-
1
-
-
33745464490
-
Fluorinated pyrimidines, a new class of tumour-inhibitory compounds
-
Heidelberger C, Chaudhuri N, Danneberg P, Mooren D, Griesbach L, Duschinsky R et al. Fluorinated pyrimidines, a new class of tumour-inhibitory compounds. Nature 1957; 179: 663-666.
-
(1957)
Nature
, vol.179
, pp. 663-666
-
-
Heidelberger, C.1
Chaudhuri, N.2
Danneberg, P.3
Mooren, D.4
Griesbach, L.5
Duschinsky, R.6
-
2
-
-
0038387494
-
5-fluorouracil: Mechanisms of action and clinical strategies
-
Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003; 3: 330-338.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 330-338
-
-
Longley, D.B.1
Harkin, D.P.2
Johnston, P.G.3
-
3
-
-
33847244929
-
Drug resistance, predictive markers and pharmacogenomics in colorectal cancer
-
Longley DB, Allen WL, Johnston PG. Drug resistance, predictive markers and pharmacogenomics in colorectal cancer. Biochim Biophys Acta 2006; 1766: 184-196.
-
(2006)
Biochim Biophys Acta
, vol.1766
, pp. 184-196
-
-
Longley, D.B.1
Allen, W.L.2
Johnston, P.G.3
-
4
-
-
0035079539
-
Ceramide glycosylation potentiates cellular multidrug resistance
-
Liu Y-Y, Han T-Y, Giuliano AE, Cabot MC. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J 2001; 15: 719-730.
-
(2001)
FASEB J
, vol.15
, pp. 719-730
-
-
Liu, Y.-Y.1
Han, T.-Y.2
Giuliano, A.E.3
Cabot, M.C.4
-
5
-
-
13644254794
-
Molecular mechanisms of drug resistance
-
Longley D, Johnston P. Molecular mechanisms of drug resistance. J Pathol 2005; 205: 275-292.
-
(2005)
J Pathol
, vol.205
, pp. 275-292
-
-
Longley, D.1
Johnston, P.2
-
6
-
-
0035038919
-
The orphan nuclear receptor sxr coordinately regulates drug metabolism and efflux
-
Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001; 7: 584-590.
-
(2001)
Nat Med
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
7
-
-
0036176510
-
Mechanisms of cancer drug resistance
-
Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med 2002; 53: 615-627.
-
(2002)
Annu Rev Med
, vol.53
, pp. 615-627
-
-
Gottesman, M.M.1
-
8
-
-
58249088751
-
Micrornas: Target recognition and regulatory functions
-
Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-233.
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
9
-
-
11844278458
-
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microrna targets
-
Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
-
(2005)
Cell
, vol.120
, pp. 15-20
-
-
Lewis, B.P.1
Burge, C.B.2
Bartel, D.P.3
-
10
-
-
84857079737
-
The microcosmos of cancer
-
Lujambio A, Lowe SW. The microcosmos of cancer. Nature 2012; 482: 347-355.
-
(2012)
Nature
, vol.482
, pp. 347-355
-
-
Lujambio, A.1
Lowe, S.W.2
-
11
-
-
12144290519
-
Human microrna genes are frequently located at fragile sites and genomic regions involved in cancers
-
Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004; 101: 2999-3004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2999-3004
-
-
Calin, G.A.1
Sevignani, C.2
Dumitru, C.D.3
Hyslop, T.4
Noch, E.5
Yendamuri, S.6
-
13
-
-
77957361864
-
Targeting micrornas in cancer: Rationale, strategies and challenges
-
Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 2010; 9: 775-789.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 775-789
-
-
Garzon, R.1
Marcucci, G.2
Croce, C.M.3
-
14
-
-
0036632368
-
The phosphatidylinositol 3-kinase-Akt pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
16
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase b
-
Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M et al. Role of translocation in the activation and function of protein kinase B. J Biol Chem 1997; 272: 31515-31524.
-
(1997)
J Biol Chem
, vol.272
, pp. 31515-31524
-
-
Andjelkovic, M.1
Alessi, D.R.2
Meier, R.3
Fernandez, A.4
Lamb, N.J.5
Frech, M.6
-
17
-
-
0032560796
-
Akt activation by growth factors is a multiple-step process: The role of the ph domain
-
Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D et al. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 1998; 17: 313-325.
