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Volumn 141, Issue 10, 2015, Pages 1757-1766

Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis

Author keywords

Apoptosis; Irradiation; Oral squamous cell carcinoma; Oxidative stress; Paraoxonase 2; Reactive oxygen species

Indexed keywords

ARYLDIALKYLPHOSPHATASE 2; CASPASE 3; CASPASE 7; REACTIVE OXYGEN METABOLITE; ARYLDIALKYLPHOSPHATASE; PON2 PROTEIN, HUMAN; SMALL INTERFERING RNA;

EID: 84939564851     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-015-1941-2     Document Type: Article
Times cited : (32)

References (67)
  • 1
    • 33751072935 scopus 로고    scopus 로고
    • Bioenergetics and the formation of mitochondrial reactive oxygen species
    • COI: 1:CAS:528:DC%2BD28Xht1eku7fF, PID: 17056127
    • Adam-Vizi V, Chinopoulos C (2006) Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 27:639–645. doi:10.1016/j.tips.2006.10.005
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 639-645
    • Adam-Vizi, V.1    Chinopoulos, C.2
  • 2
    • 77955300136 scopus 로고    scopus 로고
    • One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity
    • PID: 20530481
    • Altenhofer S et al (2010) One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity. J Biol Chem 285:24398–24403. doi:10.1074/jbc.M110.118604
    • (2010) J Biol Chem , vol.285 , pp. 24398-24403
    • Altenhofer, S.1
  • 3
    • 0032522985 scopus 로고    scopus 로고
    • Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
    • COI: 1:CAS:528:DyaK1cXisV2ru7o%3D, PID: 9541487
    • Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BN (1998) Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Investig 101:1581–1590. doi:10.1172/JCI1649
    • (1998) J Clin Investig , vol.101 , pp. 1581-1590
    • Aviram, M.1    Rosenblat, M.2    Bisgaier, C.L.3    Newton, R.S.4    Primo-Parmo, S.L.5    La Du, B.N.6
  • 4
    • 0034806972 scopus 로고    scopus 로고
    • Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress
    • COI: 1:CAS:528:DC%2BD3MXntFChtrk%3D, PID: 11564875
    • Benhar M, Dalyot I, Engelberg D, Levitzki A (2001) Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress. Mol Cell Biol 21:6913–6926. doi:10.1128/MCB.21.20.6913-6926.2001
    • (2001) Mol Cell Biol , vol.21 , pp. 6913-6926
    • Benhar, M.1    Dalyot, I.2    Engelberg, D.3    Levitzki, A.4
  • 5
    • 33747881607 scopus 로고    scopus 로고
    • Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis
    • PID: 16950362
    • Bourhis J et al (2006) Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 368:843–854. doi:10.1016/S0140-6736(06)69121-6
    • (2006) Lancet , vol.368 , pp. 843-854
    • Bourhis, J.1
  • 6
    • 61449118867 scopus 로고    scopus 로고
    • The paraoxonases: role in human diseases and methodological difficulties in measurement
    • COI: 1:CAS:528:DC%2BD1MXnvVOgtLg%3D, PID: 19255916
    • Camps J, Marsillach J, Joven J (2009) The paraoxonases: role in human diseases and methodological difficulties in measurement. Crit Rev Clin Lab Sci 46:83–106. doi:10.1080/10408360802610878
    • (2009) Crit Rev Clin Lab Sci , vol.46 , pp. 83-106
    • Camps, J.1    Marsillach, J.2    Joven, J.3
  • 7
    • 79955604131 scopus 로고    scopus 로고
    • Genetic insights into OXPHOS defect and its role in cancer
    • COI: 1:CAS:528:DC%2BC3MXlsFSisbY%3D, PID: 21074512
    • Chandra D, Singh KK (2011) Genetic insights into OXPHOS defect and its role in cancer. Biochim Biophys Acta 1807:620–625. doi:10.1016/j.bbabio.2010.10.023
