-
1
-
-
34147210574
-
Cancer stem cells: Implications for cancer causation and therapy resistance
-
Dean, M. Cancer stem cells: Implications for cancer causation and therapy resistance. Discov. Med. 5, 278-282 (2005)
-
(2005)
Discov. Med
, vol.5
, pp. 278-282
-
-
Dean, M.1
-
2
-
-
45549093647
-
Survival of the fittest: Cancer stem cells in therapeutic resistance and angiogenesis
-
Eyler, C. E. & Rich, J. N. Survival of the fittest: Cancer stem cells in therapeutic resistance and angiogenesis. J. Clin. Oncol. 26, 2839-2845 (2008)
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 2839-2845
-
-
Eyler, C.E.1
Rich, J.N.2
-
3
-
-
34548455927
-
Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer
-
DOI 10.1016/j.stem.2007.06.002, PII S1934590907000665
-
Hermann, P. C. et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1, 313-323 (2007) (Pubitemid 47355323)
-
(2007)
Cell Stem Cell
, vol.1
, Issue.3
, pp. 313-323
-
-
Hermann, P.C.1
Huber, S.L.2
Herrler, T.3
Aicher, A.4
Ellwart, J.W.5
Guba, M.6
Bruns, C.J.7
Heeschen, C.8
-
4
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
DOI 10.1038/nature05236, PII NATURE05236
-
Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756-760 (2006) (Pubitemid 44949604)
-
(2006)
Nature
, vol.444
, Issue.7120
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
Hao, Y.4
Shi, Q.5
Hjelmeland, A.B.6
Dewhirst, M.W.7
Bigner, D.D.8
Rich, J.N.9
-
5
-
-
60849118097
-
A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
-
Jimeno, A. et al. A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development. Mol. Cancer Ther. 8, 310-314 (2009)
-
(2009)
Mol. Cancer Ther
, vol.8
, pp. 310-314
-
-
Jimeno, A.1
-
6
-
-
45549100014
-
Pancreatic cancer stem cells
-
Lee, C. J., Dosch, J.&Simeone, D. M. Pancreatic cancer stem cells. J Clin Oncol. 26, 2806-2812 (2008)
-
(2008)
J Clin Oncol
, vol.26
, pp. 2806-2812
-
-
Lee, C.J.1
Dosch, J.2
Simeone, D.M.3
-
7
-
-
34848866647
-
Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4
-
DOI 10.1016/j.stem.2007.08.001, PII S193459090700118X
-
Todaro, M. et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 1, 389-402 (2007) (Pubitemid 47506537)
-
(2007)
Cell Stem Cell
, vol.1
, Issue.4
, pp. 389-402
-
-
Todaro, M.1
Alea, M.P.2
Di Stefano, A.B.3
Cammareri, P.4
Vermeulen, L.5
Iovino, F.6
Tripodo, C.7
Russo, A.8
Gulotta, G.9
Medema, J.P.10
Stassi, G.11
-
8
-
-
77957150824
-
KRAS,Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
-
Morris 4th, J. P.,Wang, S. C.&Hebrok, M. KRAS,Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat. Rev. Cancer 10, 683-695 (2010)
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 683-695
-
-
Morris, I.V.J.P.1
Wang, S.C.2
Hebrok, M.3
-
9
-
-
0036490708
-
Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit
-
DOI 10.1016/S1535-6108(02)00033-8
-
Chan, T. O. et al. Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell 1, 181-191 (2002) (Pubitemid 41039164)
-
(2002)
Cancer Cell
, vol.1
, Issue.2
, pp. 181-191
-
-
Chan, T.O.1
Rodeck, U.2
Chan, A.M.3
Kimmelman, A.C.4
Rittenhouse, S.E.5
Panayotou, G.6
Tsichlis, P.N.7
-
10
-
-
80054105872
-
PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy
-
Kennedy, A. L., Adams, P. D. & Morton, J. P. Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy. Small Gtpases. 2, 264-267 (2011)
-
(2011)
Small Gtpases
, vol.2
, pp. 264-267
-
-
Kennedy, A.L.1
Adams, P.D.2
Ras, P.M.J.3
-
11
-
-
0037380304
-
Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas
-
DOI 10.1097/00006676-200304000-00008
-
Semba, S., Moriya, T., Kimura, W. & Yamakawa, M. Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor 1and invasive ductal adenocarcinoma of the pancreas. Pancreas 26, 250-257 (2003) (Pubitemid 36384157)
-
(2003)
Pancreas
, vol.26
, Issue.3
, pp. 250-257
-
-
Semba, S.1
Moriya, T.2
Kimura, W.3
Yamakawa, M.4
-
12
-
-
9644253003
-
The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells
-
DOI 10.1038/sj.onc.1207902
-
