Small human islets comprised of more β-cells with higher insulin content than large islets

Islets

Volumn 5, Issue 2, 2013, Pages 87-94

  Farhat, Bilal ^a   Almelkar, Akshay ^b   Ramachandran, Karthik ^b,c   Williams, S Janette ^a   Huang, Han Hung ^d   Zamierowski, David ^b   Novikova, Lesya ^b   Stehno Bittel, Lisa ^b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c Likarda LLC   (United States)

^d ANGELO STATE UNIVERSITY   (United States)

Author keywords

Blood vessels; Glucagon; Human; Insulin; Islet morphology; Islets; Lymphatics; cell; cell

Indexed keywords

GLUCAGON; INSULIN;

ARTICLE; CELL COMPOSITION; CELL DENSITY; CELL VIABILITY; ENDOCRINE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; PANCREAS ISLET BETA CELL;

EID: 84879396514     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.24780     Document Type: Article

References (23)

1. Bloomfield AL. A bibliography of internal medicine; diabetes mellitus-from Rollo (1798) to Banting (1921). AMA Arch Intern Med 1958; 101:1159-71; PMID:13532070; http://dx.doi.org/10.1001/archinte.1958. 00260180149017
2. Haist R, Pugh E. Volume measurements of the Islets of Langerhans and the effects of age and fasting. Am J Physiol 1947; 152:36-41
3. Bonnevie-Nielsen V, Skovgaard LT. Pancreatic islet volume distribution: direct measurement in preparations stained by perfusion in situ. Acta Endocrinol (Copenh) 1984; 105:379-84; PMID:6199936 (Pubitemid 14193128)
4. Aizawa T, Kaneko T, Yamauchi K, Yajima H, Nishizawa T, Yada T, et al. Size-related and size-unrelated functional heterogeneity among pancreatic islets. Life Sci 2001; 69:2627-39; PMID:11712666; http://dx.doi.org/10.1016/ S0024-3205(01)01332-7 (Pubitemid 32972293)
5. White SA, Hughes D P, Contractor HH, London NJ. A comparison of cross sectional surface area densities between adult and juvenile porcine islets of Langerhans. Horm Metab Res 1999; 31:519-24; PMID:10569254; http://dx.doi.org/10. 1055/s-2007-978787 (Pubitemid 29507831)
6. Baetens D, Malaisse-Lagae F, Perrelet A, Orci L. Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans. Science 1979; 206:1323-5; PMID:390711; http://dx.doi.org/10.1126/science.390711 (Pubitemid 10170025)
7. Elayat AA, el-Naggar MM, Tahir M. An immunocyto-chemical and morphometric study of the rat pancreatic islets. J Anat 1995; 186:629-37; PMID:7559135
8. Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A 2006; 103:2334-9; PMID:16461897; http://dx.doi.org/10.1073/pnas.0510790103 (Pubitemid 43271670)
9. Bosco D, Armanet M, Morel P, Niclauss N, Sgroi A, Muller YD, et al. Unique arrangement of α-and β-cells in human islets of Langerhans. Diabetes 2010; 59:1202-10; PMID:20185817; http://dx.doi.org/10.2337/db09-1177
10. Bonner-Weir S, Like AA. A dual population of islets of Langerhans in bovine pancreas. Cell Tissue Res 1980; 206:157-70; PMID:6986987; http://dx.doi.org/10.1007/BF00233616 (Pubitemid 10098669)
11. Huang HH, Novikova L, Williams SJ, Smirnova I V, Stehno-Bittel L. Low insulin content of large islet population is present in situ and in isolated islets. Islets 2011; 3:6-13; PMID:21325888; http://dx.doi.org/10.4161/isl.3.1. 14132
12. Pepin J, Singh H, Pairent FW, Appert HE, Howard JM. A study of insulin secretion in thoracic duct lymph of the dog. Ann Surg 1970; 172:56-60; PMID:4316644
13. Rasio EA, Hampers CL, Soeldner JS, Cahill GF Jr. Diffusion of glucose, insulin, inulin, and Evans blue protein into thoracic duct lymph of man. J Clin Invest 1967; 46:903-10; PMID:6026096; http://dx.doi.org/10.1172/JCI105596
14. Heller RS. The comparative anatomy of islets. Adv Exp Med Biol 2010; 654:21-37; PMID:20217492; http://dx.doi.org/10.1007/978-90-481-3271-3-2
15. Kaihoh T, Masuda T, Sasano N, Takahashi T. The size and number of Langerhans islets correlated with their endocrine function: a morphometry on immunostained serial sections of adult human pancreases. Tohoku J Exp Med 1986; 149:1-10; PMID:3526638; http://dx.doi.org/10.1620/tjem.149.1 (Pubitemid 16056425)
16. Rackham CL, Jones PM, King AJ. Maintenance of islet morphology is beneficial for transplantation outcome in diabetic mice. PLoS One 2013; 8:e57844; PMID:23451276; http://dx.doi.org/10.1371/journal.pone.0057844
17. MacGregor RR, Williams SJ, Tong PY, Kover K, Moore W V, Stehno-Bittel L. Small rat islets are superior to large islets in in vitro function and in transplantation outcomes. Am J Physiol Endocrinol Metab 2006; 290:E771-9; PMID:16303846; http://dx.doi.org/10.1152/ajpendo.00097.2005
18. Williams S, Huang HH, Kover K, Moore W, Berkland C, Singh M, et al. Reduction of diffusion barriers in isolated islets improves survival, but not insulin secretion or transplantation outcome. Organogenesis 2010; 6:115-24; PMID:20885858; http://dx.doi.org/10.4161/org.6.2.10373
19. Lehmann R, Zuellig RA, Kugelmeier P, Baenninger PB, Moritz W, Perren A, et al. Superiority of small islets in human islet transplantation. Diabetes 2007; 56:594-603; PMID:17327426; http://dx.doi.org/10.2337/db06-0779 (Pubitemid 46348450)
20. Fujita Y, Takita M, Shimoda M, Itoh T, Sugimoto K, Noguchi H, et al. Large human islets secrete less insulin per islet equivalent than smaller islets in vitro. Islets 2011; 3:1-5; PMID:21266855; http://dx.doi.org/10.4161/isl.3.1. 14131
21. Omori K, Mitsuhashi M, Todorov I, Rawson J, Shiang KD, Kandeel F, et al. Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation. Transplantation 2010; 89:146-54; PMID:20098276; http://dx.doi.org/10.1097/TP.0b013e3181c4218d
22. O'Sullivan ES, Johnson AS, Omer A, Hollister-Lock J, Bonner-Weir S, Colton CK, et al. Rat islet cell aggregates are superior to islets for transplantation in microcapsules. Diabetologia 2010; 53:937-45; PMID:20101386; http://dx.doi.org/10.1007/s00125-009-1653-8
23. Williams SJ, Schwasinger-Schmidt T, Zamierowski D, Stehno-Bittel L. Diffusion into human islets is limited to molecules below 10 kDa. Tissue Cell 2012; 44:332-41; PMID:22717091; http://dx.doi.org/10.1016/j.tice.2012.05.001