Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761)

Journal of Molecular and Cellular Cardiology

Volumn 29, Issue 2, 1997, Pages 733-742

  Pietri, Sylvia ^a,d   Maurelli, Eziana ^a   Drieu, Katy ^b   Culcasi, Marcel ^a,c  

^a CNRS   (France)

^b Institut Henri Beaufour   (France)

^c Department of Pharmacology   (France)

^d AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Bilobalide; Cardioprotection; ESR spin trapping; Free radicals; Ginkgo biloba extract (EGb 761); Ginkgolides; Rat heart; Reperfusion injury

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; BILOBALIDE; FREE RADICAL; GINKGO BILOBA EXTRACT; GINKGOLIDE A; GINKGOLIDE B; HYDROXYL RADICAL; SUPEROXIDE; TERPENOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEMODYNAMIC PARAMETERS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

GINKGO BILOBA;

EID: 0031080693     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1996.0316     Document Type: Article

References (36)

1. BLASIG IE, EBERT B, HENNIG C, PALI T, TOSAKI A, 1990. Inverse relationship between ESR spin trapping of oxyradicals and degree of functional recovery during myocardial reperfusion in isolated working rat heart. Cardiovasc Res 24: 263-270.
2. BRAQUET P (ed.), 1988. Ginkgolides: Chemistry, Biology, Pharmacology, and Clinical Perspectives. Barcelona, JR Prous Science, Vol. 1.
3. BRUEL A, GARDETTE J, BERROU E, DROY-LEFAIX MT, PICARD J, 1989. Effects of Ginkgo biloba extract on glucose transport and glycogen synthesis of cultured smooth muscle cells from pig aorta. Pharmacol Res 21: 421-429.
4. BUETTNER GR, 1988. In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals. J Biochem Biophys Methods 16: 27-40.
5. CHAMBERS DE, PARKS DA, PATTERSON G, ROY R, MCCORD JM, YOSHIDA S, PARMLEY LF, DOWNEY JM, 1985. Xanthine oxidase as a source of free radical damage in myocardial ischemia. J Mol Cell Cardiol 17: 145-152.
6. DEFEUDIS FV, 1991. Ginkgo biloba extract (EGb 761): pharmacological activities and clinical applications. Paris, Elsevier.
7. FINKELSTEIN E, ROSEN GM, RAUCKMAN EJ, PAXTON J, 1979. Spin trapping of superoxide. Mol Pharmacol 16: 676-685.
8. FINKELSTEIN E, ROSEN GM, RAUCKMAN EJ, 1980. Spin trapping. Kinetics of the reaction of superoxide and hydroxyl radicals with nitrones. J Am Chem Soc 102: 4994-4999.
9. FOURTILLAN JB, BRISSON AM, GIRAULT J, INGRAND I, DECOURT JP, DRIEU K, JOUENNE P, BIBER A, 1995. Propriétés pharmacocinétiques du bilobalide et des ginkgolides A et B chez le sujet sain après administrations intraveineuses et orales d'extrait de Ginkgo biloba (EGb 761). Thérapie 50: 137-144.
10. GAUDUEL Y, DUVELLEROY MA, 1984. Role of oxygen radicals in cardiac injury due to reoxygenation. J Mol Cell Cardiol 16: 459-470.
11. HAGERMAN AE, BUTLER LG, 1981. The specificity of proanthocyanidin-protein interactions. J Biol Chem 256: 4494-4497.
12. HARAMAKI N, AGGARWAL S, KAWABATA T, DROY-LEFAIX MT, PACKER L, 1994. Effects of natural antioxidant Ginkgo biloba extract (EGb 761) on myocardial ischemia-reperfusion injury. Free Rad Biol Med 16: 789-794.
13. HESS ML, MANSON NH, 1984. Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/ reperfusion injury. J Mol Cell Cardiol 16: 969-985.
14. HIGUCHI M, MIYAGI K, NAKASONE J, SAKANASHI M, 1995. Role of high glycogen in underperfused diabetic rat hearts with added norepinephrine. J Cardiovasc Pharmacol 26: 899-907.
15. JANSSENS D, MICHIELS C, DELAIVE E, ELIAERS F, DRIEU K, REMACLE J, 1995. Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem Pharmacol 50: 991-999.