-
(1998)
Oncogene
, vol.17
, pp. 313-325
-
-
Bellacosa, A.1
Chan, T.O.2
Ahmed, N.N.3
Datta, K.4
Malstrom, S.5
Stokoe, D.6
-
18
-
-
0030799706
-
Dual role of phosphatidylinositol-3,4, 5-trisphosphate in the activation of protein kinase b
-
Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF et al. Dual role of phosphatidylinositol-3, 4, 5-trisphosphate in the activation of protein kinase B. Science 1997; 277: 567-570.
-
(1997)
Science
, vol.277
, pp. 567-570
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
Gaffney, P.R.4
Reese, C.B.5
Painter, G.F.6
-
19
-
-
22744449073
-
An akt/?-Arrestin 2/pp2a signaling complex mediates dopaminergic neurotransmission and behavior
-
Beaulieu J-M, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. An Akt/?-Arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 2005; 122: 261-273.
-
(2005)
Cell
, vol.122
, pp. 261-273
-
-
Beaulieu, J.-M.1
Sotnikova, T.D.2
Marion, S.3
Lefkowitz, R.J.4
Gainetdinov, R.R.5
Caron, M.G.6
-
20
-
-
84876990097
-
Protein phosphatase 2a: A target for anticancer therapy
-
Perrotti D, Neviani P. Protein phosphatase 2A: a target for anticancer therapy. Lancet Oncol 2013; 14: e229-e238.
-
(2013)
Lancet Oncol
, vol.14
, pp. e229-e238
-
-
Perrotti, D.1
Neviani, P.2
-
21
-
-
4544261227
-
An iap-iap complex inhibits apoptosis
-
Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K et al. An IAP-IAP complex inhibits apoptosis. J Biol Chem 2004; 279: 34087-34090.
-
(2004)
J Biol Chem
, vol.279
, pp. 34087-34090
-
-
Dohi, T.1
Okada, K.2
Xia, F.3
Wilford, C.E.4
Samuel, T.5
Welsh, K.6
-
22
-
-
34250892539
-
Compartmentalized phosphorylation of iap by protein kinase a regulates cytoprotection
-
Dohi T, Xia F, Altieri DC. Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell 2007; 27: 17-28.
-
(2007)
Mol Cell
, vol.27
, pp. 17-28
-
-
Dohi, T.1
Xia, F.2
Altieri, D.C.3
-
23
-
-
1242317030
-
Akt phosphorylation and stabilization of x-linked inhibitor of apoptosis protein (xiap
-
Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang H-G et al. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 2004; 279: 5405-5412.
-
(2004)
J Biol Chem
, vol.279
, pp. 5405-5412
-
-
Dan, H.C.1
Sun, M.2
Kaneko, S.3
Feldman, R.I.4
Nicosia, S.V.5
Wang, H.-G.6
-
24
-
-
80054805087
-
Syk activation of phosphatidylinositol 3-kinase/akt prevents htra2-dependent loss of x-linked inhibitor of apoptosis protein (xiap) to promote survival of Epstein-Barr virus+ (ebv+) b cell lymphomas
-
Hatton O, Phillips LK, Vaysberg M, Hurwich J, Krams SM, Martinez OM. Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas. J Biol Chem 2011; 286: 37368-37378.
-
(2011)
J Biol Chem
, vol.286
, pp. 37368-37378
-
-
Hatton, O.1
Phillips, L.K.2
Vaysberg, M.3
Hurwich, J.4
Krams, S.M.5
Martinez, O.M.6
-
25
-
-
79956017530
-
Targeting aberrant pi3k/akt activation by pi103 restores sensitivity to trail-induced apoptosis in neuroblastoma
-
Opel D, Naumann I, Schneider M, Bertele D, Debatin K-M, Fulda S. Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma. Clin Cancer Res 2011; 17: 3233-3247.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3233-3247
-
-
Opel, D.1
Naumann, I.2
Schneider, M.3
Bertele, D.4
Debatin, K.-M.5
Fulda, S.6
-
26
-
-
33847726589
-
Gefitinib reverses trail resistance in human bladder cancer cell lines via inhibition of akt-mediated x-linked inhibitor of apoptosis protein expression
-
Shrader M, Pino MS, Lashinger L, Bar-Eli M, Adam L, Dinney CP et al. Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression. Cancer Res 2007; 67: 1430-1435.
