med 2013, 368:1169-1171.
-
(2013)
N Engl J Med
, vol.368
, pp. 1169-1171
-
-
Kozauer, N.1
Katz, R.2
-
118
-
-
82755189703
-
Prevention trials in Alzheimer's disease: an EU-US task force report
-
Vellas B, Aisen PS, Sampaio C, et al. Prevention trials in Alzheimer's disease: an EU-US task force report. Prog Neurobiol 2011, 95:594-600.
-
(2011)
Prog Neurobiol
, vol.95
, pp. 594-600
-
-
Vellas, B.1
Aisen, P.S.2
Sampaio, C.3
-
119
-
-
84885444102
-
CERAD practice effects and attrition bias in a dementia prevention trial
-
Mathews M, Abner E, Caban-Holt A, Kryscio R, Schmitt F CERAD practice effects and attrition bias in a dementia prevention trial. Int Psychogeriatr 2013, 25:1115-1123.
-
(2013)
Int Psychogeriatr
, vol.25
, pp. 1115-1123
-
-
Mathews, M.1
Abner, E.2
Caban-Holt, A.3
Kryscio, R.4
Schmitt, F.5
-
120
-
-
84905969638
-
The preclinical Alzheimer cognitive composite: measuring amyloid-related decline
-
Donohue MC, Sperling RA, Salmon DP, et al. The preclinical Alzheimer cognitive composite: measuring amyloid-related decline. JAMA Neurol 2014, 71:961-970.
-
(2014)
JAMA Neurol
, vol.71
, pp. 961-970
-
-
Donohue, M.C.1
Sperling, R.A.2
Salmon, D.P.3
-
121
-
-
84927175617
-
An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease
-
Langbaum JB, Hendrix SB, Ayutyanont N, et al. An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease. Alzheimers Dement 2014, 10:666-674.
-
(2014)
Alzheimers Dement
, vol.10
, pp. 666-674
-
-
Langbaum, J.B.1
Hendrix, S.B.2
Ayutyanont, N.3
-
122
-
-
67650652432
-
I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy
-
Barker AD, Sigman CC, Kelloff GJ, Hylton NM, Berry DA, Esserman LJ I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy. Clin Pharmacol Ther 2009, 86:97-100.
-
(2009)
Clin Pharmacol Ther
, vol.86
, pp. 97-100
-
-
Barker, A.D.1
Sigman, C.C.2
Kelloff, G.J.3
Hylton, N.M.4
Berry, D.A.5
Esserman, L.J.6
-
124
-
-
34447322271
-
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria
-
Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007, 6:734-746.
-
(2007)
Lancet Neurol
, vol.6
, pp. 734-746
-
-
Dubois, B.1
Feldman, H.H.2
Jacova, C.3
-
125
-
-
82755161905
-
Biomarkers for Alzheimer's disease therapeutic trials
-
Hampel H, Wilcock G, Andrieu S, et al. Biomarkers for Alzheimer's disease therapeutic trials. Prog Neurobiol 2011, 95:579-593.
-
(2011)
Prog Neurobiol
, vol.95
, pp. 579-593
-
-
Hampel, H.1
Wilcock, G.2
Andrieu, S.3
-
126
-
-
84924358275
-
Understanding biomarkers of neurodegeneration: novel approaches to detecting tau pathology
-
Cook CN, Murray ME, Petrucelli L Understanding biomarkers of neurodegeneration: novel approaches to detecting tau pathology. Nat Med 2015, 21:219-220.
-
(2015)
Nat Med
, vol.21
, pp. 219-220
-
-
Cook, C.N.1
Murray, M.E.2
Petrucelli, L.3
-
127
-
-
38049179306
-
Chronic disease long-term drug prevention trials: lessons from the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)
-
Meinert CL, Breitner JC Chronic disease long-term drug prevention trials: lessons from the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT). Alzheimers Dement 2008, 4(1 suppl 1):S7-S14.
