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Volumn 226, Issue 1, 2011, Pages 236-247

Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; FOCAL ADHESION KINASE; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; SERINE 21; SERINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 78049262961     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22335     Document Type: Article
Times cited : (53)

References (37)
  • 1
    • 67650716492 scopus 로고    scopus 로고
    • The Ins and outs of leukocyte integrin signaling
    • Abram CL, Lowell CA. 2009. The Ins and outs of leukocyte integrin signaling. Annu Rev Immunol 27: 339-362.
    • (2009) Annu Rev Immunol , vol.27 , pp. 339-362
    • Abram, C.L.1    Lowell, C.A.2
  • 2
    • 0036408735 scopus 로고    scopus 로고
    • Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166
    • Adams DG, Sachs NA, Vaillancourt RR. 2002. Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166. Arch Biochem Biophys 407: 103-116.
    • (2002) Arch Biochem Biophys , vol.407 , pp. 103-116
    • Adams, D.G.1    Sachs, N.A.2    Vaillancourt, R.R.3
  • 6
    • 0028877919 scopus 로고
    • Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases
    • Calalb MB, Polte TR, Hanks SK. 1995. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases. Mol Cell Biol 15: 954-963.
    • (1995) Mol Cell Biol , vol.15 , pp. 954-963
    • Calalb, M.B.1    Polte, T.R.2    Hanks, S.K.3
  • 7
    • 0036205320 scopus 로고    scopus 로고
    • Src catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading
    • Cary LA, Klinghoffer RA, Sachsenmaier C, Cooper JA. 2002. Src catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading. Mol Cell Biol 22: 2427-2440.
    • (2002) Mol Cell Biol , vol.22 , pp. 2427-2440
    • Cary, L.A.1    Klinghoffer, R.A.2    Sachsenmaier, C.3    Cooper, J.A.4
  • 8
    • 0032906876 scopus 로고    scopus 로고
    • Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization
    • Chen D, Pace PE, Coombes RC, Ali S. 1999. Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization. Mol Cell Biol 19: 1002-1015.
    • (1999) Mol Cell Biol , vol.19 , pp. 1002-1015
    • Chen, D.1    Pace, P.E.2    Coombes, R.C.3    Ali, S.4
  • 9
    • 0037287071 scopus 로고    scopus 로고
    • Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1
    • Chun J, Kwon T, Kim DJ, Park I, Chung G, Lee EJ, Hong SK, Chang S-I, Kim HY, Kang SS. 2003. Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1. J Biochem 133: 103-108.
    • (2003) J Biochem , vol.133 , pp. 103-108
    • Chun, J.1    Kwon, T.2    Kim, D.J.3    Park, I.4    Chung, G.5    Lee, E.J.6    Hong, S.K.7    Chang, S.8    Kim, H.Y.9    Kang, S.S.10
  • 11
    • 20444370219 scopus 로고    scopus 로고
    • Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
    • Ezratty EJ, Partridge MA, Gundersen GG. 2005. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat Cell Biol 7: 581-590.
    • (2005) Nat Cell Biol , vol.7 , pp. 581-590
    • Ezratty, E.J.1    Partridge, M.A.2    Gundersen, G.G.3
  • 12
    • 1842584776 scopus 로고    scopus 로고
    • Newest findings on the oldest oncogene; how activated src does it
    • Frame MC. 2004. Newest findings on the oldest oncogene; how activated src does it. J Cell Sci 117: 989-998.
    • (2004) J Cell Sci , vol.117 , pp. 989-998
    • Frame, M.C.1
  • 13
    • 0037033002 scopus 로고    scopus 로고
    • Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity
    • Francis SH, Bessay EP, Kotera J, Grimes KA, Liu L, Thompson WJ, Corbin JD. 2002. Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity. J Biol Chem 277: 47581-47587.
    • (2002) J Biol Chem , vol.277 , pp. 47581-47587
    • Francis, S.H.1    Bessay, E.P.2    Kotera, J.3    Grimes, K.A.4    Liu, L.5    Thompson, W.J.6    Corbin, J.D.7
  • 14
    • 0033603826 scopus 로고    scopus 로고
    • Quantifying lamella dynamics of cultured cells by SACED, a new computer-assisted motion analysis
    • Hinz B, Alt W, Johnen C, Herzog V, Kaiser H-W. 1999. Quantifying lamella dynamics of cultured cells by SACED, a new computer-assisted motion analysis. Exp Cell Res 251: 234-243.
