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Volumn 14, Issue 8, 2015, Pages 3111-3122

Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics

Author keywords

function; Insulin resistance; metabolism; pancreatic islets; proliferation; proteome

Indexed keywords

INSULIN; PROTEOME;

EID: 84938765489     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.5b00587     Document Type: Article
Times cited : (20)

References (72)
  • 1
    • 59149104922 scopus 로고    scopus 로고
    • Growth factor control of pancreatic islet regeneration and function
    • Assmann, A.; Hinault, C.; Kulkarni, R. N. Growth factor control of pancreatic islet regeneration and function Pediatr. Diabetes 2009, 10 (1) 14-32 10.1111/j.1399-5448.2008.00468.x
    • (2009) Pediatr. Diabetes , vol.10 , Issue.1 , pp. 14-32
    • Assmann, A.1    Hinault, C.2    Kulkarni, R.N.3
  • 2
    • 9444242665 scopus 로고    scopus 로고
    • Five stages of evolving beta-cell dysfunction during progression to diabetes
    • Weir, G. C.; Bonner-Weir, S. Five stages of evolving beta-cell dysfunction during progression to diabetes Diabetes 2004, 53 (Suppl 3) S16-S21 10.2337/diabetes.53.suppl-3.S16
    • (2004) Diabetes , vol.53 , pp. 16-S21
    • Weir, G.C.1    Bonner-Weir, S.2
  • 3
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild, S.; Roglic, G.; Green, A.; Sicree, R.; King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 2004, 27, 1047-53 10.2337/diacare.27.5.1047
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 4
    • 50049086521 scopus 로고    scopus 로고
    • The emerging genetic architecture of type 2 diabetes
    • Doria, A.; Patti, M. E.; Kahn, C. R. The emerging genetic architecture of type 2 diabetes Cell Metab. 2008, 8, 186-200 10.1016/j.cmet.2008.08.006
    • (2008) Cell Metab. , vol.8 , pp. 186-200
    • Doria, A.1    Patti, M.E.2    Kahn, C.R.3
  • 7
    • 33846975788 scopus 로고    scopus 로고
    • Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1
    • Buteau, J.; Shlien, A.; Foisy, S.; Accili, D. Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1 J. Biol. Chem. 2007, 282, 287-93 10.1074/jbc.M606118200
    • (2007) J. Biol. Chem. , vol.282 , pp. 287-293
    • Buteau, J.1    Shlien, A.2    Foisy, S.3    Accili, D.4
  • 8
    • 41349117978 scopus 로고    scopus 로고
    • Preservation of beta-cell function by targeting beta-cell mass
    • de Koning, E. J.; Bonner-Weir, S.; Rabelink, T. J. Preservation of beta-cell function by targeting beta-cell mass Trends Pharmacol. Sci. 2008, 29, 218-27 10.1016/j.tips.2008.02.001
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 218-227
    • De Koning, E.J.1    Bonner-Weir, S.2    Rabelink, T.J.3
  • 9
    • 2942560866 scopus 로고    scopus 로고
    • Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders
    • Hansen, J. B.; Arkhammar, P. O.; Bodvarsdottir, T. B.; Wahl, P. Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders Curr. Med. Chem. 2004, 11, 1595-615 10.2174/0929867043365026
    • (2004) Curr. Med. Chem. , vol.11 , pp. 1595-1615
    • Hansen, J.B.1    Arkhammar, P.O.2    Bodvarsdottir, T.B.3    Wahl, P.4
  • 10
    • 84866389264 scopus 로고    scopus 로고
    • Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure
    • Talchai, C.; Xuan, S.; Lin, H. V.; Sussel, L.; Accili, D. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure Cell 2012, 150, 1223-34 10.1016/j.cell.2012.07.029
