Regulation of the renal-specific Na+-K+-2Cl - co-transporter NKCC2 by AMP-activated protein kinase (AMPK)

Biochemical Journal

Volumn 405, Issue 1, 2007, Pages 85-93

  Fraser, Scott A ^a   Gimenez, Ignacio ^b   Cook, Natasha ^a   Jennings, Ian ^c   Katerelos, Marina ^a   Katsis, Frosa ^c   Levidiotis, Vicki ^a   Kemp, Bruce E ^c,d   Power, David A ^a  

^a AUSTIN HEALTH   (Australia)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c ST VINCENT S HOSPITAL   (Australia)

^d CSIRO   (Australia)

Author keywords

AMP activated protein kinase (AMPK); Cation co transporter; Co transporter activity; Na+ K+ 2Cl co transporter 2 (NKCC2); Phosphorylation; Xenopus laevis oocytes

Indexed keywords

AMP-ACTIVATED PROTEIN KINASE (AMPK); CATION CO-TRANSPORTERS; CO-TRANSPORTER ACTIVITY; XENOPUS LAEVIS OOCYTES;

BIOCHEMISTRY; CHEMICAL ACTIVATION; COPRECIPITATION; METABOLISM; PHOSPHORYLATION;

ENZYME ACTIVITY;

ALANINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SERINE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PHOSPHO-SPECIFIC; CELL LINE; ENZYME ACTIVATION; HUMANS; KIDNEY; MICE; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; OOCYTES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; RUBIDIUM; SEQUENCE ALIGNMENT; SERINE; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 34347248366     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20061850     Document Type: Article

References (30)