    • (1999) Exp Cell Res , vol.251 , pp. 234-243
    • Hinz, B.1    Alt, W.2    Johnen, C.3    Herzog, V.4    Kaiser, H.5
  • 16
    • 0025158107 scopus 로고
    • Protein kinase recognition sequence motifs
    • Kemp BE, Pearson RB. 1990. Protein kinase recognition sequence motifs. Trends Biochem Sci 15: 342-346.
    • (1990) Trends Biochem Sci , vol.15 , pp. 342-346
    • Kemp, B.E.1    Pearson, R.B.2
  • 17
    • 0033522510 scopus 로고    scopus 로고
    • Src family kinases are required for integrin but not PDGFR signal transduction
    • Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P. 1999. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18: 2459-2471.
    • (1999) EMBO J , vol.18 , pp. 2459-2471
    • Klinghoffer, R.A.1    Sachsenmaier, C.2    Cooper, J.A.3    Soriano, P.4
  • 18
    • 0034623146 scopus 로고    scopus 로고
    • Inhibition of neuronal nitric-oxide synthase by calcium/calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG 108-15 neuronal cells
    • Komeima K, Hayashi Y, Naito Y, Watanabe Y. 2000. Inhibition of neuronal nitric-oxide synthase by calcium/calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG 108-15 neuronal cells. J Biol Chem 275: 28139-28143.
    • (2000) J Biol Chem , vol.275 , pp. 28139-28143
    • Komeima, K.1    Hayashi, Y.2    Naito, Y.3    Watanabe, Y.4
  • 19
  • 20
    • 33744904687 scopus 로고    scopus 로고
    • The phosphorylation of serine 492 of perilipin A directs lipid droplet fragmentation and dispersion
    • Marcinkiewicz A, Gauthier D, Garcia A, Brasaemle DL. 2006. The phosphorylation of serine 492 of perilipin A directs lipid droplet fragmentation and dispersion. J Biol Chem 281: 11901-11909.
    • (2006) J Biol Chem , vol.281 , pp. 11901-11909
    • Marcinkiewicz, A.1    Gauthier, D.2    Garcia, A.3    Brasaemle, D.L.4
  • 21
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-Src signaling in normal and cancer cells
    • Mitra SK, Schlaepfer DD. 2006. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18: 516-523.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2
  • 22
    • 0037326152 scopus 로고    scopus 로고
    • Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck
    • Niu S, Xie H, Marcantonio EE. 2003. Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck. Mol Biol Cell 14: 349-360.
    • (2003) Mol Biol Cell , vol.14 , pp. 349-360
    • Niu, S.1    Xie, H.2    Marcantonio, E.E.3
  • 23
    • 12344333887 scopus 로고    scopus 로고
    • PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells
    • Obara Y, Labudda K, Dillon TJ, Stork PJS. 2004. PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. J Cell Sci 117: 6085-6094.
    • (2004) J Cell Sci , vol.117 , pp. 6085-6094
    • Obara, Y.1    Labudda, K.2    Dillon, T.J.3    Stork, P.J.S.4
  • 24
    • 0033002997 scopus 로고    scopus 로고
    • Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2
    • Owen JD, Ruest PJ, Fry DW, Hanks SK. 1999. Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol 19: 4806-4818.
    • (1999) Mol Cell Biol , vol.19 , pp. 4806-4818
    • Owen, J.D.1    Ruest, P.J.2    Fry, D.W.3    Hanks, S.K.4
  • 25
    • 0030898418 scopus 로고    scopus 로고
    • Src family protein tyrosine kinases: Cooperating with growth factor and adhesion signaling pathways
    • Parsons JT, Parsons SJ. 1997. Src family protein tyrosine kinases: Cooperating with growth factor and adhesion signaling pathways. Curr Opin Cell Biol 9: 187-192.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 187-192
    • Parsons, J.T.1    Parsons, S.J.2
  • 26
    • 46249134182 scopus 로고    scopus 로고
    • Analysis of Fyn function in hemostasis and αIIbβ3-integrin signaling
    • Reddy KB, Smith DM, Plow EF. 2008. Analysis of Fyn function in hemostasis and αIIbβ3-integrin signaling. J Cell Sci 121: 1641-1648.
