Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule

Journal of Pharmaceutical Sciences

Volumn 104, Issue 9, 2015, Pages 2824-2831

  Folzer, Emilien ^a   Diepold, Katharina ^c   Bomans, Katrin ^c   Finkler, Christof ^a   Schmidt, Roland ^a   Bulau, Patrick ^c   Huwyler, Jörg ^b   Mahler, Hanns Christian ^a   Koulov, Atanas V ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

mass spectrometry; methionine; protein A binding; protein oxidation; therapeutic proteins; tryptophan

Indexed keywords

2,2' AZOBIS(2 AMIDINOPROPANE); HYDROGEN PEROXIDE; IMMUNOGLOBULIN G1; METHIONINE; MONOCLONAL ANTIBODY; PROTEIN A; TERT BUTYL HYDROPEROXIDE; TRYPTOPHAN; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; IMMUNOGLOBULIN G; METAL;

AFFINITY CHROMATOGRAPHY; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG OXIDATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TEMPERATURE; INCUBATION TIME; MASS SPECTROMETRY; OXIDATION; PROTEIN AGGREGATION; REACTION TIME; ROOM TEMPERATURE; CHEMISTRY; OXIDATION REDUCTION REACTION; ULTRAVIOLET RADIATION;

ANTIBODIES, MONOCLONAL; HYDROGEN PEROXIDE; IMMUNOGLOBULIN G; INDICATORS AND REAGENTS; METALS; METHIONINE; OXIDATION-REDUCTION; TRYPTOPHAN; ULTRAVIOLET RAYS;

EID: 84939269480     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24509     Document Type: Article

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