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 620-625
    • Chandra, D.1    Singh, K.K.2
  • 8
    • 84866770460 scopus 로고    scopus 로고
    • Association analysis of PON polymorphisms in sporadic ALS in a Chinese population
    • Chen Y et al (2012) Association analysis of PON polymorphisms in sporadic ALS in a Chinese population. Neurobiol Aging 33(2949):e2941–e2943. doi:10.1016/j.neurobiolaging.2012.06.024
    • (2012) Neurobiol Aging , vol.33 , Issue.2949 , pp. 2941-2943
    • Chen, Y.1
  • 9
    • 84879892855 scopus 로고    scopus 로고
    • Longitudinal quality of life in Turkish patients with head and neck cancer undergoing radiotherapy
    • PID: 23475195
    • Citak E, Tulek Z (2013) Longitudinal quality of life in Turkish patients with head and neck cancer undergoing radiotherapy. Support Care Cancer 21:2171–2183. doi:10.1007/s00520-013-1774-y
    • (2013) Support Care Cancer , vol.21 , pp. 2171-2183
    • Citak, E.1    Tulek, Z.2
  • 10
    • 0038799736 scopus 로고    scopus 로고
    • Oxidative DNA damage: mechanisms, mutation, and disease
    • Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J17:1195–1214. doi:10.1096/fj.02-0752rev
    • (2003) FASEB , vol.J17 , pp. 1195-1214
    • Cooke, M.S.1    Evans, M.D.2    Dizdaroglu, M.3    Lunec, J.4
  • 11
    • 0031974274 scopus 로고    scopus 로고
    • Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review)
    • COI: 1:CAS:528:DyaK1cXosVaiuw%3D%3D, PID: 9454898
    • Decaudin D, Marzo I, Brenner C, Kroemer G (1998) Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review). Int J Oncol 12:141–152
    • (1998) Int J Oncol , vol.12 , pp. 141-152
    • Decaudin, D.1    Marzo, I.2    Brenner, C.3    Kroemer, G.4
  • 12
    • 78650869947 scopus 로고    scopus 로고
    • Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis
    • COI: 1:CAS:528:DC%2BC3MXht1Sisw%3D%3D, PID: 20578959
    • Devarajan A et al (2011) Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. Antioxid Redox Signal 14:341–351. doi:10.1089/ars.2010.3430
    • (2011) Antioxid Redox Signal , vol.14 , pp. 341-351
    • Devarajan, A.1
  • 13
    • 84877104834 scopus 로고    scopus 로고
    • Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells
    • Ding ZY, Liu GH, Olsson B, Sun XF (2012) Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells. Tumour Biol. doi:10.1007/s13277-012-0596-8
    • (2012) Tumour Biol
    • Ding, Z.Y.1    Liu, G.H.2    Olsson, B.3    Sun, X.F.4
  • 14
    • 0034721761 scopus 로고    scopus 로고
    • Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation
    • COI: 1:CAS:528:DC%2BD3cXnvVOqu7Y%3D, PID: 10931838
    • Draganov DI, Stetson PL, Watson CE, Billecke SS, La Du BN (2000) Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation. J Biol Chem 275:33435–33442. doi:10.1074/jbc.M004543200
    • (2000) J Biol Chem , vol.275 , pp. 33435-33442
    • Draganov, D.I.1    Stetson, P.L.2    Watson, C.E.3    Billecke, S.S.4    La Du, B.N.5
  • 15
    • 84861668879 scopus 로고    scopus 로고
    • Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients
    • COI: 1:STN:280:DC%2BC38njvVSitg%3D%3D, PID: 22592457
    • Eckert AW, Kappler M, Schubert J, Taubert H (2012) Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients. Oral Maxillofac Surg 16:189–196. doi:10.1007/s10006-012-0335-8
    • (2012) Oral Maxillofac Surg , vol.16 , pp. 189-196
    • Eckert, A.W.1    Kappler, M.2    Schubert, J.3    Taubert, H.4
  • 16
    • 77954641944 scopus 로고    scopus 로고
