Forskolin stimulates phosphorylation and membrane accumulation of UT-A3

American Journal of Physiology - Renal Physiology

Volumn 293, Issue 4, 2007, Pages

  Blount, Mitsi A ^a   Klein, Janet D ^a   Martin, Christopher F ^a   Tchapyjnikov, Dmitry ^a   Sands, Jeff M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cAMP; Concentrating mechanism; Urea transport; Vasopressin

Indexed keywords

CYCLIC AMP; FORSKOLIN; PHOSPHOPROTEIN; PROTEIN UT A 3; UNCLASSIFIED DRUG; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; IMMUNOHISTOCHEMISTRY; KIDNEY SLICE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; STAINING;

EID: 35348922909     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00197.2007     Document Type: Article

References (29)

1. Bagnasco SM. The erythrocyte urea transporter UT-B. J Membr Biol 212: 133-138, 2006.
2. Bagnasco SM, Peng T, Janech MG, Karakashian A, Sands JM. Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol 281: F400-F406, 2001.
3. Ecelbarger CA, Chou CL, Lolait SJ, Knepper MA, DiGiovanni SR. Evidence for dual signaling pathways for V2 vasopressin receptor in rat inner medullary collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 270: F623-F633, 1996.
4. Fenton RA, Chou CL, Stewart GS, Smith CP, Knepper MA. Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct. Proc Natl Acad Sci USA 101: 7469-7474, 2004.
5. Fenton RA, Howorth A, Cooper GJ, Meccariello R, Morris ID, Smith CP. Molecular characterization of a novel UT-A urea transporter isoform (UT-A5) in testis. Am J Physiol Cell Physiol 279: C1425-C1431, 2000.
6. Fenton RA, Stewart GS, Carpenter B, Howorth A, Potter EA, Cooper GJ, Smith CP. Characterization of mouse urea transporters UT-A1 and UT-A2. Am J Physiol Renal Physiol 283: F817-F825, 2002.
7. Frohlich O, Klein JD, Smith PM, Sands JM, Gunn RB. Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells. Am J Physiol Cell Physiol 291: C600-C606, 2006.
8. Fröhlich O, Klein JD, Smith PM, Sands JM, Gunn RB. Urea transport in MDCK cells that are stably transfected with UT-A1. Am J Physiol Cell Physiol 286: C1264-C1270, 2004.
9. Jung JY, Kim YH, Cha JH, Han KH, Kim MK, Madsen KM, Kim J. Expression of aldose reductase in developing rat kidney. Am J Physiol Renal Physiol 283: F481-F491, 2002.
10. Karakashian A, Timmer RT, Klein JD, Gunn RB, Sands JM, Bagnasco SM. Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4. J Am Soc Nephrol 10: 230-237, 1999.
11. Kim YH, Kim DU, Han KH, Jung JY, Sands JM, Knepper MA, Madsen KM, Kim J. Expression of urea transporters in the developing rat kidney. Am J Physiol Renal Physiol 282: F530-F540, 2002.
12. Klein JD, Frohlich O, Blount MA, Martin CF, Smith TD, Sands JM. Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts. J Am Soc Nephrol 17: 2680-2686, 2006.
13. Klein JD, Price SR, Bailey JL, Jacobs JD, Sands JM. Glucocorticoids mediate a decrease in AVP-regulated urea transporter in diabetic rat inner medulla. Am J Physiol Renal Physiol 273: F949-F953, 1997.
14. Lim SW, Han KH, Jung JY, Kim WY, Yang CW, Sands JM, Knepper MA, Madsen KM, Kim J. Ultrastructural localization of UT-A and UT-B in rat kidneys with different hydration status. Am J Physiol Regul Integr Comp Physiol 290: R479-R492, 2006.
15. Nielsen S, Terris J, Smith CP, Hediger MA, Ecelbarger CA, Knepper MA. Cellular and subcellular localization of the vasopressin-regulated urea transporter in rat kidney. Proc Natl Acad Sci USA 93: 5495-5500, 1996.
16. Shayakul C, Knepper MA, Smith CP, DiGiovanni SR, Hediger MA. Segmental localization of urea transporter mRNAs in rat kidney. Am J Physiol Renal Physiol 272: F654-F660, 1997.
17. Shayakul C, Steel A, Hediger MA. Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts. J Clin Invest 98: 2580-2587, 1996.
18. Smith CP, Lee WS, Martial S, Knepper MA, You G, Sands JM, Hediger MA. Cloning and regulation of expression of the rat kidney urea transporter (rUT2). J Clin Invest 96: 1556-1563, 1995.
19. Smith CP, Potter EA, Fenton RA, Stewart GS. Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6. Am J Physiol Cell Physiol 287: C1087-C1093, 2004.
20. Star RA. Apical membrane limits urea permeation across the rat inner medullary collecting duct. J Clin Invest 86: 1172-1178, 1990.
21. Stewart GS, Fenton RA, Wang W, Kwon TH, White SJ, Collins VM, Cooper G, Nielsen S, Smith CP. The basolateral expression of mUT-A3 in the mouse kidney. Am J Physiol Renal Physiol 286: F979-F987, 2004.
22. Stewart GS, Graham C, Cattell S, Smith TP, Simmons NL, Smith CP. UT-B is expressed in bovine rumen: potential role in ruminal urea transport. Am J Physiol Regul Integr Comp Physiol 289: R605-R612, 2005.
23. Stewart GS, King SL, Potter EA, Smith CP. Acute regulation of mUT-A3 urea transporter expressed in a MDCK cell line. Am J Physiol Renal Physiol 292: F1157-F1163, 2007.
24. Terris JM, Knepper MA, Wade JB. UT-A3: localization and characterization of an additional urea transporter isoform in the IMCD. Am J Physiol Renal Physiol 280: F325-F332, 2001.
25. Wade JB, Lee AJ, Liu J, Ecelbarger CA, Mitchell C, Bradford AD, Terris J, Kim GH, Knepper MA. UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin. Am J Physiol Renal Physiol 278: F52-F62, 2000.
26. Xu Y, Olives B, Bailly P, Fischer E, Ripoche P, Ronco P, Cartron JP, Rondeau E. Endothelial cells of the kidney vasa recta express the urea transporter HUT11. Kidney Int 51: 138-146, 1997.
27. Yang B, Bankir L, Gillespie A, Epstein CJ, Verkman AS. Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem 277: 10633-10637, 2002.
28. You G, Smith CP, Kanai Y, Lee WS, Stelzner M, Hediger MA. Cloning and characterization of the vasopressin-regulated urea transporter. Nature 365: 844-847, 1993.
29. Zhang C, Sands JM, Klein JD. Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA. Am J Physiol Renal Physiol 282: F85-F90, 2002.