X-ray crystallography over the past decade for novel drug discovery -where are we heading next?

Expert Opinion on Drug Discovery

Volumn 10, Issue 9, 2015, Pages 975-989

  Zheng, Heping ^a,b,c,d   Handing, Katarzyna B ^a,c,d   Zimmerman, Matthew D ^a,b,c,d,e   Shabalin, Ivan G ^a,b,c,d   Almo, Steven C ^c,e,f   Minor, Wladek ^a,b,c,d,e  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Center for Structural Genomics of Infectious Diseases (CSGID)   (United States)

^c New York Structural Genomics Research Consortium (NYSGRC)   (United States)

^d Midwest Center for Structural Genomics (MCSG)   (United States)

^e Enzyme Function Initiative (EFI)   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

data management; hybrid methods; protein crystallography; reproducibility; structural data interpretation; target based drug discovery

Indexed keywords

AMINO ACID SEQUENCE; BIOINFORMATICS; BIOLOGY; CRYSTAL STRUCTURE; DRUG DEVELOPMENT; DRUG STRUCTURE; ELECTRON MICROSCOPY; ELECTRON SPIN RESONANCE; HUMAN; INFORMATION PROCESSING; MACROMOLECULE; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DATA BANK; PROTEIN STRUCTURE; PROTEOMICS; RECEPTOR BINDING ASSAY; REPRODUCIBILITY; REVIEW; SOLID STATE; STRUCTURAL BIOINFORMATICS; X RAY CRYSTALLOGRAPHY; CHEMISTRY; DRUG DESIGN; PROCEDURES; TRENDS;

DRUG;

COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG DISCOVERY; HUMANS; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS;

EID: 84938937218     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2015.1061991     Document Type: Review

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