Generation of multicellular tumor spheroids with microwell-based agarose scaffolds for drug testing

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Gong, Xue ^a   Lin, Chao ^b   Cheng, Jian ^b   Su, Jiansheng ^a   Zhao, Hang ^a   Liu, Tianlin ^a   Wen, Xuejun ^b,c   Zhao, Peng ^b  

^a TONGJI UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Virginia Commonwealth University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAROSE; DOXORUBICIN; ANTINEOPLASTIC AGENT;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL SIZE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG PENETRATION; DRUG SCREENING; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROSCOPY; MICROWELL PLATE; MULTICELLULAR TUMOR SPHEROID; TUMOR MICROENVIRONMENT; TUMOR SPHEROID; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DRUG DEVELOPMENT; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; IC50; MULTICELLULAR SPHEROID; PROCEDURES; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOXORUBICIN; DRUG DISCOVERY; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITORY CONCENTRATION 50; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 84939180539     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130348     Document Type: Article

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