Vasopressin regulation of sodium transport in the distal nephron and collecting duct

American Journal of Physiology - Renal Physiology

Volumn 309, Issue 4, 2015, Pages F280-F299

  Kortenoeven, M L ^a   Pedersen, N B ^b   Rosenbaek, L L ^b   Fenton, R A ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIDIURETIC AGENT; ARGIPRESSIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL SODIUM CHANNEL; PEPTIDE HORMONE; SODIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; SODIUM PROTON EXCHANGE PROTEIN 3; VASOPRESSIN; CATION TRANSPORT PROTEIN; SODIUM; VASOPRESSIN RECEPTOR;

ARTICLE; BODY WATER; CELL SURFACE; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; HORMONE METABOLISM; HUMAN; KIDNEY COLLECTING TUBULE; NEPHRON; NEUROHYPOPHYSIS; NONHUMAN; PRIORITY JOURNAL; SODIUM TRANSPORT; UREA CYCLE; WATER ABSORPTION; WATER METABOLISM; WATER RETENTION; ANIMAL; ION TRANSPORT; KIDNEY TUBULE ABSORPTION; METABOLISM; NATRIURESIS; SIGNAL TRANSDUCTION; URINARY EXCRETION;

ANIMALS; ARGININE VASOPRESSIN; CATION TRANSPORT PROTEINS; HUMANS; ION TRANSPORT; KIDNEY TUBULES, COLLECTING; NATRIURESIS; NEPHRONS; RECEPTORS, VASOPRESSIN; RENAL ELIMINATION; RENAL REABSORPTION; SIGNAL TRANSDUCTION; SODIUM;

EID: 84939510360     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00093.2015     Document Type: Article

References (304)

1. Andersen LJ, Andersen JL, Schutten HJ, Warberg J, Bie P. Antidiuretic effect of subnormal levels of arginine vasopressin in normal humans. Am J Physiol Regul Integr Comp Physiol 259: R53-R60, 1990.
2. Anderson MP, Berger HA, Rich DP, Gregory RJ, Smith AE, Welsh MJ. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67: 775-784, 1991.
3. Aoyagi T, Izumi Y, Hiroyama M, Matsuzaki T, Yasuoka Y, Sanbe A, Miyazaki H, Fujiwara Y, Nakayama Y, Kohda Y, Yamauchi J, Inoue T, Kawahara K, Saito H, Tomita K, Nonoguchi H, Tanoue A. Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells. Am J Physiol Renal Physiol 295: F100-F107, 2008.
4. Bankir L. Antidiuretic action of vasopressin: quantitative aspects and interaction between V1a and V2 receptor-mediated effects. Cardiovasc Res 51: 372-390, 2001.
5. Bankir L, Bichet DG, Bouby N. Vasopressin V2 receptors, ENaC, and sodium reabsorption: a risk factor for hypertension? Am J Physiol Renal Physiol 299: F917-F928, 2010.
6. Bankir L, Bouby N, Ritz E. Vasopressin: a novel target for the prevention and retardation of kidney disease? Nat Rev Nephrol 9: 223-239, 2013.
7. Bankir L, Fernandes S, Bardoux P, Bouby N, Bichet DG. Vasopres-sin-V2 receptor stimulation reduces sodium excretion in healthy humans. J Am Soc Nephrol 16: 1920-1928, 2005.
8. Bardoux P, Bichet DG, Martin H, Gallois Y, Marre M, Arthus MF, Lonergan M, Ruel N, Bouby N, Bankir L. Vasopressin increases urinary albumin excretion in rats and humans: involvement of V2 receptors and the renin-angiotensin system. Nephrol Dial Transplant 18: 497-506, 2003.
9. Bardoux P, Bruneval P, Heudes D, Bouby N, Bankir L. Diabetes-induced albuminuria: role of antidiuretic hormone as revealed by chronic V2 receptor antagonism in rats. Nephrol Dial Transplant 18: 1755-1763, 2003.
10. Bardoux P, Martin H, Ahloulay M, Schmitt F, Bouby N, Trinh-Trang-Tan MM, Bankir L. Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: study in vaso-pressin-deficient Brattleboro rats. Proc Natl Acad Sci USA 96: 10397-10402, 1999.
11. Baylis PH. Regulation of vasopressin secretion. Baillieres Clin Endo-crinolMetab 3: 313-330, 1989.
12. Bazua-Valenti S, Chavez-Canales M, Rojas-Vega L, Gonzalez-Rodriguez X, Vazquez N, Rodriguez-Gama A, Argaiz ER, Melo Z, Plata C, Ellison DH, Garcia-Valdes J, Hadchouel J, Gamba G. The effect of WNK4 on the Na+-Cl~ cotransporter is modulated by intracellular chloride. J Am Soc Nephrol [Epub ahead of print].
13. Beguin P, Beggah AT, Chibalin AV, Burgener-Kairuz P, Jaisser F, Mathews PM, Rossier BC, Cotecchia S, Geering K. Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation. J Biol Chem 269: 24437-24445, 1994.
14. Benos DJ, Awayda MS, Ismailov II, Johnson JP. Structure and function of amiloride-sensitive Na+ channels. J MembrBiol 143: 1-18, 1995.
15. Bens M, Duong Van Huyen JP, Cluzeaud F, Teulon J, Vandewalle A. CFTR disruption impairs cAMP-dependent Cl~ secretion in primary cultures of mouse cortical collecting ducts. Am J Physiol Renal Physiol 281: F434-F442, 2001.
16. Berdiev BK, Cormet-Boyaka E, Tousson A, Qadri YJ, Oosterveld-Hut HM, Hong JS, Gonzales PA, Fuller CM, Sorscher EJ, Lukacs GL, Benos DJ. Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer. J Biol Chem 282: 36481-36488, 2007.
17. Berdiev BK, Qadri YJ, Benos DJ. Assessment of the CFTR and ENaC association. Mol Biosyst 5: 123-127, 2009.
18. Berecek KH, Brody MJ. Vasopressin and deoxycorticosterone hypertension in Brattleboro rats. Ann NY Acad Sci 394: 319-329, 1982.
19. Bertuccio CA, Ibarra FR, Toledo JE, Arrizurieta EE, Martin RS. Endogenous vasopressin regulates Na-K-ATPase and Na+-K+-Cl~ cotransporter rbsc-1 in rat outer medulla. Am J Physiol Renal Physiol 282: F265-F270, 2002.
20. Besseghir K, Trimble ME, Stoner L. Action of ADH on isolated medullary thick ascending limb of the Brattleboro rat. Am J Physiol Renal Fluid Electrolyte Physiol 251: F271-F277, 1986.
21. Biemesderfer D, Rutherford PA, Nagy T, Pizzonia JH, Abu-Alfa AK, Aronson PS. Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney. Am J Physiol Renal Physiol 273: F289-F299, 1997.
22. Blanchard A, Frank M, Wuerzner G, Peyrard S, Bankir L, Jeun-emaitre X, Azizi M. Antinatriuretic effect of vasopressin in humans is amiloride sensitive, thus ENaC dependent. Clin J Am Soc Nephrol 6: 753-759, 2011.
23. Blot-Chabaud M, Djelidi S, Courtois-Coutry N, Fay M, Cluzeaud F, Hummler E, Farman N. Coordinate control of Na,K-ATPase mRNA expression by aldosterone, vasopressin and cell sodium delivery in the cortical collecting duct. Cell Mol Biol 47: 247-253, 2001.
24. Blount MA, Klein JD, Martin CF, Tchapyjnikov D, Sands JM. Forskolin stimulates phosphorylation and membrane accumulation of UT-A3. Am J Physiol Renal Physiol 293: F1308-F1313, 2007.
25. Blount MA, Mistry AC, Frohlich O, Price SR, Chen G, Sands JM, Klein JD. Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation. Am J Physiol Renal Physiol 295: F295-F299, 2008.
26. Boone M, Kortenoeven ML, Robben JH, Tamma G, Deen PM. Counteracting vasopressin-mediated water reabsorption by ATP, dopa-mine, and phorbol esters: mechanisms of action. Am J Physiol Renal Physiol 300: F761-F771, 2011.
