Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and self-renewal of lung cancer stem cells

Molecular Medicine Reports

Volumn 12, Issue 1, 2015, Pages 363-370

  Jiang, Ai Gui ^a   Lu, Hui Yu ^a   Zhang, De Geng ^a   Zhang, Li Xin ^a   Gao, Xiao Yan ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

AKT1; Lung cancer; Lung cancer stem cells; Phosphatidylinositol 3 kinase p85

Indexed keywords

ADENOVIRUS VECTOR; CYCLIN D1; CYCLINE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; PROTEIN P85; SHORT HAIRPIN RNA; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; SMALL INTERFERING RNA;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; OPEN READING FRAME; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; G1 PHASE CELL CYCLE CHECKPOINT; GENETICS; HUMAN; LUNG NEOPLASMS; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; RNA INTERFERENCE; SCID MOUSE; TUMOR CELL LINE; XENOGRAFT;

ADENOVIRIDAE; MUS;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; CYCLIN D1; DOWN-REGULATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84926657360     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3393     Document Type: Article

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