    • (2012) Cell , vol.150 , pp. 1223-1234
    • Talchai, C.1    Xuan, S.2    Lin, H.V.3    Sussel, L.4    Accili, D.5
  • 11
    • 0031154101 scopus 로고    scopus 로고
    • Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals
    • Jones, C. N.; Pei, D.; Staris, P.; Polonsky, K. S.; Chen, Y. D.; Reaven, G. M. Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals J. Clin. Endocrinol. Metab. 1997, 82, 1834-8 10.1210/jcem.82.6.3979
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1834-1838
    • Jones, C.N.1    Pei, D.2    Staris, P.3    Polonsky, K.S.4    Chen, Y.D.5    Reaven, G.M.6
  • 12
    • 0026573783 scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: Increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion
    • Parsons, J. A.; Brelje, T. C.; Sorenson, R. L. Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion Endocrinology 1992, 130, 1459-66 10.1210/endo.130.3.1537300
    • (1992) Endocrinology , vol.130 , pp. 1459-1466
    • Parsons, J.A.1    Brelje, T.C.2    Sorenson, R.L.3
  • 14
    • 0038155702 scopus 로고    scopus 로고
    • Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
    • Bruning, J. C.; Winnay, J.; Bonner-Weir, S.; Taylor, S. I.; Accili, D.; Kahn, C. R. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles Cell 1997, 88, 561-72 10.1016/S0092-8674(00)81896-6
    • (1997) Cell , vol.88 , pp. 561-572
    • Bruning, J.C.1    Winnay, J.2    Bonner-Weir, S.3    Taylor, S.I.4    Accili, D.5    Kahn, C.R.6
  • 15
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael, M. D.; Kulkarni, R. N.; Postic, C.; Previs, S. F.; Shulman, G. I.; Magnuson, M. A.; Kahn, C. R. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Mol. Cell 2000, 6, 87-97 10.1016/S1097-2765(05)00015-8
    • (2000) Mol. Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3    Previs, S.F.4    Shulman, G.I.5    Magnuson, M.A.6    Kahn, C.R.7
  • 16
    • 0028338940 scopus 로고
    • Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells
    • Chen, C.; Hosokawa, H.; Bumbalo, L. M.; Leahy, J. L. Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells J. Clin. Invest. 1994, 94, 399-404 10.1172/JCI117335
    • (1994) J. Clin. Invest. , vol.94 , pp. 399-404
    • Chen, C.1    Hosokawa, H.2    Bumbalo, L.M.3    Leahy, J.L.4
  • 17
    • 0037131246 scopus 로고    scopus 로고
    • Beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
    • Liu, Y. Q.; Jetton, T. L.; Leahy, J. L. beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats J. Biol. Chem. 2002, 277, 39163-8 10.1074/jbc.M207157200
    • (2002) J. Biol. Chem. , vol.277 , pp. 39163-39168
    • Liu, Y.Q.1    Jetton, T.L.2    Leahy, J.L.3
  • 18
    • 79955427809 scopus 로고    scopus 로고
    • Detection of differential proteomes associated with the development of type 2 diabetes in the Zucker rat model using the iTRAQ technique
    • Han, D.; Moon, S.; Kim, H.; Choi, S. E.; Lee, S. J.; Park, K. S.; Jun, H.; Kang, Y.; Kim, Y. Detection of differential proteomes associated with the development of type 2 diabetes in the Zucker rat model using the iTRAQ technique J. Proteome Res. 2011, 10, 564-77 10.1021/pr100759a
    • (2011) J. Proteome Res. , vol.10 , pp. 564-577
    • Han, D.1    Moon, S.2    Kim, H.3    Choi, S.E.4    Lee, S.J.5    Park, K.S.6    Jun, H.7    Kang, Y.8    Kim, Y.9
