Screening methods to identify indole derivatives that protect against reactive oxygen species induced tryptophan oxidation in proteins

Molecular Pharmaceutics

Volumn 11, Issue 4, 2014, Pages 1259-1272

  Grewal, Parbir ^a   Mallaney, Mary ^a   Lau, Kimberly ^a   Sreedhara, Alavattam ^a  

^a GENENTECH INC   (United States)

Author keywords

5 hydroxy indole; 5 hydroxy tryptophan; antioxidants; monoclonal antibodies; protein oxidation; reactive oxygen species; tryptophan

Indexed keywords

ANTIOXIDANT; AROMATIC CARBOXYLIC ACID; HYDROGEN PEROXIDE; HYDROXYL GROUP; HYDROXYL RADICAL; IMMUNOGLOBULIN G1 ANTIBODY; INDOLE DERIVATIVE; KYNURENINE; METHIONINE; MONOCLONAL ANTIBODY; REACTIVE OXYGEN METABOLITE; SINGLET OXYGEN; TRYPTOPHAN; TRYPTOPHAN DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DRUG MANUFACTURE; DRUG SCREENING; FENTON REACTION; IRRADIATION; LIGHT EXPOSURE; LIGHT STRESS; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; OXIDATION REDUCTION REACTION; PROCEDURES; STRUCTURE ACTIVITY RELATION;

ANTIOXIDANTS; DRUG EVALUATION, PRECLINICAL; INDOLES; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 84897992917     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4007375     Document Type: Article

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