Asano, T. et al. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene 23, 8571-8580 (2004) (Pubitemid 39576463)
-
(2004)
Oncogene
, vol.23
, Issue.53
, pp. 8571-8580
-
-
Asano, T.1
Yao, Y.2
Zhu, J.3
Li, D.4
Abbruzzese, J.L.5
Reddy, S.A.G.6
-
13
-
-
27744459507
-
Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers
-
DOI 10.1055/s-2005-858638
-
Michl, P. & Downward, J. Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers. Z. Gastroenterol. 43, 1133-1139 (2005) (Pubitemid 41584815)
-
(2005)
Zeitschrift fur Gastroenterologie
, vol.43
, Issue.10
, pp. 1133-1139
-
-
Michl, P.1
Downward, J.2
-
14
-
-
79953315567
-
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis
-
Kennedy, A. L. et al. Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol. Cell 42, 36-49 (2011)
-
(2011)
Mol. Cell
, vol.42
, pp. 36-49
-
-
Kennedy, A.L.1
-
15
-
-
34347220473
-
Defining the Role of mTOR in Cancer
-
DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
-
Guertin, D. A. & Sabatini, D. M. Defining the role of mTOR in cancer. Cancer Cell 12, 9-22 (2007) (Pubitemid 47001784)
-
(2007)
Cancer Cell
, vol.12
, Issue.1
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
16
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov, D. D. et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22, 159-168 (2006)
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
-
17
-
-
28844506274
-
Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells
-
DOI 10.1042/BST20051522
-
Takahashi, K., Murakami, M. & Yamanaka, S. Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells. Biochem. Soc. Trans. 33, 1522-1525 (2005) (Pubitemid 41779729)
-
(2005)
Biochemical Society Transactions
, vol.33
, Issue.6
, pp. 1522-1525
-
-
Takahashi, K.1
Murakami, M.2
Yamanaka, S.3
-
18
-
-
76349087812
-
Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation
-
Yamano, N., Kimura, T., Watanabe-Kushima, S., Shinohara, T. & Nakano, T. Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation. Biochem. Biophys. Res. Commun. 392, 311-316 (2010)
-
(2010)
Biochem. Biophys. Res. Commun
, vol.392
, pp. 311-316
-
-
Yamano, N.1
Kimura, T.2
Watanabe-Kushima, S.3
Shinohara, T.4
Nakano, T.5
-
19
-
-
66049149059
-
MTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells
-
Zhou, J. et al. mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc. Natl. Acad. Sci. USA 106, 7840-7845 (2009)
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 7840-7845
-
-
Zhou, J.1
-
20
-
-
3242721268
-
MTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
DOI 10.1128/MCB.24.15.6710-6718.2004
-
Murakami, M. et al. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol. Cell Biol. 24, 6710-6718 (2004) (Pubitemid 38944350)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.15
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
Kiyama, H.7
Yonezawa, K.8
Yamanaka, S.9
-
21
-
-
6344245674
-
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
-
Gangloff, Y. G. et al. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol. Cell Biol. 24, 9508-9516 (2004)
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 9508-9516
-
-
Gangloff, Y.G.1
-
22
-
-
57649134966
-
Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells
-
Schieke, S. M. et al. Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. J. Biol. Chem. 283, 28506-28512 (2008)
-
(2008)
J. Biol. Chem
, vol.283
, pp. 28506-28512
-
-
Schieke, S.M.1
-
23
-
-
60849117793
-
Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis
-
Gregorian, C. et al. Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J. Neurosci. 29, 1874-1886 (2009)
-
(2009)
J. Neurosci
, vol.29
, pp. 1874-1886
-
-
Gregorian, C.1
-
24
-
-
0035824396
-
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
-
DOI 10.1126/science.1065518
-
Groszer, M. et al. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294, 2186-2189 (2001) (Pubitemid 33150679)
-
(2001)
Science
, vol.294
, Issue.5549
, pp. 2186-2189
-
-
Groszer, M.1
Erickson, R.2
Scripture-Adams, D.D.3
Lesche, R.4
