Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts

Journal of Clinical Investigation

Volumn 98, Issue 11, 1996, Pages 2580-2587

  Shayakul, Chairat ^b   Steel, Angela ^b   Hediger, Matthias A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

alternative splicing; cyclic AMP; inner medullary collecting duct; urea transporter; vasopressin

Indexed keywords

UREA; VASOPRESSIN;

ANIMAL CELL; ARTICLE; KIDNEY COLLECTING TUBULE; KIDNEY CONCENTRATING CAPACITY; KIDNEY MEDULLA; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT; RNA SPLICING; UREA CYCLE;

EID: 0029825786     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119077     Document Type: Article

References (20)

1. Cohen, P.P. 1976. Evolutionary and comparative aspects of urea biosynthesis. John Wiley & Sons, New York. 21-38.
2. Roy, D.R., H.E. Layton, and R.L. Jamison. 1992. Countercurrent mechanism and its regulation. Raven Press, Ltd., New York. 1649-1692.
3. Knepper, M.A., and F. Roch-Ramel. 1987. Pathways of urea transport in the mammalian kidney. Kidney Int. 31:629-633.
4. Morgan, T., and R.W. Berliner. 1968. Permeability of the loop of Henle, vasa recta, and collecting duct to water, urea, and sodium. Am. J. Physiol. 215: 108-115.
5. 2O transport in inner medullary collecting duct subsegments. Am. J. Physiol. 253:F823-F832.
6. Chou, C. L., and M.A. Knepper. 1989. Inhibition of urea transport in inner medullary collecting duct by phloretin and urea analogues. Am. J. Physiol. 257:F359-F365.
7. Star, R.A., and M.A. Knepper. 1990. The vasopressin-regulated urea transporter in renal inner medullary collecting duct. Am. J. Physiol. 259:F393-F401.
8. Star, R.A., H. Nonoguchi, R. Balaban, and M.A. Knepper. 1988. Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J. Clin. Invest. 81:1879-1888.
9. Nielsen, S., and M.A. Knepper. 1993. Vasopressin activates collecting duct urea transporters and water channels by distinct physical processes. Am. J. Physiol. 265:F204-F213.
10. You, G., C.P. Smith, Y. Kanai, W.S. Lee, M. Stelzner, and M.A. Hediger. 1993. Cloning and characterization of the vasopressin-regulated urea transporter. Nature (Lond.). 365:844-847.
11. Smith, C.P., W.S. Lee, S. Martial, M.A. Knepper, G. You, J.M. Sands, and M.A. Hediger. 1995. Cloning and regulation of expression of the rat kidney urea transporter (rUT2). J. Clin. Invest. 96:1556-1563.
12. Hasegawa, H., and A.S. Verkman. 1993. Functional expression of cAMP-dependent and independent urea transporters in Xenopus oocytes. Am. J. Physiol. 265:C514-C520.
13. Wells, R.G., A.M. Pajor, Y. Kanai, E. Turk, E.N. Wright, and M.A. Hediger. 1992. Cloning of a human kidney cDNA with similarity to the sodium glucose transporter. Am. J. Physiol. 263:F459-F465.
14. Kanai, Y., M.G. Stelzner, W.S. Lee, R.G. Wells, D. Brown, and M.A. Hediger. 1992. Expression of mRNA (D2) encoding a protein involved in amino acid transport in S3 proximal tubule. Am. J. Physiol. 263:F1087-F1092.
15. Star, R.A. 1990. Apical membrane limits urea permeation across the rat inner medullary collecting duct. J. Clin. Invest. 86:1172-1178.
16. Wall, S.M., J.S. Han, C.L. Chou, and M.A. Knepper. 1992. Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD. Am. J. Physiol. 262:F989-F998.
17. Knepper, M.A., S. Nielsen, C.L. Chou, and S.R. DiGiovanni. 1994. Mechanism of vasopressin action in the renal collecting duct [Review]. Semin. Nephrol. 14:302-321.
18. Jung, J.S., G.M. Preston, B.L. Smith, W.B. Guggino, and P. Agre. 1994. Molecular structure of the water channel through aquaporin CHIP. The hourglass model. J. Biol. Chem. 269:14648-14654.
19. Olives, B., P. Neau, P. Bailly, M.A. Hediger, G. Rousselet, J.P. Cartron, and P. Ripoche. 1994. Cloning and functional expression of a urea transporter from human bone marrow cells. J. Biol. Chem. 269:31649-31652.
20. Vallejo, M., and J.F. Habener. 1994. Mechanisms of transcriptional regulation by cAMP. In Transcription: Mechanisms and Regulation. R.C. Conaway and J.W. Conaway, editors. Raven Press, Ltd., New York. 353-368.