Oral squamous cell carcinoma: Review of prognostic and predictive factors

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Volumn 102, Issue 1, 2006, Pages 67-76

  Massano, João ^a   Regateiro, Frederico S ^a   Januário, Gustavo ^a   Ferreira, Artur ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR MARKER;

AGE; CANCER STAGING; CHEMISTRY; EARLY DIAGNOSIS; GENETICS; HUMAN; ISOLATION AND PURIFICATION; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MINIMAL RESIDUAL DISEASE; MOUTH TUMOR; NEOVASCULARIZATION (PATHOLOGY); PAPILLOMA VIRUS; PATHOLOGY; PROGNOSIS; REVIEW; SEX DIFFERENCE; SOCIOECONOMICS; SQUAMOUS CELL CARCINOMA;

AGE FACTORS; CARCINOMA, SQUAMOUS CELL; EARLY DIAGNOSIS; HUMANS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MOUTH NEOPLASMS; NEOPLASM STAGING; NEOPLASM, RESIDUAL; NEOVASCULARIZATION, PATHOLOGIC; PAPILLOMAVIRIDAE; PROGNOSIS; SEX FACTORS; SOCIOECONOMIC FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 33745762931     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2005.07.038     Document Type: Review

References (107)

1. Beenken S.W., and Urist M.M. Head and neck tumors. In: Way L.W., and Doherty G.M. (Eds). Current surgical diagnosis and treatment. 11th ed. (2003), Lange Medical Books/McGraw-Hill, New York 282-297
2. Coleman J.J., and Sultan M.R. Tumors of the head and neck. In: Schwartz S.I. (Ed). Principles of surgery. 7th edition (1999), McGraw-Hill, New York 601-665
3. World Health Organization. The World Oral Health Report 2003 (2003), World Health Organization, Geneva 6-7
4. Centers for Disease Control and Prevention. Preventing and controlling oral and pharyngeal cancer. Recommendations from a national strategic planning conference. MMWR 47 RR-14 (1998) 1-12
5. U.S. Department of Health and Human Services. Oral health in America. a report of the Surgeon General-executive summary (2000), US Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health, Rockville (MD) 1-13
6. La Vecchia C., Lucchini F., Negri E., and Levi F. Trends in oral cancer mortality in Europe. Oral Oncol 40 (2004) 433-439
7. Lo W.-L., Kao S.-Y., Chi L.-Y., Wong Y.-K., and Chang R.C.-S. Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy. factors affecting survival. J Oral Maxillofac Surg 61 (2003) 751-758
8. O-charoenrat P., Pillai G., Patel S., Ficher C., Archer D., Eccles S., et al. Tumor thickness predicts cervical nodal metastases and survival in early oral tongue cancer. Oral Oncol 39 (2003) 386-390
9. Nguyen T.V., and Yueh B. Weight loss predicts mortality after recurrent oral cavity and oropharyngeal carcinomas. Cancer 95 (2002) 553-562
10. Leite I.C.G., and Koifman S. Survival analysis in a sample of oral cancer patients at a reference hospital in Rio de Janeiro, Brazil. Oral Oncol 34 (1998) 347-352
11. Al-Rajhi N., Khafaga Y., El-Husseiny J., Saleem M., Mourad W., Al-Otieschan A., et al. Early stage carcinoma of oral tongue. prognostic factors for local control and survival. Oral Oncol 36 (2000) 508-514
12. Ribeiro K.C.B., Kowalski L.P., and Latorre M.R.D.O. Perioperative complications, comorbidities, and survival in oral or oropharyngeal cancer. Arch Otolaryngol Head Neck Surg 129 (2003) 219-228
13. Ribeiro K.C.B., Kowalski L.P., and Latorre M.R.D.O. Impact of comorbidity, symptoms, and patients' characteristics on the prognosis of oral carcinomas. Arch Otolaryngol Head Neck Surg 126 (2000) 1079-1085
14. Carvalho A.L., Singh B., Spiro R.H., Kowalski L.P., and Shah J.P. Cancer of the oral cavity. a comparison between institutions in a developing and a developed nation. Head Neck 26 (2004) 31-38
15. Hall S.F., Groome P.A., and Rothwell D. The impact of comorbidity on the survival of patients with squamous cell carcinoma of the head and neck. Head Neck 22 (2000) 317-322
16. Day G.L., Blot W.J., Shore R.E., McLaughlin J.K., Austin D.F., Greenberg R.S., et al. Second cancers following oral and pharyngeal cancers. role of tobacco and alcohol. J Natl Cancer Inst 86 (1994) 131-137
