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Volumn 15, Issue 6, 2014, Pages 9579-9593

Differential proteomic analysis of the pancreas of diabetic db/db mice reveals the proteins involved in the development of complications of diabetes mellitus

Author keywords

db db mice; Diabetes mellitus; Interactome; Obesity; Pancreas; Proteomics

Indexed keywords

ALPHA AMYLASE PANCREAS ISOENZYME; AMYLASE; ASPARTYL AMINOPEPTIDASE; CARBOXYPEPTIDASE A; CHYMOTRYPSINOGEN; CYTOCHROME B5; GLYCOPROTEIN GP 96; KALLIKREIN; LITHOSTATHINE; PEROXIREDOXIN 4; PHOSPHOGLYCERATE MUTASE; TRYPSIN; TUMOR NECROSIS FACTOR; VALOSIN CONTAINING PROTEIN; PROTEOME;

EID: 84901753501     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15069579     Document Type: Article
Times cited : (17)

References (58)
  • 1
    • 79957563251 scopus 로고    scopus 로고
    • Endocrine disruptors in the etiology of type 2 diabetes mellitus
    • Alonso-Magdalena, P.; Quesada, I.; Nadal, A. Endocrine disruptors in the etiology of type 2 diabetes mellitus. Nat. Rev. Endocrinol. 2011, 7, 346-353.
    • (2011) Nat. Rev. Endocrinol. , vol.7 , pp. 346-353
    • Alonso-Magdalena, P.1    Quesada, I.2    Nadal, A.3
  • 2
    • 79960202841 scopus 로고    scopus 로고
    • Type 2 diabetes across generations: From pathophysiology to prevention and management
    • Nolan, C.J.; Damm, P.; Prentki, M. Type 2 diabetes across generations: From pathophysiology to prevention and management. Lancet 2011, 378, 169-181.
    • (2011) Lancet , vol.378 , pp. 169-181
    • Nolan, C.J.1    Damm, P.2    Prentki, M.3
  • 3
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath, M.Y.; Shoelson, S.E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 2011, 11, 98-107.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 4
    • 79953752197 scopus 로고    scopus 로고
    • Use of mouse models in studying type 2 diabetes mellitus
    • doi:10.1017/S1462399410001729
    • Lee, A.W.; Cox, R.D. Use of mouse models in studying type 2 diabetes mellitus. Expert. Rev. Mol. Med. 2011, 13, doi:10.1017/S1462399410001729.
    • (2011) Expert. Rev. Mol. Med. , vol.13
    • Lee, A.W.1    Cox, R.D.2
  • 7
    • 26844447225 scopus 로고    scopus 로고
    • Differentially expressed proteins in the pancreas of diet-induced diabetic mice
    • Qiu, L.; List, E.O.; Kopchick, J.J. Differentially expressed proteins in the pancreas of diet-induced diabetic mice. Mol. Cell Proteomics 2005, 4, 1311-1318.
    • (2005) Mol. Cell Proteomics , vol.4 , pp. 1311-1318
    • Qiu, L.1    List, E.O.2    Kopchick, J.J.3
  • 9
    • 16844382825 scopus 로고    scopus 로고
    • Glucose-induced changes of multiple mouse islet proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry
    • Ahmed, M.; Bergsten, P. Glucose-induced changes of multiple mouse islet proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry. Diabetologia 2005, 48, 477-485.
    • (2005) Diabetologia , vol.48 , pp. 477-485
    • Ahmed, M.1    Bergsten, P.2
  • 10
    • 79951978559 scopus 로고    scopus 로고
    • Hyperlipidemic versus healthy pancreases: A proteomic analysis using an animal model
    • Zhang, W.; Wang, X.P.; Yu, Z.W.; Wang, L.S.; Zhu, Y.; Yu, X.F.; Wu, K.; Zeng, Y.; Xu, M.Y. Hyperlipidemic versus healthy pancreases: A proteomic analysis using an animal model. IUBMB Life 2010, 62, 781-789.