  • 19
    • 77449154126 scopus 로고    scopus 로고
    • Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes
    • Lu, H.; Koshkin, V.; Allister, E. M.; Gyulkhandanyan, A. V.; Wheeler, M. B. Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes Diabetes 2010, 59, 448-59 10.2337/db09-0129
    • (2010) Diabetes , vol.59 , pp. 448-459
    • Lu, H.1    Koshkin, V.2    Allister, E.M.3    Gyulkhandanyan, A.V.4    Wheeler, M.B.5
  • 20
    • 50249094538 scopus 로고    scopus 로고
    • The identification of potential factors associated with the development of type 2 diabetes: A quantitative proteomics approach
    • Lu, H.; Yang, Y.; Allister, E. M.; Wijesekara, N.; Wheeler, M. B. The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach Mol. Cell. Proteomics 2008, 7, 1434-51 10.1074/mcp.M700478-MCP200
    • (2008) Mol. Cell. Proteomics , vol.7 , pp. 1434-1451
    • Lu, H.1    Yang, Y.2    Allister, E.M.3    Wijesekara, N.4    Wheeler, M.B.5
  • 21
    • 26844447225 scopus 로고    scopus 로고
    • Differentially expressed proteins in the pancreas of diet-induced diabetic mice
    • Qiu, L.; List, E. O.; Kopchick, J. J. Differentially expressed proteins in the pancreas of diet-induced diabetic mice Mol. Cell. Proteomics 2005, 4, 1311-8 10.1074/mcp.M500016-MCP200
    • (2005) Mol. Cell. Proteomics , vol.4 , pp. 1311-1318
    • Qiu, L.1    List, E.O.2    Kopchick, J.J.3
  • 23
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni, R. N.; Bruning, J. C.; Winnay, J. N.; Postic, C.; Magnuson, M. A.; Kahn, C. R. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes Cell 1999, 96, 329-39 10.1016/S0092-8674(00)80546-2
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 24
    • 0033379267 scopus 로고    scopus 로고
    • Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines
    • Kulkarni, R. N.; Winnay, J. N.; Daniels, M.; Bruning, J. C.; Flier, S. N.; Hanahan, D.; Kahn, C. R. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines J. Clin. Invest. 1999, 104, R69-75 10.1172/JCI8339
    • (1999) J. Clin. Invest. , vol.104 , pp. 69-75
    • Kulkarni, R.N.1    Winnay, J.N.2    Daniels, M.3    Bruning, J.C.4    Flier, S.N.5    Hanahan, D.6    Kahn, C.R.7
  • 26
    • 78149381050 scopus 로고    scopus 로고
    • Improved LC-MS/MS spectral counting statistics by recovering low-scoring spectra matched to confidently identified peptide sequences
    • Zhou, J. Y.; Schepmoes, A. A.; Zhang, X.; Moore, R. J.; Monroe, M. E.; Lee, J. H.; Camp, D. G.; Smith, R. D.; Qian, W. J. Improved LC-MS/MS spectral counting statistics by recovering low-scoring spectra matched to confidently identified peptide sequences J. Proteome Res. 2010, 9, 5698-704 10.1021/pr100508p
    • (2010) J. Proteome Res. , vol.9 , pp. 5698-5704
    • Zhou, J.Y.1    Schepmoes, A.A.2    Zhang, X.3    Moore, R.J.4    Monroe, M.E.5    Lee, J.H.6    Camp, D.G.7    Smith, R.D.8    Qian, W.J.9
  • 27
    • 50149117169 scopus 로고    scopus 로고
    • Spectral probabilities and generating functions of tandem mass spectra: A strike against decoy databases
    • Kim, S.; Gupta, N.; Pevzner, P. A. Spectral probabilities and generating functions of tandem mass spectra: a strike against decoy databases J. Proteome Res. 2008, 7, 3354-63 10.1021/pr8001244