1. Yang, T., Huang, Y. G., Singh, I., Schnermann, J. and Briggs, J. P. (1996) Localization of bumetanide- and thiazide-sensitive Na-K-Cl cotransporters along the rat nephron. Am. J. Physiol. 271, F931-F939
2. Starremans, P. G., Kersten, F. F., Knoers, N. V., van den Heuvel, L. P. and Bindels, R. J. (2003) Mutations in the human Na-K-2Cl cotransporter (NKCC2) identified in Bartter syndrome type I consistently result in nonfunctional transporters. J. Am. Soc. Nephrol. 14, 1419-1426
3. Takahashi, N., Chernavvsky, D. R., Gomez, R. A., Igarashi, P., Gitelman, H. J. and Smithies, O. (2000) Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc. Natl. Acad. Sci. U.S.A. 97, 5434-5439
4. Lytle, C. and Forbush, 3rd, B. (1992) The Na-K-Cl cotransport protein of shark rectal gland. II. Regulation by direct phosphorylation. J. Biol. Chem. 267, 25438-25443
5. Darman, R. B. and Forbush, B. (2002) A regulatory locus of phosphorylation in the N-terminus of the Na-K-Cl cotransporter, NKCC1. J. Biol. Chem. 277, 37542-37550
6. Piechotta, K., Lu, J. and Delpire, E. (2002) Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J. Biol. Chem. 277, 50812-50819
7. Dowd, B. F. and Forbush, B. (2003) PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). J. Biol. Chem. 278, 27347-27353
8. Gimenez, I. and Forbush, B. (2003) Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. J. Biol. Chem. 278, 26946-26951
9. Gimenez, I. and Forbush, B. (2005) Regulatory phosphorylation sites in the NH2 terminus of the renal Na-K-Cl cotransporter (NKCC2). Am. J. Physiol. Renal Physiol. 289, F1341-F1345
10. Fraser, S., Mount, P., Hill, R., Levidiotis, V., Katsis, F., Stapleton, D., Kemp, B. E. and Power, D. A. (2005) Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality. Am. J. Physiol. Renal Physiol. 288, F578-F586
11. Kemp, B. E., Stapleton, D., Campbell, D. J., Chen, Z. P., Murthy, S., Walter, M., Gupta, A., Adams, J. J., Katsis, F., van Denderen, B. et al. (2003) AMP-activated protein kinase, super metabolic regulator. Biochem. Soc. Trans. 31, 162-168
12. Hallows, K. R., Raghuram, V., Kemp, B. E., Witters, L. A. and Foskett, J. K. (2000) Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J. Clin. Invest. 105, 1711-1721
13. Light, P. E., Wallace, C. H. and Dyck, J. R. (2003) Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes. Circulation 107, 1962-1965
14. Carattino, M. D., Edinger, R. S., Grieser, H. J., Wise, R., Neumann, D., Schlattner, U., Johnson, J. P., Kleyman, T. R. and Hallows, K. R. (2005) Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J.Biol. Chem. 280, 17608-17616
15. Woollhead, A. M., Scott, J. W., Hardie, D. G. and Baines, D. L. (2005) Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. J. Physiol. 566, 781-792
16. Wang, C. Z., Wang, Y., Di, A., Magnuson, M. A., Ye, H., Roe, M. W., Nelson, D. J., Bell, G. I. and Philipson, L. H. (2005) 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. Biochem. Biophys. Res. Commun. 330, 1073-1079
17. Fryer, L. G., Parbu-Patel, A. and Carling, D. (2002) The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J. Biol. Chem. 277, 25226-25232
18. Ye, J. M., Dzamko, N., Hoy, A. J., Iglesias, M. A., Kemp, B. and Kraegen, E. (2006) Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats. Diabetes 55, 2797-2804
19. Bandyopadhyay, G. K., Yu, J. G., Ofrecio, J. and Olefsky, J. M. (2006) Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 55, 2277-2285
20. Song, J., Knepper, M. A., Hu, X., Verbalis, J. G. and Ecelbarger, C. A. (2004) Rosiglitazone activates renal sodium- and water-reabsorptive pathways and lowers blood pressure in normal rats. J. Pharmacol. Exp. Ther. 308, 426-433
21. Riazi, S., Khan, O., Tiwari, S., Hu, X. and Ecelbarger, C. A. (2006) Rosiglitazone regulates ENaC and Na-K-2Cl cotransporter (NKCC2) abundance in the obese Zucker rat. Am. J. Nephrol. 26, 245-257
22. Stapleton, D., Mitchelhill, K. I., Gao, G., Widmer, J., Michell, B. J., Teh, T., House, C. M., Fernandez, C. S., Cox, T., Witters, L. A. and Kemp, B. E. (1996) Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271, 611-614
23. Dyck, J. R., Gao, G., Widmer, J., Stapleton, D., Fernandez, C. S., Kemp, B. E. and Witters, L. A. (1996) Regulation of 5′-AMP-activated protein kinase activity by the noncatalytic β and γ subunits. J. Biol. Chem. 271, 17798-17803
24. Davies, S. P., Helps, N. R., Cohen, P. T. and Hardie, D. G. (1995) 5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2Ca and native bovine protein phosphatase-2AC. FEBS Lett. 377, 421-425
25. Michell, B. J., Stapleton, D., Mitchelhill, K. I., House, C. M., Katsis, F., Witters, L. A. and Kemp, B. E. (1996) Isoform-specific purification and substrate specificity of the 5′-AMP-activated protein kinase. J. Biol. Chem. 271, 28445-28450
26. Gimenez, I., Isenring, P. and Forbush, B. (2002) Spatially distributed alternative splice variants of the renal Na-K-Cl cotransporter exhibit dramatically different affinities for the transported ions. J. Biol. Chem. 277, 8767-8770
27. Ecelbarger, C. A., Terris, J., Hoyer, J. R., Nielsen, S., Wade, J. B. and Knepper, M. A. (1996) Localization and regulation of the rat renal Na(+)-K(+)-2Cl cotransporter, BSC-1. Am. J. Physiol. 271, F619-F628
28. Gagnon, K. B., England, R. and Delpire, E. (2006) Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. Mol. Cell. Biol. 26, 689-698
29. Kahle, K. T., Rinehart, J., de Los Heros, P., Louvi, A., Meade, P., Vazquez, N., Hebert, S. C., Gamba, G., Gimenez, I. and Lifton, R. P. (2005) WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. Proc. Natl. Acad. Sci. U.S.A. 102, 16783-16788
30. Moriguchi, T., Urushiyama, S., Hisamoto, N., Iemura, S., Uchida, S., Natsume, T., Matsumoto, K. and Shibuya, H. (2005) WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J. Biol. Chem. 280, 42685-42693