    • Radiation-induced cell death mechanisms
    • PID: 20490962
    • Eriksson D, Stigbrand T (2010) Radiation-induced cell death mechanisms. Tumour Biol 31:363–372. doi:10.1007/s13277-010-0042-8
    • (2010) Tumour Biol , vol.31 , pp. 363-372
    • Eriksson, D.1    Stigbrand, T.2
  • 17
    • 34547670578 scopus 로고    scopus 로고
    • Tumor-targeted induction of oxystress for cancer therapy
    • COI: 1:CAS:528:DC%2BD2sXosVSkt7c%3D, PID: 17671894
    • Fang J, Nakamura H, Iyer AK (2007) Tumor-targeted induction of oxystress for cancer therapy. J Drug Target 15:475–486. doi:10.1080/10611860701498286
    • (2007) J Drug Target , vol.15 , pp. 475-486
    • Fang, J.1    Nakamura, H.2    Iyer, A.K.3
  • 18
    • 31844454246 scopus 로고    scopus 로고
    • Glutathione, ascorbic acid and antioxidant enzymes in the tumor tissue and blood of patients with oral squamous cell carcinoma
    • COI: 1:STN:280:DC%2BD28%2FptlGmtA%3D%3D, PID: 16479741
    • Fiaschi AI, Cozzolino A, Ruggiero G, Giorgi G (2005) Glutathione, ascorbic acid and antioxidant enzymes in the tumor tissue and blood of patients with oral squamous cell carcinoma. Eur Rev Med Pharmacol Sci 9:361–367
    • (2005) Eur Rev Med Pharmacol Sci , vol.9 , pp. 361-367
    • Fiaschi, A.I.1    Cozzolino, A.2    Ruggiero, G.3    Giorgi, G.4
  • 19
    • 33746143590 scopus 로고    scopus 로고
    • Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients
    • COI: 1:CAS:528:DC%2BD28XntVWlu74%3D, PID: 16728981
    • Frank O et al (2006) Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients. Leukemia 20:1400–1407. doi:10.1038/sj.leu.2404270
    • (2006) Leukemia , vol.20 , pp. 1400-1407
    • Frank, O.1
  • 20
    • 84919782859 scopus 로고    scopus 로고
    • Celastrol induces unfolded protein response-dependent cell death in head and neck cancer
    • PID: 25139619
    • Fribley AM et al (2014) Celastrol induces unfolded protein response-dependent cell death in head and neck cancer. Exp Cell Res. doi:10.1016/j.yexcr.2014.08.014
    • (2014) Exp Cell Res
    • Fribley, A.M.1
  • 21
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygen species: a breath of life or death?
    • COI: 1:CAS:528:DC%2BD2sXhsVyrsrs%3D, PID: 17289868
    • Fruehauf JP, Meyskens FL Jr (2007) Reactive oxygen species: a breath of life or death? Clin Cancer Res 13:789–794. doi:10.1158/1078-0432.CCR-06-2082
    • (2007) Clin Cancer Res , vol.13 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens, F.L.2
  • 22
    • 0037399623 scopus 로고    scopus 로고
    • The p53 network in head and neck cancer
    • COI: 1:CAS:528:DC%2BD3sXhs1CktL4%3D, PID: 12618194
    • Gasco M, Crook T (2003) The p53 network in head and neck cancer. Oral Oncol 39:222–231
    • (2003) Oral Oncol , vol.39 , pp. 222-231
    • Gasco, M.1    Crook, T.2
  • 23
    • 9144222193 scopus 로고    scopus 로고
    • Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer
    • COI: 1:CAS:528:DC%2BD3sXhtVSqs7rE
    • Hashibe M et al (2003) Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer. Cancer Epidemiol Biomark Prev 12:1509–1517
    • (2003) Cancer Epidemiol Biomark Prev , vol.12 , pp. 1509-1517
    • Hashibe, M.1
  • 24
    • 34247213490 scopus 로고    scopus 로고
    • Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation
    • COI: 1:CAS:528:DC%2BD2sXjvFKjur8%3D, PID: 17404154
    • Horke S, Witte I, Wilgenbus P, Kruger M, Strand D, Forstermann U (2007) Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation. Circulation 115:2055–2064. doi:10.1161/CIRCULATIONAHA.106.681700
