Role of ellagic acid in regulation of apoptosis by modulating novel and atypical PKC in lymphoma bearing mice

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Mishra, Sudha ^a   Vinayak, Manjula ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Anaerobic glycolysis; Apoptosis; LDH A; PKC isozymes

Indexed keywords

CASPASE 3; ELLAGIC ACID; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE A; PROTEIN KINASE C; PROTEIN KINASE C DELTA; UNCLASSIFIED DRUG; ANTIOXIDANT; ENZYME ACTIVATOR; ISOENZYME; LACTATE DEHYDROGENASE 5; PLANT EXTRACT;

ADULT; ANAEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CATALYSIS; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REGULATION; GLYCOLYSIS; HISTOPATHOLOGY; LIVER PARENCHYMA; LYMPHOMA; MALE; MOUSE; NONHUMAN; OPTIMAL DRUG DOSE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG EFFECTS; HUMAN; METABOLISM; PHYTOTHERAPY; UPREGULATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CELL DIFFERENTIATION; CELL PROLIFERATION; ELLAGIC ACID; ENZYME ACTIVATORS; GLYCOLYSIS; HUMANS; ISOENZYMES; L-LACTATE DEHYDROGENASE; LYMPHOMA; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN KINASE C; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84939145823     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0810-5     Document Type: Article

References (42)

