EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex

Nature Communications

Volumn 3, Issue , 2012, Pages

  Li, Guo ^a   Ji, Xiao Dan ^a   Gao, Hong ^a   Zhao, Jiang Sha ^a   Xu, Jun Feng ^a   Sun, Zhi Jian ^a   Deng, Yue Zhen ^a   Shi, Shuo ^a   Feng, Yu Xiong ^a   Zhu, Yin Qiu ^a   Wang, Tao ^b   Li, Jing Jing ^a   Xie, Dong ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; EPHRIN RECEPTOR B3; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; RECEPTOR FOR ACTIVATED C KINASE 1; TUMOR SUPPRESSOR PROTEIN; CELL SURFACE RECEPTOR; GNB2 RS1 PROTEIN, MOUSE; GNB2-RS1 PROTEIN, MOUSE; GNB2L1 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; NEUROPEPTIDE; TUMOR PROTEIN; TYROSINE;

ARTICLE; CELL MIGRATION; DISEASE COURSE; DOWN REGULATION; HUMAN; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; METASTASIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; CANCER TRANSPLANTATION; CELL MOTION; CELL STRAIN HEK293; CHEMISTRY; GENE EXPRESSION REGULATION; LUNG TUMOR; METABOLISM; MOUSE; MUTATION; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; PHOTON;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; LIGANDS; LUNG NEOPLASMS; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MUTATION; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEUROPEPTIDES; PHOSPHORYLATION; PHOTONS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPHB3; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TYROSINE;

EID: 84863262889     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1675     Document Type: Article

References (46)

