Analysing the expression of protein kinase C eta in human hepatocellular carcinoma

Pathology

Volumn 41, Issue 7, 2009, Pages 626-629

  Lu, Hsiu Chin ^a,b   Chou, Fen Pi ^b   Yeh, Kun Tu ^c   Chang, Ya Sian ^a   Hsu, Nicholas C ^a   Chang, Jan Gowth ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

Author keywords

Expression; Hepatocellular carcinoma; Mutation analysis; Protein kinase C

Indexed keywords

PROTEIN KINASE C ETA;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL TIME;

EID: 72749096951     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.3109/00313020903273076     Document Type: Article

References (37)

1. McGlynn KA, London WT. Epidemiology and natural history of hepatocellular carcinoma. Best PractResClinGastroenterol 2005; 19: 3-23.
2. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-2576
3. Marrero CR, Marrero JA. Viral hepatitis and hepatocellular carcinoma. Arch Med Res 2007; 38: 612-620
4. Seeff LB, Hoofnagle JH. Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity. Oncogene 2006; 25: 3771-3777
5. Morgan TR, Mandayam S, Jamal MM. Alcohol and hepatocellular carcinoma. Gastroenterology 2004; 127: S87-S96.
6. Laurent-Puig P, Zucman-Rossi J. Genetics of hepatocellular tumors. Oncogene 2006; 25: 3778-3786
7. Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM. Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 2007; 27: 55-76.
8. Feitelson MA, Sun B, Tufan NLS, Liu J, Pan J, Lian Z. Genetic mechanisms of hepatocarcinogenesis. Oncogene 2002; 21: 2593-2604
9. Thoreirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002; 31: 339-346
10. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258: 607-614
11. Mellor H, Parker PJ. The extended protein kinase C superfamily. Biochem J 1998; 332: 281-292
12. Newton AC. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 2001; 101: 2353-2364
13. Ohno S, Nishizuka Y. Protein kinase C isotypes and their specific functions: prologue. J Biochem (Tokyo) 2002; 132: 509-511
14. Ng T, Shima D, Squire A, et al. PKCalpha regulates beta1 integrindependent cell motility through association and control of integrin traffic. Eur Mol Biol Org J 1999; 18: 3909-3923
15. Besson A, Yong VW. Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression. Mol Cell Biol 2000; 20: 4580-4590
16. Mandil R, Ashkenazi E, Blass M, et al. Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res 2001; 61: 4612-4619
17. Scaglione-Sewell B, Abraham C, Bissonnette M, et al. Decreased PKCalpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. Cancer Res 1998; 58: 1074-1081
18. Gutcher I, Webb PR, Anderson NG. The isoform-specific regulation of apoptosis by protein kinase C. Cell Mol Life Sci 2003; 60: 1061-1070
19. Koivunen J, Aaltonen V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett 2006; 235: 1-10.
20. Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007; 7: 281-294
21. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. Fed Am Soc Exp Biol J 1995; 9: 484-496
22. Wetsel WC, Khan WA, Merchenthaler I, et al. Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol 1992; 117: 121-133
23. Langzam L, Koren R, Gal R, et al. Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy. Am J Clin Pathol 2001; 116: 377-385
24. Varga A, Czifra G, Tallai B, et al. Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas. Eur Urol 2004; 46: 462-465
25. Koren R, Ben Meir D, Langzam L, et al. Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. Oncol Rep 2004; 11: 321-326
26. Koren R, Langzam L, Paz A, Livne PM, Gal R, Sampson SR. Protein kinase C (PKC) isoenzymes immunohistochemistry in lymph node revealing solution-fixed, paraffin-embedded bladder tumors. Appl Immunohistochem Mol Morphol 2000; 8: 166-171
27. Fournier DB, Chisamore M, Lurain JR, Rademaker AW, Jordan VC, Tonetti DA. Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer. Gynecol Oncol 2001; 81: 366-372
28. Martinez-Gimeno C, Diaz-Meco MT, Dominguez I, Moscat J. Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival. Head Neck 1995; 17: 516-525
29. Tsai JH, Hsieh YS, Kuo SJ, et al. Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma. Cancer Lett 2000; 161: 171-175
30. Neill GW, Ghali LR, Green JL, Ikram MS, Philpott MP, Quinn AG. Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. Cancer Res 2003; 63: 4692-4697
31. Kerfoot C, Huang W, Rotenberg SA. Immunohistochemical analysis of advanced human breast carcinomas reveals downregulation of protein kinase C alpha. J Histochem Cytochem 2004; 52: 419-422
32. Ainsworth PD, Winstanley JH, Pearson JM, Bishop HM, Garrod DR. Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma. Eur J Cancer 2004; 40: 2269-2273
33. Gokmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, Fields AP. Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. Cancer Res 2001; 61: 1375-1381
34. Brenner W, Farber G, Herget T, Wiesner C, Hengstler JG, Thuroff JW. Protein kinase C eta is associated with progression of renal cell carcinoma (RCC). Anticancer Res 2003; 23: 4001-4006
35. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462-503.
36. Yeh KT, Yang MY, Liu TC, et al. Abnormal expression of period (PER1) in endometrial carcinoma. J Pathol 2005; 206: 111-120
37. Chang KJ, Lin JK, Lee PH, Hsieh YS, Cheng CK, Liu JY. The altered activity of membrane-bound protein kinase C in human liver cancer. Cancer Lett 1996; 105: 211-215