27. Borensztein P, Froissart M, Laghmani K, Bichara M, Paillard M. RT-PCR analysis of Na+/H+ exchanger mRNAs in rat medullary thick ascending limb. Am J Physiol Renal Fluid Electrolyte Physiol 268: F1224-F1228, 1995.
28. Bouby N, Bachmann S, Bichet D, Bankir L. Effect of water intake on the progression of chronic renal failure in the % nephrectomized rat. Am J Physiol Renal Fluid Electrolyte Physiol 258: F973-F979, 1990.
29. Bouby N, Bankir L, Trinh-Trang-Tan MM, Minuth WW, Kriz W. Selective ADH-induced hypertrophy of the medullary thick ascending limb in Brattleboro rats. Kidney Int 28: 456-466, 1985.
30. Bouby N, Hassler C, Bankir L. Contribution of vasopressin to progression of chronic renal failure: study in Brattleboro rats. Life Sci 65: 991-1004, 1999.
31. Boulkroun S, Ruffieux-Daidie D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D, Firsov D, Kellenberger S, Staub O. Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3. Am J Physiol Renal Physiol 295: F889-F900, 2008.
32. Bradford D, Raghuram V, Wilson JL, Chou CL, Hoffert JD, Knepper MA, Pisitkun T. Use of LC-MS/MS and Bayes' theorem to identify protein kinases that phosphorylate aquaporin-2 at Ser256. Am J Physiol Cell Physiol 307: C123-C139, 2014.
33. Bubien JK. Epithelial Na+ channel (ENaC), hormones, hypertension J Biol Chem 285: 23527-23531, 2010.
34. Bugaj V, Pochynyuk O, Stockand JD. Activation of the epithelial Na+ channel in the collecting duct by vasopressin contributes to water reabsorption. Am J Physiol Renal Physiol 297: F1411-F1418, 2009.
35. Butterworth MB, Edinger RS, Johnson JP, Frizzell RA. Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool. J Gen Physiol 125: 81-101, 2005.
36. Caceres PS, Ares GR, Ortiz PA. cAMP stimulates apical exocytosis of the renal Na+-K+-2Cl~ cotransporter NKCC2 in the thick ascending limb: role of protein kinase A. J Biol Chem 284: 24965-24971, 2009.
37. Caceres PS, Mendez M, Ortiz PA. Vesicle-associated membrane protein 2 (VAMP2) but Not VAMP3 mediates cAMP-stimulated trafficking of the renal Na+-K+-2Cl~ co-transporter NKCC2 in thick ascending limbs. J Biol Chem 289: 23951-23962, 2014.
38. Carmosino M, Brooks HL, Cai Q, Davis LS, Opalenik S, Hao C, Breyer MD. Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Am J Physiol Renal Physiol 292: F351-F360, 2007.
39. Cassola AC, Giebisch G, Wang W. Vasopressin increases density of apical low-conductance K+ channels in rat CCD. Am J Physiol Renal Fluid Electrolyte Physiol 264: F502-F509, 1993.
40. Chabardes D, Gagnan-Brunette M, Imbert-Teboul M, Gontcharevskaia O, Montegut M, Clique A, Morel F. Adenylate cyclase responsiveness to hormones in various portions of the human nephron. J Clin Invest 65: 439-448, 1980.
41. Charest PG, Oligny-Longpre G, Bonin H, Azzi M, Bouvier M. The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling. Cell Signal 19: 32-41, 2006.
42. Charlton JA, Baylis PH. Stimulation of rat renal medullary Na+ /K+ -ATPase by arginine vasopressin is mediated by the V2 receptor. J Endocrinol 127: 213-216, 1990.
43. Chen L, Williams SK, Schafer JA. Differences in synergistic actions of vasopressin and deoxycorticosterone in rat and rabbit CCD. Am J Physiol Renal Fluid Electrolyte Physiol 259: F147-F156, 1990.
44. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D. Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci USA 96: 2514-2519, 1999.
45. Cheng CJ, Yoon J, Baum M, Huang CL. STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated perfused thick ascending limb. Am J Physiol Renal Physiol 308: F437-F443, 2015.
46. Chou CL, Yip KP, Michea L, Kador K, Ferraris JD, Wade JB, Knepper MA. Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct. Roles of ryanodine-sensitive Ca2+ stores and calmodulin. J Biol Chem 275: 36839-36846, 2000.
47. Christensen BM, Perrier R, Wang Q, Zuber AM, Maillard M, Mordasini D, Malsure S, Ronzaud C, Stehle JC, Rossier BC, Hum-mler E. Sodium and potassium balance depends on alphaENaC expression in connecting tubule. J Am Soc Nephrol 21: 1942-1951, 2010.
48. Christensen BM, Wang W, Frokiaer J, Nielsen S. Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin. Am J Physiol Renal Physiol 284: F701-F717, 2003.
49. Christensen BM, Zelenina M, Aperia A, Nielsen S. Localization and regulation of PKA-phosphorylated AQP2 in response to V2-receptor agonist/antagonist treatment. Am J Physiol Renal Physiol 278: F29-F42, 2000.
50. Clark WF, Sontrop JM, Macnab JJ, Suri RS, Moist L, Salvadori M, Garg AX. Urine volume and change in estimated GFR in a community-based cohort study. Clin J Am Soc Nephrol 6: 2634-2641, 2011.
51. Coleman RA, Wu DC, Liu J, Wade JB. Expression of aquaporins in the renal connecting tubule. Am J Physiol Renal Physiol 279: F874-F883, 2000.
52. Costanzo LS. Comparison of calcium and sodium transport in early and late rat distal tubules: effect of amiloride. Am J Physiol Renal Fluid Electrolyte Physiol 246: F937-F945, 1984.
53. Costanzo LS. Localization of diuretic action in microperfused rat distal tubules: Ca and Na transport. Am J Physiol Renal Fluid Electrolyte Physiol 248: F527-F535, 1985.
54. Coutry N, Farman N, Bonvalet JP, Blot-Chabaud M. Synergistic action of vasopressin and aldosterone on basolateral Na+ -K+ -ATPase in the cortical collecting duct. J Membr Biol 145: 99-106, 1995.
55. Crawford I, Maloney PC, Zeitlin PL, Guggino WB, Hyde SC, Turley H, Gatter KC, Harris A, Higgins CF. Immunocytochemical localization of the cystic fibrosis gene product CFTR. Proc Natl Acad Sci USA 88: 9262-9266, 1991.
56. Dathe C, Daigeler AL, Seifert W, Jankowski V, Mrowka R, Kalis R, Wanker E, Mutig K, Bachmann S, Paliege A. Annexin A2 mediates apical trafficking of renal Na+-K+-2Cl~ cotransporter. J Biol Chem 289: 9983-9997, 2014.
57. Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Munster C, Chraibi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression. EMBO J 20: 7052-7059, 2001.
58. Devuyst O, Burrow CR, Schwiebert EM, Guggino WB, Wilson PD. Developmental regulation of CFTR expression during human nephro-genesis. Am J Physiol Renal Fluid Electrolyte Physiol 271: F723-F735, 1996.
59. Dimke H, Flyvbjerg A, Bourgeois S, Thomsen K, Frokiaer J, Houil-lier P, Nielsen S, Frische S. Acute growth hormone administration induces antidiuretic and antinatriuretic effects and increases phosphorylation of NKCC2. Am J Physiol Renal Physiol 292: F723-F735, 2007.
60. Djelidi S, Fay M, Cluzeaud F, Escoubet B, Eugene E, Capurro C, Bonvalet JP, Farman N, Blot-Chabaud M. Transcriptional regulation of sodium transport by vasopressin in renal cells. J Biol Chem 272: 32919-32924, 1997.
61. Duong Van Huyen J, Bens M, Vandewalle A. Differential effects of aldosterone and vasopressin on chloride fluxes in transimmortalized mouse cortical collecting duct cells. J Membr Biol 164: 79-90, 1998.