17. Silverman Jr. S., Gorsky M., and Greenspan D. Tobacco usage in patients with head and neck carcinomas. a follow-up study on habit changes and second primary oral/oropharyngeal cancers. J Am Dent Assoc 106 (1983) 33-35
18. Deleyiannis F.W.-B., Thomas D.B., Vaughan T.L., and Davis S. Alcoholism. independent predictor of survival in patients with head and neck cancer. J Natl Cancer Inst 88 (1996) 542-549
19. Allison P., Locker D., and Feine J.S. The role of diagnostic delays in the prognosis of oral cancer. a review of the literature. Oral Oncol 34 (1998) 161-170
20. Piccirillo J.F., Lacy P.D., Basu A., and Spitznagel E.L. Development of a new head and neck cancer-specific comorbidity index. Arch Otolaryngol Head Neck Surg 128 (2002) 1172-1179
21. Preciado D.A., Matas A., and Adams G.L. Squamous cell carcinoma of the head and neck in solid organ transplant recipients. Head Neck 24 (2002) 319-325
22. Whiteside T.L. Immunobiology and immunotherapy of head and neck cancer. Curr Oncol Rep 3 (2001) 46-55
23. Rosenberg S.A., Yang J.C., and Restifo N.P. Cancer immunotherapy. moving beyond current vaccines. Nat Med 10 (2004) 909-915
24. Genden E.M., Ferlito A., Bradley P.J., Rinaldo A., and Scully C. Neck disease and distant metastases. Oral Oncol 39 (2003) 207-212
25. Tiwari R. Squamous cell carcinoma of the superior gingivolabial sulcus. Oral Oncol 36 (2000) 461-465
26. Gonzales-Moles M.A., Esteban F., Rodriguez-Archilla A., Ruiz-Avila I., and Gonzales-Moles S. Importance of tumour thickness measurement in prognosis of tongue cancer. Oral Oncol 38 (2002) 394-397
27. Takes R.P. Staging of the neck in patients with head and neck squamous cell cancer. Imaging techniques and biomarkers. Oral Oncol 40 (2004) 656-667
28. Shpitzer T., Chaimoff M., Gal R., Stern Y., Feinmesser R., and Segal K. Tumor angiogenesis as a prognostic factor in early oral tongue cancer. Arch Otolaryngol Head Neck Surg 122 (1996) 865-868
29. Bettendorf O., Piffkò J., and Bànkfalvi A. Prognostic and predictive factors in oral squamous cell cancer. important tools for planning individual therapy?. Oral Oncol 40 (2004) 110-119
30. Vicente J.C., Herrero-Zapatero A., Fresno M.F., and LÓpez-Arranz J.S. Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity. clinicopathological and prognostic significance. Oral Oncol 38 (2002) 301-308
31. Guerra M.F.M., Gías L.N., Campo F.R., and Pérez J.S. Marginal and segmental mandibulectomy in patients with oral cancer. a statistical analysis of 106 cases. J Oral Maxillofac Surg 61 (2003) 1289-1296
32. Ferlito A., Rinaldo A., Robbins K.T., Leemans C.R., Shah J.P., Shaha A.R., et al. Changing concepts in the surgical management of the cervical node metastasis. Oral Oncol 39 (2003) 429-435
33. Greenberg J.S., El Naggar A.K., Mo V., Roberts D., and Myers J.N. Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implications for therapeutic decision making. Cancer 98 (2003) 508-515
34. Shingaki S., Takada M., Sasai K., Bibi R., Kobayashi T., Nomura T., et al. Impact of lymph node metastasis on the pattern of failure and survival in oral carcinomas. Am J Surg 185 (2003) 278-284
35. Woolgar J.A., Rogers S.N., Lowe D., Brown J.S., and Vaughan E.D. Cervical lymph node metastasis in oral cancer. the importance of even microscopic extracapsular spread. Oral Oncol 39 (2003) 130-137
36. Greenberg J.S., Fowler R., Gomez J., Mo V., Roberts D., El Naggar A.K., et al. Extent of extracapsular spread. A critical prognosticator in oral tongue cancer. Cancer 97 (2003) 1464-1470
37. Kosunen A., Ropponen K., Kellokoski J., Pukkila M., Virtaniemi J., Valtonen H., et al. Reduced expression of hyaluronan is a strong indicator of poor survival in oral squamous cell carcinoma. Oral Oncol 40 (2004) 257-263
38. Rahima B., Shingaki S., Nagata M., and Saito C. Prognostic significance of perineural invasion in oral and oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97 (2004) 423-431
39. Kip1 protein expression. Oral Oncol 40 (2004) 92-98
40. Carmeliet P. Angiogenesis in health and disease. Nat Med 9 (2003) 653-660
