Doxorubicin delivery to 3D multicellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles

Biomaterials

Volumn 34, Issue 19, 2013, Pages 4667-4679

  Wang, Xin ^a   Zhen, Xu ^a   Wang, Jing ^a   Zhang, Jialiang ^a   Wu, Wei ^a   Jiang, Xiqun ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

3 D multicellular spheroids; Chitosan; Drug delivery; Nanoparticles; Tumor penetration

Indexed keywords

ANTI-TUMOR ACTIVITIES; BIODISTRIBUTIONS; CHITOSAN NANOPARTICLES; IN-VITRO MODELS; MULTICELLULAR SPHEROID; THREEDIMENSIONAL (3-D); TUMOR PENETRATION; TUMOR-PENETRATING PEPTIDES;

CHITOSAN; DRUG DELIVERY; ELECTRON MICROSCOPY; LOADING; MAMMALS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THREE DIMENSIONAL; TUMORS;

NANOPARTICLES;

BORONIC ACID DERIVATIVE; CHITOSAN; DOXORUBICIN; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL KILLING; DRUG PENETRATION; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; LIGHT SCATTERING; MORPHOLOGY; MOUSE; MULTICELLULAR SPHEROID; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PARTICLE SIZE; PRIORITY JOURNAL; THREE DIMENSIONAL MULTICELLULAR SPHEROID; TUMOR GROWTH;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BORONIC ACIDS; CELL LINE, TUMOR; CHITOSAN; DOXORUBICIN; DRUG CARRIERS; MALE; MICE; NANOPARTICLES; NEOPLASMS; OLIGOPEPTIDES; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

MUS;

EID: 84875861861     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.03.008     Document Type: Article

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