62. Duong Van Huyen JP, Bens M, Teulon J, Vandewalle A. Vasopressin-stimulated chloride transport in transimmortalized mouse cell lines derived from the distal convoluted tubule and cortical and inner medullary collecting ducts. Nephrol Dial Transplant 16: 238-245, 2001.
63. Ecelbarger CA, Chou CL, Lolait SJ, Knepper MA, DiGiovanni SR. Evidence for dual signaling pathways for V2 vasopressin receptor in rat inner medullary collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 270: F623-F633, 1996.
64. Ecelbarger CA, Kim GH, Knepper MA, Liu J, Tate M, Welling PA, Wade JB. Regulation of potassium channel Kir 1.1 (ROMK) abundance in the thick ascending limb of Henle's loop. J Am Soc Nephrol 12: 10-18, 2001.
65. Ecelbarger CA, Kim GH, Terris J, Masilamani S, Mitchell C, Reyes I, Verbalis JG, Knepper MA. Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am J Physiol Renal Physiol 279: F46-F53, 2000.
66. Ecelbarger CA, Kim GH, Wade JB, Knepper MA. Regulation of the abundance of renal sodium transporters and channels by vasopressin. Exp Neurol 171: 227-234, 2001.
67. Ecelbarger CA, Terris J, Frindt G, Echevarria M, Marples D, Nielsen S, Knepper MA. Aquaporin-3 water channel localization and regulation in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 269: F663-F672, 1995.
68. Ecelbarger CA, Terris J, Hoyer JR, Nielsen S, Wade JB, Knepper MA. Localization and regulation of the rat renal Na+-K+-2Cl~ cotrans-porter, BSC-1. Am J Physiol Renal Fluid Electrolyte Physiol 271: F619-F628, 1996.
69. Ecelbarger CA, Yu S, Lee AJ, Weinstein LS, Knepper MA. Decreased renal Na-K-2Cl cotransporter abundance in mice with heterozygous disruption of the GsCT gene. Am J Physiol Renal Physiol 277: F235-F244, 1999.
70. Elalouf JM, Chabane Sari D, Roinel N, de Rouffignac C. NaCl and Ca delivery at the bend of rat deep nephrons decreases during antidiuresis. Am J Physiol Renal Fluid Electrolyte Physiol 252: F1055-F1064, 1987.
71. Elalouf JM, Roinel N, de Rouffignac C. Effects of antidiuretic hormone on electrolyte reabsorption and secretion in distal tubules of rat kidney. Pflügers Arch 401:167-173,1984.
72. Ellison DH, Velazquez H, Wright FS. Adaptation of the distal convoluted tubule of the rat. Structural and functional effects of dietary salt intake and chronic diuretic infusion. J Clin Invest 83: 113-126, 1989.
73. Els WJ, Butterworth MB. Cytochemical localization of adenylate cyclase in cultured renal epithelial (A6) cells. Microsc Res Tech 40: 455-462, 1998.
74. Farfel Z, Iaina A, Rosenthal T, Waks U, Shibolet S, Gafni J. Familial hyperpotassemia and hypertension accompanied by normal plasma aldo-sterone levels: possible hereditary cell membrane defect. Arch Intern Med 138: 1828-1832, 1978.
75. Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD Jr, Hallows KR, Brown D, Bouley R, Vilardaga JP. Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem 288: 27849-27860, 2013.
76. Fenton RA. Essential role of vasopressin-regulated urea transport processes in the mammalian kidney. Pflügers Arch 458: 169-177, 2009.
77. Fenton RA, Brond L, Nielsen S, Praetorius J. Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney. Am J Physiol Renal Physiol 293: F748-F760, 2007.
78. Fenton RA, Chou CL, Stewart GS, Smith CP, Knepper MA. Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct. Proc Natl Acad Sci USA 101: 7469-7474, 2004.
79. Fenton RA, Cottingham CA, Stewart GS, Howorth A, Hewitt JA, Smith CP. Structure and characterization of the mouse UT-A gene (Slc14a2). Am J Physiol Renal Physiol 282: F630-F638, 2002.
80. Fenton RA, Flynn A, Shodeinde A, Smith CP, Schnermann J, Knepper MA. Renal phenotype of UT-A urea transporter knockout mice. J Am Soc Nephrol 16: 1583-1592, 2005.
81. Fenton RA, Knepper MA. Mouse models and the urinary concentrating mechanism in the new millennium. Physiol Rev 87: 1083-1112, 2007.
82. Fenton RA, Moeller HB, Hoffert JD, Yu MJ, Nielsen S, Knepper MA. Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin. Proc Natl Acad Sci USA 105: 3134-3139, 2008.
83. Fenton RA, Pedersen CN, Moeller HB. New insights into regulated aquaporin-2 function. Curr Opin Nephrol Hypertens 22: 551-558, 2013.
84. Fenton RA, Poulsen SB, de la Mora Chavez S, Soleimani M, Bus-slinger M, Dominguez Rieg JA, Rieg T. Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3. Am J Physiol Renal Physiol 308: F1409-F1420, 2015.
85. Fenton RA, Stewart GS, Carpenter B, Howorth A, Potter EA, Cooper GJ, Smith CP. Characterization of mouse urea transporters UT-A1 and UT-A2. Am J Physiol Renal Physiol 283: F817-F825, 2002.
86. Fenton RA, Yang B. Urea transporter knockout mice and their renal phenotypes. Subcell Biochem 73: 137-152, 2014.
87. Feraille E, Mordasini D, Gonin S, Deschenes G, Vinciguerra M, Doucet A, Vandewalle A, Summa V, Verrey F, Martin PY. Mechanism of control of Na,K-ATPase in principal cells of the mammalian collecting duct. Ann NY Acad Sci 986: 570-578, 2003.
88. Fernandes S, Bruneval P, Hagege A, Heudes D, Ghostine S, Bouby N. Chronic V2 vasopressin receptor stimulation increases basal blood pressure and exacerbates deoxycorticosterone acetate-salt hypertension. Endocrinology 143: 2759-2766, 2002.
89. Field MJ, Stanton BA, Giebisch GH. Influence of ADH on renal potassium handling: a micropuncture and microperfusion study. Kidney Int 25: 502-511, 1984.
90. Firsov D, Mandon B, Morel A, Merot J, Le Maout S, Bellanger AC, De Rouffignac C, Elalouf JM, Buhler JM. Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor. Pflügers Arch 429: 79-89, 1994.
91. Flamion B, Spring KR. Water permeability of apical and basolateral cell membranes of rat inner medullary collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 259: F986-F999, 1990.
92. Fraser SA, Gimenez I, Cook N, Jennings I, Katerelos M, Katsis F, Levidiotis V, Kemp BE, Power DA. Regulation of the renal-specific Na+-K+-2Cl~ co-transporter NKCC2 by AMP-activated protein kinase (AMPK). Biochem J 405: 85-93, 2007.
93. Frindt G, Palmer LG. Na channels in the rat connecting tubule. Am J Physiol Renal Physiol 286: F669-F674, 2004.
94. Fukushima K, Naito H, Funayama Y, Yonezawa H, Haneda S, Shibata C, Sasaki I. In vivo induction of prostasin mRNA in colonic epithelial cells by dietary sodium depletion and aldosterone infusion in rats. J Gastroenterol 39: 940-947, 2004.
95. Fushimi K, Sasaki S, Marumo F. Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel. J Biol Chem 272: 14800-14804, 1997.
96. Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F, Sasaki S. Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature 361: 549-552, 1993.
97. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potas-sium)-chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994.
98. Garty H, Palmer LG. Epithelial sodium channels: function, structure, and regulation. Physiol Rev 77: 359-396, 1997.
99. Gilbert ML, Yang L, Su T, McKnight GS. Expression of a dominant negative protein kinase A (PKA) mutation in kidney elicits a diabetes insipidus phenotype. Am J Physiol Renal Physiol 308: F627-F638, 2015.
100. Gimenez I, Forbush B. Regulatory phosphorylation sites in the NH2 terminus of the renal Na-K-Cl cotransporter (NKCC2). Am J Physiol Renal Physiol 289: F1341-F1345, 2005.