-
(2007)
Cancer Res
, vol.67
, pp. 1430-1435
-
-
Shrader, M.1
Pino, M.S.2
Lashinger, L.3
Bar-Eli, M.4
Adam, L.5
Dinney, C.P.6
-
27
-
-
0035131433
-
A highresolution integrated map spanning the sdhd gene at 11q23: A 1.1-mb bac contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region
-
Baysal BE, Willett-Brozick JE, Taschner P, Dauwerse J, Devilee P, Devlin B. A highresolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. Eur J Hum Genet 2001; 9: 121-129.
-
(2001)
Eur J Hum Genet
, vol.9
, pp. 121-129
-
-
Baysal, B.E.1
Willett-Brozick, J.E.2
Taschner, P.3
Dauwerse, J.4
Devilee, P.5
Devlin, B.6
-
28
-
-
0032500792
-
Alterations of the ppp2r1b gene in human lung and colon cancer
-
Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J et al. Alterations of the PPP2R1B gene in human lung and colon cancer. Science 1998; 282: 284-287.
-
(1998)
Science
, vol.282
, pp. 284-287
-
-
Wang, S.S.1
Esplin, E.D.2
Li, J.L.3
Huang, L.4
Gazdar, A.5
Minna, J.6
-
29
-
-
0033916381
-
Alterations of the ppp2r1b gene located at 11q23 in human colorectal cancers
-
Takagi Y, Futamura M, Yamaguchi K, Aoki S, Takahashi T, Saji S. Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers. Gut 2000; 47: 268-271.
-
(2000)
Gut
, vol.47
, pp. 268-271
-
-
Takagi, Y.1
Futamura, M.2
Yamaguchi, K.3
Aoki, S.4
Takahashi, T.5
Saji, S.6
-
30
-
-
0035810043
-
Alterations in protein phosphatase 2a subunit interaction in human carcinomas of the lung and colon with mutations in the a beta subunit gene
-
Ruediger R, Pham HT, Walter G. Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. Oncogene 2001; 20: 1892-1899.
-
(2001)
Oncogene
, vol.20
, pp. 1892-1899
-
-
Ruediger, R.1
Pham, H.T.2
Walter, G.3
-
31
-
-
4644344978
-
Ppp2r1b gene alterations inhibit interaction of pp2a-A? and pp2a-c proteins in colorectal cancers
-
Tamaki M, Goi T, Hirono Y, Katayama K, Yamaguchi A. PPP2R1B gene alterations inhibit interaction of PP2A-A? and PP2A-C proteins in colorectal cancers. Oncol Rep 2004; 11: 655-659.
-
(2004)
Oncol Rep
, vol.11
, pp. 655-659
-
-
Tamaki, M.1
Goi, T.2
Hirono, Y.3
Katayama, K.4
Yamaguchi, A.5
-
32
-
-
0036170771
-
Integrin ?2?1 promotes activation of protein phosphatase 2a and dephosphorylation of akt and glycogen synthase kinase 3?
-
Ivaska J, Nissinen L, Immonen N, Eriksson JE, Kähäri V-M, Heino J. Integrin ?2?1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3?. Mol Cell Biol 2002; 22: 1352-1359.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1352-1359
-
-
Ivaska, J.1
Nissinen, L.2
Immonen, N.3
Eriksson, J.E.4
Kähäri, V.-M.5
Heino, J.6
-
33
-
-
84863262889
-
Ephb3 suppresses non-small-cell lung cancer metastasis via a pp2a/rack1/akt signalling complex
-
Li G, Ji X-D, Gao H, Zhao J-S, Xu J-F, Sun Z-J et al. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. Nat Commun 2012; 3: 667.
