Alterations in the Glucose-Stimulated Insulin Secretory Dose-Response Curve and in Insulin Clearance in Nondiabetic Insulin-Resistant Individuals

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 6, 1997, Pages 1834-1838

  Jones, Clare N O ^b   Pei, Dee ^b   Staris, Patricia ^b   Polonsky, Kenneth S ^b   Chen, Y D Ida ^b   Reaven, Gerald M ^a  

^a Shaman Pharmaceuticals Inc   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; BLOOD; CLINICAL TRIAL; DOSE RESPONSE; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; METABOLIC CLEARANCE RATE; METABOLISM; MIDDLE AGED; OSMOLARITY;

ADULT; BLOOD GLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; METABOLIC CLEARANCE RATE; MIDDLE AGED; OSMOLAR CONCENTRATION;

EID: 0031154101     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.6.3979     Document Type: Article

References (22)

1. Hollenbeck CB, Chen N, Chen Y-DI, Reaven GM. 1984 Relationship between the plasma insulin response to oral glucose and insulin-stimulated glucose utilization in normal subjects. Diabetes. 33:460-463.
2. Hollenbeck C, Reaven GM. 1987 Variations in insulin-stimulated glucose uptake in healthy individuals with normal oral glucose tolerance. J Clin Endocrinol Metab. 64:1169-1173.
3. Reaven GM, Brand RJ, Chen Y-D, et al. 1993 Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals. Diabetes. 42:1324-1332.
4. Byrne MM, Sturis J, Polonsky KS. 1995 Insulin secretion and clearance during low-close graded glucose infusion. Am J Physiol. 268:E21-E27.
5. Byrne MM, Sturis J, Clement K, et al. 1994 Insulin secretion abnormalities in subjects with hyperglycemia due to glucokinase mutations. J Clin Invest. 93:1120-1130.
6. Kadish AH, Litle RL, Sternberg JC. 1968 A new and rapid method for the determination of glucose by measurement of rate of oxygen consumption. Clin Chem. 14:116-131.
7. Hales CH, Randle PJ. 1963 Immunoassay of insulin and insulin-antibody precipitate. Biochem J. 88:137-146.
8. National Diabetes Data Group. 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
9. Harano Y, Hidaka H, Takatsuki K, et al. 1978 Glucose, insulin and somatostatin infusion for determination of insulin sensitivity in vivo. Metabolism. 27:1449-1459.
10. Shen S-W, Reaven GM, Farquar J. 1970 Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest. 49:2151-2150.
11. Polonsky KS, Licinio-Paixao J, Given BD, et al. 1986 Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest. 77:98-105.
12. Van Cauter E, Mestrez F, Sturis J, et al. 1992 Estimation of insulin secretion rates from C-peptide levels-comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes. 41:368-377.
13. Polonsky KS, Given BD, Hirsch L, et al. 1987 Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest. 81:435-441.
14. Pilo A, Navalesi R, Ferrannini E. 1976 Insulin kinetics after portal and peripheral injection of I-insulin. Data analysis and modeling. Am J Physiol. 230:1626-1629.
15. Ferrannini E, Wahren J, Faber OK, et al. 1983 Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. Am J Physiol. 244:E517-E527.
16. Zawalich W, Maturo S, Felig P. 1982 Influence of physical training on insulin release and glucose utilization by islet cells and liver glucokinase activity in the rat. Am J Physiol. 6:E464-E469.
17. Mikines KJ, Sonne B, Tronier B, Galbo H. 1989 Effects of training and detraining on dose-response relationship between glucose and insulin secretion. Am J Physiol. 256:E588-E596.
18. Pigon J, Karlsson J, Ostenson C-G. 1994 Physical fitness and insulin sensitivity in human subjects with a low insulin response to glucose. Clin Sci. 87:187-192.
19. Haffner SM, Stern MP, Watanbe RM, et al. 1992 Relationship of insulin clearance and secretion to insulin sensitivity in non-diabetic Mexican Americans. Eur J Clin Invest. 22:147-153.
20. Osei K, Schuster DP. 1994 Ethnic differences in secretion, sensitivity, and hepatic extraction of insulin in black and white Americans. Diabetes Med. 11:753-762.
21. Cozzolino D, Sessa G, Salvatore T, et al. 1995 Hyperinsulinemia in offspring of non-insulin-dependent diabetes mellitus patients: the role played by abnormal clearance of insulin. Metabolism. 44:1278-1282.
22. Meistas MT, Margolis S, Kowarski AA. 1983 Hyperinsulinemia of obesity is due to decreased clearance of insulin. Am J Physiol. 245:E155-E159.