    • (2008) J. Proteome Res. , vol.7 , pp. 3354-3363
    • Kim, S.1    Gupta, N.2    Pevzner, P.A.3
  • 28
    • 0042338362 scopus 로고    scopus 로고
    • A statistical model for identifying proteins by tandem mass spectrometry
    • Nesvizhskii, A. I.; Keller, A.; Kolker, E.; Aebersold, R. A statistical model for identifying proteins by tandem mass spectrometry Anal. Chem. 2003, 75, 4646-58 10.1021/ac0341261
    • (2003) Anal. Chem. , vol.75 , pp. 4646-4658
    • Nesvizhskii, A.I.1    Keller, A.2    Kolker, E.3    Aebersold, R.4
  • 29
    • 33847630405 scopus 로고    scopus 로고
    • Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
    • Elias, J. E.; Gygi, S. P. Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry Nat. Methods 2007, 4, 207-14 10.1038/nmeth1019
    • (2007) Nat. Methods , vol.4 , pp. 207-214
    • Elias, J.E.1    Gygi, S.P.2
  • 31
    • 33646264529 scopus 로고    scopus 로고
    • Advances in proteomics data analysis and display using an accurate mass and time tag approach
    • Zimmer, J. S.; Monroe, M. E.; Qian, W. J.; Smith, R. D. Advances in proteomics data analysis and display using an accurate mass and time tag approach Mass Spectrom. Rev. 2006, 25, 450-82 10.1002/mas.20071
    • (2006) Mass Spectrom. Rev. , vol.25 , pp. 450-482
    • Zimmer, J.S.1    Monroe, M.E.2    Qian, W.J.3    Smith, R.D.4
  • 32
    • 34548136221 scopus 로고    scopus 로고
    • VIPER: An advanced software package to support high-throughput LC-MS peptide identification
    • Monroe, M. E.; Tolic, N.; Jaitly, N.; Shaw, J. L.; Adkins, J. N.; Smith, R. D. VIPER: an advanced software package to support high-throughput LC-MS peptide identification Bioinformatics 2007, 23, 2021-3 10.1093/bioinformatics/btm281
    • (2007) Bioinformatics , vol.23 , pp. 2021-2023
    • Monroe, M.E.1    Tolic, N.2    Jaitly, N.3    Shaw, J.L.4    Adkins, J.N.5    Smith, R.D.6
  • 34
    • 66749156510 scopus 로고    scopus 로고
    • A simple procedure for effective quenching of trypsin activity and prevention of 18O-labeling back-exchange
    • Petritis, B. O.; Qian, W. J.; Camp, D. G., 2nd; Smith, R. D. A simple procedure for effective quenching of trypsin activity and prevention of 18O-labeling back-exchange J. Proteome Res. 2009, 8, 2157-63 10.1021/pr800971w
    • (2009) J. Proteome Res. , vol.8 , pp. 2157-2163
    • Petritis, B.O.1    Qian, W.J.2    Camp, D.G.3    Smith, R.D.4
  • 35
    • 83055182120 scopus 로고    scopus 로고
    • 18O-labeled proteome reference as global internal standards for targeted quantification by selected reaction monitoring-mass spectrometry
    • Kim, J. S.; Fillmore, T. L.; Liu, T.; Robinson, E.; Hossain, M.; Champion, B. L.; Moore, R. J.; Camp, D. G., 2nd; Smith, R. D.; Qian, W. J. 18O-labeled proteome reference as global internal standards for targeted quantification by selected reaction monitoring-mass spectrometry Mol. Cell. Proteomics 2011, 10, M110.007302 10.1074/mcp.M110.007302
    • (2011) Mol. Cell. Proteomics , vol.10 , pp. 110007302
    • Kim, J.S.1    Fillmore, T.L.2    Liu, T.3    Robinson, E.4    Hossain, M.5    Champion, B.L.6    Moore, R.J.7    Camp, D.G.8    Smith, R.D.9    Qian, W.J.10
  • 37
    • 84873573303 scopus 로고    scopus 로고
    • Antibody-free PRISM-SRM for multiplexed protein quantification: Is this the new competition for immunoassays in bioanalysis?