    • (2007) Circulation , vol.115 , pp. 2055-2064
    • Horke, S.1    Witte, I.2    Wilgenbus, P.3    Kruger, M.4    Strand, D.5    Forstermann, U.6
  • 25
    • 58949085858 scopus 로고    scopus 로고
    • Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis
    • Horke S, Witte I, Wilgenbus P, Altenhofer S, Kruger M, Li H, Forstermann U (2008) Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis. Biochem J416:395–405. doi:10.1042/BJ20080775
    • (2008) Biochem , vol.J416 , pp. 395-405
    • Horke, S.1    Witte, I.2    Wilgenbus, P.3    Altenhofer, S.4    Kruger, M.5    Li, H.6    Forstermann, U.7
  • 26
    • 76549114781 scopus 로고    scopus 로고
    • Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-l-homoserine lactone and attenuates oxidative stress induced by pyocyanin
    • Horke S et al (2010) Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-l-homoserine lactone and attenuates oxidative stress induced by pyocyanin. Biochem J426:73–83. doi:10.1042/BJ20091414
    • (2010) Biochem , vol.J426 , pp. 73-83
    • Horke, S.1
  • 27
    • 84905898161 scopus 로고    scopus 로고
    • YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer
    • PID: 24993889
    • Jerhammar F et al (2014) YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer. Oral Oncol. doi:10.1016/j.oraloncology.2014.06.003
    • (2014) Oral Oncol
    • Jerhammar, F.1
  • 29
    • 77949879862 scopus 로고    scopus 로고
    • Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia
    • COI: 1:CAS:528:DC%2BC3cXjtVWru74%3D, PID: 19880498
    • Kang H et al (2010) Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Blood 115:1394–1405. doi:10.1182/blood-2009-05-218560
    • (2010) Blood , vol.115 , pp. 1394-1405
    • Kang, H.1
  • 30
    • 17644367506 scopus 로고    scopus 로고
    • Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
    • COI: 1:CAS:528:DC%2BD2MXis1ahtr8%3D, PID: 15835926
    • Khersonsky O, Tawfik DS (2005) Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase. Biochemistry 44:6371–6382. doi:10.1021/bi047440d
    • (2005) Biochemistry , vol.44 , pp. 6371-6382
    • Khersonsky, O.1    Tawfik, D.S.2
  • 31
    • 84867846527 scopus 로고    scopus 로고
    • Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer
    • COI: 1:CAS:528:DC%2BC38XovVGrtLo%3D, PID: 22694909
    • Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu GF, Sasaki A (2012) Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer. Oral Oncol 48:1120–1127. doi:10.1016/j.oraloncology.2012.05.009
    • (2012) Oral Oncol , vol.48 , pp. 1120-1127
    • Kishimoto, K.1    Yoshida, S.2    Ibaragi, S.3    Yoshioka, N.4    Okui, T.5    Hu, G.F.6    Sasaki, A.7
  • 32
    • 79961125772 scopus 로고    scopus 로고
    • Enhanced nitrosative and oxidative stress with decreased total antioxidant capacity in patients with oral precancer and oral squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC3MXhtFCls7fI, PID: 21829039
    • Korde SD, Basak A, Chaudhary M, Goyal M, Vagga A (2011) Enhanced nitrosative and oxidative stress with decreased total antioxidant capacity in patients with oral precancer and oral squamous cell carcinoma. Oncology 80:382–389. doi:10.1159/000329811
    • (2011) Oncology , vol.80 , pp. 382-389
    • Korde, S.D.1    Basak, A.2    Chaudhary, M.3    Goyal, M.4    Vagga, A.5
  • 33
    • 0037228326 scopus 로고    scopus 로고
    • High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia
    • PID: 12525204