41. Hannen E.J.M., and Riediger D. The quantification of angiogenesis in relation to metastasis in oral cancer. a review. Int J Oral Maxillofac Surg 33 (2004) 2-7
42. Offersen B.V., Borre M., and Overgaard J. Quantification of angiogenesis as a prognostic marker in human carcinomas. a critical evaluation of histopathological methods for estimation of vascular density. Eur J Cancer 39 (2003) 881-890
43. Shintani S., Li C., Ishikawa T., Mihara M., Nakashiro K., and Hamakawa H. Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma. Oral Oncol 40 (2004) 13-20
44. Uehara M., Sano K., Ikeda H., Sekine J., Irie A., Yokota T., et al. Expression of vascular endothelial growth factor and prognosis of oral squamous cell carcinoma. Oral Oncol 40 (2004) 321-325
45. Itoh S., Matsui K., Furuta I., and Takano Y. Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity. its importance as a prognostic predictor. Oral Oncol 39 (2003) 829-835
46. Thomas G.T., Lewis M.P., and Speight P.M. Matrix metalloproteinases and oral cancer. Oral Oncol 35 (1999) 227-233
47. Terakado N., Shintani S., Yano J., Chunnan L., Mihara M., Nakashiro K., et al. Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma. Oral Oncol 40 (2004) 383-389
48. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
49. Scully C., Field J.K., and Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN): 1. Carcinogen metabolism, DNA repair and cell cycle control. Oral Oncol 36 (2000) 256-263
50. Scully C., Field J.K., and Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 2. chromosomal aberrations. Oral Oncol 36 (2000) 311-327
51. Scully C., Field J.K., and Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 3. clinico-pathological applications. Oral Oncol 36 (2000) 404-413
52. Rhee J.C., Khuri F.R., and Shin D.M. Advances in chemoprevention of head and neck cancer. Oncologist 9 (2004) 302-311
53. Grünwald V., and Hidalgo M. Developing inhibitors of the epidermal growth factor receptor for cancer treatment. J Natl Cancer Inst 95 (2003) 851-867
54. Ulanovski D., Stern Y., Roizman P., Shpitzer T., Popovter A., and Feinmesser R. Expression of EGFR and Cerb-B2 as prognostic factors in cancer of the tongue. Oral Oncol 40 (2004) 532-537
55. KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines. Oral Oncol 40 (2004) 43-51
56. Myers J.N., Holsinger F.C., Bekele B.N., Li E., Jasser S.A., Killion J.J., et al. Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade. Arch Otolaryngol Head Neck Surg 128 (2002) 875-879
57. Miyamoto R., Uzawa N., Nagaoka S., Hirata Y., and Amagasa T. Prognostic significance of cyclin D1 amplification and overexpression in oral squamous cell carcinomas. Oral Oncol 39 (2003) 610-618
58. Schneeberger C., Eder S., Swoboda H., Ullrich R., and Zeillinger R. A differential PCR system for the determination of CCND1 (cyclin D1) gene amplification in head and neck squamous cell carcinomas. Oral Oncol 34 (1998) 257-260
59. Chen H.-M., Kuo M.Y.-P., Lin K.-H., Lin C.-Y., and Chiang C.-P. Expression of cyclin A is related to progression of oral squamous cell carcinoma in Taiwan. Oral Oncol 39 (2003) 476-482
60. Yamazaki Y., Chiba I., Hirai A., Sugiura C., Notani K., Kashiwazaki H., et al. Specific p53 mutations predict poor prognosis in oral squamous cell carcinoma. Oral Oncol 39 (2003) 163-169
61. Huang M.-F., Chang Y.-C., Liao P.-S., Huang T.-H., Tsay C.-H., and Chou M.-Y. Loss of heterozigosity of p53 gene of oral cancer detected by exfoliative cytology. Oral Oncol 35 (1999) 296-301
62. Atula S., Grénman R., Laippala P., and Syrjänen S. Cancer of the tongue in patients younger than 40 years. A distinct entity?. Arch Otolaryngol Head Neck Surg 122 (1996) 1313-1319
63. Dijkema I.M., Struikmans H., Dullens H.F.J., Kal H.B., van der Tweel I., and Batterman J.J. Influence of p53 and bcl-2 on proliferative activity and treatment outcome in head and neck cancer patients. Oral Oncol 36 (2000) 54-60
64. Takes R.P., de Jong R.J.B., Alles M.J.R.C., Meeuwis C.A., Marres H.A.M., Knegt P.P.M., et al. Markers for nodal metastases in head and neck squamous cell cancer. Arch Otolaryngol Head Neck Surg 128 (2002) 512-518