101. Gimenez I, Forbush B. Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. J Biol Chem 278: 26946-26951, 2003.
102. Gonin S, Deschenes G, Roger F, Bens M, Martin PY, Carpentier JL, Vandewalle A, Doucet A, Feraille E. Cyclic AMP increases cell surface expression of functional Na,K-ATPase units in mammalian cortical collecting duct principal cells. Mol Biol Cell 12: 255-264, 2001.
103. Gonzalez CB, Figueroa CD, Reyes CE, Caorsi CE, Troncoso S, Menzel D. Immunolocalization of V1 vasopressin receptors in the rat kidney using anti-receptor antibodies. Kidney Int 52: 1206-1215, 1997.
104. Good DW. Inhibition of bicarbonate absorption by peptide hormones and cyclic adenosine monophosphate in rat medullary thick ascending limb. J Clin Invest 85: 1006-1013, 1990.
105. Good DW, Di Mari JF, Watts BA, 3rd. Hyposmolality stimulates Na+/H+ exchange and HCOJ absorption in thick ascending limb via PI 3-kinase. Am J Physiol Cell Physiol 279: C1443-C1454, 2000.
106. Gottschalk CW, Mylle M. Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis. Am J Physiol 196: 927-936, 1959.
107. Greger R. Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Physiol Rev 65: 760-797, 1985.
108. Greger R. Physiology of renal sodium transport. Am J Med Sci 319: 51-62, 2000.
109. Greger R, Schlatter E. Presence of luminal K+, a prerequisite for active NaCl transport in the cortical thick ascending limb of Henle's loop of rabbit kidney. Pflügers Arch 392: 92-94, 1981.
110. Gunaratne R, Braucht DW, Rinschen MM, Chou CL, Hoffert JD, Pisitkun T, Knepper MA. Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells. Proc Natl Acad Sci USA 107: 15653-15658, 2010.
111. Harrington AR, Valtin H. Impaired urinary concentration after vaso-pressin and its gradual correction in hypothalamic diabetes insipidus. J Clin Invest 47: 502-510, 1968.
112. Hasler U, Mordasini D, Bens M, Bianchi M, Cluzeaud F, Rousselot M, Vandewalle A, Feraille E, Martin PY. Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells. J Biol Chem 277: 10379-10386, 2002.
113. Hawk CT, Li L, Schafer JA. AVP and aldosterone at physiological concentrations have synergistic effects on Na+ transport in rat CCD. Kidney Int Suppl 57: S35-S41, 1996.
114. Hebert SC, Friedman PA, Andreoli TE. Effects of antidiuretic hormone on cellular conductive pathways in mouse medullary thick ascending limbs of Henle: I. ADH increases transcellular conductance pathways. J Membr Biol 80: 201-219, 1984.
115. Helies-Toussaint C, Aarab L, Gasc JM, Verbavatz JM, Chabardes D. Cellular localization of type 5 and type 6 ACs in collecting duct and regulation of cAMP synthesis. Am J Physiol Renal Physiol 279: F185-F194, 2000.
116. Hernando F, Schoots O, Lolait SJ, Burbach JP. Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin. Endocrinology 142: 1659-1668, 2001.
117. Higashihara E, Torres VE, Chapman AB, Grantham JJ, Bae K, Watnick TJ, Horie S, Nutahara K, Ouyang J, Krasa HB, Czerwiec FS, Tempoformula Study I. Tolvaptan in autosomal dominant polycys-tic kidney disease: three years' experience. Clin J Am Soc Nephrol 6: 2499-2507, 2011.
118. Hoffert JD, Chou CL, Fenton RA, Knepper MA. Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct. J Biol Chem 280: 13624-13630, 2005.
119. Hoffert JD, Fenton RA, Moeller HB, Simons B, Tchapyjnikov D, McDill BW, Yu MJ, Pisitkun T, Chen F, Knepper MA. Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. J Biol Chem 283: 24617-24627, 2008.
120. Hoffert JD, Nielsen J, Yu MJ, Pisitkun T, Schleicher SM, Nielsen S, Knepper MA. Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol 292: F691-F700, 2007.
121. Hoffert JD, Pisitkun T, Saeed F, Song JH, Chou CL, Knepper MA. Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics. Mol Cell Proteomics 11: M111-014613, 2012.
122. Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci USA 103: 7159-7164, 2006.
123. Hoorn EJ, Nelson JH, McCormick JA, Ellison DH. The WNK kinase network regulating sodium, potassium, and blood pressure. J Am Soc Nephrol 22: 605-614, 2011.
124. Hozawa S, Holtzman EJ, Ausiello DA. cAMP motifs regulating transcription in the aquaporin 2 gene. Am J Physiol Cell Physiol 270: C1695-C1702, 1996.
125. Hwang S, Gunaratne R, Rinschen MM, Yu MJ, Pisitkun T, Hoffert JD, Fenton RA, Knepper MA, Chou CL. Vasopressin increases phos-phorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters. Am J Physiol Renal Physiol 299: F559-F567, 2010.
126. Igarashi P, Whyte DA, Li K, Nagami GT. Cloning and kidney cell-specific activity of the promoter of the murine renal Na-K-Cl cotransporter gene. J Biol Chem 271: 9666-9674, 1996.
127. Ishibashi K, Sasaki S, Fushimi K, Yamamoto T, Kuwahara M, Marumo F. Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts. Am J Physiol Renal Physiol 272: F235-F241, 1997.
128. Izumi Y, Nakayama Y, Mori T, Miyazaki H, Inoue H, Kohda Y, Inoue T, Nonoguchi H, Tomita K. Downregulation of vasopressin V2 receptor promoter activity via V1a receptor pathway. Am J Physiol Renal Physiol 292: F1418-F1426, 2007.
129. Juul KV, Bichet DG, Nielsen S, Norgaard JP. The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors. Am J Physiol Renal Physiol 306: F931-F940, 2014.
130. Kamsteeg EJ, Hendriks G, Boone M, Konings IB, Oorschot V, van der Sluijs P, Klumperman J, Deen PM. Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel. Proc Natl Acad Sci USA 103: 18344-18349, 2006.
131. Kaplan MR, Plotkin MD, Lee WS, Xu ZC, Lytton J, Hebert SC. Apical localization of the Na-K-Cl cotransporter, rBSC1, on rat thick ascending limbs. Kidney Int 49: 40-47, 1996.
132. Karakashian A, Timmer RT, Klein JD, Gunn RB, Sands JM, Bagnasco SM. Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4. J Am Soc Nephrol 10: 230-237, 1999.
133. Katsura T, Ausiello DA, Brown D. Direct demonstration of aqua-porin-2 water channel recycling in stably transfected LLC-PK1 epithelial cells. Am J Physiol Renal Fluid Electrolyte Physiol 270: F548-F553, 1996.
134. Katsura T, Gustafson CE, Ausiello DA, Brown D. Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells. Am J Physiol Renal Physiol 272: F816-F822, 1997.
135. Keverne EB, Curley JP. Vasopressin, oxytocin and social behaviour. Curr Opin Neurobiol 14: 777-783, 2004.
136. Khuri RN, Strieder N, Wiederholt M, Giebisch G. Effects of graded solute diuresis on renal tubular sodium transport in the rat. Am J Physiol 228: 1262-1268, 1975.
137. Kim D, Sands JM, Klein JD. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. Am J Physiol Renal Physiol 286: F760-F766, 2004.
138. Kim GH, Ecelbarger CA, Mitchell C, Packer RK, Wade JB, Knepper MA. Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop. Am J Physiol Renal Physiol 276: F96-F103, 1999.
139. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-in-duced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998.
140. Kiroytcheva M, Cheval L, Carranza ML, Martin PY, Favre H, Doucet A, Feraille E. Effect of cAMP on the activity and the phosphor-ylation of Na+ ,K+-ATPase in rat thick ascending limb of Henle. Kidney Int 55: 1819-1831, 1999.
141. Kittikulsuth W, Stuart D, Van Hoek AN, Stockand JD, Bugaj V, Mironova E, Blount MA, Kohan DE. Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure. Am J Physiol Renal Physiol 306: F597-F607, 2014.