    • Kutler DI et al (2003) High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia. Arch Otolaryngol Head Neck Surg 129:106–112
    • (2003) Arch Otolaryngol Head Neck Surg , vol.129 , pp. 106-112
    • Kutler, D.I.1
  • 34
    • 1242315463 scopus 로고    scopus 로고
    • Trends in oral cancer mortality in Europe
    • PID: 14969823
    • La Vecchia C, Lucchini F, Negri E, Levi F (2004) Trends in oral cancer mortality in Europe. Oral Oncol 40:433–439. doi:10.1016/j.oraloncology.2003.09.013
    • (2004) Oral Oncol , vol.40 , pp. 433-439
    • La Vecchia, C.1    Lucchini, F.2    Negri, E.3    Levi, F.4
  • 35
    • 84898661795 scopus 로고    scopus 로고
    • Genetic susceptibility to head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC2cXmtlCls7w%3D, PID: 24725688
    • Lacko M et al (2014) Genetic susceptibility to head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 89:38–48. doi:10.1016/j.ijrobp.2013.09.034
    • (2014) Int J Radiat Oncol Biol Phys , vol.89 , pp. 38-48
    • Lacko, M.1
  • 36
    • 0036326801 scopus 로고    scopus 로고
    • Discovery and analysis of hepatocellular carcinoma genes using cDNA microarrays
    • COI: 1:CAS:528:DC%2BD38XltlOntL8%3D, PID: 12136251
    • Li Y et al (2002) Discovery and analysis of hepatocellular carcinoma genes using cDNA microarrays. J Cancer Res Clin Oncol 128:369–379. doi:10.1007/s00432-002-0347-0
    • (2002) J Cancer Res Clin Oncol , vol.128 , pp. 369-379
    • Li, Y.1
  • 37
    • 10344222124 scopus 로고    scopus 로고
    • The role of the unfolded protein response in tumour development: friend or foe?
    • COI: 1:CAS:528:DC%2BD2cXhtVarsLjI, PID: 15573118
    • Ma Y, Hendershot LM (2004) The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer 4:966–977. doi:10.1038/nrc1505
    • (2004) Nat Rev Cancer , vol.4 , pp. 966-977
    • Ma, Y.1    Hendershot, L.M.2
  • 38
    • 84892900901 scopus 로고    scopus 로고
    • Measurement of serum paraoxonase activity and MDA concentrations in patients suffering with oral squamous cell carcinoma
    • Malik UU, Siddiqui IA, Hashim Z, Zarina S (2014) Measurement of serum paraoxonase activity and MDA concentrations in patients suffering with oral squamous cell carcinoma. Clin Chim Acta 430C:38–42. doi:10.1016/j.cca.2013.12.033
    • (2014) Clin Chim Acta , vol.430C , pp. 38-42
    • Malik, U.U.1    Siddiqui, I.A.2    Hashim, Z.3    Zarina, S.4
  • 39
    • 44949214649 scopus 로고    scopus 로고
    • Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues
    • COI: 1:CAS:528:DC%2BD1cXntlSnu7g%3D, PID: 18440321
    • Marsillach J, Mackness B, Mackness M, Riu F, Beltran R, Joven J, Camps J (2008) Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues. Free Radic Biol Med 45:146–157. doi:10.1016/j.freeradbiomed.2008.03.023
    • (2008) Free Radic Biol Med , vol.45 , pp. 146-157
    • Marsillach, J.1    Mackness, B.2    Mackness, M.3    Riu, F.4    Beltran, R.5    Joven, J.6    Camps, J.7
  • 41
    • 84899987170 scopus 로고    scopus 로고
    • DeltaNp63 expression in four carcinoma cell lines and the effect on radioresistance-a siRNA knockdown model
    • Moergel M, Goldschmitt J, Stockinger M, Kunkel M (2013) DeltaNp63 expression in four carcinoma cell lines and the effect on radioresistance-a siRNA knockdown model. Clin Oral Investig. doi:10.1007/s00784-013-1078-0
    • (2013) Clin Oral Investig
    • Moergel, M.1    Goldschmitt, J.2    Stockinger, M.3    Kunkel, M.4
  • 42
    • 84860168136 scopus 로고    scopus 로고
