Analysis of 2,2'-Azobis (2-amidinopropane) dihydrochloride degradation and hydrolysis in aqueous solutions

Journal of Pharmaceutical Sciences

Volumn 100, Issue 8, 2011, Pages 3307-3315

  Werber, Jay ^a   Wang, Y John ^a   Milligan, Michael ^a   Li, Xiaohua ^b   Ji, Junyan A ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AAPH; ABAP; Azonitrile; Free radicals; Liquid chromatographymass spectrometry; Oxidation; Polysorbate; Stability; Surfactants

Indexed keywords

2,2' AZOBIS(2 AMIDINOPROPANE); AZO COMPOUND; OXIDIZING AGENT;

AQUEOUS SOLUTION; ARTICLE; DRUG DEGRADATION; HYDROLYSIS; LIQUID CHROMATOGRAPHY; OXIDATION; PH; REACTION ANALYSIS; TANDEM MASS SPECTROMETRY; ULTRAVIOLET SPECTROSCOPY;

EID: 79958838317     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22578     Document Type: Article

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