Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells

Evidence-based Complementary and Alternative Medicine

Volumn 2015, Issue , 2015, Pages

  Bhummaphan, Narumol ^a   Chanvorachote, Pithi ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BIBENZYL DERIVATIVE; CD133 ANTIGEN; GIGANTOL; OCTAMER TRANSCRIPTION FACTOR 4; PERIFOSINE; PROTEIN KINASE B; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; CANCER CELL; CANCER STEM CELL; CELL DEATH; CELL RENEWAL; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DENDROBIUM; DENDROBIUM DRACONIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KERATINOCYTE; LUNG CANCER; NECROSIS; PHENOTYPE; PRIORITY JOURNAL; TUMOR SPHEROID; WESTERN BLOTTING;

EID: 84939493243     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/836564     Document Type: Article

References (53)

1. B. Bao, A. Ahmad, A. S. Azmi, S. Ali, and F. H. Sarkar, "Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy, " in Current Protocols in Pharmacology, S. J. Enna, Ed., Unit 14.25, pp. 1-14, JohnWiley & Sons, 2013.
2. F. Li, B. Tiede, J. Massagúe, and Y. Kang, "Beyond tumorigenesis: cancer stem cells in metastasis, " Cell Research, vol. 17, no. 1, pp. 3-14, 2007.
3. L. Cheng, A. V. Ramesh, A. Flesken-Nikitin, J. Choi, and A. Y. Nikitin, "Mouse models for cancer stem cell research, " Toxicologic Pathology, vol. 38, no. 1, pp. 62-71, 2010.
4. S. Vinogradov and X. Wei, "Cancer stem cells and drug resistance: The potential of nanomedicine, " Nanomedicine, vol. 7, no. 4, pp. 597-615, 2012.
5. N. A. Lobo, Y. Shimono, D. Qian, and M.F. Clarke, "The biology of cancer stem cells, " Annual Review of Cell and Developmental Biology, vol. 23, pp. 675-699, 2007.
6. N. Yongsanguanchai, V. Pongrakhananon, A. Mutirangura, Y. Rojanasakul, and P. Chanvorachote, "Nitric oxide induces cancer stem cell-like phenotypes in human lung cancer cells, " The American Journal of Physiology-Cell Physiology, vol. 308, no. 2, pp. C89-C100, 2014.
7. S.-H. Chiou, M.-L. Wang, Y.-T. Chou et al., "Coexpression of Oct4 andNanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelialmesenchymal transdifferentiation, " Cancer Research, vol. 70, no. 24, pp. 10433-10444, 2010.
8. K.-H. Wang, A.-P. Kao, C.-C. Chang, T.-C. Lin, and T.-C. Kuo, "Upregulation of Nanog and Sox-2 genes following ectopic expression of Oct-4 in amniotic fluid mesenchymal stem cells, " Biotechnology and Applied Biochemistry, 2015.
9. T. Nagata, Y. Shimada, S. Sekine et al., "Prognostic significance of NANOG and KLF4 for breast cancer, " Breast Cancer, vol. 21, no. 1, pp. 96-101, 2014.
10. J. Shan, J. Shen, L. Liu et al., "Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma, " Hepatology, vol. 56, no. 3, pp. 1004-1014, 2012.
11. S. M. Kumar, S. Liu, H. Lu et al., "Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation, " Oncogene, vol. 31, no. 47, pp. 4898-4911, 2012.
12. C. Samardzija, M. Quinn, J. K. Findlay, and N. Ahmed, "Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary, " Journal of Ovarian Research, vol. 5, pp. 1757-2215, 2012.
13. Y. Atlasi, S. J. Mowla, S. A. M. Ziaee, and A.-R. Bahrami, "OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer, " International Journal of Cancer, vol. 120, no. 7, pp. 1598-1602, 2007.
14. J. Zhang, L. A. Espinoza, R. J. Kinders et al., "NANOG modulates stemness in human colorectal cancer, " Oncogene, vol. 32, no. 37, pp. 4397-4405, 2013.
15. C.-C. Tsai, P.-F. Su, Y.-F. Huang, T.-L. Yew, and S.-C. Hung, "Oct4 and nanog directly regulate dnmt1 to maintain selfrenewal and undifferentiated state in mesenchymal stem cells, " Molecular Cell, vol. 47, no. 2, pp. 169-182, 2012.