    • (2010) IUBMB Life , vol.62 , pp. 781-789
    • Zhang, W.1    Wang, X.P.2    Yu, Z.W.3    Wang, L.S.4    Zhu, Y.5    Yu, X.F.6    Wu, K.7    Zeng, Y.8    Xu, M.Y.9
  • 11
    • 84857915698 scopus 로고    scopus 로고
    • Hyperlipidemic versus normal-lipid acute necrotic pancreatitis: Proteomic analysis using an animal model
    • Zhang, W.; Zhao, Y.; Zeng, Y.; Yu, X.; Yao, J.; Zhao, S.; Bao, Z.; Chen, J.; Wang, X. Hyperlipidemic versus normal-lipid acute necrotic pancreatitis: Proteomic analysis using an animal model. Pancreas 2012, 41, 317-322.
    • (2012) Pancreas , vol.41 , pp. 317-322
    • Zhang, W.1    Zhao, Y.2    Zeng, Y.3    Yu, X.4    Yao, J.5    Zhao, S.6    Bao, Z.7    Chen, J.8    Wang, X.9
  • 12
    • 84875546392 scopus 로고    scopus 로고
    • Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling
    • Mathew, J.; Loranger, A.; Gilbert, S.; Faure, R.; Marceau, N. Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling. Exp. Cell Res. 2013, 319, 474-486.
    • (2013) Exp. Cell Res. , vol.319 , pp. 474-486
    • Mathew, J.1    Loranger, A.2    Gilbert, S.3    Faure, R.4    Marceau, N.5
  • 13
    • 84874405179 scopus 로고    scopus 로고
    • Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes
    • Hinder, L.M.; Vivekanandan-Giri, A.; McLean, L.L.; Pennathur, S.; Feldman, E.L. Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes. J. Endocrinol. 2013, 216, 1-11.
    • (2013) J. Endocrinol. , vol.216 , pp. 1-11
    • Hinder, L.M.1    Vivekanandan-Giri, A.2    McLean, L.L.3    Pennathur, S.4    Feldman, E.L.5
  • 16
    • 78649454844 scopus 로고    scopus 로고
    • Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation
    • doi:10.1371/journal.pone.0009923
    • Folli, F.; Guzzi, V.; Perego, L.; Coletta, D.K.; Finzi, G.; Placidi, C.; La Rosa, S.; Capella, C.; Socci, C.; Lauro, D.; et al. Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation. PLoS One 2010, 5, doi:10.1371/journal.pone.0009923.
    • (2010) PLoS One , vol.5
    • Folli, F.1    Guzzi, V.2    Perego, L.3    Coletta, D.K.4    Finzi, G.5    Placidi, C.6    La Rosa, S.7    Capella, C.8    Socci, C.9    Lauro, D.10
  • 18
    • 84876793165 scopus 로고    scopus 로고
    • Insulin resistance of protein metabolism in type 2 diabetes and impact on dietary needs: A review
    • Gougeon, R. Insulin resistance of protein metabolism in type 2 diabetes and impact on dietary needs: A review. Can. J. Diabetes 2013, 37, 115-120.
    • (2013) Can. J. Diabetes , vol.37 , pp. 115-120
    • Gougeon, R.1
  • 20
    • 0026344743 scopus 로고
    • Characterization of secretory responses in exocrine pancreas of genetically obese zucker rats
    • Habara, Y.; Uehara, A.; Takasugi, Y.; Namiki, M.; Kanno, T. Characterization of secretory responses in exocrine pancreas of genetically obese zucker rats. Int. J. Pancreatol. 1991, 10, 237-245.
    • (1991) Int. J. Pancreatol. , vol.10 , pp. 237-245
    • Habara, Y.1    Uehara, A.2    Takasugi, Y.3    Namiki, M.4    Kanno, T.5
  • 23
    • 0036833421 scopus 로고    scopus 로고
    • Pancreatic elastase IIIa and its variants are expressed in pancreatic carcinoma cells
    • Shimada, S.; Yamaguchi, K.; Takahashi, M.; Ogawa, M. Pancreatic elastase IIIa and its variants are expressed in pancreatic carcinoma cells. Int. J. Mol. Med. 2002, 10, 599-603.