-
(2012)
Nat Commun
, vol.3
, pp. 667
-
-
Li, G.1
Ji, X.-D.2
Gao, H.3
Zhao, J.-S.4
Xu, J.-F.5
Sun, Z.-J.6
-
34
-
-
38349190654
-
Regulation of phosphorylation of thr-308 of akt, cell proliferation, and survival by the b55? Regulatory subunit targeting of the protein phosphatase 2a holoenzyme to akt
-
Kuo Y-C, Huang K-Y, Yang C-H, Yang Y-S, Lee W-Y, Chiang C-W. Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55? regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J Biol Chem 2008; 283: 1882-1892.
-
(2008)
J Biol Chem
, vol.283
, pp. 1882-1892
-
-
Kuo, Y.-C.1
Huang, K.-Y.2
Yang, C.-H.3
Yang, Y.-S.4
Lee, W.-Y.5
Chiang, C.-W.6
-
35
-
-
0035899332
-
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines
-
Gayet J, Zhou X-P, Duval A, Rolland S, Hoang J-M, Cottu P et al. Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. Oncogene 2001; 20: 5025-5032.
-
(2001)
Oncogene
, vol.20
, pp. 5025-5032
-
-
Gayet, J.1
Zhou, X.-P.2
Duval, A.3
Rolland, S.4
Hoang, J.-M.5
Cottu, P.6
-
36
-
-
84924885748
-
Anticancer activity of marine sponge hyrtios sp. Extract in human colorectal carcinoma rko cells with different p53 status
-
Lim HK, Bae W, Lee HS, Jung J. Anticancer activity of marine sponge Hyrtios sp. extract in human colorectal carcinoma RKO cells with different p53 status. Biomed Res Int 2014; 413575: 27.
-
(2014)
Biomed Res Int
, vol.27
, pp. 413575
-
-
Lim, H.K.1
Bae, W.2
Lee, H.S.3
Jung, J.4
-
37
-
-
84924911759
-
Microrna-520 g confers drug resistance by regulating p21 expression in colorectal cancer
-
Zhang Y, Geng L, Talmon G, Wang J. MicroRNA-520 g confers drug resistance by regulating p21 expression in colorectal cancer. J Biol Chem 2015; 290: 6215-6225.
-
(2015)
J Biol Chem
, vol.290
, pp. 6215-6225
-
-
Zhang, Y.1
Geng, L.2
Talmon, G.3
Wang, J.4
-
38
-
-
78650500590
-
Microrna-21 induces resistance to 5-fluorouracil by down-regulating human DNA muts homolog 2 (hmsh2
-
Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M et al. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci 2010; 107: 21098-21103.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 21098-21103
-
-
Valeri, N.1
Gasparini, P.2
Braconi, C.3
Paone, A.4
Lovat, F.5
Fabbri, M.6
-
39
-
-
34250805982
-
Microrna targeting specificity in mammals: Determinants beyond seed pairing
-
Grimson A, Farh KK-H, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 2007; 27: 91-105.
-
(2007)
Mol Cell
, vol.27
, pp. 91-105
-
-
Grimson, A.1
Farh, K.K.-H.2
Johnston, W.K.3
Garrett-Engele, P.4
Lim, L.P.5
Bartel, D.P.6
-
40
-
-
20944450160
-
Combinatorial microrna target predictions
-
Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ et al. Combinatorial microRNA target predictions. Nature genetics 2005; 37: 495-500.
-
(2005)
Nature Genetics
, vol.37
, pp. 495-500
-
-
Krek, A.1
Grün, D.2
Poy, M.N.3
Wolf, R.4
Rosenberg, L.5
Epstein, E.J.6
-
41
-
-
77955963884
-
Comprehensive modeling of microrna targets predicts functional non-conserved and non-canonical sites
-
Betel D, Koppal A, Agius P, Sander C, Leslie C. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol 2010; 11: R90.
-
(2010)
Genome Biol
, vol.11
, pp. R90
-
-
Betel, D.1
Koppal, A.2
Agius, P.3
Sander, C.4
Leslie, C.5
-
43
-
-
1342321750
-
Pi 3-kinase akt and cell survival
-
Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004; 15: 177-182.