16. A. Liu, X. Yu, and S. Liu, "Pluripotency transcription factors and cancer stem cells: small genes make a big difference, " Chinese Journal of Cancer, vol. 32, no. 9, pp. 483-487, 2013.
17. K. H. Noh, B. W. Kim, K.-H. Song et al., "Nanog signaling in cancer promotes stem-like phenotype and immune evasion, " The Journal of Clinical Investigation, vol. 122, no. 11, pp. 4077-4093, 2012.
18. A. G. Jiang, H. Y. Lu, G. Zhang, L. X. Zhang, and X. Y. Gao, "Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and self-renewal of lung cancer stem cells, " Molecular Medicine Reports, vol. 12, no. 1, pp. 363-370, 2015.
19. W. S. Kim, Y. Zhu, Q. Deng et al., "Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling, " Stem Cells, vol. 32, no. 6, pp. 1503-1514, 2014.
20. Y. Lin, Z. Yang, A. Xu et al., "PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway, " Scientific Reports, vol. 5, article 8997, 2015.
21. A. Dubrovska, S. Kim, R. J. Salamone et al., "The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations, " Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 1, pp. 268-273, 2009.
22. R. Gargini, J. P. Cerliani, M. Escoll, I. M. Anton, and F. Wandosell, "Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/bim pathway, " Stem Cells, vol. 33, no. 3, pp. 646-660, 2014.
23. D. Kumar, S. Shankar, and R. K. Srivastava, "Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms, " Molecular Cancer, vol. 12, no. 1, article 171, 2013.
24. Y. Lin, Y. Yang, W. Li et al., "Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells, " Molecular Cell, vol. 48, no. 4, pp. 627-640, 2012.
25. M.-L. Wang, S.-H. Chiou, and C.-W. Wu, "Targeting cancer stem cells: emerging role of Nanog transcription factor, " Onco-Targets andTherapy, vol. 6, pp. 1207-1220, 2013.
26. Q.-W. Zhao, Y.-W. Zhou, W.-X. Li et al., "Akt-mediatedphosphorylation of Oct4 is associated with the proliferation of stem-like cancer cells, "Oncology Reports, vol. 33, no. 4, pp. 1621-1629, 2015.
27. S. Charoenrungruang, P. Chanvorachote, B. Sritularak, and V. Pongrakhananon, "Gigantol, a bibenzyl from Dendrobium draconis, inhibits the migratory behavior of non-small cell lung cancer cells, " Journal of Natural Products, vol. 77, no. 6, pp. 1359-1366, 2014.
28. B. Sritularak, M. Anuwat, and K. Likhitwitayawuid, "A new phenanthrenequinone from Dendrobium draconis, " Journal of Asian Natural Products Research, vol. 13, no. 3, pp. 251-255, 2011.
29. G. Fotakis and J. A. Timbrell, "In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride, " Toxicology Letters, vol. 160, no. 2, pp. 171-177, 2006.
30. C. Foglieni, C. Meoni, and A. M. Davalli, "Fluorescent dyes for cell viability: An application on prefixed conditions, " Histochemistry and Cell Biology, vol. 115, no. 3, pp. 223-229, 2001.
31. C. Kantara, M. OConnell, S. Sarkar, S. Moya, R. Ullrich, and P. Singh, "Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA, " Cancer Research, vol. 74, no. 9, pp. 2487-2498, 2014.
32. A. M. Martelli, C. Evangelisti, M. Y. Follo et al., "Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cells, " Current Medicinal Chemistry, vol. 18, no. 18, pp. 2715-2726, 2011.
33. D. Hambardzumyan, O. J. Becher, M. K. Rosenblum, P. P. Pandolfi, K. Manova-Todorova, and E. C. Holland, "PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo, " Genes and Development, vol. 22, no. 4, pp. 436-448, 2008.
34. K. C. Davidson, A. M. Adams, J. M. Goodson et al., "Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4, " Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 12, pp. 4485-4490, 2012.