    • Apoptosis-modulating drugs for improved cancer therapy
    • COI: 1:CAS:528:DC%2BC38XoslansLs%3D, PID: 22538523
    • Ocker M, Hopfner M (2012) Apoptosis-modulating drugs for improved cancer therapy. Eur Surg Res 48:111–120. doi:10.1159/000336875
    • (2012) Eur Surg Res , vol.48 , pp. 111-120
    • Ocker, M.1    Hopfner, M.2
  • 43
    • 34247490186 scopus 로고    scopus 로고
    • Mitochondria, oxidative stress and cell death
    • COI: 1:CAS:528:DC%2BD2sXksFamtrw%3D, PID: 17453160
    • Ott M, Gogvadze V, Orrenius S, Zhivotovsky B (2007) Mitochondria, oxidative stress and cell death. Apoptosis 12:913–922. doi:10.1007/s10495-007-0756-2
    • (2007) Apoptosis , vol.12 , pp. 913-922
    • Ott, M.1    Gogvadze, V.2    Orrenius, S.3    Zhivotovsky, B.4
  • 44
    • 84881123014 scopus 로고    scopus 로고
    • X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells
    • COI: 1:CAS:528:DC%2BC3sXhtF2qsbrL, PID: 22788682
    • Panganiban RA, Mungunsukh O, Day RM (2013) X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells. Int J Radiat Biol 89:656–667. doi:10.3109/09553002.2012.711502
    • (2013) Int J Radiat Biol , vol.89 , pp. 656-667
    • Panganiban, R.A.1    Mungunsukh, O.2    Day, R.M.3
  • 46
    • 0029937118 scopus 로고    scopus 로고
    • The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family
    • COI: 1:CAS:528:DyaK28XjtVWjtrw%3D, PID: 8661009
    • Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (1996) The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics 33:498–507
    • (1996) Genomics , vol.33 , pp. 498-507
    • Primo-Parmo, S.L.1    Sorenson, R.C.2    Teiber, J.3    La Du, B.N.4
  • 47
    • 33947148750 scopus 로고    scopus 로고
    • Enhanced lipid peroxidation and nitric oxide products with deranged antioxidant status in patients with head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BD2sXjtFKjt74%3D, PID: 16857409
    • Rasheed MH, Beevi SS, Geetha A (2007) Enhanced lipid peroxidation and nitric oxide products with deranged antioxidant status in patients with head and neck squamous cell carcinoma. Oral Oncol 43:333–338. doi:10.1016/j.oraloncology.2006.02.013
    • (2007) Oral Oncol , vol.43 , pp. 333-338
    • Rasheed, M.H.1    Beevi, S.S.2    Geetha, A.3
  • 48
    • 84877052308 scopus 로고    scopus 로고
    • Quality-of-life (QOL) outcomes in patients with head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiation therapy (IMRT) compared to three-dimensional conformal radiotherapy (3D-CRT): evidence from a prospective randomized study
    • PID: 23562564
    • Rathod S, Gupta T, Ghosh-Laskar S, Murthy V, Budrukkar A, Agarwal J (2013) Quality-of-life (QOL) outcomes in patients with head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiation therapy (IMRT) compared to three-dimensional conformal radiotherapy (3D-CRT): evidence from a prospective randomized study. Oral Oncol 49:634–642. doi:10.1016/j.oraloncology.2013.02.013
    • (2013) Oral Oncol , vol.49 , pp. 634-642
    • Rathod, S.1    Gupta, T.2    Ghosh-Laskar, S.3    Murthy, V.4    Budrukkar, A.5    Agarwal, J.6
  • 49
    • 77950937747 scopus 로고    scopus 로고
    • Epigenetic inactivation of the placentally imprinted tumor suppressor gene TFPI2 in prostate carcinoma
    • COI: 1:CAS:528:DC%2BC3cXktVOrtrg%3D, PID: 20335518
    • Ribarska T, Ingenwerth M, Goering W, Engers R, Schulz WA (2010) Epigenetic inactivation of the placentally imprinted tumor suppressor gene TFPI2 in prostate carcinoma. Cancer Genomics Proteomics 7:51–60