Trumpp, A.5
Zack, J.A.6
Kornblum, H.I.7
Liu, X.8
Wu, H.9
-
25
-
-
30444455577
-
1 cell cycle entry
-
DOI 10.1073/pnas.0509939103
-
Groszer, M. et al. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc. Natl. Acad. Sci. USA 103, 111-116 (2006) (Pubitemid 43076113)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.1
, pp. 111-116
-
-
Groszer, M.1
Erickson, R.2
Scripture-Adams, D.D.3
Dougherty, J.D.4
Le Belle, J.5
Zack, J.A.6
Geschwind, D.H.7
Liu, X.8
Kornblum, H.I.9
Wu, H.10
-
26
-
-
78649880050
-
Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells
-
Sunayama, J. et al. Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells. Neuro. Oncol. 12, 1205-1219 (2010)
-
(2010)
Neuro. Oncol
, vol.12
, pp. 1205-1219
-
-
Sunayama, J.1
-
27
-
-
84858184063
-
Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer
-
Ding, Q. et al. Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer. Hum. Cell 25, 1-8 (2012)
-
(2012)
Hum. Cell
, vol.25
, pp. 1-8
-
-
Ding, Q.1
-
28
-
-
84860237519
-
Interferon-alpha modulates the chemosensitivity of CD133-expressing pancreatic cancer cells to gemcitabine
-
Hayashi, T. et al. Interferon-alpha modulates the chemosensitivity of CD133-expressing pancreatic cancer cells to gemcitabine. Cancer Sci. 103, 889-896 (2012)
-
(2012)
Cancer Sci
, vol.103
, pp. 889-896
-
-
Hayashi, T.1
-
29
-
-
69249156565
-
Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer
-
Mueller, M. T. et al. Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer. Gastroenterology 137, 1102-1113 (2009)
-
(2009)
Gastroenterology
, vol.137
, pp. 1102-1113
-
-
Mueller, M.T.1
-
30
-
-
43049165453
-
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
-
DOI 10.1016/j.cell.2008.03.027, PII S0092867408004443
-
Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008) (Pubitemid 351636299)
-
(2008)
Cell
, vol.133
, Issue.4
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.-J.3
Eaton, E.Ng.4
Ayyanan, A.5
Zhou, A.Y.6
Brooks, M.7
Reinhard, F.8
Zhang, C.C.9
Shipitsin, M.10
Campbell, L.L.11
Polyak, K.12
Brisken, C.13
Yang, J.14
Weinberg, R.A.15
-
31
-
-
84855472067
-
Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway
-
Hsu, H. S. et al. Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway. Lung Cancer 75, 167-177 (2011)
-
(2011)
Lung Cancer
, vol.75
, pp. 167-177
-
-
Hsu, H.S.1
-
32
-
-
79959994448
-
SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells
-
Hwang, W. L. et al. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology 141, 279-291 (2011)
-
(2011)
Gastroenterology
, vol.141
, pp. 279-291
-
-
Hwang, W.L.1
-
33
-
-
80053430963
-
Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions
-
doi: 10.1038/cddis.2011.80.
-
Lathia, J. D. et al. Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. Cell Death Dis. 2, e200, doi: 10.1038/cddis.2011.80. (2011)
-
(2011)
Cell Death Dis
, vol.2
-
-
Lathia, J.D.1
-
34
-
-
33646358694
-
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
-
DOI 10.1016/j.ccr.2006.03.030, PII S1535610806001176
-
Lee, J. et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9, 391-403 (2006) (Pubitemid 43668737)
-
(2006)
Cancer Cell
, vol.9
, Issue.5
, pp. 391-403
-
-
Lee, J.1
Kotliarova, S.2
Kotliarov, Y.3
Li, A.4
Su, Q.5
Donin, N.M.6
Pastorino, S.7
Purow, B.W.8
Christopher, N.9
Zhang, W.10
Park, J.K.11
Fine, H.A.12
-
35
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
DOI 10.1083/jcb.200403069
-
Harrington, L. S. et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166, 213-223 (2004) (Pubitemid 38988774)
-
(2004)
Journal of Cell Biology
, vol.166
, Issue.2
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
Gout, I.11
Downes, C.P.12
Lamb, R.F.13
-
36
-
-
79958696694
-
The mTOR-regulated phosphoproteome leveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
Hsu, P. P. et al. The mTOR-regulated phosphoproteome leveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-1322 (2011)
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