142. Klein JD, Blount MA, Frohlich O, Denson CE, Tan X, Sim JH, Martin CF, Sands JM. Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells. Am J Physiol Renal Physiol 298: F935-F940, 2010.
143. Klein JD, Frohlich O, Blount MA, Martin CF, Smith TD, Sands JM. Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts. J Am Soc Nephrol 17: 2680-2686, 2006.
144. Kleyman TR, Carattino MD, Hughey RP. ENaC at the cutting edge: regulation of epithelial sodium channels by proteases. J Biol Chem 284: 20447-20451, 2009.
145. Knoers NV, Levtchenko EN. Gitelman syndrome. Orphanet JRare Dis 3: 22, 2008.
146. Kobayashi K, Uchida S, Mizutani S, Sasaki S, Marumo F. Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. JAm Soc Nephrol 12: 1327-1334, 2001.
147. Kocinsky HS, Dynia DW, Wang T, Aronson PS. NHE3 phosphoryla-tion at serines 552 and 605 does not directly affect NHE3 activity. Am J Physiol Renal Physiol 293: F212-F218, 2007.
148. Kocinsky HS, Girardi AC, Biemesderfer D, Nguyen T, Mentone S, Orlowski J, Aronson PS. Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+ /H+ exchanger NHE3 at PKA consensus sites. Am J Physiol Renal Physiol 289: F249-F258, 2005.
149. Konstas AA, Koch JP, Tucker SJ, Korbmacher C. Cystic fibrosis transmembrane conductance regulator-dependent up-regulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel. J Biol Chem 277: 25377-25384, 2002.
150. Kortenoeven ML, Fenton RA. Renal aquaporins and water balance disorders. Biochim Biophys Acta 1840: 1533-1549, 2014.
151. Kortenoeven ML, Trimpert C, van den Brand M, Li Y, Wetzels JF, Deen PM. In mpkCCD cells, long-term regulation of aquaporin-2 by vasopressin occurs independent of protein kinase A and CREB but may involve Epac. Am J Physiol Renal Physiol 302: F1395-F1401, 2012.
152. Koshimizu TA, Nakamura K, Egashira N, Hiroyama M, Nonoguchi H, Tanoue A. Vasopressin V1a and V1b receptors: from molecules to physiological systems. Physiol Rev 92: 1813-1864, 2012.
153. Koshimizu TA, Nasa Y, Tanoue A, Oikawa R, Kawahara Y, Kiyono Y, Adachi T, Tanaka T, Kuwaki T, Mori T, Takeo S, Okamura H, Tsujimoto G. V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity. Proc Natl Acad Sci USA 103: 7807-7812, 2006.
154. Kuwahara M, Fushimi K, Terada Y, Bai L, Marumo F, Sasaki S. cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes. J Biol Chem 270: 10384-10387, 1995.
155. Kwon TH, Nielsen J, Knepper MA, Frokiaer J, Nielsen S. Angioten-sin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. Am J Physiol Renal Physiol 288: F673-F684, 2005.
156. Ledderhos C, Mattson DL, Skelton MM, Cowley AW In Vivo diuretic actions of renal vasopressin V1 receptor stimulation in rats. Am J Physiol Regul Integr Comp Physiol 268: R796-R807, 1995.
157. Lee WS, Hebert SC. ROMK inwardly rectifying ATP-sensitive K+ channel. I. Expression in rat distal nephron segments. Am J Physiol Renal Fluid Electrolyte Physiol 268: F1124-F1131, 1995.
158. Lemmink HH, Knoers NV, Karolyi L, van Dijk H, Niaudet P, Antignac C, Guay-Woodford LM, Goodyer PR, Carel JC, Hermes A, Seyberth HW, Monnens LA, van den Heuvel LP. Novel mutations in the thiazide-sensitive NaCl cotransporter gene in patients with Gitelman syndrome with predominant localization to the C-terminal domain. Kidney Int 54: 720-730, 1998.
159. Leviel F, Hubner CA, Houillier P, Morla L, El MS, Brideau G, Hatim H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D. The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest 120: 1627-1635, 2010.
160. Levin EJ, Zhou M. Structure of urea transporters. Subcell Biochem 73: 65-78, 2014.
161. Lieberthal W, Vasilevsky ML, Valeri CR, Levinsky NG. Interactions between ADH and prostaglandins in isolated erythrocyte-perfused rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 252: F331-F337, 1987.
162. Lin SH, Shiang JC, Huang CC, Yang SS, Hsu YJ, Cheng CJ. Phenotype and genotype analysis in Chinese patients with Gitelman's syndrome. J Clin Endocrinol Metab 90: 2500-2507, 2005.
163. Loffing J, Kaissling B. Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. Am J Physiol Renal Physiol 284: F628-F643, 2003.
164. Loffing J, Pietri L, Aregger F, Bloch-Faure M, Ziegler U, Meneton P, Rossier BC, Kaissling B. Differential subcellular localization of ENaC subunits in mouse kidney in response to highand low-Na diets. Am J Physiol Renal Physiol 279: F252-F258, 2000.
165. Lu M, Leng Q, Egan ME, Caplan MJ, Boulpaep EL, Giebisch GH, Hebert SC. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest 116: 797-807, 2006.
166. Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Nephrogenic diabetes insipidus in mice lacking aqua-porin-3 water channels. Proc Natl Acad Sci USA 97: 4386-4391, 2000.
167. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest 100: 957-962, 1997.
168. Maki N, Komatsuda A, Wakui H, Ohtani H, Kigawa A, Aiba N, Hamai K, Motegi M, Yamaguchi A, Imai H, Sawada K. Four novel mutations in the thiazide-sensitive Na-Cl co-transporter gene in Japanese patients with Gitelman's syndrome. Nephrol Dial Transplant 19: 1761-1766, 2004.
169. Malnic G, Klose RM, Giebisch G. Micropuncture study ofdistal tubular potassium and sodium transport in rat nephron. Am J Physiol 211: 529-547, 1966.
170. Martin PY, Abraham WT, Lieming X, Olson BR, Oren RM, Ohara M, Schrier RW. Selective V2-receptor vasopressin antagonism decreases urinary aquaporin-2 excretion in patients with chronic heart failure. J Am Soc Nephrol 10: 2165-2170, 1999.
171. Mastroianni N, Bettinelli A, Bianchetti M, Colussi G, De Fusco M, Sereni F, Ballabio A, Casari G. Novel molecular variants of the Na-Cl cotransporter gene are responsible for Gitelman syndrome. Am J Hum Genet 59: 1019-1026, 1996.
172. Matsumura Y, Uchida S, Rai T, Sasaki S, Marumo F. Transcriptional regulation of aquaporin-2 water channel gene by cAMP. JAmSoc Nephrol 8: 861-867, 1997.
173. McDonough AA. Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol 298: R851-R861, 2010.
174. Meneton P, Loffing J, Warnock DG. Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule. Am J Physiol Renal Physiol 287: F593-F601, 2004.
175. Mennitt PA, Wade JB, Ecelbarger CA, Palmer LG, Frindt G. Localization of ROMK channels in the rat kidney. J Am Soc Nephrol 8: 1823-1830, 1997.
176. Mironova E, Chen Y, Pao AC, Roos KP, Kohan DE, Bugaj V, Stockand JD. Activation of ENaC by AVP contributes to the urinary concentrating mechanism and dilution of plasma. Am J Physiol Renal Physiol 308: F237-F243, 2015.
177. Moeller HB, Aroankins TS, Slengerik-Hansen J, Pisitkun T, Fenton RA. Phosphorylation and ubiquitylation are opposing processes that regulate endocytosis of the water channel aquaporin-2. J Cell Sci 127: 3174-3183, 2014.
178. Moeller HB, Fenton RA. Cell biology of vasopressin-regulated aqua-porin-2 trafficking. Pflügers Arch 464: 133-144, 2012.
179. Moeller HB, Knepper MA, Fenton RA. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney Int 75: 295-303, 2009.
180. Moeller HB, Olesen ET, Fenton RA. Regulation of the water channel aquaporin-2 by posttranslational modification. Am J Physiol Renal Physiol 300: F1062-F1073, 2011.
