Oxidation of human growth hormone by oxygen-centered radicals: Formation of Leu-101 hydroperoxide and Tyr-103 oxidation products

Molecular Pharmaceutics

Volumn 9, Issue 4, 2012, Pages 803-814

  Steinmann, Daniel ^a   Ji, J Andrea ^b   Wang, Y John ^b   Schöneich, Christian ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b GENENTECH INC   (United States)

Author keywords

AAPH; alkoxy radicals; dityrosine; hGH; human growth hormone; leucine hydroperoxide; oxidation; peroxyl radicals; protein stability; reactive oxygen species; ROS; tyrosine oxidation

Indexed keywords

CARBONYL DERIVATIVE; HUMAN GROWTH HORMONE; HYDROPEROXIDE; METHIONINE; OXYGEN RADICAL; SUPEROXIDE; TRYPTOPHAN; TYROSINE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DECOMPOSITION; HUMAN; OXIDATION; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DENATURATION;

FREE RADICALS; HUMAN GROWTH HORMONE; HUMANS; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; PEROXIDES; PROTEIN STABILITY; REACTIVE OXYGEN SPECIES;

EID: 84859312740     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3001028     Document Type: Article

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