16. KOLTAI M, TOSAKI A, HOSFORD D, BRAQUET P, 1989. Ginkgolide B protects isolated hearts against arrhythmias induced by ischemia but not reperfusion. Eur J Pharmacol 164: 293-302.
17. KRAMER JH, ARROYO CM, DICKENS BF, WEGLICKI WB, 1987. Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production. Free Rad Biol Med 3: 153-159.
18. MAITRA I, MARCOCCI L, DROY-LEFAIX MT, PACKER L, 1995. Peroxyl radical scavenging activity of Ginkgo biloba extract EGb 761. Biochem Pharmacol 49: 1649-1655.
19. MARCOCCI L, MAGUIRE JJ, DROY-LEFAIX MT, PACKER L, 1994. The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761. Biochem Biophys Res Commun 201: 748-755.
20. MONTRUCCHIO G, ALLOATTI G, TETTA C, DE LUCA R, SAUNDERS RN, EMANUELLI G, CAMUSSI G, 1989. Release of platelet-activating factor from ischemic-reperfused rabbit heart. Am J Physiol 256: H1236-H1246.
21. MRAZ M, KREN V, KRSIAKOVA D, VRANA A, HYNIE S, 1995. The role of myocardial glycogen content for the development of isoprenaline-induced myocardial lesions in different inbred strains of rats. Basic Res Cardiol 90: 467-474.
22. OPIE LH, 1989. Reperfusion injury and its pharmacologic modification. Circulation 80: 1049-1062.
23. PIETRI S, CULCASI M, COZZONE PJ, 1989. Real-time continuous-flow spin trapping of hydroxyl free radical in the ischemic and post-ischemic myocardium. Eur J Biochem 186: 163-173.
24. PIETRI S, CULCASI M, STELLA L, COZZONE PJ, 1990. Ascorbyl free radical as a reliable indicator of free-radical-mediated myocardial ischemic and post-ischemic injury. A real-time continuous-flow ESR study. Eur J Biochem 193: 845-854.
25. PINCEMAIL J, THIRION A, DUPUIS M, BRAQUET P, DRIEU K, DEBY C, 1987. Ginkgo biloba extract inhibits oxygen species production generated by phorbol myristate acetate stimulated human leukocytes. Experientia 43: 181-184.
26. PINCEMAIL J, DUPUIS M, NASR C, HANS P, HAAG-BERRURIER M, ANTON R, DEBY C, 1989. Superoxide anion scavenging and superoxide dismutase activity of Ginkgo biloba extract. Experientia 45: 708-712.
27. RAO PS, COHEN MV, MUELLER HS, 1983. Production of free radicals and lipid peroxides in early experimental myocardial ischemia. J Mol Cell Cardiol 15: 713-716.
28. RAPIN JR, PROVOST P, DEFEUDIS FV, DRIEU K, 1994. Effects of repeated treatments with an extract of Ginkgo biloba (EGb 761) and bilobalide on glucose uptake and glycogen synthesis in rat erythrocytes: an ex vivo study. Drug Dev Res 31: 164-169.
29. ROBAK J, GRYGLEWSKI RJ, 1988. Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 37: 837-841.
30. SHEN JG, ZHOU DY, 1995. Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochem Mol Biol Int 35: 125-134.
31. TOSAKI A, DROY-LEFAIX MT, PALI T, DAS DK, 1993. Effects of SOD, catalase, and a novel antiarrhythmic drug, EGb 761, on reperfusion-induced arrhythmias in isolated rat hearts. Free Rad Biol Med 14: 361-370.
32. TOSAKI A, ENGELMAN DT, PALI T, ENGELMAN RM, DROY-LEFAIX MT, 1994. Ginkgo biloba extract (EGb 761) improves postischemic function in isolated preconditioned working rat hearts. Cor Artery Dis 5: 443-450.
33. WEGLICKI WB, MAK IT, SIMIC MG, 1990. Mechanisms of cardiovascular drugs as antioxidants. J Mol Cell Cardiol 22: 1199-1208.
34. YAMAZAKI I, PIETTE LH, 1991. EPR spin-trapping study on the oxidizing species formed in the reaction of the ferrous ion with hydrogen peroxide. J Am Chem Soc 113: 7588-7593.
35. YAN LJ, DROY-LEFAIX MT, PACKER L, 1995. Ginkgo biloba extract (EGb 761) protects human low density lipoproteins against oxidative modification mediated by copper. Biochem Biophys Res Commun 212: 360-366.
36. ZWEIER JL, 1988. Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury. J Biol Chem 263: 1353-1357.