Metal-catalyzed oxidation of protein methionine residues in human parathyroid hormone (1-34): Formation of homocysteine and a novel methionine-dependent hydrolysis reaction

Molecular Pharmaceutics

Volumn 10, Issue 2, 2013, Pages 739-755

  Mozziconacci, Olivier ^a   Ji, Junyan A ^b   Wang, Y John ^b   Schöneich, Christian ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b GENENTECH INC   (United States)

Author keywords

alanine; Fenton reaction; homocysteine; hydrolysis; mass spectrometry; methionine; methionine radical cation; parathyroid hormone

Indexed keywords

ALANINE; AMMONIUM ACETATE; HOMOCYSTEINE; METHIONINE; PARATHYROID HORMONE; SCAVENGER; SULFOXIDE;

ARTICLE; BACTERIUM CONTAMINATION; CONTROLLED STUDY; CROSS LINKING; ELECTROSPRAY; ELECTROSPRAY MASS SPECTROMETRY; FENTON REACTION; HORMONE STRUCTURE; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METAL BINDING; MICHAEL ADDITION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; REACTION TIME; TANDEM MASS SPECTROMETRY;

CATALYSIS; HOMOCYSTEINE; HUMANS; HYDROLYSIS; MASS SPECTROMETRY; METHIONINE; OXIDATION-REDUCTION; PARATHYROID HORMONE; PENTETIC ACID;

EID: 84873327051     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300563m     Document Type: Article

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