181. Moeller HB, Praetorius J, Rutzler MR, Fenton RA. Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions. Proc Natl Acad Sci USA 107: 424-429, 2010.
182. Moeller HB, Rittig S, Fenton RA. Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment. Endocr Rev 34: 278-301, 2013.
183. Monkawa T, Kurihara I, Kobayashi K, Hayashi M, Saruta T. Novel mutations in thiazide-sensitive Na-Cl cotransporter gene of patients with Gitelman's syndrome. J Am Soc Nephrol 11: 65-70, 2000.
184. Morales MM, Carroll TP, Morita T, Schwiebert EM, Devuyst O, Wilson PD, Lopes AG, Stanton BA, Dietz HC, Cutting GR, Guggino WB. Both the wild-type and a functional isoform of CFTR are expressed in kidney. Am J Physiol Renal Fluid Electrolyte Physiol 270: F1038-F1048, 1996.
185. Morales MM, Nascimento DS, Capella MA, Lopes AG, Guggino WB. Arginine vasopressin regulates CFTR and ClC-2 mRNA expression in rat kidney cortex and medulla. Pflügers Arch 443: 202-211, 2001.
186. Mordasini D, Bustamante M, Rousselot M, Martin PY, Hasler U, Feraille E. Stimulation of Na+ transport by AVP is independent of PKA phosphorylation of the Na-K-ATPase in collecting duct principal cells. Am J Physiol Renal Physiol 289: F1031-F1039, 2005.
187. Morel F, Imbert-Teboul M, Chabardes D. Distribution of hormone-dependent adenylate cyclase in the nephron and its physiological significance. Annu Rev Physiol 43: 569-581, 1981.
188. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H. WNK1 regulates phosphoryla-tion of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280: 42685-42693, 2005.
189. Murillo-Carretero MI, Ilundain AA, Echevarria M. Regulation of aquaporin mRNA expression in rat kidney by water intake. JAmSoc Nephrol 10: 696-703, 1999.
190. Mutig K, Kahl T, Saritas T, Godes M, Persson P, Bates J, Rampoldi L, Uchida S, Hille C, Dosche C, Kumar S, Castaneda-Bueno M, Gamba G, Bachmann S. Activation of the bumetanide-sensitive Na+,K+,2CL~-cotransporter NKCC2 is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner. J Biol Chem 286: 30200-30210, 2011.
191. Mutig K, Paliege A, Kahl T, Jons T, Muller-Esterl W, Bachmann S. Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL. Am J Physiol Renal Physiol 293: F1166-F1177, 2007.
192. Mutig K, Saritas T, Uchida S, Kahl T, Borowski T, Paliege A, Bohlick A, Bleich M, Shan Q, Bachmann S. Short-term stimulation of the thiazide-sensitive Na+-Cl-cotransporter by vasopressin involves phosphorylation and membrane translocation. Am J Physiol Renal Physiol 298: F502-F509, 2010.
193. Nakayama Y, Naruse M, Karakashian A, Peng T, Sands JM, Bag-nasco SM. Cloning of the rat Slc14a2 gene and genomic organization of the UT-A urea transporter. Biochim Biophys Acta 1518: 19-26, 2001.
194. Nakayama Y, Peng T, Sands JM, Bagnasco SM. The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression. J Biol Chem 275: 38275-38280, 2000.
195. Neville DC, Rozanas CR, Price EM, Gruis DB, Verkman AS, Townsend RR. Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry. Protein Sci 6: 2436-2445, 1997.
196. Nicco C, Wittner M, DiStefano A, Jounier S, Bankir L, Bouby N. Chronic exposure to vasopressin upregulates ENaC and sodium transport in the rat renal collecting duct and lung. Hypertension 38: 1143-1149, 2001.
197. Nielsen J, Kwon TH, Frokiaer J, Knepper MA, Nielsen S. Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade. Am J Physiol Renal Physiol 292: F382-F394, 2007.
198. Nielsen J, Kwon TH, Masilamani S, Beutler K, Hager H, Nielsen S, Knepper MA. Sodium transporter abundance profiling in kidney: effect of spironolactone. Am J Physiol Renal Physiol 283: F923-F933, 2002.
199. Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA. Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci USA 92:1013-1017, 1995.
200. Nielsen S, Digiovanni SR, Christensen EI, Knepper MA, Harris HW. Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proc Natl Acad Sci USA 90: 11663-11667, 1993.
201. Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82: 205-244, 2002.
202. Nielsen S, Maunsbach AB, Ecelbarger CA, Knepper MA. Ultrastructural localization of Na-K-2Cl cotransporter in thick ascending limb and macula densa of rat kidney. Am J Physiol Renal Physiol 275: F885-F893, 1998.
203. Nielsen S, Terris J, Smith CP, Hediger MA, Ecelbarger CA, Knepper MA. Cellular and subcellular localization of the vasopressin-regulated urea transporter in rat kidney. Proc Natl Acad Sci USA 93: 5495-5500, 1996.
204. Obermuller E, Praetorius HA, Leipziger J. AVP-stimulated Ellison DH, Bachmann S. Expression of the thiazide-sensitive Na-Cl cotrans-porter in rat and human kidney. Am J Physiol Renal Fluid Electrolyte Physiol 269: F900-F910, 1995.
205. Odgaard E, Praetorius HA, Leipziger J. AVP-stimulated nucleotide secretion in perfused mouse medullary thick ascending limb and cortical collecting duct. Am J Physiol Renal Physiol 297: F341-F349, 2009.
206. Ohara M, Martin PY, Xu DL, St John J, Pattison TA, Kim JK, Schrier RW. Upregulation of aquaporin 2 water channel expression in pregnant rats. J Clin Invest 101: 1076-1083, 1998.
207. Okada H, Suzuki H, Kanno Y, Saruta T. Effect of nonpeptide vasopressin receptor antagonists on developing, and established DOCA-salt hypertension in rats. Clin Exp Hypertens 17: 469-483, 1995.
208. Ortiz PA. cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP. Am J Physiol Renal Physiol 290: F608-F616, 2006.
209. Pacheco-Alvarez D, Cristobal PS, Meade P, Moreno E, Vazquez N, Munoz E, Diaz A, Juarez ME, Gimenez I, Gamba G. The Na+:Cl~ cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion. J Biol Chem 281: 28755-28763, 2006.
210. Palmer LG, Schnermann J. Integrated control of Na transport along the nephron. Clin J Am Soc Nephrol 10: 676-687, 2015.
211. Pedersen NB, Hofmeister MV, Rosenbaek LL, Nielsen J, Fenton RA. Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule. Kidney Int 78: 160-169, 2010.
212. Perucca J, Bichet DG, Bardoux P, Bouby N, Bankir L. Sodium excretion in response to vasopressin and selective vasopressin receptor antagonists. J Am Soc Nephrol 19: 1721-1731, 2008.
213. Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ. Chloride sensing by WNK1 involves inhibition of autophosphorylation. Sci Signal 7: ra41, 2014.
214. Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC. Phosphorylation of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 267: 12742-12752, 1992.
215. Piechotta K, Lu J, Delpire E. Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J Biol Chem 277: 50812-50819, 2002.
216. Pippard C, Baylis PH. The stimulation of Na+ ,K+ -ATPase activity in the medulla of the rat kidney by [arginine] vasopressin and its analogues. Clin Sci 66: 561-567, 1984.
217. Plotkin MD, Kaplan MR, Verlander JW, Lee WS, Brown D, Poch E, Gullans SR, Hebert SC. Localization of the thiazide sensitive Na-Cl cotransporter, rTSC1 in the rat kidney. Kidney Int 50: 174-183, 1996.
218. Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juarez P, Munoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. Proc Natl Acad Sci USA 105: 8458-8463, 2008.
219. Poulsen SB, Kim YH, Frokiaer J, Nielsen S, Christensen BM. Long-term vasopressin-V2-receptor stimulation induces regulation of aqua-porin 4 protein in renal inner medulla and cortex of Brattleboro rats. Nephrol Dial Transplant 28: 2058-2065, 2013.
