Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment

Protein Science

Volumn 24, Issue 8, 2015, Pages 1292-1300

  Konijnenberg, Albert ^a   Bannwarth, Ludovic ^b   Yilmaz, Duygu ^c   Koçer, Armaʇan ^c   Venien Bryan, Catherine ^b   Sobott, Frank ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITÉ PIERRE ET MARIE CURIE   (France)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Collision induced dissociation; Integral membrane proteins; Ion channels; Mass spectrometry; Top down sequencing

Indexed keywords

DETERGENT; KIRBAC3.1 POTASSIUM CHANNEL; MECHANOSENSITIVE ION CHANNEL OF LARGE CONDUCTANCE PROTEIN; MEMBRANE PROTEIN; MONOMER; POTASSIUM CHANNEL; PROTEIN VP7; UNCLASSIFIED DRUG; ION CHANNEL; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL INTERACTION; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; HEPATITIS C VIRUS; IONIC STRENGTH; MASS SPECTROMETER; MASS SPECTROMETRY; MICELLE; MOLECULAR WEIGHT; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; STOICHIOMETRY; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HEPACIVIRUS; HEPATITIS C; HUMAN; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION; VIROLOGY;

AMINO ACID SEQUENCE; HEPACIVIRUS; HEPATITIS C; HUMANS; ION CHANNELS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS; PROTEIN MULTIMERIZATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VIRAL PROTEINS;

EID: 84938910338     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2703     Document Type: Article

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