A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

mAbs

Volumn 6, Issue 5, 2014, Pages 1229-1242

  Stracke, Jan ^a,b   Emrich, Thomas ^c   Rueger, Petra ^a   Schlothauer, Tilman ^a   Kling, Lothar ^c   Knaupp, Alexer ^a   Hertenberger, Hubert ^a   Wolfert, Andreas ^c   Spick, Christian ^a   Lau, Wilma ^a   Drabner, Georg ^a   Reiff, Ulrike ^a   Koll, Hans ^a   Papadimitriou, Apollon ^c  

^a ROCHE DIAGNOSTICS GMBH   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c ROCHE INNOVATION CENTER MUNICH   (Germany)

Author keywords

Affinity chromatography; Antibody; Column; Degradation; FcRn; Met252; Met428; Methionine oxidation; Neonatal fc receptor; PH gradient; Pharmacokinetics

Indexed keywords

IMMUNOGLOBULIN G1; METHIONINE;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; FEMALE; HEAVY CHAIN; HUMAN; IN VITRO STUDY; MOUSE; NONHUMAN; OXIDATION; PEPTIDE MAPPING; PHARMACOKINETICS; TRANSGENIC MOUSE;

EID: 84913525738     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.29601     Document Type: Article

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