One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity

Journal of Biological Chemistry

Volumn 285, Issue 32, 2010, Pages 24398-24403

  Altenhöfer, Sebastian ^a   Witte, Ines ^a   Teiber, John F ^b   Wilgenbus, Petra ^a   Pautz, Andrea ^a   Li, Huige ^a   Daiber, Andreas ^c   Witan, Heidrun ^a   Clement, Albrecht M ^a   Förstermann, Ulrich ^a   Horke, Sven ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL MEMBRANES; ENZYMES; ESTERIFICATION; GLYCOSYLATION; SIGNALING;

APOPTOSIS; APOPTOTIC FUNCTION; CELL SURVIVAL; CYTOCHROME C; DISMUTASE; ELECTRON TRANSPORT CHAIN; HUMAN ENZYMES; HYDROLYTIC ACTIVITIES; INNATE IMMUNITY; LACTONASE; LACTONASE ACTIVITY; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL SUPEROXIDE; OXIDATIVE DAMAGE; OXIDATIVE FUNCTIONS; POINT MUTATIONS; PSEUDOMONAS AERUGINOSA; REDOX SIGNALING; SIGNALING MOLECULES; SUPEROXIDES; TUMOR CELLS;

OXYGEN;

ARYLDIALKYLPHOSPHATASE 2; CYSTINE; CYTOCHROME C; GLUCONOLACTONASE; HISTIDINE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SERINE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; SUPEROXIDE DISMUTASE; ANTIOXIDANT; ARYLDIALKYLPHOSPHATASE; LACTONE; OXYGEN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; ENZYME POLYMORPHISM; HUMAN; HUMAN CELL; HYDROLYSIS; INNATE IMMUNITY; MITOCHONDRIAL MEMBRANE; NEOPLASM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; POINT MUTATION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; TUMOR CELL; BIOLOGICAL MODEL; CELL FRACTIONATION; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; GLYCOSYLATION; METABOLISM; MITOCHONDRION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANTIOXIDANTS; APOPTOSIS; ARYLDIALKYLPHOSPHATASE; ENDOTHELIUM, VASCULAR; GLYCOSYLATION; HUMANS; LACTONES; MITOCHONDRIA; MODELS, BIOLOGICAL; OXIDATIVE STRESS; OXYGEN; PSEUDOMONAS AERUGINOSA; REACTIVE OXYGEN SPECIES; SUBCELLULAR FRACTIONS; SUPEROXIDES;

EID: 77955300136     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.118604     Document Type: Article

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