220. Reeves WB, McDonald GA, Mehta P, Andreoli TE. Activation of K+ channels in renal medullary vesicles by cAMP-dependent protein kinase. J Membr Biol 109: 65-72, 1989.
221. Reif MC, Troutman SL, Schafer JA. Sodium transport by rat cortical collecting tubule. Effects of vasopressin and desoxycorticosterone. J Clin Invest 77: 1291-1298, 1986.
222. Reif MC, Troutman SL, Schafer JA. Sustained response to vasopressin in isolated rat cortical collecting tubule. Kidney Int 26: 725-732, 1984.
223. Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR. Activation of the thiazide-sensitive Na+-Cl~ cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci 121: 675-684, 2008.
224. Richardson C, Sakamoto K, de los Heros P, Deak M, Campbell DG, Prescott AR, Alessi DR. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci 124: 789-800, 2011.
225. Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol 21: 2059-2068, 2010.
226. Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Am J Pathol 182: 96-106, 2013.
227. Riepe FG. Clinical and molecular features of type 1 pseudohypoaldo-steronism. Hormone Res 72: 1-9, 2009.
228. Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl~ cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci USA 102: 16777-16782, 2005.
229. Robben JH, Knoers NV, Deen PM. Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephro-genic diabetes insipidus. Am J Physiol Renal Physiol 291: F257-F270, 2006.
230. Roman RJ, Cowley AW. Abnormal pressure-diuresis-natriuresis response in spontaneously hypertensive rats. Am J Physiol Renal Fluid Electrolyte Physiol 248: F199-F205, 1985.
231. Roos KP, Bugaj V, Mironova E, Stockand JD, Ramkumar N, Rees S, Kohan DE. Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity. J Am Soc Nephrol 24: 218-227, 2013.
232. Roos KP, Strait KA, Raphael KL, Blount MA, Kohan DE. Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice. Am J Physiol Renal Physiol 302: F78-F84, 2012.
233. Rosenbaek LL, Assentoft M, Pedersen NB, MacAulay N, Fenton RA. Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. J Physiol 590: 6121-6139, 2012.
234. Rossier BC, Schild L. Epithelial sodium channel: Mendelian versus essential hypertension. Hypertension 52: 595-600, 2008.
235. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E, Rossier BC. Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest 112: 554-565, 2003.
236. Ruggles BT, Murayama N, Werness JL, Gapstur SM, Bentley MD, Dousa TP. The vasopressin-sensitive adenylate cyclase in collecting tubules and in thick ascending limb of Henle's loop of human and canine kidney. J Clin Endocrinol Metab 60: 914-921, 1985.
237. Saito M, Tahara A, Sugimoto T, Abe K, Furuichi K. Evidence that atypical vasopressin V2 receptor in inner medulla of kidney is V1B receptor. Eur J Pharmacol 401: 289-296, 2000.
238. Saito T, Yajima Y. Development of DOCA-salt hypertension in the Brattleboro rat. Ann NY Acad Sci 394: 309-318, 1982.
239. San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci USA 106: 4384-4389, 2009.
240. Sands JM, Nonoguchi H, Knepper MA. Vasopressin effects on urea and H2O transport in inner medullary collecting duct subsegments. Am J Physiol Renal Fluid Electrolyte Physiol 253: F823-F832, 1987.
241. Saritas T, Borschewski A, McCormick JA, Paliege A, Dathe C, Uchida S, Terker A, Himmerkus N, Bleich M, Demaretz S, Laghmani K, Delpire E, Ellison DH, Bachmann S, Mutig K. SPAK differentially mediates vasopressin effects on sodium cotransporters. J Am Soc Nephrol 24: 407-418, 2013.
242. Sarmiento JM, Ehrenfeld P, Anazco CC, Reyes CE, Troncoso S, Figueroa CD, Muller-Esterl W, Gonzalez CB. Differential distribution of the vasopressin V receptor along the rat nephron during renal ontogeny and maturation. Kidney Int 68: 487-496, 2005.
243. Sauter D, Fernandes S, Goncalves-Mendes N, Boulkroun S, Bankir L, Loffing J, Bouby N. Long-term effects of vasopressin on the subcel-lular localization of ENaC in the renal collecting system. Kidney Int 69: 1024-1032, 2006.
244. Schafer JA. Abnormal regulation of ENaC: syndromes of salt retention and salt wasting by the collecting duct. Am J Physiol Renal Physiol 283: F221-F235, 2002.
245. Schafer JA, Hawk CT. Regulation of Na+ channels in the cortical collecting duct by AVP and mineralocorticoids. Kidney Int 41: 255-268, 1992.
246. Schlatter E, Schafer JA. Electrophysiological studies in principal cells of rat cortical collecting tubules. ADH increases the apical membrane Na+-conductance. Pflügers Arch 409: 81-92, 1987.
247. Schnermann J, Briggs JP. Tubuloglomerular feedback: mechanistic insights from gene-manipulated mice. Kidney Int 74: 418-426, 2008.
248. Schrier RW. Water and sodium retention in edematous disorders: role of vasopressin and aldosterone. Am J Med 119: S47-S53, 2006.
249. Seibert FS, Tabcharani JA, Chang XB, Dulhanty AM, Mathews C, Hanrahan JW, Riordan JR. cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation. J Biol Chem 270: 2158-2162, 1995.
250. Seyberth HW, Schlingmann KP. Bartter-and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects. Pediatr Nephrol 26: 1789-1802, 2011.
251. Shao L, Ren H, Wang W, Zhang W, Feng X, Li X, Chen N. Novel SLC12A3 mutations in Chinese patients with Gitelman's syndrome. Nephron Physiol 108: p29-p36, 2008.
252. Shayakul C, Steel A, Hediger MA. Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts. J Clin Invest 98: 2580-2587, 1996.
253. Silva GB, Garvin JL. Extracellular ATP inhibits transport in medullary thick ascending limbs: role of P2X receptors. Am J Physiol Renal Physiol 297: F1168-F1173, 2009.
254. Simon DB, Karet FE, Hamdan JM, DiPietro A, Sanjad SA, Lifton RP. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet 13: 183-188, 1996.
255. Simon DB, Karet FE, Rodriguez-Soriano J, Hamdan JH, DiPietro A, Trachtman H, Sanjad SA, Lifton RP. Genetic heterogeneity of Bart-ter's syndrome revealed by mutations in the K+ channel, ROMK. Nat Genet 14: 152-156, 1996.
256. Simon DB, Nelson-Williams C, Bia MJ, Ellison D, Karet FE, Molina AM, Vaara I, Iwata F, Cushner HM, Koolen M, Gainza FJ, Gitleman HJ, Lifton RP. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 12: 24-30, 1996.
257. Sladek CD, Blair ML, Chen YH, Rockhold RW. Vasopressin and renin response to plasma volume loss in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 250: H443-H452, 1986.
258. Sladek CD, Blair ML, Sterling C, Mangiapane ML. Attenuation of spontaneous hypertension in rats by a vasopressin antagonist. Hypertension 12: 506-512, 1988.
259. Snyder HM, Noland TD, Breyer MD. cAMP-dependent protein kinase mediates hydrosmotic effect of vasopressin in collecting duct. Am J Physiol Cell Physiol 263: C147-C153, 1992.
260. Snyder PM. The epithelial Na+ channel: cell surface insertion and retrieval in Na+ homeostasis and hypertension. Endocrine Rev 23: 258-275, 2002.
261. Snyder PM, Olson DR, Kabra R, Zhou R, Steines JC. cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na+ channel through convergent phosphorylation of Nedd4-2. J Biol Chem 279: 45753-45758, 2004.
262. Sonalker PA, Tofovic SP, Jackson EK. Cellular distribution of the renal bumetanide-sensitive Na-K-2Cl cotransporter BSC-1 in the inner stripe of the outer medulla during the development of hypertension in the spontaneously hypertensive rat. Clin Exp Pharmacol Physiol 34: 1307-1312, 2007.
263. Sonalker PA, Tofovic SP, Jackson EK. Increased expression of the sodium transporter BSC-1 in spontaneously hypertensive rats. J Pharmacol Exp Ther 311: 1052-1061, 2004.