35. P. Xenopoulos, M. Kang, A. Puliafito, S. Di Talia, and A. K. Hadjantonakis, "Heterogeneities in nanog expression drive stable commitment to pluripotency in the mouse blastocyst, " Cell Reports, vol. 10, no. 9, pp. 1508-1520, 2015.
36. S. Mora-Castilla, J. R. Tejedo, A. Hmadcha et al., "Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation, " Cell Death and Differentiation, vol. 17, no. 6, pp. 1025-1033, 2010.
37. E. M. Abdelalim and I. Tooyama, "NPR-Aregulates self-renewal and pluripotency of embryonic stem cells, " Cell Death and Disease, vol. 2, no. 3, article e127, 2011.
38. H. Korkaya, A. Paulson, E. Charafe-Jauffret et al., "Regulation of mammary stem/progenitor cells by PTEN/Akt/β-catenin signaling, " PLoS Biology, vol. 7, no. 6, Article ID e1000121, 2009.
39. T. Tada, H. Fukuda, K. Nakagawa et al., "Non-small cell lung cancer: radiation therapy for locoregional recurrence after complete resection, " International Journal of Clinical Oncology, vol. 10, no. 6, pp. 425-428, 2005.
40. J. P. Sullivan, J. D. Minna, and J. W. Shay, "Evidence for selfrenewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy, " Cancer and Metastasis Reviews, vol. 29, no. 1, pp. 61-72, 2010.
41. M. A. Lawlor and D. R. Alessi, "PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?" Journal of Cell Science, vol. 114, no. 16, pp. 2903-2910, 2001.
42. J. Qin, J. Ji, R. Deng et al., "DC120, a novelAKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2, " Oncotarget, vol. 4, 4 pages, 2015.
43. Y. Wu and P. Y. Wu, "CD133 as a marker for cancer stem cells: progresses and concerns, " Stem Cells and Development, vol. 18, no. 8, pp. 1127-1134, 2009.
44. H. Mizugaki, J. Sakakibara-Konishi, J. Kikuchi et al., "CD133 expression: A potential prognostic marker for non-small cell lung cancers, " International Journal of Clinical Oncology, vol. 19, no. 2, pp. 254-259, 2014.
45. K. Okudela, T. Woo, H. Mitsui et al., "Downregulation of ALDH1A1 expression in non-small cell lung carcinomas-its clinicopathologic and biological significance, " International Journal of Clinical and Experimental Pathology, vol. 6, no. 1, pp. 1-12, 2013.
46. M. Patel, L. Lu, D. S. Zander, L. Sreerama, D. Coco, and J. S. Moreb, "ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors, " Lung Cancer, vol. 59, no. 3, pp. 340-349, 2008.
47. X. Zhang, Y. Lou, H. Wang et al., "Wnt signaling regulates the stemness of lung cancer stem cells and its inhibitors exert anticancer effect on lung cancer SPC-A1 cells, " Medical Oncology, vol. 32, no. 4, 2015.
48. C. R. Jeter, B. Liu, X. Liu et al., "NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation, " Oncogene, vol. 30, no. 36, pp. 3833-3845, 2011.
49. M. Zhu, F. Yin, L. Yang et al., "Contribution of TIP30 to chemoresistance in laryngeal carcinoma, " Cell Death and Disease, vol. 5, no. 10, article e1468, 2014.
50. C.-E. Huang, F.-W. Hu, C.-H. Yu et al., "Concurrent expression of Oct4 and Nanog maintains mesenchymal stem-like property of human dental pulp cells, " International Journal of Molecular Sciences, vol. 15, no. 10, pp. 18623-18639, 2014.
51. E. M. Abdelalim and I. Tooyama, "Knockdown of p53 suppresses Nanog expression in embryonic stem cells, " Biochemical and Biophysical Research Communications, vol. 443, no. 2, pp. 652-657, 2014.
52. Y.-D. Wang, N. Cai, X.-L. Wu, H.-Z. Cao, L.-L. Xie, and P.-S. Zheng, "OCT4 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells by miR-125b/BAK1 pathway, " Cell Death and Disease, vol. 4, no. 8, article e760, 2013.
53. S. Matsubara, Q. Ding, Y. Miyazaki, T. Kuwahata, K. Tsukasa, and S. Takao, "MTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions, " Scientific Reports, vol. 3, article 3230, 2013.