Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin

Biochemical Journal

Volumn 426, Issue 1, 2010, Pages 73-83

  Horke, Sven ^a   Witte, Ines ^a   Altenhöfer, Sebastian ^a   Wilgenbus, Petra ^a   Goldeck, Marion ^a   Förstermann, Ulrich ^a   Xiao, Junhui ^b   Kramer, Gerald L ^b   Haines, Donovan C ^c,d   Chowdhary, Puneet K ^d   Haley, Robert W ^b   Teiber, John F ^b  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c SAM HOUSTON STATE UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Lactonase; Paraoxonase (PON); Pseudomonas aeruginosa; Pyocyanin (PCN); Quorum sensing; Virulence

Indexed keywords

ACETOXYMETHYL ESTERS; ANTIOXIDATIVE PROPERTY; BACTERIAL GENES; CYTOSOLIC; HOMOSERINE LACTONES; HOST CELLS; HOST IMMUNE RESPONSE; HYDROLYTIC ACTIVITIES; INTRACELLULAR CA; LACTONASE; OVER-EXPRESSION; PS. AERUGINOSA; PSEUDOMONAS AERUGINOSA; PYOCYANIN; QUORUM-SENSING; REACTIVE OXYGEN SPECIES; SIGNALLING MOLECULES; SMALL INTERFERING RNA; TETRAACETIC ACID; TETRAKIS; VIRULENCE FACTORS;

BACTERIA; ESTERS; ETHANE; GENE EXPRESSION; OXYGEN; PASSIVE NETWORKS; PROTEINS; RNA;

CALCIUM;

ARYLDIALKYLPHOSPHATASE 2; CALCIMYCIN; ETHYLENEGLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID BIS(2 OCTYLOXYETHYL) ESTER; N (3 OXODODECANOYL)HOMOSERINE LACTONE; PYOCYANINE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; ARYLDIALKYLPHOSPHATASE; CALCIUM; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; HOMOSERINE; N-(3-OXODODECANOYL)HOMOSERINE LACTONE;

ANTIOXIDANT ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; CALCIUM TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; HOST RESISTANCE; HUMAN; HUMAN CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN PROCESSING; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; CELL LINE; CELL SURVIVAL; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; VIRULENCE; WESTERN BLOTTING;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA;

4-BUTYROLACTONE; ARYLDIALKYLPHOSPHATASE; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CALCIMYCIN; CALCIUM; CELL LINE; CELL SURVIVAL; DOWN-REGULATION; ENZYME ACTIVATION; HOMOSERINE; HUMANS; OXIDATIVE STRESS; PSEUDOMONAS AERUGINOSA; PYOCYANINE; QUORUM SENSING; RNA, SMALL INTERFERING; VIRULENCE;

EID: 76549114781     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091414     Document Type: Article

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