-
37
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Yu, Y. et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-1326 (2011)
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
-
38
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
DOI 10.1126/science.1106148
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M. & Sabatini, D. M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005) (Pubitemid 40262113)
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
39
-
-
78649831949
-
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells
-
Sunayama, J. et al. Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells 28, 1930-1939 (2010)
-
(2010)
Stem Cells
, vol.28
, pp. 1930-1939
-
-
Sunayama, J.1
-
40
-
-
0033107768
-
In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice
-
Bruns, C. J., Harbison, M. T., Kuniyasu, H., Eue, I. & Fidler, I. J. In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia 1, 50-62 (1999)
-
(1999)
Neoplasia
, vol.1
, pp. 50-62
-
-
Bruns, C.J.1
Harbison, M.T.2
Kuniyasu, H.3
Eue, I.4
Fidler, I.J.5
-
41
-
-
0029880379
-
Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors
-
DOI 10.1053/gast.1996.v110.pm8613012
-
Naumann, M. et al. Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. Gastroenterology 110, 1215-1224 (1996) (Pubitemid 26113762)
-
(1996)
Gastroenterology
, vol.110
, Issue.4
, pp. 1215-1224
-
-
Naumann, M.1
Savitskaia, N.2
Eilert, C.3
Schramm, A.4
Kalthoff, A.5
Schmiegel, W.6
-
42
-
-
0026334753
-
Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer
-
Barton, C. M. et al. Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. Br. J. Cancer 64, 1076-1082 (1991)
-
(1991)
Br. J. Cancer
, vol.64
, pp. 1076-1082
-
-
Barton, C.M.1
-
43
-
-
0027404269
-
P53 and K-RAS alterations in pancreatic epithelial cell lesions
-
Kalthoff, H. et al. p53 and K-RAS alterations in pancreatic epithelial cell lesions. Oncogene 8, 289-298 (1993) (Pubitemid 23073744)
-
(1993)
Oncogene
, vol.8
, Issue.2
, pp. 289-298
-
-
Kalthoff, H.1
Schmiegel, W.2
Roeder, C.3
Kasche, D.4
Schmidt, A.5
Lauer, G.6
Thiele, H.-G.7
Honold, G.8
Pantel, K.9
Riethmuller, G.10
Scherer, E.11
Maurer, J.12
Maacke, H.13
Depperts, W.14
-
44
-
-
0028109165
-
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer
-
DOI 10.1002/ijc.2910580207
-
Berrozpe, G., Schaeffer, J., Peinado, M. A., Real, F. X. & Perucho, M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int. J. Cancer 58, 185-191 (1994) (Pubitemid 24240093)
-
(1994)
International Journal of Cancer
, vol.58
, Issue.2
, pp. 185-191
-
-
Berrozpe, G.1
Schaeffer, J.2
Peinado, M.A.3
Real, F.X.4
Perucho, M.5
-
45
-
-
9344223357
-
DPC4 gene in various tumor types
-
Schutte, M. et al. DPC4 gene in various tumor types. Cancer Res. 56, 2527-2530 (1996) (Pubitemid 26170688)
-
(1996)
Cancer Research
, vol.56
, Issue.11
, pp. 2527-2530
-
-
Schutte, M.1
Hruban, R.H.2
Hedrick, L.3
Cho, K.R.4
Nadasdy, G.M.5
Weinstein, C.L.6
Bova, G.S.7
Isaacs, W.B.8
Cairns, P.9
Nawroz, H.10
Sidransky, D.11
Casero Jr., R.A.12
Meltzer, P.S.13
Hahn, S.A.14
Kern, S.E.15
-
46
-
-
2342504277
-
Genetic abnormalities in pancreatic cancer
-
DOI 10.1186/1476-4598-2-7
-
Moore, P. S., Beghelli, S., Zamboni, G. & Scarpa, A. Genetic abnormalities in pancreatic cancer. Mol. Cancer 2, 7, doi: 10.1186/1476-4598-2-7 (2003) (Pubitemid 38751490)
-
(2003)
Molecular Cancer
, vol.2
, pp. 7
-
-
Moore, P.S.1
Beghelli, S.2
Zamboni, G.3
Scarpa, A.4
-
47
-
-
4644266467
-
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity
-
DOI 10.1097/00006676-200410000-00004
-
Loukopoulos, P. et al. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas 29, 193-203 (2004) (Pubitemid 39304976)
-
(2004)
Pancreas
, vol.29
, Issue.3
, pp. 193-203
-
-
Loukopoulos, P.1
Kanetaka, K.2
Takamura, M.3
Shibata, T.4
Sakamoto, M.5
Hirohashi, S.6
-
48
-
-
0035156850
-
Pancreatic tumours: Molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis
-
DOI 10.1054/bjoc.2000.1567
-