    • (2010) Cancer Genomics Proteomics , vol.7 , pp. 51-60
    • Ribarska, T.1    Ingenwerth, M.2    Goering, W.3    Engers, R.4    Schulz, W.A.5
  • 50
    • 33645760938 scopus 로고    scopus 로고
    • Chemotherapeutic approaches for targeting cell death pathways
    • COI: 1:CAS:528:DC%2BD28XhtFKqsbzN, PID: 16614230
    • Ricci MS, Zong WX (2006) Chemotherapeutic approaches for targeting cell death pathways. Oncologist 11:342–357. doi:10.1634/theoncologist.11-4-342
    • (2006) Oncologist , vol.11 , pp. 342-357
    • Ricci, M.S.1    Zong, W.X.2
  • 51
    • 0141993002 scopus 로고    scopus 로고
    • Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
    • COI: 1:CAS:528:DC%2BD3sXotF2msr0%3D, PID: 12730115
    • Ross ME et al (2003) Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 102:2951–2959. doi:10.1182/blood-2003-01-0338
    • (2003) Blood , vol.102 , pp. 2951-2959
    • Ross, M.E.1
  • 52
    • 84861805678 scopus 로고    scopus 로고
    • The molecular pathogenesis of head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC38XosFartbk%3D, PID: 22833868
    • Rothenberg SM, Ellisen LW (2012) The molecular pathogenesis of head and neck squamous cell carcinoma. J Clin Investig 122:1951–1957
    • (2012) J Clin Investig , vol.122 , pp. 1951-1957
    • Rothenberg, S.M.1    Ellisen, L.W.2
  • 53
    • 69949101473 scopus 로고    scopus 로고
    • Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
    • COI: 1:CAS:528:DC%2BD1MXhtVWhsbjK, PID: 19693011
    • Schafer ZT et al (2009) Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 461:109–113. doi:10.1038/nature08268
    • (2009) Nature , vol.461 , pp. 109-113
    • Schafer, Z.T.1
  • 54
    • 84865185479 scopus 로고    scopus 로고
    • PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death
    • PID: 22441669
    • Schweikert EM et al (2012) PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell Death Differ. doi:10.1038/cdd.2012.35
    • (2012) Cell Death Differ
    • Schweikert, E.M.1
  • 55
    • 68449096849 scopus 로고    scopus 로고
    • The roles of PON1 and PON2 in cardiovascular disease and innate immunity
    • COI: 1:CAS:528:DC%2BD1MXotFCjur8%3D, PID: 19474728
    • Shih DM, Lusis AJ (2009) The roles of PON1 and PON2 in cardiovascular disease and innate immunity. Curr Opin Lipidol 20:288–292. doi:10.1097/MOL.0b013e32832ca1ee
    • (2009) Curr Opin Lipidol , vol.20 , pp. 288-292
    • Shih, D.M.1    Lusis, A.J.2
  • 56
  • 57
    • 84892846995 scopus 로고    scopus 로고
    • A Case control study to evaluate oxidative stress in plasma samples of oral malignancy
    • COI: 1:CAS:528:DC%2BC3sXitlKitLk%3D, PID: 23293480
    • Srivastava KC, Austin RD, Shrivastava D, Sethupathy S, Rajesh S (2012) A Case control study to evaluate oxidative stress in plasma samples of oral malignancy. Contemp Clin Dent 3:271–276. doi:10.4103/0976-237X.103617
    • (2012) Contemp Clin Dent , vol.3 , pp. 271-276
    • Srivastava, K.C.1    Austin, R.D.2    Shrivastava, D.3    Sethupathy, S.4    Rajesh, S.5
  • 58
    • 84920749964 scopus 로고    scopus 로고
    • Genomic medicine and targeted therapy for solid tumors
    • PID: 25042935
    • Stevens EA, Rodriguez CP (2014) Genomic medicine and targeted therapy for solid tumors. J Surg Oncol. doi:10.1002/jso.23699
    • (2014) J Surg Oncol
    • Stevens, E.A.1    Rodriguez, C.P.2
  • 59
    • 84867363671 scopus 로고    scopus 로고
    • Unfolded protein response to autophagy as a promising druggable target for anticancer therapy