1. Haughian JM, Jackson TA, Koterwas DM, Bradford AP. Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta. Endocr Relat Cancer. 2006;13:1251-67.
2. Ruvolo VR, Karanjeet KB, Schuster TF, Brown R, Deng Y, Hinchcliffe E, et al. Role for PKC δ in fenretinide-mediated apoptosis in lymphoid leukemia cells. J Signal Transduct. 2010;2010:1-15.
3. Limesand KH, Schneider JC, Nakayama KI, Anderson SM, Reyland ME. Suppression of apoptosis in the protein kinase Cδ null mouse in vivo. J Biol Chem. 2006;281:9728-37.
4. Mishra S, Vinayak M. Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathway. Mol Biol Rep. 2013;40:1417-28.
5. Jackson DN, Foster DA. The enigmatic protein kinase c delta: complex roles in cell proliferation and survival. FASEB J. 2004;18:627-36.
6. Humphries MJ, Limesand KH, Schneider JC, Nakayama KI, Anderson SM, Reyland ME. Suppression of apoptosis in the protein kinase Cδ null mouse in vivo. J Biol Chem. 2006;281:9728-37.
7. Cataldi A, Di Giacomo R, Zara V, Rana MS. Ionizing radiation induces apoptotic signal through protein kinase delta and survival signal through Akt and Cyclic-nucleotide Response Element-binding Protein (CREB) in jurkat T cells. Biol Bull. 2009;217:202-12.
8. Ohba M, Ishino K, Kashiwagi M, Kawabe S, Chida K, Huh NH, et al. Induction of differentiation in normal human keratinocytes by adenovirus mediated introduction of the eta and delta isoforms of protein kinase C. Mol Cell Biol. 1998;18:5199-207.
9. Sanz-Navares E, Fernandez N, Kazanietz MG, Rotenberg SA. Atypical protein kinase C zeta suppresses migration of mouse melanoma cells. Cell Growth Differ. 2001;12:517-24.
10. Zhang L, Huang J, Yang N, Liang S, Barchetti A, Giannakakis A, et al. Integrative genomic analysis of protein kinase C (PKC) family identifies PKC iota as a biomarker and potential oncogene in ovarian carcinoma. Cancer Res. 2006;66:4627-35.
11. Pathak C, Jaiswal YK, Vinayak M. Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer. Biosci Rep. 2008;28:73-81.
12. Kivinena K, Kallajokia M, Taimena P. Caspase-3 is required in the apoptotic disintegration of the nuclear matrix. Exp Cell Res. 2005;311:62-73.
13. Kanthasamy AG, Kitazawa M, Yang Y, Anantharam V, Kanthasamy A. Environmental neurotoxin dieldrin induces apoptosis via caspase-3 dependent proteolytic activation of protein kinase C delta: Implications for neurodegeneration in Parkinson's disease. Mol Brain. 2008;1:12.
14. Brodie C, Blumberg PM. Regulation of cell apoptosis by protein kinase c δ. Apoptosis. 2003;8:19-27.
15. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
16. Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, et al. c-Myc transactivation of LDH-a: implications for tumor metabolism and growth. Proc Natl Acad Sci. 1997;94:6658-63.
17. Fjaeraa C, Nanberg E. Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells. Biomed Pharmacother. 2009;63:254-61.
18. Losso JN, Bansode RR, Trappey A, Bawadi HA, Truax R. In vitro anti-proliferative activities of ellagic acid. J Nutr Biochem. 2004;15:672-8.
19. Mishra S, Vinayak M. Anti-carcinogenic action of ellagic acid mediated via modulation of oxidative stress regulated genes in Dalton lymphoma bearing mice. Leuk Lymphoma. 2011;52:2155-216.
20. Schwartz MK, Bodansky O. Lactic dehydrogenase (Clinical aspects). Methods Enzymol. 1966;9:294-302.
21. Pathak C, Vinayak M. Modulation of lactate dehydrogenase isozymes by modified base queuine. Mol Biol Rep. 2005;32:191-6.
22. Birt DB, Hendrich S, Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther. 2001;90:157-77.
23. Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, et al. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Res. 2008;68:1204-12.
24. Vargo MA, Voss OH, Poustka F, Cardounel AJ, Grotewold E, Doseff AI. Apigenin-induced-apoptosis is mediated by the activation of PKC delta and caspases in leukemia cells. Biochem Pharmacol. 2006;72:681-92.
25. Powell TC, Yin L. Over expression of PKC epsilon sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin. Int J Cancer. 2006;118:1572-6.
26. Ishidaa M, Itsukaichi T, Daisuke K, Kikuchia H. Alteration of the PKCΘ-Vav1 complex and phosphorylation of Vav1 in TCDD-induced apoptosis in the lymphoblastic T cell line, L-MAT. Toxicology. 2010;275:72-8.
27. Schultz A, Jonsson JI, Larsson C. The regulatory domain of protein kinase CΘ localises to the Golgi complex and induces apoptosis in neuroblastoma and Jurkat cells. Cell Death Differ. 2003;10:662-75.
28. Lu HC, Chou FP, Yeh KT, Chang YS, Hsu NC, Chang JG. Analysing the expression of protein kinase C eta in human hepatocellular carcinoma. Pathology. 2009;41:626-9.
29. Zhao M, Xia L, Chen GO. Protein kinase Cd in apoptosis: a brief overview. Arch Immunol Ther Exp (Warsz). 2012;60:361-72. doi: 10.1007/s00005-012-0188-8 .
30. Oh JI, Chun KH, Joo SH, Oh YT, Lee SK. Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2 induced apoptosis in SK-HEP-1 cells. Cancer Lett. 2005;230:228-38.
31. Lan Q, Morton LM, Armstrong B, Hartge P, Menashe I, Zheng T. Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies. Blood. 2009;114:264-7.
32. Devarajan E, Sahin AA, Chen JS. Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene. 2002;21:8843-51.
33. Voss OH, Kim S, Wewers MD, Dose AI. Regulation of monocyte apoptosis by the protein kinase C_-dependent phosphorylation of caspase-3. J Biol Chem. 2005;280:17371-9.
34. Xin M, Gao F, May WS, Flagg T, Deng X. Protein Kinase Cζ abrogates the pro apoptotic function of bax through phosphorylation. J Biol Chem. 2007;282:21268-77.
35. Nazarenko I, Jenny MKJ, Gieseler CWK, Sehouli J, Legewie S, Herbst L, et al. Atypical protein kinase c zeta exhibits a pro apoptotic function. Mol Cancer Res. 2010;8:919-34.
36. Galvez AS, Duran A, Linares JF, Pathrose P, Castilla EA, Abu-Baker S, et al. Protein kinase C zeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol Cell Biol. 2009;29:104-15.
37. Scotti ML, Bamlet W, Smyrk TC, Fields AP, Murray NR. Protein kinase C iota is required for pancreatic cancer cell transformed growth and tumorigenesis. Cancer Res. 2010;70:2064-74.
38. Staiger K, Schatz U, Staiger H, Weyrich P, Haas C, Guirguis A, et al. Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. Microvasc Res. 2009;78:40-4.
39. Kim JW, Chi V, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 2006;66:8927-30.
40. Kato Y, Ozawa S, Miyamoto C, Maehata Y, Suzuki A, et al. Acidic extracellular microenvironment and cancer. Cancer Cell Int. 2013;13:1-8.
41. Verma N, Vinayak M. Semecarpus anacardium nut extract promotes the antioxidant defence system and inhibits anaerobic metabolism during development of lymphoma. Biosci Rep. 2009;29:151-64.
42. Mishra S and Vinayak M. Ellagic acid induces novel and atypical PKC isoforms and promotes caspase-3 dependent apoptosis by blocking energy metabolism. NutrCancer: An International Journal 2014, In Press DOI: 10.1080/01635581.2013.878735.