    • (2002) Int. J. Mol. Med. , vol.10 , pp. 599-603
    • Shimada, S.1    Yamaguchi, K.2    Takahashi, M.3    Ogawa, M.4
  • 25
    • 34249781156 scopus 로고    scopus 로고
    • Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphateactivated protein kinase signaling pathways
    • Yuan, G.; Deng, J.; Wang, T.; Zhao, C.; Xu, X.; Wang, P.; Voltz, J.W.; Edin, M.L.; Xiao, X.; Chao, L.; et al. Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphateactivated protein kinase signaling pathways. Endocrinology 2007, 148, 2016-2026.
    • (2007) Endocrinology , vol.148 , pp. 2016-2026
    • Yuan, G.1    Deng, J.2    Wang, T.3    Zhao, C.4    Xu, X.5    Wang, P.6    Voltz, J.W.7    Edin, M.L.8    Xiao, X.9    Chao, L.10
  • 27
    • 1642413540 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic β cells
    • Nozaki, J.; Kubota, H.; Yoshida, H.; Naitoh, M.; Goji, J.; Yoshinaga, T.; Mori, K.; Koizumi, A.; Nagata, K. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic β cells. Genes Cells 2004, 9, 261-270.
    • (2004) Genes Cells , vol.9 , pp. 261-270
    • Nozaki, J.1    Kubota, H.2    Yoshida, H.3    Naitoh, M.4    Goji, J.5    Yoshinaga, T.6    Mori, K.7    Koizumi, A.8    Nagata, K.9
  • 28
    • 79957689114 scopus 로고    scopus 로고
    • ER stress is implicated in mitochondrial dysfunctioninduced apoptosis of pancreatic β cells
    • Lee, J.W.; Kim, W.H.; Yeo, J.; Jung, M.H. ER stress is implicated in mitochondrial dysfunctioninduced apoptosis of pancreatic β cells. Mol. Cells 2010, 30, 545-549.
    • (2010) Mol. Cells , vol.30 , pp. 545-549
    • Lee, J.W.1    Kim, W.H.2    Yeo, J.3    Jung, M.H.4
  • 29
    • 84866349146 scopus 로고    scopus 로고
    • Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes
    • Sims-Robinson, C.; Zhao, S.; Hur, J.; Feldman, E.L. Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes. Diabetologia 2012, 55, 2276-2284.
    • (2012) Diabetologia , vol.55 , pp. 2276-2284
    • Sims-Robinson, C.1    Zhao, S.2    Hur, J.3    Feldman, E.L.4
  • 30
    • 33750528166 scopus 로고    scopus 로고
    • Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells
    • Wojcik, C.; Rowicka, M.; Kudlicki, A.; Nowis, D.; McConnell, E.; Kujawa, M.; DeMartino, G.N. Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells. Mol. Biol. Cell 2006, 17, 4606-4618.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 4606-4618
    • Wojcik, C.1    Rowicka, M.2    Kudlicki, A.3    Nowis, D.4    McConnell, E.5    Kujawa, M.6    DeMartino, G.N.7
  • 31
    • 77949281428 scopus 로고    scopus 로고
    • Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome
    • Dreja, T.; Jovanovic, Z.; Rasche, A.; Kluge, R.; Herwig, R.; Tung, Y.C.; Joost, H.G.; Yeo, G.S.; Al-Hasani, H. Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome. Diabetologia 2010, 53, 309-320.
    • (2010) Diabetologia , vol.53 , pp. 309-320
    • Dreja, T.1    Jovanovic, Z.2    Rasche, A.3    Kluge, R.4    Herwig, R.5    Tung, Y.C.6    Joost, H.G.7    Yeo, G.S.8    Al-Hasani, H.9
  • 33
    • 77957727460 scopus 로고    scopus 로고
    • Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice
    • Ding, Y.; Yamada, S.; Wang, K.Y.; Shimajiri, S.; Guo, X.; Tanimoto, A.; Murata, Y.; Kitajima, S.; Watanabe, T.; Izumi, H.; et al. Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice. Antioxid. Redox Signal 2010, 13, 1477-1490.
    • (2010) Antioxid. Redox Signal , vol.13 , pp. 1477-1490
    • Ding, Y.1    Yamada, S.2    Wang, K.Y.3    Shimajiri, S.4    Guo, X.5    Tanimoto, A.6    Murata, Y.7    Kitajima, S.8    Watanabe, T.9    Izumi, H.10
  • 34
    • 77955359156 scopus 로고    scopus 로고
    • 2 produced during disulphide formation
    • 2 produced during disulphide formation. J. Cell Sci. 2010, 123, 2672-2679.