264. Star RA, Nonoguchi H, Balaban R, Knepper MA. Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J Clin Invest 81: 1879-1888, 1988.
265. Stewart GS, Fenton RA, Wang W, Kwon TH, White SJ, Collins VM, Cooper G, Nielsen S, Smith CP. The basolateral expression of mUT-A3 in the mouse kidney. Am J Physiol Renal Physiol 286: F979-F987, 2004.
266. Strait KA, Stricklett PK, Chapman M, Kohan DE. Characterization of vasopressin-responsive collecting duct adenylyl cyclases in the mouse. Am J Physiol Renal Physiol 298: F859-F867, 2010.
267. Strange K, Spring KR. Cell membrane water permeability of rabbit cortical collecting duct. J Membr Biol 96: 27-43, 1987.
268. Strippoli GF, Craig JC, Rochtchina E, Flood VM, Wang JJ, Mitchell P. Fluid and nutrient intake and risk of chronic kidney disease. Nephrol-ogy 16: 326-334, 2011.
269. Tamma G, Robben JH, Trimpert C, Boone M, Deen PM. Regulation of AQP2 localization by S256 and S261 phosphorylation and ubiquitination. Am J Physiol Cell Physiol 300: C636-C646, 2011.
270. Tashima Y, Kohda Y, Nonoguchi H, Ikebe M, Machida K, Star RA, Tomita K. Intranephron localization and regulation of the V1a vasopres-sin receptor during chronic metabolic acidosis and dehydration in rats. Pflügers Arch 442: 652-661, 2001.
271. Terada Y, Tomita K, Nonoguchi H, Yang T, Marumo F. Different localization and regulation of two types of vasopressin receptor messenger RNA in microdissected rat nephron segments using reverse transcription polymerase chain reaction. J Clin Invest 92: 2339-2345, 1993.
272. Terker AS, Zhang C, McCormick JA, Lazelle RA, Zhang C, Meermeier NP, Siler DA, Park HJ, Fu Y, Cohen DM, Weinstein AM, Wang WH, Yang CL, Ellison DH. Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride. Cell Metab 21: 39-50, 2015.
273. Terrillon S, Bouvier M. Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modes. EMBO J 23: 3950-3961, 2004.
274. Terris J, Ecelbarger CA, Marples D, Knepper MA, Nielsen S. Distribution of aquaporin-4 water channel expression within rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 269: F775-F785, 1995.
275. Terris J, Ecelbarger CA, Nielsen S, Knepper MA. Long-term regulation of four renal aquaporins in rats. Am J Physiol Renal FluidElectrolyte Physiol 271: F414-F422, 1996.
276. Terris J, Ecelbarger CA, Sands JM, Knepper MA. Long-term regulation of renal urea transporter protein expression in rat. JAmSoc Nephrol 9: 729-736, 1998.
277. Todd-Turla KM, Rusvai E, Naray-Fejes-Toth A, Fejes-Toth G. CFTR expression in cortical collecting duct cells. Am J Physiol Renal Fluid Electrolyte Physiol 270: F237-F244, 1996.
278. Tomita K, Pisano JJ, Knepper MA. Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone. J Clin Invest 76: 132-136, 1985.
279. Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Grantham JJ, Higashihara E, Perrone RD, Krasa HB, Ouyang J, Czerwiec FS, TEMPO 3.4 Trial Investigators. Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med 367: 2407-2418, 2012.
280. Torres VE, Grantham JJ, Chapman AB, Mrug M, Bae KT, King BF, Wetzel LH, Martin D, Lockhart ME, Bennett WM, Moxey-Mims M, Abebe KZ, Lin Y, Bost JE, Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease. Potentially modifiable factors affecting the progression of autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 6: 640-647, 2011.
281. Treschan TA, Peters J. The vasopressin system: physiology and clinical strategies. Anesthesiology 105: 599-612, 2006.
282. Tsukaguchi H, Shayakul C, Berger UV, Tokui T, Brown D, Hediger MA. Cloning and characterization of the urea transporter UT3—localization in rat kidney and testis. J Clin Invest 99: 1506-1515, 1997.
283. Uchida S, Sohara E, Rai T, Sasaki S. Regulation of with-no-lysine kinase signaling by Kelch-like proteins. Biol Cell 106: 45-56, 2014.
284. Uyehara CF, Sarkar J. Role of vasopressin in maintenance of potassium homeostasis in severe hemorrhage. Am J Physiol Regul Integr Comp Physiol 305: R101-R103, 2013.
285. Van Balkom BWM, Savelkoul PJ, Markovich D, Hofman E, Nielsen S, van der Sluijs P, Deen PMT. The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel. J Biol Chem 277: 41473-41479, 2002.
286. Vitari AC, Deak M, Morrice NA, Alessi DR. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391: 17-24, 2005.
287. Voisin DL, Bourque CW. Integration of sodium and osmosensory signals in vasopressin neurons. Trends Neurosci 25: 199-205, 2002.
288. Wade JB, Lee AJ, Liu J, Ecelbarger CA, Mitchell C, Bradford AD, Terris J, Kim GH, Knepper MA. UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin. Am J Physiol Renal Physiol 278: F52-F62, 2000.
289. Wang WH. Two types of K+ channel in thick ascending limb of rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 267: F599-F605, 1994.
290. Wang Y, Klein JD, Blount MA, Martin CF, Kent KJ, Pech V, Wall SM, Sands JM. Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts. J Am Soc Nephrol 20: 2018-2024, 2009.
291. Welker P, Bohlick A, Mutig K, Salanova M, Kahl T, Schluter H, Blottner D, Ponce-Coria J, Gamba G, Bachmann S. Renal Na+ -K+ -Cl~ cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent. Am J Physiol Renal Physiol 295: F789-F802, 2008.
292. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, NelsonWilliams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.
293. Xu JZ, Hall AE, Peterson LN, Bienkowski MJ, Eessalu TE, Hebert SC. Localization of the ROMK protein on apical membranes of rat kidney nephron segments. Am J Physiol Renal Physiol 273: F739-F748, 1997.
294. Xu YC, Olives B, Bailly P, Fischer E, Ripoche P, Ronco P, Cartron JP, Rondeau E. Endothelial cells of the kidney vasa recta express the urea transporter HUT11. Kidney Int 51: 138-146, 1997.
295. Xu ZC, Yang Y, Hebert SC. Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase. J Biol Chem 271: 9313-9319, 1996.
296. Yan W, Samaha FF, Ramkumar M, Kleyman TR, Rubenstein RC. Cystic fibrosis transmembrane conductance regulator differentially regulates human and mouse epithelial sodium channels in Xenopus oocytes. J Biol Chem 279: 23183-23192, 2004.
297. Yang CL, Liu X, Paliege A, Zhu X, Bachmann S, Dawson DC, Ellison DH. WNK1 and WNK4 modulate CFTR activity. Biochem Biophys Res Commun 353: 535-540, 2007.
298. Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest 121: 956-965, 2011.
299. Yasui M, Zelenin SM, Celsi G, Aperia A. Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol Renal Physiol 272: F443-F450, 1997.
300. Yip KP. Epac-mediated Ca2+ mobilization and exocytosis in inner medullary collecting duct. Am J Physiol Renal Physiol 291: F882-F890, 2006.
301. Yoo D, Flagg TP, Olsen O, Raghuram V, Foskett JK, Welling PA. Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions. J Biol Chem 279: 6863-6873, 2004.
302. Zhang C, Sands JM, Klein JD. Vasopressin rapidly increases phos-phorylation of UT-A1 urea transporter in rat IMCDs through PKA. Am J Physiol Renal Physiol 282: F85-F90, 2002.
303. Zhang C, Wang L, Zhang J, Su XT, Lin DH, Scholl UI, Giebisch G, Lifton RP, Wang WH. KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1). Proc Natl Acad Sci USA 111: 11864-11869, 2014.
304. Zhao H, Wiederkehr MR, Fan L, Collazo RL, Crowder LA, Moe OW. Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase a and NHE-3 phosphoserines 552 and 605. J Biol Chem 274: 3978-3987, 1999.