-
(2008)
Alzheimers Dement
, vol.4
, Issue.1 SUPPL 1
, pp. S7-S14
-
-
Meinert, C.L.1
Breitner, J.C.2
-
128
-
-
77958467736
-
Design considerations in long-term intervention studies for the prevention of cognitive decline or dementia
-
Dangour AD, Allen E, Richards M, Whitehouse P, Uauy R Design considerations in long-term intervention studies for the prevention of cognitive decline or dementia. Nutr Rev 2010, 68(suppl 1):S16-S21.
-
(2010)
Nutr Rev
, vol.68
, pp. S16-S21
-
-
Dangour, A.D.1
Allen, E.2
Richards, M.3
Whitehouse, P.4
Uauy, R.5
-
129
-
-
18744394346
-
The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study
-
Amieva H, Jacqmin-Gadda H, Orgogozo JM, et al. The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study. Brain 2005, 128(pt 5):1093-1101.
-
(2005)
Brain
, vol.128
, pp. 1093-1101
-
-
Amieva, H.1
Jacqmin-Gadda, H.2
Orgogozo, J.M.3
-
130
-
-
84897568536
-
Simulating effects of biomarker enrichment on Alzheimer's disease prevention trials: conceptual framework and example
-
Leoutsakos JM, Bartlett AL, Forrester SN, Lyketsos CG Simulating effects of biomarker enrichment on Alzheimer's disease prevention trials: conceptual framework and example. Alzheimers Dement 2014, 10:152-161.
-
(2014)
Alzheimers Dement
, vol.10
, pp. 152-161
-
-
Leoutsakos, J.M.1
Bartlett, A.L.2
Forrester, S.N.3
Lyketsos, C.G.4
-
131
-
-
84904042612
-
A comparison of the constant piecewise weighted logrank and Fleming-Harrington tests
-
Gares V, Andrieu S, Dupuy JF, Savy N A comparison of the constant piecewise weighted logrank and Fleming-Harrington tests. Electron J Stat 2014, 8:841-860.
-
(2014)
Electron J Stat
, vol.8
, pp. 841-860
-
-
Gares, V.1
Andrieu, S.2
Dupuy, J.F.3
Savy, N.4
-
132
-
-
84920446257
-
An omnibus test for several hazard alternatives in prevention randomized controlled clinical trials
-
Gares V, Andrieu S, Dupuy JF, Savy N An omnibus test for several hazard alternatives in prevention randomized controlled clinical trials. Stat Med 2014, 34:541-557.
-
(2014)
Stat Med
, vol.34
, pp. 541-557
-
-
Gares, V.1
Andrieu, S.2
Dupuy, J.F.3
Savy, N.4
-
133
-
-
79959364066
-
How should we deal with missing data in clinical trials involving Alzheimer's disease patients?
-
Coley N, Gardette V, Cantet C, et al. How should we deal with missing data in clinical trials involving Alzheimer's disease patients?. Curr Alzheimer Res 2011, 8:421-433.
-
(2011)
Curr Alzheimer Res
, vol.8
, pp. 421-433
-
-
Coley, N.1
Gardette, V.2
Cantet, C.3
-
134
-
-
84920834831
-
Charting a path toward combination therapy for Alzheimer's disease
-
Stephenson D, Perry D, Bens C, et al. Charting a path toward combination therapy for Alzheimer's disease. Expert Rev Neurother 2015, 15:107-113.
-
(2015)
Expert Rev Neurother
, vol.15
, pp. 107-113
-
-
Stephenson, D.1
Perry, D.2
Bens, C.3
-
135
-
-
77955474351
-
The Alzheimer's disease neuroimaging initiative: progress report and future plans
-
11.e7
-
Weiner MW, Aisen PS, Jack CR, et al. The Alzheimer's disease neuroimaging initiative: progress report and future plans. Alzheimers Dement 2010, 6:202. 11.e7.
