Reactive impurities in excipients: Profiling, identification and mitigation of drug-excipient incompatibility

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1248-1263

  Wu, Yongmei ^a   Levons, Jaquan ^a   Narang, Ajit S ^a   Raghavan, Krishnaswamy ^a   Rao, Venkatramana M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

excipients; impurities; interaction; mitigation; variability

Indexed keywords

ALDEHYDE; CARBOXYLIC ACID; CROSCARMELLOSE SODIUM; CROSPOVIDONE; EXCIPIENT; HEAVY METAL; HYDROGEN PEROXIDE; HYDROPEROXIDE; HYDROXYPROPYLCELLULOSE; LACTOSE; MAGNESIUM STEARATE; METAL; MICROCRYSTALLINE CELLULOSE; NITRATE; NITRITE; PEROXIDE; PIPERAZINE; POVIDONE; SILICON DIOXIDE; STARCH GLYCOLATE SODIUM; STEARIC ACID; SUGAR; TRACE METAL; VIGABATRIN;

CHEMICAL INTERACTION; DRUG IMPURITY; DRUG INCOMPATIBILITY; DRUG PACKAGING; DRUG STORAGE; EXCIPIENT COMPATIBILITY; PRIORITY JOURNAL; REVIEW;

CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG CONTAMINATION; DRUG STABILITY; EXCIPIENTS; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 83555168209     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9677-z     Document Type: Review

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