The LIFE Cognition Study: Design and baseline characteristics

Clinical Interventions in Aging

Volumn 9, Issue , 2014, Pages 1425-1436

  Sink, Kaycee M ^a   Espeland, Mark A ^a   Rushing, Julia ^a   Castro, Cynthia M ^b   Church, Timothy S ^c   Cohen, Ronald ^d   Gill, Thomas M ^e   Henkin, Leora ^a   Jennings, Janine M ^f   Kerwin, Diana R ^g   Manini, Todd M ^d   Myers, Valerie ^h   Pahor, Marco ^d   Reid, Kieran F ⁱ   Woolard, Nancy ^a   Rapp, Stephen R ^a   Williamson, Jeff D ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f WAKE FOREST UNIVERSITY   (United States)

^g PRESBYTERIAN HOSPITAL OF DALLAS   (United States)

^h KLEIN BUENDEL INC   (United States)

ⁱ TUFTS UNIVERSITY   (United States)

Author keywords

Dementia; Exercise; Older adults; Physical activity

Indexed keywords

AGE DISTRIBUTION; AGED; AGING; ARTICLE; CONTROLLED STUDY; DEMENTIA; EXECUTIVE FUNCTION; FEMALE; FOLLOW UP; HEALTH EDUCATION; HUMAN; HUMAN EXPERIMENT; LIFESTYLE INTERVENTIONS AND INDEPENDENCE FOR ELDERS COGNITION STUDY; MALE; MENTAL PERFORMANCE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SEDENTARY LIFESTYLE; SEX RATIO; STUDY DESIGN; CLINICAL TRIAL; DISABILITY; GERIATRIC ASSESSMENT; KINESIOTHERAPY; METHODOLOGY; NEUROPSYCHOLOGICAL TEST; PHASE 3 CLINICAL TRIAL; PROCEDURES; RISK FACTOR; UNITED STATES; VERY ELDERLY; WALKING DIFFICULTY;

AGED; AGED, 80 AND OVER; DEMENTIA; DISABILITY EVALUATION; EXERCISE THERAPY; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MALE; MILD COGNITIVE IMPAIRMENT; MOBILITY LIMITATION; NEUROPSYCHOLOGICAL TESTS; RESEARCH DESIGN; RISK FACTORS; SEDENTARY LIFESTYLE; UNITED STATES;

EID: 84907507193     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S65381     Document Type: Article

References (45)

1. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25(6):295–301.
2. Black JE, Isaacs KR, Anderson BJ, Alcantara AA, Greenough WT. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc Natl Acad Sci U S A. 1990; 87(14):5568–5572.
3. Colcombe SJ, Erickson KI, Raz N, et al. Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Biol Sci Med Sci. 2003;58(2): 176–180.
4. Colcombe SJ, Erickson KI, Scalf PE, et al. Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci. 2006;61(11):1166–1170.
5. Burdette JH, Laurienti PJ, Espeland MA, et al. Using network science to evaluate exercise-associated brain changes in older adults. Front Aging Neurosci. 2010;2:23.
6. Erickson KI, Prakash RS, Voss MW, et al. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci. 2010;30(15):5368–5375.
7. Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011;108(7):3017–3022.
8. Erickson KI, Prakash RS, Voss MW, et al. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus. 2009; 19(10):1030–1039.
9. Erickson KI, Raji CA, Lopez OL, et al. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology. 2010;75(16):1415–1422.
10. Adlard PA, Perreau VM, Pop V, Cotman CW. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer’s disease. J Neurosci. 2005;25(17):4217–4221.
11. Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Intern Med. 2001;161(14):1703–1708.
12. Larson EB, Wang L, Bowen JD, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med. 2006;144(2):73–81.
13. Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H. Walking and dementia in physically capable elderly men. JAMA. 2004; 292(12):1447–1453.
14. Kramer AF, Hahn S, Cohen NJ, et al. Ageing, fitness and neurocognitive function. Nature. 1999;400(6743):418–419.
15. Klusmann V, Evers A, Schwarzer R, et al. Complex mental and physical activity in older women and cognitive performance: a 6-month randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2010;65(6): 680–688.
16. Lautenschlager NT, Cox KL, Flicker L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008;300(9):1027–1037.
17. Williamson JD, Espeland M, Kritchevsky SB, et al; LIFE Study Investigators. Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot study. J Gerontol A Biol Sci Med Sci. 2009;64(6):688–694.
18. Fielding RA, Rejeski WJ, Blair S, et al; LIFE Research Group. The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci. 2011;66(11):1226–1237.
19. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332(9):556–561.
20. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49(2):M85–M94.
21. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry. 1987;48(8):314–318.
22. Wechsler D. Wais-R Manual: Wechsler Adult Intelligence Scale – Revised. New York, NY: Psychological Corporation; 1981.
23. Brandt J, Benedict RHB. Hopkins Verbal Learning Test – Revised: Professional Manual. Lutz, FL: Psychological Assessment Resources, Inc; 2001.
24. Becker JT, Boller F, Saxton J, McGonigle-Gibson KL. Normal rates of forgetting of verbal and non-verbal material in Alzheimer’s disease. Cortex. 1987;23(1):59–72.
25. Salthouse TA. The role of memory in the age decline in digit-symbol substitution performance. J Gerontol. 1978;33(2):232–238.
26. Kaplan E, Goodglass H, Weintraub S. The Boston Naming Test. 2nd ed. Philadelphia, PA: Lea & Febiger; 1983.
27. Reitan RM. Trail Making Test. Manual for Administration and Scoring. Tucson, AZ: Neuropsychological Laboratory; 1992.
28. Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37(3):323–329.
29. Radloff LS. The CES-D Scale: A self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1(3): 385–401.
30. Kohout FJ, Berkman LF, Evans DA, Cornoni-Huntley J. Two shorter forms of the CES-D (Center for Epidemiological Studies Depression) depression symptoms index. J Aging Health. 1993;5(2): 179–193.
31. Espeland MA, Katula JA, Rushing J, et al; LIFE Study Group. Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors. Int J Geriatr Psychiatry. 2013;28(12):1239–1250.
32. Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14(2):125–130.
33. Kramer AF, Hahn S, McAuley E, McAuley E. Exercise, aging and cognition: healthy body, healthy mind? In: Rogers WA, Fisk AD, editors. Human Factors Interventions for the Health Care of Older Adults. Mahwah, NJ: Laurence Erlbaum Associates Publishing; 2001: 91–120.
34. Dobbs AR, Rule BG. Adult age differences in working memory. Psychol Aging. 1989;4(4):500–503.
35. Jonides J, Schumacher EH, Smith EE, et al. Verbal Working Memory Load Affects Regional Brain Activation as Measured by PET. J Cogn Neurosci. 1997;9(4):462–475.
36. Eriksen BA, Eriksen CW. Effects of noise letters upon the identification of a target letter in a nonsearch task. Percept Psychophys. 1974;16(1):143–149.
37. Rogers RD, Monsell S. The cost of a predictable switch between simple cognitive tasks. J Exp Psychol Gen. 1995;124:207–231.
38. Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–279.
39. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–269.
40. Marsh AP, Lovato LC, Glynn NW, et al; LIFE Study Research Group. Lifestyle interventions and independence for elders study: recruitment and baseline characteristics. J Gerontol A Biol Sci Med Sci. 2013; 68(12):1549–1558.
41. Physical Activity Guidelines writing group. 2008 Physical Activity Guidelines for Americans. Washington, DC: US Department of Health and Human Services; 2008.
42. Snitz BE, O’Meara ES, Carlson MC, et al; Ginkgo Evaluation of Memory (GEM) Study Investigators. Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA. 2009;302(24):2663–2670.
43. Rapp SR, Espeland MA, Hogan P, Jones BN, Dugan E; WHIMS investigators. Baseline experience with Modified Mini Mental State Exam: The Women’s Health Initiative Memory Study (WHIMS). Aging Ment Health. 2003;7(3):217–223.
44. Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1–2):125–132.
45. Jack CR, Knopman DS, Jagust WJ, et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol. 2010;9(1):119–128.