    • (2010) J. Cell Sci. , vol.123 , pp. 2672-2679
    • Tavender, T.J.1    Bulleid, N.J.2
  • 35
    • 84874406268 scopus 로고    scopus 로고
    • Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis
    • Liu, Y.; Turdi, S.; Park, T.; Morris, N.J.; Deshaies, Y.; Xu, A.; Sweeney, G. Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis. Diabetes 2013, 62, 743-752.
    • (2013) Diabetes , vol.62 , pp. 743-752
    • Liu, Y.1    Turdi, S.2    Park, T.3    Morris, N.J.4    Deshaies, Y.5    Xu, A.6    Sweeney, G.7
  • 37
    • 67349123432 scopus 로고    scopus 로고
    • Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver
    • Gupte, R.S.; Floyd, B.C.; Kozicky, M.; George, S.; Ungvari, Z.I.; Neito, V.; Wolin, M.S.; Gupte, S.A. Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Free Radic. Biol. Med. 2009, 47, 219-228.
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 219-228
    • Gupte, R.S.1    Floyd, B.C.2    Kozicky, M.3    George, S.4    Ungvari, Z.I.5    Neito, V.6    Wolin, M.S.7    Gupte, S.A.8
  • 38
    • 84857047370 scopus 로고    scopus 로고
    • Effects of laparoscopic Roux-en-Y gastric bypass on glucose-6 phosphate dehydrogenase activity in obese type 2 diabetics
    • Schneider, A.M.; Rawat, D.; Weinstein, L.S.; Gupte, S.A.; Richards, W.O. Effects of laparoscopic Roux-en-Y gastric bypass on glucose-6 phosphate dehydrogenase activity in obese type 2 diabetics. Surg. Endosc. 2012, 26, 823-830.
    • (2012) Surg. Endosc. , vol.26 , pp. 823-830
    • Schneider, A.M.1    Rawat, D.2    Weinstein, L.S.3    Gupte, S.A.4    Richards, W.O.5
  • 39
    • 84874265819 scopus 로고    scopus 로고
    • Obesity and endoplasmic reticulum (ER) stresses
    • Tripathi, Y.B.; Pandey, V. Obesity and endoplasmic reticulum (ER) stresses. Front. Immunol. 2012, 3, 240.
    • (2012) Front. Immunol. , vol.3 , pp. 240
    • Tripathi, Y.B.1    Pandey, V.2
  • 40
    • 67049172152 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response and aging
    • Naidoo, N. The endoplasmic reticulum stress response and aging. Rev. Neurosci. 2009, 20, 23-37.
    • (2009) Rev. Neurosci. , vol.20 , pp. 23-37
    • Naidoo, N.1
  • 41
    • 80055115839 scopus 로고    scopus 로고
    • Type 2 diabetes and the aging pancreatic β cell
    • Gunasekaran, U.; Gannon, M. Type 2 diabetes and the aging pancreatic β cell. Aging 2011, 3, 565-575.
    • (2011) Aging , vol.3 , pp. 565-575
    • Gunasekaran, U.1    Gannon, M.2
  • 42
    • 0034990329 scopus 로고    scopus 로고
    • Detection and identification of subcutaneous adipose tissue protein related to obesity in New Zealand obese mouse
    • Takahashi, H.; Oh-Ishi, M.; Shimizu, H.; Mori, M. Detection and identification of subcutaneous adipose tissue protein related to obesity in New Zealand obese mouse. Endocr. J. 2001, 48, 205-211.
    • (2001) Endocr. J. , vol.48 , pp. 205-211
    • Takahashi, H.1    Oh-Ishi, M.2    Shimizu, H.3    Mori, M.4
  • 43
    • 79957987902 scopus 로고    scopus 로고
    • State of the union between metabolism and the immune system in type 2 diabetes
    • Nikolajczyk, B.S.; Jagannathan-Bogdan, M.; Shin, H.; Gyurko, R. State of the union between metabolism and the immune system in type 2 diabetes. Genes Immun. 2011, 12, 239-250.
