The WNK kinase network regulating sodium, potassium, and blood pressure

Journal of the American Society of Nephrology

Volumn 22, Issue 4, 2011, Pages 605-614

  Hoorn, Ewout J ^a,d   Nelson, Joshua H ^a   McCormick, James A ^a   Ellison, David H ^a,b,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; PHOSPHOTRANSFERASE; POTASSIUM; SODIUM; SODIUM CHLORIDE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; WNK KINASE;

BLOOD PRESSURE REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ESSENTIAL HYPERTENSION; HEREDITARY HYPERTENSION; HUMAN; HYPERKALEMIA; ION TRANSPORT; NONHUMAN; PHENOTYPE; POTASSIUM BALANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY; SODIUM BALANCE;

EID: 79953304695     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010080827     Document Type: Short Survey

References (95)

1. Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH: WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem 275: 16795-16801, 2000 (Pubitemid 30398913)
2. Furgeson S, Linas S: Mechanisms of type I and type II Pseudohypoaldosteronism. J Am Soc Nephrol 21: 1842-1845, 2010
3. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP: Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001 (Pubitemid 32758085)
4. Lazrak A, Liu Z, Huang CL: Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci USA 103: 1615-1620, 2006 (Pubitemid 43191213)
5. Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP: WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci USA 102: 16777-16782, 2005 (Pubitemid 41688853)
6. Yang CL, Angell J, Mitchell R, Ellison DH: WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 111: 1039-1045, 2003 (Pubitemid 36397480)
7. Naray-Fejes-Toth A, Snyder PM, Fejes-Toth G: The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport. Proc Natl Acad Sci USA 101: 17434-17439, 2004 (Pubitemid 39657422)
8. McCormick JA, Ellison DH: The WNKs: Atypical protein kinases with pleiotropic actions. Physiol Rev 9:177-219, 2011
9. Subramanya AR, Yang CL, McCormick JA, Ellison DH: WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. Kidney Int 70: 630-634, 2006 (Pubitemid 44215335)
10. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H: WNK1 regulates phosphorylation of cation-chloride- coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280: 42685-42693, 2005 (Pubitemid 43049227)
11. Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR: Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci 121: 675-684, 2008 (Pubitemid 351524166)
12. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D: Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci USA 96: 2514-2519, 1999 (Pubitemid 29117947)
13. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V: (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 86: 1151-1178, 2006 (Pubitemid 44521650)
14. Bradbury NA, Bridges RJ: Role of membrane trafficking in plasma membrane solute transport. Am J Physiol 267: C1-C24, 1994 (Pubitemid 24239096)
15. Yang CL, Zhu X, Ellison DH: The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest 117: 3403-3411, 2007 (Pubitemid 350096996)
16. Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH: Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest 115: 1379-1387, 2005 (Pubitemid 40629058)
17. Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proc Natl Acad Sci USA 103: 10883-10888, 2006 (Pubitemid 44148390)
18. Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juarez P, Munoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G: Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. Proc Natl Acad Sci USA 105: 8458-8463, 2008 (Pubitemid 351904778)
19. Vitari AC, Deak M, Morrice NA, Alessi DR: The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391: 17-24, 2005 (Pubitemid 41445471)
20. Zagorska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR: Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. J Cell Biol 176: 89-100, 2007 (Pubitemid 46041683)
21. Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH: WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci USA 102: 10315-10320, 2005 (Pubitemid 41023368)
22. Butterworth MB: Regulation of the epithelial sodium channel (ENaC) by membrane trafficking. Biochim Biophys Acta 1802: 1166-1177, 2010
23. Subramanya AR, Ellison DH: Sorting out lysosomal trafficking of the thiazide-sensitive Na-Cl Co-transporter. J Am Soc Nephrol 21: 7-9, 2010
24. Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB: WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int 69: 2162-2170, 2006 (Pubitemid 43882102)
25. Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'Shaughnessy KM: Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: Evidence that accelerated dynamin-dependent endocytosis is not involved. Am J Physiol Renal Physiol 291: F1369-F1376, 2006 (Pubitemid 44887251)
26. Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA: WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J Biol Chem 284: 18471-18480, 2009
27. Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, Cai H: WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. J AM Soc Nephrol 21: 82-92, 2010
28. Ellison DH, Yang CL: WNK kinases interact with SNARE proteins to regulate NCC activity. J Am Soc Nephrol 20: 66A, 2009
29. Glover M, Zuber AM, O'Shaughnessy KM: Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. J Am Soc Nephrol 20: 1314-1322, 2009
30. Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S: Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int 74: 1403-1409, 2008
31. Rozansky DJ, Cornwall T, Subramanya AR, Rogers S, Yang YF, David LL, Zhu X, Yang CL, Ellison DH: Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest 119: 2601-2612, 2009
32. Van der Lubbe N, Lim C, Meima M, Fenton RA, Danser AH, Zietse R, Hoorn EJ: Angiotensin II regulates the thiazide-sensitive sodium chloride cotransporter through SPAK independently of aldosterone. Kidney Int 79: 66-76, 2011
33. San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G: Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci USA 106: 4384-4389, 2009
34. Mutig K, Saritas T, Uchida S, Kahl T, Borowski T, Paliege A, Bohlick A, Bleich M, Shan Q, Bachmann S: Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation. Am J Physiol Renal Physiol 298: F502-F509, 2010
35. Pedersen NB, Hofmeister MV, Rosenbaek LL, Nielsen J, Fenton RA: Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule. Kidney Int 78: 160-169, 2010
36. Gimenez I, Forbush B: Regulatory phosphorylation sites in the NH2 terminus of the renal Na-K-Cl cotransporter (NKCC2). Am J Physiol Renal Physiol 289: F1341-F1345, 2005 (Pubitemid 41681369)
37. Reiche J, Theilig F, Rafiqi FH, Militz D, Mutig K, Todiras M, Christensen EI, Ellison DH, Bader M, Nykjaer A, Bachmann S, Alessi D, Willnow TE: SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2. Mol Cell Biol 30: 3027-3037, 2010
38. He G, Wang HR, Huang SK, Huang CL: Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest 117: 1078-1087, 2007 (Pubitemid 46556764)
39. Huang CL, Yang SS, Lin SH: Mechanism of regulation of renal ion transport by WNK kinases. Curr Opin Nephrol Hypertens 17: 519-525, 2008
40. Fang L, Garuti R, Kim BY, Wade JB, Welling PA: The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney. J Clin Invest 119: 3278-3289, 2009
41. Adrogue HJ, Madias NE: Sodium and potassium in the pathogenesis of hypertension. N Engl J Med 356: 1966-1978, 2007
42. Halperin ML, Cheema-Dhadli S, Lin SH, Kamel KS: Control of potassium excretion: A Paleolithic perspective. Curr Opin Nephrol Hypertens 15: 430-436, 2006 (Pubitemid 44297986)
43. Masilamani S, Kim GH, Mitchell C, Wade JB, Knepper MA: Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest 104: R19-R23, 1999 (Pubitemid 29536348)
44. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA: The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998 (Pubitemid 28549405)
45. Beesley AH, Hornby D, White SJ: Regulation of distal nephron K+ channels (ROMK) mRNA expression by aldosterone in rat kidney. J Physiol 509:629-634, 1998 (Pubitemid 28306129)
46. Wald H, Garty H, Palmer LG, Popovtzer MM: Differential regulation of ROMK expression in kidney cortex and medulla by aldosterone and potassium. Am J Physiol 275: F239-F245, 1998
47. Vasuvattakul S, Quaggin SE, Scheich AM, Bayoumi A, Goguen JM, Cheema-Dhadli S, Halperin ML: Kaliuretic response to aldosterone: influence of the content of potassium in the diet. Am J Kidney Dis 21: 152-160, 1993 (Pubitemid 23087607)
48. Kahle KT, Wilson FH, Lifton RP: Regulation of diverse ion transport pathways by WNK4 kinase: A novel molecular switch. Trends Endocrinol Metab 16: 98-103, 2005 (Pubitemid 40432458)