65. WAF1/CIP1 expression in tongue squamous cell carcinomas. Arch Otolaryngol Head Neck Surg 128 (2002) 897-902
66. Kip1 expression in oral squamous cell carcinoma in Taiwan. Oral Oncol 38 (2002) 172-178
67. cdc2 expression in tongue squamous cell carcinoma. Oral Oncol 40 (2004) 164-169
68. Partridge M., Emilion G., Pateromichelakis S., A'Hern R., Lee G., Phillips E., et al. The prognostic significance of allelic imbalance at key chromosomal loci in oral cancer. Br J Cancer 79 (1999) 1821-1827
69. Yamamoto N., Mizoe J., Numasawa H., Tsujii H., Shibahara T., and Noma H. Allelic loss on chromosomes 2q, 3p and 21q. possibly a poor prognostic factor in oral squamous cell carcinoma. Oral Oncol 39 (2003) 796-805
70. Bueno P.R., Gias L.N., Delgado R.G., Cebollada J.D., and González F.J.D. Tumor DNA content as a prognostic indicator in squamous cell carcinoma of the oral cavity and tongue base. Head Neck 20 (1998) 232-239
71. Sudbø J., Ried T., Bryne M., Kildal W., Danielsen H., and Reith A. Abnormal DNA content predicts the occurrence in carcinomas in nondysplastic oral white patches. Oral Oncol 37 (2001) 558-565
72. Byers R.M., El Naggar A.K., Lee Y.-Y., Rao B., Fornage B., Terry N.H.A., et al. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?. Head Neck 20 (1998) 138-144
73. Baretton G., Li X., Stoll C., Fischer-Brandies E., Schmidt M., and Lohrs U. Prognostic significance of DNA ploidy in oral squamous cell carcinomas. A retrospective flow and image cytometric study with comparison of DNA ploidy in excisional biopsy specimens and resection specimens, primary tumors, and lymph node metastases. Oral Surg Oral Med Oral Path Oral Radiol Endod 79 (1995) 68-76
74. Diwakar N., Sperandio M., Sherriff M., Brown A., and Odell E.W. Heterogeneity, histological features and DNA ploidy in oral carcinoma by image-based analysis. Oral Oncol 41 (2005) 416-422
75. Noguchi M., Kinjyo H., Kohama G.I., and Nakamori K. Invasive front in oral squamous cell carcinoma. image and flow cytometric analysis with clinicopathologic correlation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93 (2002) 682-687
76. Pich A., Chiusa L., and Navone R. Prognostic relevance of cell proliferation in head and neck tumors. Ann Oncol 15 (2004) 1319-1329
77. Bánkfalvi A., Krassort M., Buchwalow I.B., Végh A., Felszeghy E., and PiffkÓ J. Gains and losses of adhesion molecules (CD44, E-cadherin, and beta-catenin) during oral carcinogenesis and tumour progression. J Pathol 198 (2002) 343-351
78. Chow V., Yuen A.P.W., Lam K.Y., Tsao G.S.W., Ho W.K., and Wei W.I. A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha, beta, gamma) expression in the surgical management of oral tongue carcinoma. J Cancer Res Clin Oncol 127 (2001) 59-63
79. Muñ;oz-Guerra M.F., Marazuela E.G., Fernandez-Contreras M.E., and Gamallo C. P-cadherin expression reduced in squamous cell carcinoma of the oral cavity. an indicator of poor prognosis. Cancer 103 (2005) 960-969
80. Bánkfalvi A., Krassort M., Végh A., Felszeghy E., and PiffkÓ J. Deranged expression of the E-cadherin/beta-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas. J Oral Pathol Med 31 (2002) 450-457
81. Chang H.W., Chow V., Lam K.Y., Wei W.I., and Yuen A.P.W. Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 94 (2002) 386-392
82. Gillison M.L., Koch W.M., Capone R.B., Spafford M., Westra W.H., Wu L., et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92 (2000) 709-720
83. Chiba I., Shindoh M., Yasuda M., Yamazaki Y., Amemiya A., Sato Y., et al. Mutations in the p53 gene and human papillomavirus infection as significant prognostic factors in squamous cell carcinomas of the oral cavity. Oncogene 12 (1996) 1663-1668
84. Báez A., AlmodÓvar J.I., Cantor A., Celestin F., Cruz-Cruz L., Fonseca S., et al. High frequency of HPV16-associated head and neck squamous cell carcinoma in the Puerto Rican population. Head Neck 26 (2004) 778-784