-
(2010)
Alzheimers Dement
, vol.6
, pp. 202
-
-
Weiner, M.W.1
Aisen, P.S.2
Jack, C.R.3
-
136
-
-
84876340374
-
The European Dementia Prevention Initiative
-
Dehnel T The European Dementia Prevention Initiative. Lancet Neurol 2013, 12:227-228.
-
(2013)
Lancet Neurol
, vol.12
, pp. 227-228
-
-
Dehnel, T.1
-
137
-
-
84862119222
-
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)
-
Perk J, De Backer G, Gohlke H, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 2012, 33:1635-1701.
-
(2012)
Eur Heart J
, vol.33
, pp. 1635-1701
-
-
Perk, J.1
De Backer, G.2
Gohlke, H.3
-
138
-
-
84855904437
-
Dementia prevention: current epidemiological evidence and future perspective
-
Mangialasche F, Kivipelto M, Solomon A, Fratiglioni L Dementia prevention: current epidemiological evidence and future perspective. Alzheimers Res Ther 2012, 4:6.
-
(2012)
Alzheimers Res Ther
, vol.4
, pp. 6
-
-
Mangialasche, F.1
Kivipelto, M.2
Solomon, A.3
Fratiglioni, L.4
-
139
-
-
0346463189
-
Designing a large prevention trial: statistical issues
-
Kryscio RJ, Mendiondo MS, Schmitt FA, Markesbery WR Designing a large prevention trial: statistical issues. Stat Med 2004, 23:285-296.
-
(2004)
Stat Med
, vol.23
, pp. 285-296
-
-
Kryscio, R.J.1
Mendiondo, M.S.2
Schmitt, F.A.3
Markesbery, W.R.4
-
140
-
-
84857707554
-
A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910)
-
Stough CK, Pase MP, Cropley V, et al. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910). Nutr J 2012, 11:11.
-
(2012)
Nutr J
, vol.11
, pp. 11
-
-
Stough, C.K.1
Pase, M.P.2
Cropley, V.3
-
141
-
-
84920749654
-
A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol
-
Boss HM, Van Schaik SM, Deijle IA, et al. A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol. BMJ Open 2014, 4:e007065.
-
(2014)
BMJ Open
, vol.4
, pp. e007065
-
-
Boss, H.M.1
Van Schaik, S.M.2
Deijle, I.A.3
-
142
-
-
84929516661
-
Prevention of poststroke cognitive decline: ASPIS - a multicenter, randomized, observer-blind, parallel group clinical trial to evaluate multiple lifestyle interventions - study design and baseline characteristics
-
published online Nov 10.
-
Brainin M, Matz K, Nemec M, et al. Prevention of poststroke cognitive decline: ASPIS - a multicenter, randomized, observer-blind, parallel group clinical trial to evaluate multiple lifestyle interventions - study design and baseline characteristics. Int J Stroke 2013, published online Nov 10. 10.1111/ijs.12188.
-
(2013)
Int J Stroke
-
-
Brainin, M.1
Matz, K.2
Nemec, M.3
-
143
-
-
84865636076
-
Rationale and design of a double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of nimodipine in preventing cognitive impairment in ischemic cerebrovascular events (NICE)
-
Wang P, Wang Y, Feng T, et al. Rationale and design of a double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of nimodipine in preventing cognitive impairment in ischemic cerebrovascular events (NICE). BMC Neurol 2012, 12:88.
-
(2012)
BMC Neurol
, vol.12
, pp. 88
-
-
Wang, P.1
Wang, Y.2
Feng, T.3
-
144
-
-
84861571474
-
Preventing cognitive decline in older African Americans with mild cognitive impairment: design and methods of a randomized clinical trial
-
Rovner BW, Casten RJ, Hegel MT, Leiby BE Preventing cognitive decline in older African Americans with mild cognitive impairment: design and methods of a randomized clinical trial. Contemp Clin Trials 2012, 33:712-720.
-
(2012)
Contemp Clin Trials
, vol.33
, pp. 712-720
-
-
Rovner, B.W.1
Casten, R.J.2
Hegel, M.T.3
Leiby, B.E.4
|