49. Schambelan M, Sebastian A, Rector FC Jr: Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): Role of increased renal chloride reabsorption. Kidney Int 19: 716-727, 1981 (Pubitemid 11064677)
50. Take C, Ikeda K, Kurasawa T, Kurokawa K: Increased chloride reabsorption as an inherited renal tubular defect in familial type II pseudohypoaldosteronism. N Engl J Med 324: 472-476, 1991
51. O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW: Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. J Am Soc Nephrol 17: 2402-2413, 2006
52. Wade JB, Fang L, Liu J, Li D, Yang CL, Subramanya AR, Maouyo D, Mason A, Ellison DH, Welling PA: WNK1 kinase isoform switch regulates renal potassium excretion. Proc Natl Acad Sci USA 103: 8558-8563, 2006 (Pubitemid 43838494)
53. McCormick JA, Yang CL, Ellison DH: WNK kinases and renal sodium transport in health and disease: An integrated view. Hypertension 51: 588-596, 2008
54. Takahashi N, Chernavvsky DR, Gomez RA, Igarashi P, Gitelman HJ, Smithies O: Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci USA 97: 5434-5439, 2000 (Pubitemid 30313736)
55. Loffing J, Vallon V, Loffing-Cueni D, Aregger F, Richter K, Pietri L, Bloch-Faure M, Hoenderop JG, Shull GE, Meneton P, Kaissling B: Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome. J Am Soc Nephrol 15: 2276-2288, 2004 (Pubitemid 39159328)
56. Schultheis PJ, Lorenz JN, Meneton P, Nieman ML, Riddle TM, Flagella M, Duffy JJ, Doetschman T, Miller ML, Shull GE: Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. J Biol Chem 273: 29150-29155, 1998 (Pubitemid 28507614)
57. Morris RG, Hoorn EJ, Knepper MA: Hypokalemia in a mouse model of Gitelman's syndrome. Am J Physiol Renal Physiol 290: F1416-F1420, 2006 (Pubitemid 43830767)
58. Chang SS, Grunder S, Hanukoglu A, Rosler A, Mathew PM, Hanukoglu I, Schild L, Lu Y, Shimkets RA, Nelson-Williams C, Rossier BC, Lifton RP: Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet 12: 248-253, 1996 (Pubitemid 26080082)
59. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E, Rossier BC: Collecting duct-specific gene inactivation of alpha-ENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest 112: 554-565, 2003 (Pubitemid 38056340)
60. Wulff P, Vallon V, Huang DY, Volkl H, Yu F, Richter K, Jansen M, Schlunz M, Klingel K, Loffing J, Kauselmann G, Bosl MR, Lang F, Kuhl D: Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest 110: 1263-1268, 2002 (Pubitemid 35285752)
61. Vallon V, Schroth J, Lang F, Kuhl D, Uchida S: Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol 297: F704-F712, 2009
62. Fejes-Toth G, Frindt G, Naray-Fejes-Toth A, Palmer LG: Epithelial Na+ channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol 294: F1298-F1305, 2008
63. Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP: Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 38: 1124-1132, 2006 (Pubitemid 44470357)
64. Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S: Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet 18: 3978-3986, 2009
65. Welling PA, Chang YP, Delpire E, Wade JB: Multigene kinase network, kidney transport, and salt in essential hypertension. Kidney Int 77: 1063-1069, 2010
66. Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH: SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol 21: 1812- 1814, 2010
67. Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanovic S, Jovanovic A, O'Shaughnessy KM, Alessi DR: Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med 2: 63-75, 2010
68. Hadchouel J, Delaloy C, Faure S, Achard JM, Jeunemaitre X: Familial hyperkalemic hypertension. J Am Soc Nephrol 17: 208-217, 2006
69. Achard JM, Warnock DG, Disse-Nicodeme S, Fiquet-Kempf B, Corvol P, Fournier A, Jeunemaitre X: Familial hyperkalemic hypertension: Phenotypic analysis in a large family with the WNK1 deletion mutation. Am J Med 114: 495-498, 2003 (Pubitemid 36515112)
70. Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S: Molecular pathogenesis of pseudohypoaldosteronism type II: Generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab 5: 331-344, 2007 (Pubitemid 46679517)
71. McCormick JA, Nelson JH, Ellison DH: Over-expression of the sodium chloride cotransporter (NCC) is not sufficient to cause familial hyperkalemic hypertension.
72. Delaloy C, Elvira-Matelot E, Clemessy M, Zhou XO, Imbert-Teboul M, Houot AM, Jeunemaitre X, Hadchouel J: Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues. Hypertension 52: 1149-1154, 2008