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 177-182
-
-
Downward, J.1
-
44
-
-
2442464889
-
Apoptosis defects and chemotherapy resistance: Molecular interaction maps and networks
-
Pommier Y, Sordet O, Antony S, Hayward RL, Kohn KW. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 2004; 23: 2934-2949.
-
(2004)
Oncogene
, vol.23
, pp. 2934-2949
-
-
Pommier, Y.1
Sordet, O.2
Antony, S.3
Hayward, R.L.4
Kohn, K.W.5
-
45
-
-
79955783609
-
Identification of a novel tgf?/pka signaling transduceome in mediating control of cell survival and metastasis in colon cancer
-
Chowdhury S, Howell GM, Rajput A, Teggart CA, Brattain LE, Weber HR et al. Identification of a novel TGF?/PKA signaling transduceome in mediating control of cell survival and metastasis in colon cancer. PLoS One 2011; 6: e19335.
-
(2011)
PLoS One
, vol.6
, pp. e19335
-
-
Chowdhury, S.1
Howell, G.M.2
Rajput, A.3
Teggart, C.A.4
Brattain, L.E.5
Weber, H.R.6
-
46
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase b
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
47
-
-
84920995116
-
Pathological axonal death through a mapk cascade that triggers a local energy deficit
-
Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS et al. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell 2015; 160: 161-176.
-
(2015)
Cell
, vol.160
, pp. 161-176
-
-
Yang, J.1
Wu, Z.2
Renier, N.3
Simon, D.J.4
Uryu, K.5
Park, D.S.6
-
48
-
-
84891913160
-
Direct reversal of glucocorticoid resistance by akt inhibition in acute lymphoblastic leukemia
-
Piovan E, Yu J, Tosello V, Herranz D, Ambesi-Impiombato A, Da Silva AC et al. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. Cancer Cell 2013; 24: 766-776.
-
(2013)
Cancer Cell
, vol.24
, pp. 766-776
-
-
Piovan, E.1
Yu, J.2
Tosello, V.3
Herranz, D.4
Ambesi-Impiombato, A.5
Da Silva, A.C.6
-
49
-
-
0032585197
-
Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
-
Rougier P, Van Cutsem E, Bajetta E, Niederle N, Possinger K, Labianca R et al. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 1998; 352: 1407-1412.
-
(1998)
Lancet
, vol.352
, pp. 1407-1412
-
-
Rougier, P.1
Van Cutsem, E.2
Bajetta, E.3
Niederle, N.4
Possinger, K.5
Labianca, R.6
-
50
-
-
44849127680
-
Transforming growth factor ? Induces apoptosis through repressing the phosphoinositide 3-kinase/akt/survivin pathway in colon cancer cells
-
Wang J, Yang L, Yang J, Kuropatwinski K, Wang W, Liu X-Q et al. Transforming growth factor ? induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells. Cancer Res 2008; 68: 3152-3160.
-
(2008)
Cancer Res
, vol.68
, pp. 3152-3160
-
-
Wang, J.1
Yang, L.2
Yang, J.3
Kuropatwinski, K.4
Wang, W.5
Liu, X.-Q.6
-
51
-
-
34147172885
-
Colon carcinoma cells harboring pik3ca mutations display resistance to growth factor deprivation induced apoptosis
-
Wang J, Kuropatwinski K, Hauser J, Rossi MR, Zhou Y, Conway A et al. Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis. Mol Cancer Ther 2007; 6: 1143-1150.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1143-1150
-
-
Wang, J.1
Kuropatwinski, K.2
Hauser, J.3
Rossi, M.R.4
Zhou, Y.5
Conway, A.6
-
52
-
-
3042823521
-
Regulation of sensitivity to trail by the pten tumor suppressor
-
Whang YE, Yuan X-J, Liu Y, Majumder S, Lewis TD. Regulation of sensitivity to TRAIL by the PTEN tumor suppressor. Vitam Horm 2004; 67: 409-426.