    • COI: 1:CAS:528:DC%2BC38XhvVeks77O, PID: 23050960
    • Suh DH, Kim MK, Kim HS, Chung HH, Song YS (2012) Unfolded protein response to autophagy as a promising druggable target for anticancer therapy. Ann NY Acad Sci 1271:20–32. doi:10.1111/j.1749-6632.2012.06739.x
    • (2012) Ann NY Acad Sci , vol.1271 , pp. 20-32
    • Suh, D.H.1    Kim, M.K.2    Kim, H.S.3    Chung, H.H.4    Song, Y.S.5
  • 60
    • 0035253479 scopus 로고    scopus 로고
    • Predictors of response and survival after concurrent chemotherapy and radiation for locally advanced squamous cell carcinomas of the head and neck
    • COI: 1:STN:280:DC%2BD3M7ktFOgsQ%3D%3D, PID: 11169937
    • Suntharalingam M et al (2001) Predictors of response and survival after concurrent chemotherapy and radiation for locally advanced squamous cell carcinomas of the head and neck. Cancer 91:548–554
    • (2001) Cancer , vol.91 , pp. 548-554
    • Suntharalingam, M.1
  • 61
    • 0038399940 scopus 로고    scopus 로고
    • Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review
    • PID: 12742264
    • Trotti A et al (2003) Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol 66:253–262
    • (2003) Radiother Oncol , vol.66 , pp. 253-262
    • Trotti, A.1
  • 62
    • 32444433202 scopus 로고    scopus 로고
    • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    • COI: 1:CAS:528:DC%2BD28XhsF2hsrY%3D, PID: 16430879
    • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160:1–40. doi:10.1016/j.cbi.2005.12.009
    • (2006) Chem Biol Interact , vol.160 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Izakovic, M.4    Mazur, M.5
  • 63
    • 67349086630 scopus 로고    scopus 로고
    • The mitochondrial p53 pathway
    • COI: 1:CAS:528:DC%2BD1MXlslajurc%3D, PID: 19007744
    • Vaseva AV, Moll UM (2009) The mitochondrial p53 pathway. Biochim Biophys Acta 1787:414–420. doi:10.1016/j.bbabio.2008.10.005
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 414-420
    • Vaseva, A.V.1    Moll, U.M.2
  • 64
    • 57049132739 scopus 로고    scopus 로고
    • Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
    • COI: 1:CAS:528:DC%2BD1cXhsVentbbE, PID: 19029908
    • Vaughn AE, Deshmukh M (2008) Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol 10:1477–1483. doi:10.1038/ncb1807
    • (2008) Nat Cell Biol , vol.10 , pp. 1477-1483
    • Vaughn, A.E.1    Deshmukh, M.2
  • 65
    • 0032565577 scopus 로고    scopus 로고
    • Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
    • COI: 1:CAS:528:DyaK1cXks1Onsr8%3D, PID: 9685598
    • Wang D, Kreutzer DA, Essigmann JM (1998) Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions. Mutat Res 400:99–115
    • (1998) Mutat Res , vol.400 , pp. 99-115
    • Wang, D.1    Kreutzer, D.A.2    Essigmann, J.M.3
  • 66
    • 0030049032 scopus 로고    scopus 로고
    • Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer
    • Wiseman H, Halliwell B (1996) Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J313(Pt 1):17–29
    • (1996) Biochem , vol.J313 , pp. 17-29
    • Wiseman, H.1    Halliwell, B.2
  • 67
    • 79251528324 scopus 로고    scopus 로고
    • Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells
    • COI: 1:STN:280:DC%2BC3M3jsVWmsA%3D%3D, PID: 21368884
    • Witte I et al (2011) Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells. Cell Death Dis 2:e112. doi:10.1038/cddis.2010.91
    • (2011) Cell Death Dis , vol.2 , pp. 112
    • Witte, I.1


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