1. Rosell, R. et al. Optimization of genetics to create therapies for metastatic (stage IV) non-small-cell lung cancer. Expert Opin. Pharmacother. 11, 1683-1693 (2010).
2. Sone, S. & Yano, S. Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone. Cancer Metastasis Rev. 26, 685-689 (2007). (Pubitemid 350115111)
3. Sordella, R., Bell, D. W., Haber, D. A. & Settleman, J. Geftinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305, 1163-1167 (2004). (Pubitemid 39100331)
4. Sequist, L. V., Bell, D. W., Lynch, T. J. & Haber, D. A. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J. Clin. Oncol. 25, 587-595 (2007). (Pubitemid 350002967)
5. Kullander, K. & Klein, R. Mechanisms and functions of Eph and ephrin signalling. Nat. Rev. Mol. Cell Biol. 3, 475-486 (2002). (Pubitemid 34733429)
6. Pasquale, E. B. Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell Biol. 6, 462-475 (2005). (Pubitemid 40780558)
7. Pasquale, E. B. Eph-ephrin bidirectional signaling in physiology and disease. Cell 133, 38-52 (2008). (Pubitemid 351442996)
8. Batlle, E. et al. EphB receptor activity suppresses colorectal cancer progression. Nature 435, 1126-1130 (2005). (Pubitemid 40910522)
9. Ireton, R. C. & Chen, J. EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics. Curr. Cancer Drug Targets 5, 149-157 (2005). (Pubitemid 40694857)
10. Fang, W. B., Brantley-Sieders, D. M., Parker, M. A., Reith, A. D. & Chen, J. A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene 24, 7859-7868 (2005). (Pubitemid 41715192)
11. Noblitt, L. W. et al. Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1. Cancer Gene Ter. 11, 757-766 (2004). (Pubitemid 39488474)
12. Ji, X. D. et al. EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. Cancer Res. 71, 1156-1166 (2011).
13. Ron, D. et al. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc. Natl Acad. Sci. USA 91, 839-843 (1994). (Pubitemid 24048462)
14. McCahill, A., Warwicker, J., Bolger, G. B., Houslay, M. D. & Yarwood, S. J. The RACK1 scafold protein: a dynamic cog in cell response mechanisms. Mol. Pharmacol. 62, 1261-1273 (2002). (Pubitemid 35403822)
15. Sengupta, J. et al. Identifcation of the versatile scafold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nat. Struct. Mol. Biol. 11, 957-962 (2004). (Pubitemid 39315299)
16. Mamidipudi, V. et al. RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints. Oncogene 26, 2914-2924 (2007). (Pubitemid 46701439)
17. Besson, A., Wilson, T. L. & Yong, V. W. The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility. J. Biol. Chem. 277, 22073-22084 (2002). (Pubitemid 34952362)
18. Bhattacharjee, A. et al. Classifcation of human lung carcinomas by mRNA expression profling reveals distinct adenocarcinoma subclasses. Proc. Natl Acad. Sci. USA 98, 13790-13795 (2001). (Pubitemid 33115977)
19. Wybenga-Groot, L. E. et al. Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell 106, 745-757 (2001). (Pubitemid 32900665)
20. Zisch, A. H. et al. Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene 19, 177-187 (2000). (Pubitemid 30077213)
21. Hock, B. et al. Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. Oncogene 17, 255-260 (1998). (Pubitemid 28371900)
22. Egea, J. et al. Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron 47, 515-528 (2005). (Pubitemid 41139210)
23. Bohme, B. et al. Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity. J. Biol. Chem. 271, 24747-24752 (1996). (Pubitemid 26333220)
24. Nilsson, J., Sengupta, J., Frank, J. & Nissen, P. Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep. 5, 1137-1141 (2004). (Pubitemid 40103606)
25. Li, L., Ren, C. H., Tahir, S. A., Ren, C. & Tompson, T. C. Caveolin-1 maintains activated Akt in prostate cancer cells through scafolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol. Cell Biol. 23, 9389-9404 (2003). (Pubitemid 37499824)
26. Chen, C. S., Weng, S. C., Tseng, P. H. & Lin, H. P. Histone acetylation-independent efect of histone deacetylase inhibitors on Akt through the reshufing of protein phosphatase 1 complexes. J. Biol. Chem. 280, 38879-38887 (2005).
27. Cohen, P. T. Protein phosphatase 1-targeted in many directions. J. Cell Sci. 115, 241-256 (2002). (Pubitemid 34145174)
28. Janssens, V., Longin, S. & Goris, J. PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). Trends Biochem. Sci. 33, 113-121 (2008).
29. Beevers, C. S. et al. Curcumin disrupts the mammalian target of rapamycin-raptor complex. Cancer Res. 69, 1000-1008 (2009).
30. Noren, N. K. & Pasquale, E. B. Paradoxes of the EphB4 receptor in cancer. Cancer Res. 67, 3994-3997 (2007). (Pubitemid 46815041)
31. Miao, H. et al. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell 16, 9-20 (2009).
32. Genander, M. et al. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 139, 679-692 (2009).
33. Kumar, S. R. et al. Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. Am. J. Pathol. 169, 279-293 (2006).
34. Noren, N. K., Foos, G., Hauser, C. A. & Pasquale, E. B. The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat. Cell Biol. 8, 815-825 (2006). (Pubitemid 44151584)
35. Clevers, H. & Batlle, E. EphB/EphrinB receptors and Wnt signaling in colorectal cancer. Cancer Res. 66, 2-5 (2006). (Pubitemid 43165998)
36. Huusko, P. et al. Nonsense-mediated decay microarray analysis identifes mutations of EPHB2 in human prostate cancer. Nat. Genet. 36, 979-983 (2004). (Pubitemid 39167494)
37. Astin, J. W. et al. Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells. Nat. Cell Biol. 12, 1194-1204 (2010).
38. Chiu, S. T. et al. Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells. Carcinogenesis 30, 1475-1486 (2009).
39. Qiu, Y. et al. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci. Signal 3, ra7 (2010).
40. Kiely, P. A., O'Gorman, D., Luong, K., Ron, D. & O'Connor, R. Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Mol. Cell Biol. 26, 4041-4051 (2006). (Pubitemid 43788008)
41. De Toni-Costes, F. et al. A New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cells. PLoS One 5, e9807 (2010).
42. Kiely, P. A., Sant, A. & O'Connor, R. RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. J. Biol. Chem. 277, 22581-22589 (2002). (Pubitemid 34967235)
43. He, X., Wang, J., Messing, E. M. & Wu, G. Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness. Oncogene 30, 535-547 (2011).
44. Carles-Kinch, K., Kilpatrick, K. E., Stewart, J. C. & Kinch, M. S. Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior. Cancer Res. 62, 2840-2847 (2002). (Pubitemid 34525769)
45. Wang, Y. et al. Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers. Cancer Res. 67, 2535-2543 (2007). (Pubitemid 46548938)
46. Rui, Y. et al. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23, 4583-4594 (2004). (Pubitemid 39657858)