    • (2008) J Cell Sci , vol.121 , pp. 1641-1648
    • Reddy, K.B.1    Smith, D.M.2    Plow, E.F.3
  • 27
    • 34548282678 scopus 로고    scopus 로고
    • The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements
    • Sandilands E, Brunton VG, Frame MC. 2007. The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J Cell Sci 120: 2555-2564.
    • (2007) J Cell Sci , vol.120 , pp. 2555-2564
    • Sandilands, E.1    Brunton, V.G.2    Frame, M.C.3
  • 28
    • 0032859988 scopus 로고    scopus 로고
    • Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases
    • Schaller MD, Hildebrand JD, Parsons JT. 1999. Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases. Mol Biol Cell 10: 3489-3505.
    • (1999) Mol Biol Cell , vol.10 , pp. 3489-3505
    • Schaller, M.D.1    Hildebrand, J.D.2    Parsons, J.T.3
  • 29
    • 0036161707 scopus 로고    scopus 로고
    • PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1
    • Schmitt JM, Stork PJ. 2002. PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. Mol Cell 9: 85-94.
    • (2002) Mol Cell , vol.9 , pp. 85-94
    • Schmitt, J.M.1    Stork, P.J.2
  • 30
    • 8544270944 scopus 로고    scopus 로고
    • cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na+ channel through convergent phosphorylation of Nedd 4-2
    • Snyder PM, Olson DR, Kabra R, Zhou R, Steines JC. 2004. cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na+ channel through convergent phosphorylation of Nedd 4-2. J Biol Chem 279: 45753-45758.
    • (2004) J Biol Chem , vol.279 , pp. 45753-45758
    • Snyder, P.M.1    Olson, D.R.2    Kabra, R.3    Zhou, R.4    Steines, J.C.5
  • 31
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM, Brugge JS. 1997. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13: 513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 33
    • 0028557441 scopus 로고
    • Multiple pathway signal transduction by the cAMP-dependent protein kinase
    • Walsh DA, Van Patten SM. 1994. Multiple pathway signal transduction by the cAMP-dependent protein kinase. FASEB J 8: 1227-1236.
    • (1994) FASEB J , vol.8 , pp. 1227-1236
    • Walsh, D.A.1    Van Patten, S.M.2
  • 34
    • 0037177904 scopus 로고    scopus 로고
    • Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)
    • Werz O, Szellas D, Steinhilber D, Radmark O. 2002. Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2). J Biol Chem 277: 14793-14800.
    • (2002) J Biol Chem , vol.277 , pp. 14793-14800
    • Werz, O.1    Szellas, D.2    Steinhilber, D.3    Radmark, O.4
  • 35
    • 0034778518 scopus 로고    scopus 로고
    • Positive regulation of cell-cell and cell-substrate adhesion by protein kinase A
    • Whittard JD, Akiyama SK. 2001. Positive regulation of cell-cell and cell-substrate adhesion by protein kinase A. J Cell Sci 114: 3265-3272.
    • (2001) J Cell Sci , vol.114 , pp. 3265-3272
    • Whittard, J.D.1    Akiyama, S.K.2
  • 36
    • 33745049204 scopus 로고    scopus 로고
    • Src SH2 arginine 175 is required for cell motility: Specific focal adhesion kinase targeting and focal adhesion assembly function
    • Yeo MG, Partridge MA, Ezratty EJ, Shen Q, Gundersen GG, Marcantonio EE. 2006. Src SH2 arginine 175 is required for cell motility: Specific focal adhesion kinase targeting and focal adhesion assembly function. Mol Cell Biol 26: 4399-4409.
    • (2006) Mol Cell Biol , vol.26 , pp. 4399-4409
    • Yeo, M.G.1    Partridge, M.A.2    Ezratty, E.J.3    Shen, Q.4    Gundersen, G.G.5    Marcantonio, E.E.6
  • 37
    • 38449109790 scopus 로고    scopus 로고
    • Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient Src family kinases or p130CAS
    • Yeo MG, Sung BH, Oh HJ, Park ZY, Marcantonio EE, Song WK. 2008. Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient Src family kinases or p130CAS. J Cell Physiol 214: 604-613.
    • (2008) J Cell Physiol , vol.214 , pp. 604-613
    • Yeo, M.G.1    Sung, B.H.2    Oh, H.J.3    Park, Z.Y.4    Marcantonio, E.E.5    Song, W.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.