Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects

Cell and Tissue Research

Volumn 346, Issue 3, 2011, Pages 393-405

  Riva, Matteo ^a   Nitert, Marloes Dekker ^a   Voss, Ulrikke ^a   Sathanoori, Ramasri ^a   Lindqvist, Andreas ^a   Ling, Charlotte ^a   Wierup, Nils ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Human islets; Immunochemistry; In situ hybridization; Regulatory peptide; Rodent islets

Indexed keywords

GLUCAGON; INSULIN; MESSENGER RNA; NESFATIN 1; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION REGULATION; GLUCAGON RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; LIPOTOXICITY; MALE; MICROARRAY ANALYSIS; MOLECULAR PHYLOGENY; MOUSE; N TERMINAL PART OF NUCLEOBINDIN 2 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CALCIUM-BINDING PROTEINS; DIABETES MELLITUS, TYPE 2; DNA-BINDING PROTEINS; FEMALE; GLUCAGON; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

MUS; RATTUS; RODENTIA;

EID: 84856758557     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-011-1268-5     Document Type: Article

References (27)

1. Brailoiu GC, Dun SL, Brailoiu E, Inan S, Yang J, Chang JK, Dun NJ (2007) Nesfatin-1: distribution and interaction with a G proteincoupled receptor in the rat brain. Endocrinology 148:5088-5094 (Pubitemid 47481535)
2. Foo KS, Brauner H, Ostenson CG, Broberger C (2010) Nucleobindin- 2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. J Endocrinol 204:255-263
3. Gonzalez R, Perry RL, Gao X, Gaidhu MP, Tsushima RG, Ceddia RB, Unniappan S (2011a) Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats. Endocrinology 152:3628-3637
4. Gonzalez R, Reingold BK, Gao X, Gaidhu MP, Tsushima RG, Unniappan S (2011b) Nesfatin-1 exerts a direct, glucosedependent insulinotropic action on mouse islet beta- and MIN6 cells. J Endocrinol 208:R9-R16
5. Gonzalez R, Tiwari A, Unniappan S (2009) Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents. Biochem Biophys Res Commun 381:643-648
6. Gromada J, Franklin I, Wollheim CB (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 28:84-116 (Pubitemid 46220851)
7. Hohmeier HE, Mulder H, Chen G, Henkel-Rieger R, Prentki M, Newgard CB (2000) Isolation of INS-1-derived cell lines with robust ATP-sensitive K+channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes 49:424-430 (Pubitemid 30131788)
8. Iwasaki Y, Nakabayashi H, Kakei M, Shimizu H, Mori M, Yada T (2009) Nesfatin-1 evokes Ca(2+) signaling in isolated vagal afferent neurons via Ca(2+) influx through N-type channels. Biochem Biophys Res Commun 390:958-962
9. Li QC, Wang HY, Chen X, Guan HZ, Jiang ZY (2010) Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regul Pept 159:72-77
10. Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spegel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M, Altshuler D, Sundler F, Eriksson JG, Jackson AU, Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L (2009) Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41:82-88
11. Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, Oh IS, Hashimoto K, Shimizu H, Nakata M, Mori M, Yada T (2009) Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab 10:355-365
12. Mulder H, Lindh AC, Sundler F (1993) Islet amyloid polypeptide gene expression in the endocrine pancreas of the rat: a combined in situ hybridization and immunocytochemical study. Cell Tissue Res 274:467-474 (Pubitemid 23339235)
13. Nakata M, Manaka K, Yamamoto S, Mori M, Yada T (2011) Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet beta-cells. Endocr J (in press)
14. Oh IS, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, Tsuchiya T, Monden T, Horiguchi K, Yamada M, Mori M (2006) Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 443:709-712 (Pubitemid 44564715)
15. Pan W, Hsuchou H, Kastin AJ (2007) Nesfatin-1 crosses the bloodbrain barrier without saturation. Peptides 28:2223-2228 (Pubitemid 47600423)
16. Price TO, Samson WK, Niehoff ML, Banks WA (2007) Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Peptides 28:2372-2381 (Pubitemid 350123562)
17. Ramanjaneya M, Chen J, Brown JE, Tripathi G, Hallschmid M, Patel S, Kern W, Hillhouse EW, Lehnert H, Tan BK, Randeva HS (2010) Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology 151:3169-3180
18. Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, Groop L, Rorsman P, Salehi A, Lyssenko V, Luthman H, Renstrom E (2010) Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science 327:217-220
19. Shimizu H, Oh IS, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M (2009a) Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology 150:662-671
20. Shimizu H, Oh IS, Okada S, Mori M (2009b) Nesfatin-1: an overview and future clinical application. Endocr J 56:537-543
21. Stengel A, Goebel M, Wang L, Tache Y (2010) Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight. Peptides 31:357-369
22. Stengel A, Goebel M, Yakubov I, Wang L, Witcher D, Coskun T, Tache Y, Sachs G, Lambrecht NW (2009) Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 150:232-238
23. Wierup N, Björkqvist M, Weström B, Pierzynowski S, Sundler F, Sjölund K (2007) Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine. J Clin Endocrinol Metab 92:3573-3581 (Pubitemid 47435337)
24. Wierup N, Richards WG, Bannon AW, Kuhar MJ, Ahren B, Sundler F (2005) CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight. Regul Pept 129:203-211 (Pubitemid 40775804)
25. Wierup N, Svensson H, Mulder H, Sundler F (2002) The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 107:63-69 (Pubitemid 34876446)
26. Wierup N, Yang S, McEvilly RJ, Mulder H, Sundler F (2004) Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells. J Histochem Cytochem 52:301-310 (Pubitemid 38229096)
27. Voss U, Riva M, Nitert M, Ling C, Lindqvist A, Wierup N (2010) Nesfatin-1 stimulates insulin secretion, inhibits glucagon secretion and is expressed in human and rodent beta cells. 46th Annual Meeting of the European Association for the Study of Diabetes (EASD), Stockholm, Sweden, Sep 20-24, 2010