73. Hadchouel J, Soukaseum C, Büsst C, Zhou XO, Baudrie V, Zürrer T, Cambillau M, Elghozi JL, Lifton RP, Loffing J, Jeunemaitre X: Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension. Proc Natl Acad Sci USA 107: 18109-18114, 2010.
74. Liu Z, Wang HR, Huang CL: Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase. J Biol Chem 284: 12198-12206, 2009
75. Subramanya AR, Yang CL, Zhu X, Ellison DH: Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Am J Physiol Renal Physiol 290: F619-F624, 2006 (Pubitemid 43724963)
76. Chobanian AV: Shattuck Lecture. The hypertension paradox: More uncontrolled disease despite improved therapy. N Engl J Med 361: 878-887, 2009
77. Lifton RP, Gharavi AG, Geller DS: Molecular mechanisms of human hypertension. Cell 104: 545-556, 2001 (Pubitemid 32201949)
78. Guyton AC: Blood pressure control: Special role of the kidneys and body fluids. Science 252: 1813-1816, 1991
79. Hoorn EJ, van der Lubbe N, Zietse R: The renal WNK kinase pathway: A new link to hypertension. Nephrol Dial Transplant 24: 1074-1077, 2009
80. Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J, Hayes S, Smith T, Ridge C, Caulfield M, Sheehan NA, Munroe PB, Burton PR, Samani NJ: Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation 112: 3423-3429, 2005 (Pubitemid 43739557)
81. Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell JM, Webster J, Lathrop GM, Caulfield M, Munroe PB: Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Hum Mol Genet 14: 1805-1814, 2005
82. Osada Y, Miyauchi R, Goda T, Kasezawa N, Horiike H, Iida M, Sasaki S, Yamakawa-Kobayashi K: Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination. J Hum Genet 54: 474-478, 2009
83. Turner ST, Schwartz GL, Chapman AB, Boerwinkle E: WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic. Hypertension 46: 758-765, 2005 (Pubitemid 43186750)
84. Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K, Shaw-Hawkins S, Dobson R, Brown M, Samani NJ, Dominiczak AF, Connell JM, Lathrop GM, Kooner J, Chambers J, Elliott P, Clarke R, Collins R, Laan M, Org E, Juhanson P, Veldre G, Viigimaa M, Eyheramendy S, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Kumari M, Marmot M, Brunner E, Caulfield M, Munroe PB: Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion. PLoS One 4: e5003, 2009
85. Sun ZJ, Li Y, Lu JY, Ding Q, Liang Y, Shi JP, Li-Ling J, Zhao YY: Association of Ala589Ser polymorphism of WNK4 gene with essential hypertension in a high-risk Chinese population. J Physiol Sci 59: 81-86, 2009
86. Manunta P, Lavery G, Lanzani C, Braund PS, Simonini M, Bodycote C, Zagato L, Delli Carpini S, Tantardini C, Brioni E, Bianchi G, Samani NJ: Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation. Hypertension 52: 366-372, 2008
87. Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP: Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet 40: 592-599, 2008 (Pubitemid 351601207)
88. Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Jr., Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci USA 100: 14109-14114, 2003 (Pubitemid 37499199)
89. Yagi YI, Abe K, Ikebukuro K, Sode K: Kinetic mechanism and inhibitor characterization of WNK1 kinase. Biochemistry 48: 10255-10266, 2009
90. Tiwari S, Riazi S, Ecelbarger CA: Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes. Am J Physiol Renal Physiol 293: F974-F984, 2007 (Pubitemid 47583930)
91. Song J, Hu X, Riazi S, Tiwari S, Wade JB, Ecelbarger CA: Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats. Am J Physiol Renal Physiol 290: F1055-F1064, 2006 (Pubitemid 43724904)
92. Bickel CA, Verbalis JG, Knepper MA, Ecelbarger CA: Increased renal Na-K-ATPase NCC, and beta-ENaC abundance in obese Zucker rats. Am J Physiol Renal Physiol 281: F639-F648, 2001
93. Ellison DH, Oyama TT, Yang CL, Rogers S, Beard DR, Komers R: Altered WNK4/NCC signaling in a rat model of insulin resistance. J AM Soc Nephrol 20: 100A, 2009
94. Tiwari S, Sharma N, Gill PS, Igarashi P, Kahn CR, Wade JB, Ecelbarger CM: Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor. Proc Natl Acad Sci USA 105: 6469-6474, 2008 (Pubitemid 351758369)
95. Hollenberg NK, Stevanovic R, Agarwal A, Lansang MC, Price DA, Laffel LM, Williams GH, Fisher ND: Plasma aldosterone concentration in the patient with diabetes mellitus. Kidney Int 65: 1435-1439, 2004 (Pubitemid 38406985)