    • (2011) Genes Immun. , vol.12 , pp. 239-250
    • Nikolajczyk, B.S.1    Jagannathan-Bogdan, M.2    Shin, H.3    Gyurko, R.4
  • 44
    • 84867798919 scopus 로고    scopus 로고
    • Cells of innate and adaptive immunity in type 2 diabetes and obesity
    • Guzman-Flores, J.M.; Lopez-Briones, S. Cells of innate and adaptive immunity in type 2 diabetes and obesity. Gac. Med. Mex. 2012, 148, 381-389.
    • (2012) Gac. Med. Mex. , vol.148 , pp. 381-389
    • Guzman-Flores, J.M.1    Lopez-Briones, S.2
  • 45
    • 67650434290 scopus 로고    scopus 로고
    • Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes
    • Keel, M.; Harter, L.; Reding, T.; Sun, L.K.; Hersberger, M.; Seifert, B.; Bimmler, D.; Graf, R. Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes. Crit. Care Med. 2009, 37, 1642-1648.
    • (2009) Crit. Care Med. , vol.37 , pp. 1642-1648
    • Keel, M.1    Harter, L.2    Reding, T.3    Sun, L.K.4    Hersberger, M.5    Seifert, B.6    Bimmler, D.7    Graf, R.8
  • 48
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang D.W.; Sherman, B.T.; Lempicki, R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 2009, 4, 44-57.
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 49
    • 84892646801 scopus 로고    scopus 로고
    • Unfolded protein response signaling and metabolic diseases
    • Lee, J.; Ozcan, U. Unfolded protein response signaling and metabolic diseases. J. Biol. Chem. 2014, 289, 1203-1211.
    • (2014) J. Biol. Chem. , vol.289 , pp. 1203-1211
    • Lee, J.1    Ozcan, U.2
  • 50
    • 84861905329 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and type 2 diabetes
    • Back, S.H.; Kaufman, R.J. Endoplasmic reticulum stress and type 2 diabetes. Annu. Rev. Biochem. 2012, 81, 767-793.
    • (2012) Annu. Rev. Biochem. , vol.81 , pp. 767-793
    • Back, S.H.1    Kaufman, R.J.2
  • 51
    • 84879459608 scopus 로고    scopus 로고
    • Inflammation, cytokines and insulin resistance: A clinical perspective
    • Wieser, V.; Moschen, A.R.; Tilg, H. Inflammation, cytokines and insulin resistance: A clinical perspective. Arch. Immunol. Ther. Exp. 2013, 61, 119-125.
    • (2013) Arch. Immunol. Ther. Exp. , vol.61 , pp. 119-125
    • Wieser, V.1    Moschen, A.R.2    Tilg, H.3
  • 52
    • 84883530920 scopus 로고    scopus 로고
    • Macrophages and islet inflammation in type 2 diabetes
    • Eguchi, K.; Manabe, I. Macrophages and islet inflammation in type 2 diabetes. Diabetes Obes. Metab. 2013, 15, 152-158.
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 152-158
    • Eguchi, K.1    Manabe, I.2
  • 53
    • 0032832391 scopus 로고    scopus 로고
    • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for the mouse leptin receptor (Lepr(db) mutation
    • Horvat, S.; Bunger, L. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for the mouse leptin receptor (Lepr(db) mutation. Lab. Anim. 1999, 33, 380-384.
    • (1999) Lab. Anim. , vol.33 , pp. 380-384
    • Horvat, S.1    Bunger, L.2
  • 56
    • 0033434080 scopus 로고    scopus 로고
    • Probability-based protein identification by searching sequence databases using mass spectrometry data
    • Perkins, D.N.; Pappin, D.J.; Creasy, D.M.; Cottrell, J.S. Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 1999, 20, 3551-3567.
    • (1999) Electrophoresis , vol.20 , pp. 3551-3567
    • Perkins, D.N.1    Pappin, D.J.2    Creasy, D.M.3    Cottrell, J.S.4
  • 57
    • 58149191270 scopus 로고    scopus 로고
    • The universal protein resource (uniprot) 2009
    • UniProt Consortium. The universal protein resource (uniprot) 2009. Nucleic Acids Res. 2009, 37, D169-D174.
    • (2009) Nucleic Acids Res. , vol.37
  • 58
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang D.W.; Sherman, B.T.; Lempicki, R.A. Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009, 37, 1-13.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1-13
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3


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