    • Shi, T.; Qian, W. J. Antibody-free PRISM-SRM for multiplexed protein quantification: is this the new competition for immunoassays in bioanalysis? Bioanalysis 2013, 5, 267-9 10.4155/bio.12.336
    • (2013) Bioanalysis , vol.5 , pp. 267-269
    • Shi, T.1    Qian, W.J.2
  • 38
    • 0028335225 scopus 로고
    • Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells
    • Neerman-Arbez, M.; Cirulli, V.; Halban, P. A. Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells Biochem. J. 1994, 300, 57-61
    • (1994) Biochem. J. , vol.300 , pp. 57-61
    • Neerman-Arbez, M.1    Cirulli, V.2    Halban, P.A.3
  • 40
    • 84857975722 scopus 로고    scopus 로고
    • Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
    • Blum, B.; Hrvatin, S. S.; Schuetz, C.; Bonal, C.; Rezania, A.; Melton, D. A. Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3 Nat. Biotechnol. 2012, 30, 261-4 10.1038/nbt.2141
    • (2012) Nat. Biotechnol. , vol.30 , pp. 261-264
    • Blum, B.1    Hrvatin, S.S.2    Schuetz, C.3    Bonal, C.4    Rezania, A.5    Melton, D.A.6
  • 41
    • 84893069305 scopus 로고    scopus 로고
    • SH2B1 in beta cells regulates glucose metabolism by promoting beta cell survival and islet expansion
    • Chen, Z.; Morris, D. L.; Jiang, L.; Liu, Y.; Rui, L. SH2B1 in beta cells regulates glucose metabolism by promoting beta cell survival and islet expansion Diabetes 2014, 63, 585-95 10.2337/db13-0666
    • (2014) Diabetes , vol.63 , pp. 585-595
    • Chen, Z.1    Morris, D.L.2    Jiang, L.3    Liu, Y.4    Rui, L.5
  • 44
    • 79959353420 scopus 로고    scopus 로고
    • Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia
    • Francisco, A. B.; Singh, R.; Sha, H.; Yan, X.; Qi, L.; Lei, X.; Long, Q. Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia J. Biol. Chem. 2011, 286, 22275-82 10.1074/jbc.M111.239418
    • (2011) J. Biol. Chem. , vol.286 , pp. 22275-22282
    • Francisco, A.B.1    Singh, R.2    Sha, H.3    Yan, X.4    Qi, L.5    Lei, X.6    Long, Q.7
  • 46
    • 84856758557 scopus 로고    scopus 로고
    • Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects
    • Riva, M.; Nitert, M. D.; Voss, U.; Sathanoori, R.; Lindqvist, A.; Ling, C.; Wierup, N. Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects Cell Tissue Res. 2011, 346, 393-405 10.1007/s00441-011-1268-5
    • (2011) Cell Tissue Res. , vol.346 , pp. 393-405
    • Riva, M.1    Nitert, M.D.2    Voss, U.3    Sathanoori, R.4    Lindqvist, A.5    Ling, C.6    Wierup, N.7
  • 47
    • 79954581842 scopus 로고    scopus 로고
    • Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis
    • Mak, G. W.; Chan, M. M.; Leong, V. Y.; Lee, J. M.; Yau, T. O.; Ng, I. O.; Ching, Y. P. Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis Cancer Res. 2011, 71, 2949-58 10.1158/0008-5472.CAN-10-4046
    • (2011) Cancer Res. , vol.71 , pp. 2949-2958
    • Mak, G.W.1    Chan, M.M.2    Leong, V.Y.3    Lee, J.M.4    Yau, T.O.5    Ng, I.O.6    Ching, Y.P.7
  • 49
    • 84857457272 scopus 로고    scopus 로고
    • Septins: The fourth component of the cytoskeleton
    • Mostowy, S.; Cossart, P. Septins: the fourth component of the cytoskeleton Nat. Rev. Mol. Cell Biol. 2012, 13, 183-94 10.1038/nrm3284
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 183-194
    • Mostowy, S.1    Cossart, P.2
  • 50
    • 84876104926 scopus 로고    scopus 로고
    • Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription
    • Li, Z.; Hann, S. R. Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription Oncogene 2013, 32, 1988-94 10.1038/onc.2012.227
    • (2013) Oncogene , vol.32 , pp. 1988-1994
    • Li, Z.1    Hann, S.R.2
  • 52
    • 0018830388 scopus 로고
    • A dual population of islets of Langerhans in bovine pancreas
    • Bonner-Weir, S.; Like, A. A. A dual population of islets of Langerhans in bovine pancreas Cell Tissue Res. 1980, 206, 157-70 10.1007/BF00233616
    • (1980) Cell Tissue Res. , vol.206 , pp. 157-170
    • Bonner-Weir, S.1    Like, A.A.2
  • 54
    • 79951591634 scopus 로고    scopus 로고
    • Low insulin content of large islet population is present in situ and in isolated islets
    • Huang, H. H.; Novikova, L.; Williams, S. J.; Smirnova, I. V.; Stehno-Bittel, L. Low insulin content of large islet population is present in situ and in isolated islets Islets 2011, 3, 6-13 10.4161/isl.3.1.14132
    • (2011) Islets , vol.3 , pp. 6-13
    • Huang, H.H.1    Novikova, L.2    Williams, S.J.3    Smirnova, I.V.4    Stehno-Bittel, L.5
  • 55
    • 70349398318 scopus 로고    scopus 로고
    • Beta-cell deterioration during diabetes: Whats in the gun?
    • Robertson, R. P. Beta-cell deterioration during diabetes: whats in the gun? Trends Endocrinol. Metab. 2009, 20, 388-93 10.1016/j.tem.2009.05.004
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 388-393
    • Robertson, R.P.1
  • 56
    • 84885392656 scopus 로고    scopus 로고
    • Chronic high glucose induced INS-1beta cell mitochondrial dysfunction: A comparative mitochondrial proteome with SILAC
    • Chen, X.; Cui, Z.; Wei, S.; Hou, J.; Xie, Z.; Peng, X.; Li, J.; Cai, T.; Hang, H.; Yang, F. Chronic high glucose induced INS-1beta cell mitochondrial dysfunction: a comparative mitochondrial proteome with SILAC Proteomics 2013, 13, 3030-9 10.1002/pmic.201200448
    • (2013) Proteomics , vol.13 , pp. 3030-3039
    • Chen, X.1    Cui, Z.2    Wei, S.3    Hou, J.4    Xie, Z.5    Peng, X.6    Li, J.7    Cai, T.8    Hang, H.9    Yang, F.10
  • 58
    • 78649826295 scopus 로고    scopus 로고
    • High glucose induces dysfunction in insulin secretory cells by different pathways: A proteomic approach
    • Maris, M.; Ferreira, G. B.; DHertog, W.; Cnop, M.; Waelkens, E.; Overbergh, L.; Mathieu, C. High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach J. Proteome Res. 2010, 9, 6274-87 10.1021/pr100557w
    • (2010) J. Proteome Res. , vol.9 , pp. 6274-6287
    • Maris, M.1    Ferreira, G.B.2    DHertog, W.3    Cnop, M.4    Waelkens, E.5    Overbergh, L.6    Mathieu, C.7
  • 62
    • 84878723903 scopus 로고    scopus 로고
    • Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: Down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress
    • Paula, F. M.; Ferreira, S. M.; Boschero, A. C.; Souza, K. L. Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress Mol. Cell. Endocrinol. 2013, 374, 56-64 10.1016/j.mce.2013.04.009
    • (2013) Mol. Cell. Endocrinol. , vol.374 , pp. 56-64
    • Paula, F.M.1    Ferreira, S.M.2    Boschero, A.C.3    Souza, K.L.4
  • 64
    • 84871276716 scopus 로고    scopus 로고
    • Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells
    • van der Meulen, T.; Xie, R.; Kelly, O. G.; Vale, W. W.; Sander, M.; Huising, M. O. Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells PLoS One 2012, 7, e52181 10.1371/journal.pone.0052181
