Chemical modifications in therapeutic protein aggregates generated under different stress conditions

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 25134-25144

  Luo, Quanzhou ^a   Joubert, Marisa K ^a   Stevenson, Riki ^a   Ketchem, Randal R ^b   Narhi, Linda O ^a   Wypych, Jette ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIR LIQUID INTERFACES; BIOPHYSICAL CHARACTERIZATION; CLASSIFICATION SYSTEM; CONFORMATIONAL STABILITIES; COPPER BINDING; DEAMIDATION; METAL-CATALYZED OXIDATIONS; NO OXIDATION; PROTEIN AGGREGATES; PROTEIN AGGREGATION; PROTEIN INTERACTION; SITE-SPECIFIC; STRESS CONDITION; THERAPEUTIC PROTEIN; THERMALLY INDUCED;

AGGREGATES; BINDING SITES; MONOCLONAL ANTIBODIES; OXIDATION; PHASE INTERFACES; PROTEINS; STRESSES;

CHEMICAL MODIFICATION;

COPPER; HISTIDINE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN G2 MONOCLONAL ANTIBODY; METHIONINE; MONOCLONAL ANTIBODY; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRESS; CONTROLLED STUDY; DEAMINATION; HEAT TREATMENT; MECHANICAL STRESS; OXIDATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN STABILITY; TEMPERATURE STRESS;

ANIMALS; COPPER; HOT TEMPERATURE; HUMANS; HYDROGEN PEROXIDE; IMMUNOGLOBULIN FC FRAGMENTS; MICE; OXIDATION-REDUCTION; PROTEIN CONFORMATION;

EID: 79960135244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.160440     Document Type: Article

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