Moore, P. S. et al. Pancreatic tumours: Molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. Br. J. Cancer 84, 253-262 (2001) (Pubitemid 32113454)
-
(2001)
British Journal of Cancer
, vol.84
, Issue.2
, pp. 253-262
-
-
Moore, P.S.1
Orlandini, S.2
Zamboni, G.3
Capelli, P.4
Rigaud, G.5
Falconi, M.6
Bassi, C.7
Lemoine, N.R.8
Scarpa, A.9
-
49
-
-
14444284330
-
Tumor-suppressive pathways in pancreatic carcinoma
-
Rozenblum, E. et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 57, 1731-1734 (1997) (Pubitemid 27199667)
-
(1997)
Cancer Research
, vol.57
, Issue.9
, pp. 1731-1734
-
-
Rozenblum, E.1
Schutte, M.2
Goggins, M.3
Hahn, S.A.4
Panzer, S.5
Zahurak, M.6
Goodman, S.N.7
Sohn, T.A.8
Hruban, R.H.9
Yeo, C.J.10
Kern, S.E.11
-
50
-
-
84857735480
-
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-kB-cytokine network
-
Ying, H. et al. PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-kB-cytokine network. Cancer Discov. 1, 158-169 (2011)
-
(2011)
Cancer Discov
, vol.1
, pp. 158-169
-
-
Ying, H.1
-
51
-
-
44849117768
-
Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK
-
DOI 10.1101/gad.1662308
-
Dan, H. C. et al. Akt-dependent regulation of NF-kB is controlled by mTOR and Raptor in association with IKK. Genes & Dev. 22, 1490-1500 (2008) (Pubitemid 351793083)
-
(2008)
Genes and Development
, vol.22
, Issue.11
, pp. 1490-1500
-
-
Dan, H.C.1
Cooper, M.J.2
Cogswell, P.C.3
Duncan, J.A.4
Ting, J.P.-Y.5
Baldwin, A.S.6
-
52
-
-
84884368877
-
Influence of tumour micro-environment heterogeneity on therapeutic response
-
Junttila, M. R. & de Sauvage, F. J. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501, 346-354 (2013)
-
(2013)
Nature
, vol.501
, pp. 346-354
-
-
Junttila, M.R.1
De Sauvage, F.J.2
-
53
-
-
33947254016
-
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
-
DOI 10.1158/0008-5472.CAN-06-3281
-
Feldmann, G. et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers. Cancer Res. 67, 2187-2196 (2007) (Pubitemid 46424238)
-
(2007)
Cancer Research
, vol.67
, Issue.5
, pp. 2187-2196
-
-
Feldmann, G.1
Dhara, S.2
Fendrich, V.3
Bedja, D.4
Beaty, R.5
Mullendore, M.6
Karikari, C.7
Alvarez, H.8
Iacobuzio-Donahue, C.9
Jimeno, A.10
Gabrielson, K.L.11
Matsui, W.12
Maitra, A.13
-
54
-
-
54049115162
-
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
-
Feldmann, G. et al. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol. Cancer Ther. 7, 2725-2735 (2008)
-
(2008)
Mol. Cancer Ther
, vol.7
, pp. 2725-2735
-
-
Feldmann, G.1
-
55
-
-
84872861115
-
GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft
-
Fu, J. et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 330, 22-32 (2013)
-
(2013)
Cancer Lett
, vol.330
, pp. 22-32
-
-
Fu, J.1
-
56
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
DOI 10.1038/nature04703, PII NATURE04703
-
Yilmaz, O. H. et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482 (2006) (Pubitemid 44050144)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
57
-
-
58649114084
-
MTOR complex 2 is required for the development of prostate cancer induced by PTEN loss in mice
-
Guertin, D. A. et al. mTOR complex 2 is required for the development of prostate cancer induced by PTEN loss in mice. Cancer Cell 15, 148-159 (2009)
-
(2009)
Cancer Cell
, vol.15
, pp. 148-159
-
-
Guertin, D.A.1
-
58
-
-
79959353534
-
Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cells
-
Martelli, A. M. et al. Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cells. Curr. Med. Chem. 18, 2715-2726 (2011)
-
(2011)
Curr. Med. Chem
, vol.18
, pp. 2715-2726
-
-
Martelli, A.M.1
-
59
-
-
78049496814
-
MTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
-
Lee, J. Y. et al. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell 7, 593-605 (2010)
-
(2010)
Cell Stem Cell
, vol.7
, pp. 593-605
-
-
Lee, J.Y.1
-
60
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685 (1970)
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
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