85. Kreimer A.R., Clifford G.M., Snijders P.J.F., Castellsagué X., Meijer C.J.L.M., Pawlita M., et al. HPV16 semiquantitative viral load and serologic biomarkers in oral and oropharyngeal squamous cell carcinomas. Int J Cancer 115 (2005) 329-332
86. Miller C.S., and Johnstone B.M. Human papillomavirus as a risk factor for oral squamous cell carcinoma. a meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91 (2001) 622-635
87. Paz I.B., Cook N., Odom-Maryon T., Xie Y., and Wilczynski S.P. Human papillomavirus (HPV) in head and neck cancer. An association of HPV 16 with squamous cell carcinoma of Waldeyer's tonsillar ring. Cancer 79 (1997) 595-604
88. Syrjänen S. Human papillomavirus (HPV) in head and neck cancer. J Clin Virol 32S (2005) S59-S66
89. Zhang Z.-y., Sdek P., Cao J., and Chen W.-t. Human papillomavirus type 16 and 18 DNA in oral squamous cell carcinoma and normal mucosa. Int J Oral Maxillofac Surg 33 (2004) 71-74
90. Schwartz S.R., Yueh B., McDougall J.K., Daling J.R., and Schwartz S.M. Human papillomavirus infection and survival in oral squamous cell cancer. A population-based study. Otolaryngol Head Neck Surg 125 (2001) 1-9
91. Ritchie J.M., Smith E.M., Summersgill K.F., Hoffman H.T., Wang D., Klussmann J.P., et al. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer 104 (2003) 336-344
92. Gascoa M., and Crookb T. The p53 network in head and neck cancer. Oral Oncol 39 (2003) 222-231
93. Mork J., Lie A.K., Glattre E., Hallmans G., Jellum E., Koskela P., et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 344 (2001) 1125-1131
94. Pintos J., Franco E.L., Black M.J., Bergeron J., and Arella M. Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract. Cancer 85 (1999) 1903-1909
95. Miyashita H., Takebayashi Y., Eliason J.F., Fujimori F., Nitta Y., Sato A., et al. Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma. Cancer 94 (2002) 2959-2966
96. Moriyama-Kita M., Endo Y., Yonemura Y., Heizmann C.W., Schäfer B.W., Sasaki T., et al. Correlation of S100A4 expression with invasion and metastasis in oral squamous cell carcinoma. Oral Oncol 40 (2004) 496-500
97. Kunkel M., Reichert T.E., Benz P., Lehr H.-A., Jeong J.-H., Wieand S., et al. Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Cancer 97 (2003) 1015-1024
98. Onizawa K., Okamura N., Saginoya H., and Yoshida H. Characterization of autofluorescence in oral squamous cell carcinoma. Oral Oncol 39 (2003) 150-156
99. Som P.M., Curtin H.D., and Mancuso A.A. An imaging-based classification for the cervical nodes designed as an adjunct to recent clinically based nodal classifications. Arch Otolaryngol Head Neck Surg 125 (1999) 388-396
100. Ross G., Shoaib T., Soutar D.S., Camilleri I.G., Gray H.W., Bessent R.G., et al. The use of sentinel node biopsy to upstage the clinically N0 neck in head and neck cancer. Arch Otolaryngol Head Neck Surg 128 (2002) 1287-1291
101. Taylor R.J., Wahl R.L., Sharma P.K., Bradford C.R., Terrell J.E., Teknos T.N., et al. Sentinel node localization in oral cavity and oropharynx squamous cell cancer. Arch Otolaryngol Head Neck Surg 127 (2001) 970-974
102. Aitman T.J. DNA microarrays in medical practice. BMJ 323 (2001) 611-615
103. Méndez E., Cheng C., Farwell D.G., Ricks S., Agoff S.N., Futran N.D., et al. Transcriptional expression profiles of oral squamous cell carcinomas. Cancer 95 (2002) 1482-1494
104. Schmalbach C.E., Chepeha D.B., Giordano T.J., Rubin M.A., Teknos T.N., Bradford C.R., et al. Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 130 (2004) 295-302
105. Vitorino R., Lobo M.J.C., Ferrer-Correira A.J., Dubin J.R., Tomer K.B., Domingues P.M., et al. Identification of human whole saliva protein components using proteomics. Proteomics 4 (2004) 1109-1115
106. Hu S., Xie Y., Ramachandran P., Loo R.R.O., Li Y., Loo J.A., et al. Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and 2-dimensional gel electrophoresis-mass spectrometry. Proteomics 5 (2005) 1714-1728
107. Petricoin E.F., and Liotta L.A. Proteomic analysis at the bedside. early detection of cancer. Trends Biotechnol 20 (2002) S30-S34