    • (2012) PLoS One , vol.7 , pp. 52181
    • Van Der Meulen, T.1    Xie, R.2    Kelly, O.G.3    Vale, W.W.4    Sander, M.5    Huising, M.O.6
  • 65
    • 34247279657 scopus 로고    scopus 로고
    • Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis
    • Li, C.; Chen, P.; Vaughan, J.; Lee, K. F.; Vale, W. Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 4206-11 10.1073/pnas.0611641104
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 4206-4211
    • Li, C.1    Chen, P.2    Vaughan, J.3    Lee, K.F.4    Vale, W.5
  • 66
    • 0037677695 scopus 로고    scopus 로고
    • Increased islet volume but unchanged islet number in ob/ob mice
    • Bock, T.; Pakkenberg, B.; Buschard, K. Increased islet volume but unchanged islet number in ob/ob mice Diabetes 2003, 52, 1716-22 10.2337/diabetes.52.7.1716
    • (2003) Diabetes , vol.52 , pp. 1716-1722
    • Bock, T.1    Pakkenberg, B.2    Buschard, K.3
  • 67
    • 23944525524 scopus 로고    scopus 로고
    • Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: Evidence for specificity of impaired beta cell adaptation
    • Hull, R. L.; Kodama, K.; Utzschneider, K. M.; Carr, D. B.; Prigeon, R. L.; Kahn, S. E. Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation Diabetologia 2005, 48, 1350-8 10.1007/s00125-005-1772-9
    • (2005) Diabetologia , vol.48 , pp. 1350-1358
    • Hull, R.L.1    Kodama, K.2    Utzschneider, K.M.3    Carr, D.B.4    Prigeon, R.L.5    Kahn, S.E.6
  • 68
    • 84879583340 scopus 로고    scopus 로고
    • Adaptive beta-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression
    • Stamateris, R. E.; Sharma, R. B.; Hollern, D. A.; Alonso, L. C. Adaptive beta-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression Am. J. Physiol Endocrinol Metab 2013, 305, E149-59 10.1152/ajpendo.00040.2013
    • (2013) Am. J. Physiol Endocrinol Metab , vol.305 , pp. 149-159
    • Stamateris, R.E.1    Sharma, R.B.2    Hollern, D.A.3    Alonso, L.C.4
  • 70
    • 34447301769 scopus 로고    scopus 로고
    • Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma
    • Stav, D.; Bar, I.; Sandbank, J. Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma IInt. J. Biol. Markers 2007, 22, 108-13
    • (2007) IInt. J. Biol. Markers , vol.22 , pp. 108-113
    • Stav, D.1    Bar, I.2    Sandbank, J.3
  • 71
    • 84862734144 scopus 로고    scopus 로고
    • Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation
    • Tagaya, Y.; Miura, A.; Okada, S.; Ohshima, K.; Mori, M. Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation Endocrinology 2012, 153, 3308-19 10.1210/en.2011-2154
    • (2012) Endocrinology , vol.153 , pp. 3308-3319
    • Tagaya, Y.1    Miura, A.2    Okada, S.3    Ohshima, K.4    Mori, M.5
  • 72
    • 79551697659 scopus 로고    scopus 로고
    • The role of eIF5A in epidermal growth factor-induced proliferation of corneal epithelial cell association with PI3-k/Akt activation
    • Ding, L.; Gao, L. J.; Gu, P. Q.; Guo, S. Y.; Cai, Y. Q.; Zhou, X. T. The role of eIF5A in epidermal growth factor-induced proliferation of corneal epithelial cell association with PI3-k/Akt activation Mol. Vision 2011, 17, 16-22
    • (2011) Mol. Vision , vol.17 , pp. 16-22
    • Ding, L.1    Gao, L.J.2    Gu, P.Q.3    Guo, S.Y.4    Cai, Y.Q.5    Zhou, X.T.6


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