-
(2004)
Vitam Horm
, vol.67
, pp. 409-426
-
-
Whang, Y.E.1
Yuan, X.-J.2
Liu, Y.3
Majumder, S.4
Lewis, T.D.5
-
53
-
-
0009643165
-
P21 promotes ceramide-induced apoptosis and antagonizes the antideath effect of bcl-2 in human hepatocarcinoma cells
-
Kang KH, Kim WH, Choi KH. p21 promotes ceramide-induced apoptosis and antagonizes the antideath effect of Bcl-2 in human hepatocarcinoma cells. Exp Cell Res 1999; 253: 403-412.
-
(1999)
Exp Cell Res
, vol.253
, pp. 403-412
-
-
Kang, K.H.1
Kim, W.H.2
Choi, K.H.3
-
54
-
-
27844497945
-
Foxo transcription factors at the interface between longevity and tumor suppression
-
Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005; 24: 7410-7425.
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
55
-
-
84902554025
-
X-chromosomelinked inhibitor of apoptosis as a key factor for chemoresistance in clear cell carcinoma of the ovary
-
Miyamoto M, Takano M, Iwaya K, Shinomiya N, Kato M, Aoyama T et al. X-chromosomelinked inhibitor of apoptosis as a key factor for chemoresistance in clear cell carcinoma of the ovary. Br J Cancer 2014; 110: 2881-2886.
-
(2014)
Br J Cancer
, vol.110
, pp. 2881-2886
-
-
Miyamoto, M.1
Takano, M.2
Iwaya, K.3
Shinomiya, N.4
Kato, M.5
Aoyama, T.6
-
56
-
-
84882440944
-
Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, x-linked inhibitor of apoptosis protein (xiap), and mitochondrial fission
-
Farrand L, Byun S, Kim JY, Im-Aram A, Lee J, Lim S et al. Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem 2013; 288: 23740-23750.
-
(2013)
J Biol Chem
, vol.288
, pp. 23740-23750
-
-
Farrand, L.1
Byun, S.2
Kim, J.Y.3
Im-Aram, A.4
Lee, J.5
Lim, S.6
-
57
-
-
38649135366
-
Akt and xiap regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol
-
Gagnon V, Van Themsche C, Turner S, Leblanc V, Asselin E. Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis 2008; 13: 259-271.
-
(2008)
Apoptosis
, vol.13
, pp. 259-271
-
-
Gagnon, V.1
Van Themsche, C.2
Turner, S.3
Leblanc, V.4
Asselin, E.5
-
58
-
-
84866550518
-
The pp2a-A? Gene is regulated by multiple transcriptional factors including ets-1 sp1/sp3, and rxr
-
Liu J, Ji W, Sun S, Zhang L, Chen HG, Mao Y et al. The PP2A-A? gene is regulated by multiple transcriptional factors including Ets-1, SP1/SP3, and RXR?/?. Curr Mol Med 2012; 12: 982-994.
-
(2012)
Curr Mol Med
, vol.12
, pp. 982-994
-
-
Liu, J.1
Ji, W.2
Sun, S.3
Zhang, L.4
Chen, H.G.5
Mao, Y.6
-
59
-
-
0023927618
-
Comparison of growth requirements of two human intratumoral colon carcinoma cell lines in monolayer and soft agarose
-
Boyd D, Levine A, Brattain D, McKnight M, Brattain M. Comparison of growth requirements of two human intratumoral colon carcinoma cell lines in monolayer and soft agarose. Cancer Res 1988; 48: 2469-2474.
-
(1988)
Cancer Res
, vol.48
, pp. 2469-2474
-
-
Boyd, D.1
Levine, A.2
Brattain, D.3
McKnight, M.4
Brattain, M.5
-
60
-
-
85027932009
-
Microrna-192 suppresses liver metastasis of colon cancer
-
Geng L, Chaudhuri A, Talmon G, Wisecarver J, Are C, Brattain M et al. MicroRNA-192 suppresses liver metastasis of colon cancer. Oncogene 2013; 33: 5332-5340.
-
(2013)
Oncogene
, vol.33
, pp. 5332-5340
-
-
Geng, L.1
Chaudhuri, A.2
Talmon, G.3
Wisecarver, J.4
Are, C.5
Brattain, M.6
|